Ferroptosis in hepatic ischemia‑reperfusion injury: Regulatory mechanisms and new methods for therapy (Review)

  • Authors:
    • Linfeng Luo
    • Guoheng Mo
    • Deqiang Huang
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  • Published online on: January 24, 2021     https://doi.org/10.3892/mmr.2021.11864
  • Article Number: 225
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Abstract

Ischemia‑reperfusion injury (IRI), also called reoxygenation injury, is the outcome of inflammatory processes and oxidative damage through the induction of oxidative stress. In the clinical setting, IRI contributes to severe hepatic injury, including liver cell death by apoptosis and ferroptosis. Ferroptosis is a novel type of cell death in hepatic IRI that involves small molecules that inhibit glutathione biosynthesis or glutathione peroxidase 4 (GPX4), which is a glutathione‑dependent antioxidant enzyme, causing mitochondrial damage. Currently, ferroptosis has been systematically described in neurological settings, kidney diseases and different types of cancer, while few studies have analysed the presence of ferroptosis and the regulatory mechanism of ferroptosis in hepatic IRI. Exploring the exact role played by ferroptosis in the liver following hepatic IRI in accordance with existing evidence and mechanisms could guide potential therapeutic interventions and provide a novel research avenue.
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March-2021
Volume 23 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos Publications style
Luo L, Mo G and Huang D: Ferroptosis in hepatic ischemia‑reperfusion injury: Regulatory mechanisms and new methods for therapy (Review). Mol Med Rep 23: 225, 2021
APA
Luo, L., Mo, G., & Huang, D. (2021). Ferroptosis in hepatic ischemia‑reperfusion injury: Regulatory mechanisms and new methods for therapy (Review). Molecular Medicine Reports, 23, 225. https://doi.org/10.3892/mmr.2021.11864
MLA
Luo, L., Mo, G., Huang, D."Ferroptosis in hepatic ischemia‑reperfusion injury: Regulatory mechanisms and new methods for therapy (Review)". Molecular Medicine Reports 23.3 (2021): 225.
Chicago
Luo, L., Mo, G., Huang, D."Ferroptosis in hepatic ischemia‑reperfusion injury: Regulatory mechanisms and new methods for therapy (Review)". Molecular Medicine Reports 23, no. 3 (2021): 225. https://doi.org/10.3892/mmr.2021.11864