Open Access

Inflammatory response in epilepsy is mediated by glial cell gap junction pathway (Review)

  • Authors:
    • Guangliang Wang
    • Jiangtao Wang
    • Cuijuan Xin
    • Jinyu Xiao
    • Jianmin Liang
    • Xuemei Wu
  • View Affiliations

  • Published online on: May 5, 2021     https://doi.org/10.3892/mmr.2021.12132
  • Article Number: 493
  • Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Epilepsy is a common neurological disease that affects more than 50 million people worldwide. Neuro­inflammation plays an important role in epilepsy. Activation of the immune system and an excessive inflammatory response can increase the frequency of seizures and increase the susceptibility to epilepsy. Therefore, anti-inflammatory therapies may have antiepileptic effects. Connexin 43 (Cx43) is a major component of astroglial hemichannels and gap junctions. Gap junctions are important for the direct exchange of substances and information between cells, as well as regulating the neuroinflammatory response, changing neuronal excitability, neuronal apoptosis, and synaptic remodeling. Cx43-mediated gap junction pathway can be crucial in epilepsy-induced neuroinflammatory cascades. Further, pro-inflammatory cytokines may in turn directly affect the expression of the Cx43 protein in astrocytes. Therefore, examining the association between neuroinflammation and epilepsy can be instrumental in uncovering the pathogenesis of epilepsy, which can lead to the development of novel and more effective antiepileptic drugs.
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July-2021
Volume 24 Issue 1

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Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Wang G, Wang J, Xin C, Xiao J, Liang J and Wu X: Inflammatory response in epilepsy is mediated by glial cell gap junction pathway (Review). Mol Med Rep 24: 493, 2021
APA
Wang, G., Wang, J., Xin, C., Xiao, J., Liang, J., & Wu, X. (2021). Inflammatory response in epilepsy is mediated by glial cell gap junction pathway (Review). Molecular Medicine Reports, 24, 493. https://doi.org/10.3892/mmr.2021.12132
MLA
Wang, G., Wang, J., Xin, C., Xiao, J., Liang, J., Wu, X."Inflammatory response in epilepsy is mediated by glial cell gap junction pathway (Review)". Molecular Medicine Reports 24.1 (2021): 493.
Chicago
Wang, G., Wang, J., Xin, C., Xiao, J., Liang, J., Wu, X."Inflammatory response in epilepsy is mediated by glial cell gap junction pathway (Review)". Molecular Medicine Reports 24, no. 1 (2021): 493. https://doi.org/10.3892/mmr.2021.12132