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Article Open Access

Regulation of angiogenesis by microRNAs in cancer

  • Authors:
    • Qi Zheng
    • Wei Hou
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China
    Copyright: © Zheng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 583
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    Published online on: June 15, 2021
       https://doi.org/10.3892/mmr.2021.12222
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Abstract

MicroRNAs (miRs) are endogenous, small, non‑coding RNA molecules with ~22 nucleotides, and are involved in regulating the expression of multiple genes and controlling cellular functions. miRs serve key roles in angiogenesis by regulating the proliferation, differentiation, apoptosis and migration of endothelial cells. Regulation of angiogenesis is essential for several physiological and pathological processes, particularly for tumor development and progression. Therefore, it is important to investigate the roles served by miRs in angiogenesis as this may aid in discovering novel strategies for treating tumors via modulating angiogenesis. In this review, miRNA biogenesis, regulation and functions are described with new information and corresponding references. In particular, the latest advances in the role of various miRs and their target genes involved in tumor angiogenesis were updated. Next, different signaling pathways by which miRNAs could be regulated in different types of tumor progression were addressed. Furthermore, the potential clinical value of miRs as biomarkers for diagnosing and monitoring the response to therapy, as well as their ability to regulate tumor angiogenesis and the mechanism underlying this regulation, were investigated.
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Copy and paste a formatted citation
Spandidos Publications style
Zheng Q and Hou W: Regulation of angiogenesis by microRNAs in cancer. Mol Med Rep 24: 583, 2021.
APA
Zheng, Q., & Hou, W. (2021). Regulation of angiogenesis by microRNAs in cancer. Molecular Medicine Reports, 24, 583. https://doi.org/10.3892/mmr.2021.12222
MLA
Zheng, Q., Hou, W."Regulation of angiogenesis by microRNAs in cancer". Molecular Medicine Reports 24.2 (2021): 583.
Chicago
Zheng, Q., Hou, W."Regulation of angiogenesis by microRNAs in cancer". Molecular Medicine Reports 24, no. 2 (2021): 583. https://doi.org/10.3892/mmr.2021.12222
Copy and paste a formatted citation
x
Spandidos Publications style
Zheng Q and Hou W: Regulation of angiogenesis by microRNAs in cancer. Mol Med Rep 24: 583, 2021.
APA
Zheng, Q., & Hou, W. (2021). Regulation of angiogenesis by microRNAs in cancer. Molecular Medicine Reports, 24, 583. https://doi.org/10.3892/mmr.2021.12222
MLA
Zheng, Q., Hou, W."Regulation of angiogenesis by microRNAs in cancer". Molecular Medicine Reports 24.2 (2021): 583.
Chicago
Zheng, Q., Hou, W."Regulation of angiogenesis by microRNAs in cancer". Molecular Medicine Reports 24, no. 2 (2021): 583. https://doi.org/10.3892/mmr.2021.12222
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