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Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model

  • Authors:
    • Han Li
    • Dong Peng
    • Shi-Jie Zhang
    • Yang Zhang
    • Qi Wang
    • Li Guan
  • View Affiliations / Copyright

    Affiliations: College of Basic Medicine, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510006, P.R. China, Department of Neurology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, Guangdong 510120, P.R. China, Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, Guangdong 510405, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 791
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    Published online on: September 10, 2021
       https://doi.org/10.3892/mmr.2021.12431
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Abstract

Stroke is one of the main causes of disease‑related mortality worldwide. Buyang Huanwu Decoction (BHD) has been used to protect against stroke and stroke‑induced disability for several years in China. Studies have shown that BHD can relieve neuronal damage in rats with cerebral ischemia/reperfusion (I/R) injury. However, the mechanism remains unclear. A middle cerebral artery occlusion and reperfusion (MCAO‑R) model was used in the present study. The animals were treated with BHD (5, 10 and 20 g/kg) or rapamycin. Infarct size and modified neurological severity score were calculated on day 5 following MCAO‑R surgery. Cellular changes around the ischemic penumbra were revealed by hematoxylin and eosin and Nissl staining. The protein expression levels of nestin, brain‑derived neurotrophic factor (BDNF), doublecortin on the X chromosome (DCX) and autophagy‑related proteins (beclin 1, LC3‑II and p62) in the peri‑ischemic area of the brain were detected. The results demonstrated that post‑surgical treatment with BHD reduced the brain infarct size and improved neurological deficits in MCAO‑R rats. BHD protected against MCAO‑R‑induced neuronal impairment and promoted neurogenesis, increased the protein expression of nestin, BDNF and DCX and markedly enhanced autophagy by increasing beclin 1 and LC3‑II and decreasing p62. Meanwhile, BHD promoted the expression of sirtuin 1 (SIRT1), an important regulator of autophagy. In conclusion, the present study suggested that post‑surgical treatment with BHD could protect rat brains from I/R injury, potentially through the SIRT1/autophagy pathway.
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View References

1 

Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, et al: Heart disease and stroke statistics-2018 update: A report from the American heart association. Circulation. 137:e67–e492. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Zhou M, Wang H, Zhu J, Chen W, Wang L, Liu S, Li Y, Wang L, Liu Y, Yin P, et al: Cause-specific mortality for 240 causes in China during 1990–2013: A systematic subnational analysis for the Global Burden of Disease Study 2013. Lancet. 387:251–272. 2016. View Article : Google Scholar : PubMed/NCBI

3 

GBD 2016 Lifetime Risk of Stroke Collaborators, ; Feigin VL, Nguyen G, Cercy K, Johnson CO, Alam T, Parmar PG, Abajobir AA, Abate KH, Abd-Allah F, et al: Global, regional, and country-specific lifetime risks of stroke, 1990 and 2016. N Engl J Med. 379:2429–2437. 2018. View Article : Google Scholar : PubMed/NCBI

4 

Dai W, Liu X, Zhang Z, Chen J, Guo R, Zheng H, Jin X, Wen S, Gao Y, Li T, et al: A two-level model for the analysis of syndrome of acute ischemic stroke: From diagnostic model to molecular mechanism. Evid Based Complement Alternat Med. 2013:2930102013. View Article : Google Scholar : PubMed/NCBI

5 

Han CH, Kim M, Cho SY, Jung WS, Moon SK, Park JM, Ko CN, Cho KH and Kwon S: Adjunctive herbal medicine treatment for patients with acute ischemic stroke: A systematic review and meta-analysis. Complement Ther Clin Pract. 33:124–137. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Hodges H: Graft-induced recovery of cognitive function after diffuse and focal brain damage: Implications for neural transplantation in man. Zh Vyssh Nerv Deiat Im I P Pavlova. 45:29–58. 1995.PubMed/NCBI

7 

Hossmann KA: Pathophysiology and therapy of experimental stroke. Cell Mol Neurobiol. 26:1057–1083. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Patel RAG and McMullen PW: Neuroprotection in the treatment of acute ischemic stroke. Prog Cardiovasc Dis. 59:542–548. 2017. View Article : Google Scholar : PubMed/NCBI

9 

George PM and Steinberg GK: Novel stroke therapeutics: Unraveling stroke pathophysiology and its impact on clinical treatments. Neuron. 87:297–309. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Prabhakaran S, Ruff I and Bernstein RA: Acute stroke intervention: A systematic review. JAMA. 313:1451–1462. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Zhang S, Boyd J, Delaney K and Murphy TH: Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. J Neurosci. 25:5333–5338. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Nakagiri A, Sunamoto M and Murakami M: NADPH oxidase is involved in ischaemia/reperfusion-induced damage in rat gastric mucosa via ROS production-role of NADPH oxidase in rat stomachs. Inflammopharmacology. 15:278–281. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Gage FH: Adult neurogenesis in mammals. Science. 364:827–828. 2019. View Article : Google Scholar : PubMed/NCBI

14 

Cavallucci V, Fidaleo M and Pani G: Nutrients and neurogenesis: The emerging role of autophagy and gut microbiota. Curr Opin Pharmacol. 50:46–52. 2020. View Article : Google Scholar : PubMed/NCBI

15 

Duan X, Chen B, Cui Y, Zhou L, Wu C, Yang Z, Wen Y, Miao X, Li Q, Xiong L and He J: Ready player one? Autophagy shapes resistance to photodynamic therapy in cancers. Apoptosis. 23:587–606. 2018. View Article : Google Scholar : PubMed/NCBI

16 

Liang K, Zhu L, Tan J, Shi W, He Q and Yu B: Identification of autophagy signaling network that contributes to stroke in the ischemic rodent brain via gene expression. Neurosci Bull. 31:480–490. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Sheng R, Zhang LS, Han R, Liu XQ, Gao B and Qin ZH: Autophagy activation is associated with neuroprotection in a rat model of focal cerebral ischemic preconditioning. Autophagy. 6:482–494. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Su J, Zhang T, Wang K, Zhu T and Li X: Autophagy activation contributes to the neuroprotection of remote ischemic perconditioning against focal cerebral ischemia in rats. Neurochem Res. 39:2068–2077. 2014. View Article : Google Scholar : PubMed/NCBI

19 

Gao L, Jiang T, Guo J, Liu Y, Cui G, Gu L, Su L and Zhang Y: Inhibition of autophagy contributes to ischemic postconditioning-induced neuroprotection against focal cerebral ischemia in rats. PLoS One. 7:e460922012. View Article : Google Scholar : PubMed/NCBI

20 

Vázquez P, Arroba AI, Cecconi F, de la Rosa EJ, Boya P and de Pablo F: Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells. Autophagy. 8:187–199. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Lv X, Jiang H, Li B, Liang Q, Wang S, Zhao Q and Jiao J: The crucial role of Atg5 in cortical neurogenesis during early brain development. Sci Rep. 4:60102014. View Article : Google Scholar : PubMed/NCBI

22 

Chen X, Pan Z, Fang Z, Lin W, Wu S, Yang F, Li Y, Fu H, Gao H and Li S: Omega-3 polyunsaturated fatty acid attenuates traumatic brain injury-induced neuronal apoptosis by inducing autophagy through the upregulation of SIRT1-mediated deacetylation of Beclin-1. J Neuroinflammation. 15:3102018. View Article : Google Scholar : PubMed/NCBI

23 

Tang Q, Len Q, Liu Z and Wang W: Overexpression of miR-22 attenuates oxidative stress injury in diabetic cardiomyopathy via Sirt 1. Cardiovasc Ther. 36:2018. View Article : Google Scholar

24 

Carloni S, Albertini MC, Galluzzi L, Buonocore G, Proietti F and Balduini W: Melatonin reduces endoplasmic reticulum stress and preserves sirtuin 1 expression in neuronal cells of newborn rats after hypoxia-ischemia. J Pineal Res. 57:192–199. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Wang Q, Liu M, Liu WW, Hao WB, Tashiro S, Onodera S and Ikejima T: In vivo recovery effect of silibinin treatment on streptozotocin-induced diabetic mice is associated with the modulations of Sirt-1 expression and autophagy in pancreatic β-cell. J Asian Nat Prod Res. 14:413–423. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Guo Q, Zhong M, Xu H, Mao X, Zhang Y and Lin N: A systems biology perspective on the molecular mechanisms underlying the therapeutic effects of buyang huanwu decoction on ischemic stroke. Rejuvenation Res. 18:313–325. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Hao CZ, Wu F, Shen J, Lu L, Fu DL, Liao WJ and Zheng GQ: Clinical efficacy and safety of buyang huanwu decoction for acute ischemic stroke: A systematic review and meta-analysis of 19 randomized controlled trials. Evid Based Complement Alternat Med. 2012:6301242012. View Article : Google Scholar : PubMed/NCBI

28 

Zheng XW, Shan CS, Xu QQ, Wang Y, Shi YH, Wang Y and Zheng GQ: Buyang huanwu decoction targets SIRT1/VEGF pathway to promote angiogenesis after cerebral ischemia/reperfusion injury. Front Neurosci. 12:9112018. View Article : Google Scholar : PubMed/NCBI

29 

Liu B, Cai G, Yi J and Chen X: Buyang huanwu decoction regulates neural stem cell behavior in ischemic brain. Neural Regen Res. 8:2336–2342. 2013.PubMed/NCBI

30 

Luo L, Deng S, Yi J, Zhou S, She Y and Liu B: Buyang huanwu decoction ameliorates poststroke depression via promoting neurotrophic pathway mediated neuroprotection and neurogenesis. Evid Based Complement Alternat Med. 2017:40726582017. View Article : Google Scholar : PubMed/NCBI

31 

Wang Y, Liu X, Hu T, Li X, Chen Y, Xiao G, Huang J, Chang Y, Zhu Y, Zhang H and Wang Y: Astragalus saponins improves stroke by promoting the proliferation of neural stem cells through phosphorylation of Akt. J Ethnopharmacol. 277:1142242021. View Article : Google Scholar : PubMed/NCBI

32 

Li JH, Liu AJ, Li HQ, Wang Y, Shang HC and Zheng GQ: Buyang huanwu decoction for healthcare: Evidence-based theoretical interpretations of treating different diseases with the same method and target of vascularity. Evid Based Complement Alternat Med. 2014:5067832014. View Article : Google Scholar : PubMed/NCBI

33 

Zhang ZQ, Song JY, Jia YQ and Zhang YK: Buyanghuanwu decoction promotes angiogenesis after cerebral ischemia/reperfusion injury: Mechanisms of brain tissue repair. Neural Regen Res. 11:435–440. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Zhang WW, Xu F, Wang D, Ye J and Cai SQ: Buyang huanwu decoction ameliorates ischemic stroke by modulating multiple targets with multiple components: In vitro evidences. Chin J Nat Med. 16:194–202. 2018.PubMed/NCBI

35 

Luo C, Ouyang MW, Fang YY, Li SJ, Zhou Q, Fan J, Qin ZS and Tao T: Dexmedetomidine protects mouse brain from ischemia-reperfusion injury via inhibiting neuronal autophagy through Up-Regulating HIF-1α. Front Cell Neurosci. 11:1972017. View Article : Google Scholar : PubMed/NCBI

36 

Shen J, Zhu Y, Huang K, Jiang H, Shi C, Xiong X, Zhan R and Pan J: Buyang Huanwu Decoction attenuates H2O2-induced apoptosis by inhibiting reactive oxygen species-mediated mitochondrial dysfunction pathway in human umbilical vein endothelial cells. BMC Complement Altern Med. 16:1542016. View Article : Google Scholar : PubMed/NCBI

37 

Huang YT, Chen YY, Lai YH, Cheng CC, Lin TC, Su YS, Liu CH and Lai PC: Resveratrol alleviates the cytotoxicity induced by the radiocontrast agent, ioxitalamate, by reducing the production of reactive oxygen species in HK-2 human renal proximal tubule epithelial cells in vitro. Int J Mol Med. 37:83–91. 2016. View Article : Google Scholar : PubMed/NCBI

38 

Chong ZZ, Shang YC, Zhang L, Wang S and Maiese K: Mammalian target of rapamycin: Hitting the bull's-eye for neurological disorders. Oxid Med Cell Longev. 3:374–391. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Xia D, Zhang Z and Zhao Y: Acteoside attenuates oxidative stress and neuronal apoptosis in rats with focal cerebral ischemia-reperfusion injury. Biol Pharm Bull. 41:1645–1651. 2018. View Article : Google Scholar : PubMed/NCBI

40 

Yang J, Yan H, Li S and Zhang M: Berberine ameliorates MCAO induced Cerebral Ischemia/Reperfusion injury via activation of the BDNF-TrkB-PI3K/Akt signaling pathway. Neurochem Res. 43:702–710. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Li YQ, Hui ZR, Tao T, Shao KY, Liu Z, Li M and Gu LL: Protective effect of hypoxia inducible factor-1α gene therapy using recombinant adenovirus in cerebral ischaemia-reperfusion injuries in rats. Pharm Biol. 58:438–446. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Song M, Mohamad O, Gu X, Wei L and Yu SP: Restoration of intracortical and thalamocortical circuits after transplantation of bone marrow mesenchymal stem cells into the ischemic brain of mice. Cell Transplant. 22:2001–2015. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Lee JH, Yu WH, Kumar A, Lee S, Mohan PS, Peterhoff CM, Wolfe DM, Martinez-Vicente M, Massey AC, Sovak G, et al: Lysosomal proteolysis and autophagy require presenilin 1 and are disrupted by Alzheimer-related PS1 mutations. Cell. 141:1146–1158. 2010. View Article : Google Scholar : PubMed/NCBI

44 

Hou K, Xu D, Li F, Chen S and Li Y: The progress of neuronal autophagy in cerebral ischemia stroke: Mechanisms, roles and research methods. J Neurol Sci. 400:72–82. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Carloni S, Girelli S, Scopa C, Buonocore G, Longini M and Balduini W: Activation of autophagy and Akt/CREB signaling play an equivalent role in the neuroprotective effect of rapamycin in neonatal hypoxia-ischemia. Autophagy. 6:366–377. 2010. View Article : Google Scholar : PubMed/NCBI

46 

Zhang Y, Cao Y and Liu C: Autophagy and ischemic stroke. Adv Exp Med Biol. 1207:111–134. 2020. View Article : Google Scholar : PubMed/NCBI

47 

Kim KJ and Namgung U: Facilitating effects of Buyang Huanwu decoction on axonal regeneration after peripheral nerve transection. J Ethnopharmacol. 213:56–64. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Zhang M, Chai Y, Liu T, Xu N and Yang C: Synergistic effects of Buyang Huanwu decoction and embryonic neural stem cell transplantation on the recovery of neurological function in a rat model of spinal cord injury. Exp Ther Med. 9:1141–1148. 2015. View Article : Google Scholar : PubMed/NCBI

49 

Min L, Ling W, Hua R, Qi H, Chen S, Wang H, Tang L and Shangguan W: Anti-angiogenic therapy for normalization of tumor vasculature: A potential effect of Buyang Huanwu decoction on nude mice bearing human hepatocellular carcinoma xenografts with high metastatic potential. Mol Med Rep. 13:2518–2526. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Wu L, Zhang W, Li H, Chen BY, Zhang GM, Tang YH, He FY and Deng CQ: Inhibition of aortic intimal hyperplasia and cell cycle protein and extracellular matrix protein expressions by BuYang HuanWu Decoction. J Ethnopharmacol. 125:423–435. 2009. View Article : Google Scholar : PubMed/NCBI

51 

Rodrigo R, Fernández-Gajardo R, Gutiérrez R, Matamala JM, Carrasco R, Miranda-Merchak A and Feuerhake W: Oxidative stress and pathophysiology of ischemic stroke: Novel therapeutic opportunities. CNS Neurol Disord Drug Targets. 12:698–714. 2013. View Article : Google Scholar : PubMed/NCBI

52 

Orellana-Urzúa S, Rojas I, Líbano L and Rodrigo R: Pathophysiology of ischemic stroke: Role of oxidative stress. Curr Pharm Des. 26:4246–4260. 2020. View Article : Google Scholar : PubMed/NCBI

53 

Wu MY, Yiang GT, Liao WT, Tsai AP, Cheng YL, Cheng PW, Li CY and Li CJ: Current mechanistic concepts in ischemia and reperfusion injury. Cell Physiol Biochem. 46:1650–1667. 2018. View Article : Google Scholar : PubMed/NCBI

54 

Filomeni G, De Zio D and Cecconi F: Oxidative stress and autophagy: The clash between damage and metabolic needs. Cell Death Differ. 22:377–388. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Yamashita T and Abe K: Recent progress in therapeutic strategies for ischemic stroke. Cell Transplant. 25:893–898. 2016. View Article : Google Scholar : PubMed/NCBI

56 

Kalogeris T, Bao Y and Korthuis RJ: Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning. Redox Biol. 2:702–714. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Lum JJ, DeBerardinis RJ and Thompson CB: Autophagy in metazoans: Cell survival in the land of plenty. Nat Rev Mol Cell Biol. 6:439–448. 2005. View Article : Google Scholar : PubMed/NCBI

58 

Kroemer G and Jäättelä M: Lysosomes and autophagy in cell death control. Nat Rev Cancer. 5:886–897. 2005. View Article : Google Scholar : PubMed/NCBI

59 

Eriksson PS, Perfilieva E, Björk-Eriksson T, Alborn AM, Nordborg C, Peterson DA and Gage FH: Neurogenesis in the adult human hippocampus. Nat Med. 4:1313–1317. 1998. View Article : Google Scholar : PubMed/NCBI

60 

Zhang RL, Zhang ZG, Zhang L and Chopp M: Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia. Neuroscience. 105:33–41. 2001. View Article : Google Scholar : PubMed/NCBI

61 

Jin K, Minami M, Lan JQ, Mao XO, Batteur S, Simon RP and Greenberg DA: Neurogenesis in dentate subgranular zone and rostral subventricular zone after focal cerebral ischemia in the rat. Proc Natl Acad Sci USA. 98:4710–4715. 2001. View Article : Google Scholar : PubMed/NCBI

62 

Doetsch F, Caillé I, Lim DA, García-Verdugo JM and Alvarez-Buylla A: Subventricular zone astrocytes are neural stem cells in the adult mammalian brain. Cell. 97:703–716. 1999. View Article : Google Scholar : PubMed/NCBI

63 

Palmer TD, Takahashi J and Gage FH: The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci. 8:389–404. 1997. View Article : Google Scholar : PubMed/NCBI

64 

Boya P, Codogno P and Rodriguez-Muela N: Autophagy in stem cells: Repair, remodelling and metabolic reprogramming. Development. 145:dev1465062018. View Article : Google Scholar : PubMed/NCBI

65 

Dhaliwal J, Xi Y, Bruel-Jungerman E, Germain J, Francis F and Lagace DC: Doublecortin (DCX) is not essential for survival and differentiation of Newborn Neurons in the adult mouse dentate gyrus. Front Neurosci. 9:4942015.PubMed/NCBI

66 

Fasemore TM, Patzke N, Kaswera-Kyamakya C, Gilissen E, Manger PR and Ihunwo AO: The Distribution of Ki-67 and doublecortin-immunopositive cells in the brains of three strepsirrhine primates: Galago demidoff, perodicticus potto, and Lemur catta. Neuroscience. 372:46–57. 2018. View Article : Google Scholar : PubMed/NCBI

67 

Shahsavani M, Pronk RJ, Falk R, Lam M, Moslem M, Linker SB, Salma J, Day K, Schuster J, Anderlid BM, et al: An in vitro model of lissencephaly: Expanding the role of DCX during neurogenesis. Mol Psychiatry. 23:1674–1684. 2018. View Article : Google Scholar : PubMed/NCBI

68 

Bojnordi MN, Azizi H, Skutella T, Movahedin M, Pourabdolhossein F, Shojaei A and Hamidabadi HG: Differentiation of spermatogonia stem cells into functional mature neurons characterized with differential gene expression. Mol Neurobiol. 54:5676–5682. 2017. View Article : Google Scholar : PubMed/NCBI

69 

Chen X, Chen H, He Y, Fu S, Liu H, Wang Q and Shen J: Proteomics-guided study on buyang huanwu decoction for its neuroprotective and neurogenic mechanisms for transient ischemic stroke: Involvements of EGFR/PI3K/Akt/Bad/14-3-3 and Jak2/Stat3/Cyclin D1 signaling cascades. Mol Neurobiol. 57:4305–4321. 2020. View Article : Google Scholar : PubMed/NCBI

70 

Lapierre LR, Kumsta C, Sandri M, Ballabio A and Hansen M: Transcriptional and epigenetic regulation of autophagy in aging. Autophagy. 11:867–880. 2015. View Article : Google Scholar : PubMed/NCBI

71 

Zhang JF, Zhang YL and Wu YC: The role of sirt1 in ischemic stroke: Pathogenesis and therapeutic strategies. Front Neurosci. 12:8332018. View Article : Google Scholar : PubMed/NCBI

72 

Wang P, Guan YF, Du H, Zhai QW, Su DF and Miao CY: Induction of autophagy contributes to the neuroprotection of nicotinamide phosphoribosyltransferase in cerebral ischemia. Autophagy. 8:77–87. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li H, Peng D, Zhang S, Zhang Y, Wang Q and Guan L: Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model. Mol Med Rep 24: 791, 2021.
APA
Li, H., Peng, D., Zhang, S., Zhang, Y., Wang, Q., & Guan, L. (2021). Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model. Molecular Medicine Reports, 24, 791. https://doi.org/10.3892/mmr.2021.12431
MLA
Li, H., Peng, D., Zhang, S., Zhang, Y., Wang, Q., Guan, L."Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model". Molecular Medicine Reports 24.5 (2021): 791.
Chicago
Li, H., Peng, D., Zhang, S., Zhang, Y., Wang, Q., Guan, L."Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model". Molecular Medicine Reports 24, no. 5 (2021): 791. https://doi.org/10.3892/mmr.2021.12431
Copy and paste a formatted citation
x
Spandidos Publications style
Li H, Peng D, Zhang S, Zhang Y, Wang Q and Guan L: Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model. Mol Med Rep 24: 791, 2021.
APA
Li, H., Peng, D., Zhang, S., Zhang, Y., Wang, Q., & Guan, L. (2021). Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model. Molecular Medicine Reports, 24, 791. https://doi.org/10.3892/mmr.2021.12431
MLA
Li, H., Peng, D., Zhang, S., Zhang, Y., Wang, Q., Guan, L."Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model". Molecular Medicine Reports 24.5 (2021): 791.
Chicago
Li, H., Peng, D., Zhang, S., Zhang, Y., Wang, Q., Guan, L."Buyang Huanwu Decoction promotes neurogenesis via sirtuin 1/autophagy pathway in a cerebral ischemia model". Molecular Medicine Reports 24, no. 5 (2021): 791. https://doi.org/10.3892/mmr.2021.12431
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