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Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways

  • Authors:
    • Namkyung Kim
    • Soyoung Lee
    • Jinjoo Kang
    • Taeg Kyu Kwon
    • Dongwoo Khang
    • Sang-Hyun Kim
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea, Immunoregulatory Materials Research Center, Korea Research Institute of Bioscience and Biotechnology, Jeongeup, Jeollabuk‑do 56212, Republic of Korea, Department of Immunology, School of Medicine, Keimyung University, Daegu 42601, Republic of Korea, Department of Physiology, School of Medicine, Gachon University, Yeonsu, Incheon 21999, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 859
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    Published online on: October 19, 2021
       https://doi.org/10.3892/mmr.2021.12499
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Abstract

Psoriasis, a chronic inflammatory skin disease, is characterized by the excessive proliferation and impaired differentiation of epidermal keratinocytes and is accompanied by the increased infiltration of inflammatory cells. The condition requires long‑term treatment and has no definitive cure. Hence, supplements and therapeutic agents have been intensely investigated. Gomisin M2 (GM2), a lignan extracted from Schisandra chinensis (Turcz). Baill. (Schisandraceae; S. chinensis), has demonstrated diverse pharmacological properties, including anticancer, anti‑inflammatory and antiallergic effects. Based on these findings, the present study examined the effects of GM2 on an imiquimod (IMQ)‑induced psoriasis mouse model and on keratinocytes stimulated by tumor necrosis factor (TNF)‑α and interferon‑γ. IMQ was topically applied to the back skin of mice for 7 consecutive days, and the mice were orally administered CD. These results showed that the oral administration of GM2 suppressed the symptoms of psoriasis, as evidenced by reductions in skin thickness, psoriasis area severity index scores for psoriasis lesions, transepidermal water loss and myeloperoxidase (MPO)‑associated cell infiltration. Furthermore, GM2 reduced the pathologically increased levels of immunoglobulin G2a, MPO and TNF‑α in the serum and T helper (Th)1 and Th17 cell populations in the spleen. GM2 decreased the gene expression of inflammatory‑related cytokines and chemokines and inhibited the expression of signal transducer and activator of transcription 1 and nuclear factor‑κB in the activated keratinocytes. These results suggested that GM2 from S. chinensis is a potential therapeutic candidate to alleviate psoriasis‑like skin inflammation.
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Copy and paste a formatted citation
Spandidos Publications style
Kim N, Lee S, Kang J, Kwon TK, Khang D and Kim S: Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways. Mol Med Rep 24: 859, 2021.
APA
Kim, N., Lee, S., Kang, J., Kwon, T.K., Khang, D., & Kim, S. (2021). Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways. Molecular Medicine Reports, 24, 859. https://doi.org/10.3892/mmr.2021.12499
MLA
Kim, N., Lee, S., Kang, J., Kwon, T. K., Khang, D., Kim, S."Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways". Molecular Medicine Reports 24.6 (2021): 859.
Chicago
Kim, N., Lee, S., Kang, J., Kwon, T. K., Khang, D., Kim, S."Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways". Molecular Medicine Reports 24, no. 6 (2021): 859. https://doi.org/10.3892/mmr.2021.12499
Copy and paste a formatted citation
x
Spandidos Publications style
Kim N, Lee S, Kang J, Kwon TK, Khang D and Kim S: Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways. Mol Med Rep 24: 859, 2021.
APA
Kim, N., Lee, S., Kang, J., Kwon, T.K., Khang, D., & Kim, S. (2021). Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways. Molecular Medicine Reports, 24, 859. https://doi.org/10.3892/mmr.2021.12499
MLA
Kim, N., Lee, S., Kang, J., Kwon, T. K., Khang, D., Kim, S."Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways". Molecular Medicine Reports 24.6 (2021): 859.
Chicago
Kim, N., Lee, S., Kang, J., Kwon, T. K., Khang, D., Kim, S."Gomisin M2 alleviates psoriasis‑like skin inflammation by inhibiting inflammatory signaling pathways". Molecular Medicine Reports 24, no. 6 (2021): 859. https://doi.org/10.3892/mmr.2021.12499
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