Cardioprotective effects of hydrogen sulfide in attenuating myocardial ischemia‑reperfusion injury (Review)

Wu,Dan; Gu,Yijing; Zhu,Deqiu

doi:10.3892/mmr.2021.12515

Cardioprotective effects of hydrogen sulfide in attenuating myocardial ischemia‑reperfusion injury (Review)

Authors:
- Dan Wu
- Yijing Gu
- Deqiu Zhu
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Affiliations: Tongji Hospital, School of Medicine, Tongji University, Shanghai 200065, P.R. China
Published online on: October 29, 2021 https://doi.org/10.3892/mmr.2021.12515
Article Number: 875

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Abstract

Ischemic heart disease is one of the major causes of cardiovascular‑related mortality worldwide. Myocardial ischemia can be attenuated by reperfusion that restores the blood supply. However, injuries occur during blood flow restoration that induce cardiac dysfunction, which is known as myocardial ischemia‑reperfusion injury (MIRI). Hydrogen sulfide (H₂S), the third discovered endogenous gasotransmitter in mammals (after NO and CO), participates in various pathophysiological processes. Previous in vitro and in vivo research have revealed the protective role of H₂S in the cardiovascular system that render it useful in the protection of the myocardium against MIRI. The cardioprotective effects of H₂S in attenuating MIRI are summarized in the present review.

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