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Article Open Access

Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling

  • Authors:
    • Yimin Sun
    • Bingyan Liu
    • Jianping Xie
    • Xuefeng Jiang
    • Baolai Xiao
    • Xiaomiao Hu
    • Jinjian Xiang
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China, Department of Neurology, The First Affiliated Hospital of Yangtze University, Jingzhou, Hubei 434000, P.R. China
    Copyright: © Sun et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 181
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    Published online on: March 23, 2022
       https://doi.org/10.3892/mmr.2022.12697
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Abstract

Aspirin reduces the liver fibrosis index and inflammation in patients and rats. However, the specific mechanism underlying the effects of aspirin are yet to be elucidated. The present study aimed to investigate the effects of aspirin on thioacetamide (TAA)‑induced liver fibrosis in rats and hepatic stellate cells (HSCs) via the TGF‑β1/Smad signaling pathway. Liver fibrosis was induced in Sprague Dawley rats by intraperitoneal injection of 200 mg/kg TAA twice weekly for 8 weeks. Aspirin (30 mg/kg) was administered to rats by gavage once every morning over a period of 8 weeks. Masson's trichrome and H&E staining were used to detect and analyze the pathological changes in liver tissues. Western blot analysis and immunohistochemistry were applied to determine the protein expression levels of α‑smooth muscle actin (α‑SMA), collagen I, TGF‑β1, phosphorylated (p)‑Smad2 and p‑Smad3. In addition, reverse transcription‑quantitative PCR was performed to detect the mRNA expression levels of α‑SMA, collagen type I α 1 chain (COL1A1) and TGF‑β1. The results demonstrated that treatment with aspirin significantly reduced the serum levels of alanine aminotransferase, aspartate aminotransferase and hydroxyproline in the TAA + aspirin compared with that in the TAA group. In the rat liver fibrosis model, pathological changes in liver tissues were improved following treatment with aspirin. Similarly, a marked decrease was observed in protein expression levels of α‑SMA, collagen I, TGF‑β1, p‑Smad2 and p‑Smad3. Furthermore, aspirin administration decreased the mRNA levels of α‑SMA, COL1A1 and TGF‑β1. In addition, HSCs were treated with different concentrations of aspirin (10, 20 and 40 mmol/l), and the protein expression levels of α‑SMA, collagen I, TGF‑β1, p‑Smad2 and p‑Smad3 were reduced in a dose‑dependent manner. Overall, the present study showed that aspirin attenuated liver fibrosis and reduced collagen production by suppressing the TGF‑β1/Smad signaling pathway, thus revealing a potential mechanism of aspirin in the treatment of liver fibrosis.
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1 

Friedman SL: Liver fibrosis-from bench to bedside. J Hepatol. 38 (Suppl 1):S38–S53. 2003. View Article : Google Scholar : PubMed/NCBI

2 

Friedman SL: Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med. 328:1828–1835. 1993. View Article : Google Scholar : PubMed/NCBI

3 

Kisseleva T and Brenner DA: Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol. 22 (Suppl 1):S73–S78. 2007. View Article : Google Scholar : PubMed/NCBI

4 

Friedman SL: Evolving challenges in hepatic fibrosis. Nat Rev Gastroenterol Hepatol. 7:425–436. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Szabo G and Bala S: Alcoholic liver disease and the gut-liver axis. World J Gastroenterol. 16:1321–1329. 2010. View Article : Google Scholar : PubMed/NCBI

6 

Zhang D, Hao X, Xu L, Cui J, Xue L and Tian Z: Intestinal flora imbalance promotes alcohol-induced liver fibrosis by the TGFβ/smad signaling pathway in mice. Oncol Lett. 14:4511–4516. 2017. View Article : Google Scholar : PubMed/NCBI

7 

Yang Y, Kim B, Park YK, Koo SI and Lee JY: Astaxanthin prevents TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells. Biochim Biophys Acta. 1850:178–185. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Liu Q, Duan ZP, Ha DK, Bengmark S, Kurtovic J and Riordan SM: Synbiotic modulation of gut flora: Effect on minimal hepatic encephalopathy in patients with cirrhosis. Hepatology. 39:1441–1449. 2004. View Article : Google Scholar : PubMed/NCBI

9 

Vonkeman HE and van de Laar MA: Nonsteroidal anti-inflammatory drugs: Adverse effects and their prevention. Semin Arthritis Rheum. 39:294–312. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Berk M, Woods RL, Nelson MR, Shah RC, Reid CM, Storey E, Fitzgerald S, Lockery JE, Wolfe R, Mohebbi M, et al: Effect of aspirin vs. placebo on the prevention of depression in older people: A randomized clinical trial. JAMA Psychiatry. 77:1012–1020. 2020. View Article : Google Scholar : PubMed/NCBI

11 

Antman EM: Evaluating the cardiovascular safety of nonsteroidal anti-inflammatory drugs. Circulation. 135:2062–2072. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Henry WS, Laszewski T, Tsang T, Beca F, Beck AH, McAllister SS and Toker A: Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 Signaling. Cancer Res. 77:790–801. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Gray RT, Coleman HG, Hughes C, Murray LJ and Cardwell CR: Low-dose aspirin use and survival in colorectal cancer: Results from a population-based cohort study. BMC Cancer. 18:2282018. View Article : Google Scholar : PubMed/NCBI

14 

Jiang ZG, Feldbrügge L, Tapper EB, Popov Y, Ghaziani T, Afdhal N, Robson SC and Mukamal KJ: Aspirin use is associated with lower indices of liver fibrosis among adults in the United States. Aliment Pharmacol Ther. 43:734–743. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Li CJ, Yang ZH, Shi XL and Liu DL: Effects of aspirin and enoxaparin in a rat model of liver fibrosis. World J Gastroenterol. 23:6412–6419. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Liu Y, Nong L, Jia Y, Tan A, Duan L, Lu Y and Zhao J: Aspirin alleviates hepatic fibrosis by suppressing hepatic stellate cells activation via the TLR4/NF-κB pathway. Aging (Albany NY). 12:6058–6066. 2020. View Article : Google Scholar : PubMed/NCBI

17 

Zhang W, Chen XP, Zhang WG, Zhang F, Xiang S, Dong HH and Zhang L: Hepatic non-parenchymal cells and extracellular matrix participate in oval cell-mediated liver regeneration. World J Gastroenterol. 15:552–560. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

19 

Dranoff JA and Wells RG: Portal fibroblasts: Underappreciated mediators of biliary fibrosis. Hepatology. 51:1438–1444. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Sherman M and Klein A: AASLD single-topic research conference on hepatocellular carcinoma: Conference proceedings. Hepatology. 40:1465–1473. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Yanguas SC, Cogliati B, Willebrords J, Maes M, Colle I, van den Bossche B, de Oliveira C, Andraus W, Alves VAF, Leclercq I and Vinken M: Experimental models of liver fibrosis. Arch Toxicol. 90:1025–1048. 2016. View Article : Google Scholar : PubMed/NCBI

22 

Dai N, Zou Y, Zhu L, Wang HF and Dai MG: Antioxidant properties of proanthocyanidins attenuate carbon tetrachloride (CCl4)-induced steatosis and liver injury in rats via CYP2E1 regulation. J Med Food. 17:663–669. 2014. View Article : Google Scholar : PubMed/NCBI

23 

Li S, Zheng X, Zhang X, Yu H, Han B, Lv Y, Liu Y, Wang X and Zhang Z: Exploring the liver fibrosis induced by deltamethrin exposure in quails and elucidating the protective mechanism of resveratrol. Ecotoxicol Environ Saf. 207:1115012021. View Article : Google Scholar : PubMed/NCBI

24 

Simon TG, Henson J, Osganian S, Masia R, Chan AT, Chung RT and Corey KE: Daily aspirin use associated with reduced risk for fibrosis progression in patients with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 17:2776–2784.e2774. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Jiao W, Bai M, Yin H, Liu J, Sun J, Su X, Zeng H and Wen J: Therapeutic effects of an inhibitor of thioredoxin reductase on liver fibrosis by inhibiting the transforming growth factor-β1/smads pathway. Front Mol Biosci. 8:6901702021. View Article : Google Scholar : PubMed/NCBI

26 

Zhangdi HJ, Su SB, Wang F, Liang ZY, Yan YD, Qin SY and Jiang HX: Crosstalk network among multiple inflammatory mediators in liver fibrosis. World J Gastroenterol. 25:4835–4849. 2019. View Article : Google Scholar : PubMed/NCBI

27 

Cai X, Li Z, Zhang Q, Qu Y, Xu M, Wan X and Lu L: CXCL6-EGFR-induced Kupffer cells secrete TGF-β1 promoting hepatic stellate cell activation via the SMAD2/BRD4/C-MYC/EZH2 pathway in liver fibrosis. J Cell Mol Med. 22:5050–5061. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Wree A, Holtmann TM, Inzaugarat ME and Feldstein AE: Novel drivers of the inflammatory response in liver injury and fibrosis. Semin Liver Dis. 39:275–282. 2019. View Article : Google Scholar : PubMed/NCBI

29 

Chávez E, Castro-Sánchez L, Shibayama M, Tsutsumi V, Salazar EP, Moreno MG and Muriel P: Effects of acetyl salycilic acid and ibuprofen in chronic liver damage induced by CCl4. J Appl Toxicol. 32:51–59. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Shek FW and Benyon RC: How can transforming growth factor beta be targeted usefully to combat liver fibrosis? Eur J Gastroenterol Hepatol. 16:123–126. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Liu N, Feng J, Lu X, Yao Z, Liu Q, Lv Y, Han Y, Deng J and Zhou Y: Isorhamnetin inhibits liver fibrosis by reducing autophagy and inhibiting extracellular matrix formation via the TGF-β1/smad3 and TGF-β1/p38 MAPK pathways. Mediators Inflamm. 2019:61750912019. View Article : Google Scholar : PubMed/NCBI

32 

Achyut BR and Yang L: Transforming growth factor-β in the gastrointestinal and hepatic tumor microenvironment. Gastroenterology. 141:1167–1178. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Ahamed J and Laurence J: Role of platelet-derived transforming growth factor-β1 and reactive oxygen species in radiation-induced organ fibrosis. Antioxid Redox Signal. 27:977–988. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Meng XM, Nikolic-Paterson DJ and Lan HY: TGF-β: The master regulator of fibrosis. Nat Rev Nephrol. 12:325–338. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Mao Y, Zhang S, Yu F, Li H, Guo C and Fan X: Ghrelin attenuates liver fibrosis through regulation of TGF-β1 expression and autophagy. Int J Mol Sci. 16:21911–21930. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Liu X, Hu H and Yin JQ: Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis. Liver Int. 26:8–22. 2006. View Article : Google Scholar : PubMed/NCBI

37 

Wang Y, Zhao L, Jiao FZ, Zhang WB, Chen Q and Gong ZJ: Histone deacetylase inhibitor suberoylanilide hydroxamic acid alleviates liver fibrosis by suppressing the transforming growth factor-β1 signal pathway. Hepatobiliary Pancreat Dis Int. 17:423–429. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Lin H, Ying Y, Wang YY, Wang G, Jiang SS, Huang D, Luo L, Chen YG, Gerstenfeld LC and Luo Z: AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation. Biochim Biophys Acta Mol Cell Res. 1864:2369–2377. 2017. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Sun Y, Liu B, Xie J, Jiang X, Xiao B, Hu X and Xiang J: Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling. Mol Med Rep 25: 181, 2022.
APA
Sun, Y., Liu, B., Xie, J., Jiang, X., Xiao, B., Hu, X., & Xiang, J. (2022). Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling. Molecular Medicine Reports, 25, 181. https://doi.org/10.3892/mmr.2022.12697
MLA
Sun, Y., Liu, B., Xie, J., Jiang, X., Xiao, B., Hu, X., Xiang, J."Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling". Molecular Medicine Reports 25.5 (2022): 181.
Chicago
Sun, Y., Liu, B., Xie, J., Jiang, X., Xiao, B., Hu, X., Xiang, J."Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling". Molecular Medicine Reports 25, no. 5 (2022): 181. https://doi.org/10.3892/mmr.2022.12697
Copy and paste a formatted citation
x
Spandidos Publications style
Sun Y, Liu B, Xie J, Jiang X, Xiao B, Hu X and Xiang J: Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling. Mol Med Rep 25: 181, 2022.
APA
Sun, Y., Liu, B., Xie, J., Jiang, X., Xiao, B., Hu, X., & Xiang, J. (2022). Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling. Molecular Medicine Reports, 25, 181. https://doi.org/10.3892/mmr.2022.12697
MLA
Sun, Y., Liu, B., Xie, J., Jiang, X., Xiao, B., Hu, X., Xiang, J."Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling". Molecular Medicine Reports 25.5 (2022): 181.
Chicago
Sun, Y., Liu, B., Xie, J., Jiang, X., Xiao, B., Hu, X., Xiang, J."Aspirin attenuates liver fibrosis by suppressing TGF‑β1/Smad signaling". Molecular Medicine Reports 25, no. 5 (2022): 181. https://doi.org/10.3892/mmr.2022.12697
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