Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Molecular Medicine Reports
Join Editorial Board Propose a Special Issue
Print ISSN: 1791-2997 Online ISSN: 1791-3004
Journal Cover
February-2023 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2023 Volume 27 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis

  • Authors:
    • Tomoya Hatori
    • Toyonobu Maeda
    • Atsuko Suzuki
    • Keiso Takahashi
    • Yasumasa Kato
  • View Affiliations / Copyright

    Affiliations: Department of Oral Physiology and Biochemistry, Ohu University Graduate School of Dentistry, Koriyama, Fukushima 963‑8611, Japan, Department of Conservative Dentistry, Ohu University School of Dentistry, Koriyama, Fukushima 963‑8611, Japan
    Copyright: © Hatori et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 50
    |
    Published online on: January 10, 2023
       https://doi.org/10.3892/mmr.2023.12937
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Secreted protein acidic and rich in cysteine (SPARC), also called basement‑membrane protein 40 or osteonectin, is a matricellular protein that is abundant not only in bone tissue as a non‑collagenous protein but is also ubiquitously expressed in non‑calcified tissue. SPARC is located intracellularly and disruption of the Sparc gene has been reported to reduce bone formation and increase fat tissue; however, the mechanism by which SPARC inhibits adipogenesis remains unclear. The present study evaluated the intracellular function of SPARC in adipogenesis using the bone marrow stromal cell line ST2. When ST2 cells with low SPARC production were cloned, intrinsic activator protein‑1 (AP‑1) activity was markedly higher, mineralized nodule formation was significantly lower and lipid accumulation was significantly increased compared with in the parental ST2 cells. Forced expression of secreted SPARC with the signal peptide‑coding sequences of wild‑type Sparc or preprotrypsin in SPARC‑low ST2 cells significantly reduced AP‑1 transcription activity; however, these reductions were not observed in the absence of signal peptide sequences. Recombinant SPARC, produced using Brevibacillus brevis, specifically bound to c‑Fos but not c‑Jun and inhibited the binding of c‑Fos/c‑Jun to a TPA‑response element sequence. These data suggested that SPARC was incorporated into the cells from the extracellular spaces and serves an intracellular role as a decoy counterpart for c‑Fos, as well as being associated with osteoblastogenesis through the inhibition of adipogenesis. These findings may provide new insights into regenerative medicine.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Termine JD, Kleinman HK, Whitson SW, Conn KM, McGarvey ML and Martin GR: Osteonectin, a bone-specific protein linking mineral to collagen. Cell. 26:99–105. 1981. View Article : Google Scholar : PubMed/NCBI

2 

Yan Q and Sage EH: SPARC, a matricellular glycoprotein with important biological functions. J Histochem Cytochem. 47:1495–1506. 1999. View Article : Google Scholar : PubMed/NCBI

3 

Bradshaw AD: The role of SPARC in extracellular matrix assembly. J Cell Commun Signal. 3:239–246. 2009. View Article : Google Scholar : PubMed/NCBI

4 

Murphy-Ullrich JE and Sage EH: Revisiting the matricellular concept. Matrix Biol. 37:1–14. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Giudici C, Raynal N, Wiedemann H, Cabral WA, Marini JC, Timpl R, Bächinger HP, Farndale RW, Sasaki T and Tenni R: Mapping of SPARC/BM-40/osteonectin-binding sites on fibrillar collagens. J Biol Chem. 283:19551–19560. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Duncan S, Delage S, Chioran A, Sirbu O, Brown TJ and Ringuette MJ: The predicted collagen-binding domains of Drosophila SPARC are essential for survival and for collagen IV distribution and assembly into basement membranes. Dev Biol. 461:197–209. 2020. View Article : Google Scholar : PubMed/NCBI

7 

Cydzik M, Abdul-Wahid A, Park S, Bourdeau A, Bowden K, Prodeus A, Kollara A, Brown TJ, Ringuette MJ and Gariépy J: Slow binding kinetics of secreted protein, acidic, rich in cysteine-VEGF interaction limit VEGF activation of VEGF receptor 2 and attenuate angiogenesis. FASEB J. 29:3493–3505. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Gilmour DT, Lyon GJ, Carlton MB, Sanes JR, Cunningham JM, Anderson JR, Hogan BL, Evans MJ and Colledge WH: Mice deficient for the secreted glycoprotein SPARC/osteonectin/BM40 develop normally but show severe age-onset cataract formation and disruption of the lens. EMBO J. 17:1860–1870. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Delany AM, Amling M, Priemel M, Howe C, Baron R and Canalis E: Osteopenia and decreased bone formation in osteonectin-deficient mice. J Clin Invest. 105:915–923. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Bradshaw AD, Graves DC, Motamed K and Sage EH: SPARC-null mice exhibit increased adiposity without significant differences in overall body weight. Proc Natl Acad Sci USA. 100:6045–6050. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Delany AM, Kalajzic I, Bradshaw AD, Sage EH and Canalis E: Osteonectin-null mutation compromises osteoblast formation, maturation, and survival. Endocrinology. 144:2588–2596. 2003. View Article : Google Scholar : PubMed/NCBI

12 

Francki A, Bradshaw AD, Bassuk JA, Howe CC, Couser WG and Sage EH: SPARC regulates the expression of collagen type I and transforming growth factor-beta1 in mesangial cells. J Biol Chem. 274:32145–32152. 1999. View Article : Google Scholar : PubMed/NCBI

13 

Yan Q, Weaver M, Perdue N and Sage EH: Matricellular protein SPARC is translocated to the nuclei of immortalized murine lens epithelial cells. J Cell Physiol. 203:286–294. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Gooden MD, Vernon RB, Bassuk JA and Sage EH: Cell cycle-dependent nuclear location of the matricellular protein SPARC: Association with the nuclear matrix. J Cell Biochem. 74:152–167. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Hecht JT and Sage EH: Retention of the matricellular protein SPARC in the endoplasmic reticulum of chondrocytes from patients with pseudoachondroplasia. J Histochem Cytochem. 54:269–274. 2006. View Article : Google Scholar : PubMed/NCBI

16 

Huynh MH, Hong H, Delovitch S, Desser S and Ringuette M: Association of SPARC (osteonectin, BM-40) with extracellular and intracellular components of the ciliated surface ectoderm of Xenopus embryos. Cell Motil Cytoskeleton. 47:154–162. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Sodek J, Zhu B, Huynh MH, Brown TJ and Ringuette M: Novel functions of the matricellular proteins osteopontin and osteonectin/SPARC. Connect Tissue Res. 43:308–319. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Krstulja M, Car A, Bonifacić D, Braut T and Kujundzić M: Nasopharyngeal angiofibroma with intracellular accumulation of SPARC-a hypothesis (SPARC in nasopharyngeal angiofibroma). Med Hypotheses. 70:600–604. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Fenouille N, Puissant A, Dufies M, Robert G, Jacquel A, Ohanna M, Deckert M, Pasquet JM, Mahon FX, Cassuto JP, et al: Persistent activation of the Fyn/ERK kinase signaling axis mediates imatinib resistance in chronic myelogenous leukemia cells through upregulation of intracellular SPARC. Cancer Res. 70:9659–9670. 2010. View Article : Google Scholar : PubMed/NCBI

20 

Vinayagam A, Stelzl U, Foulle R, Plassmann S, Zenkner M, Timm J, Assmus HE, Andrade-Navarro MA and Wanker EE: A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 4:rs82011. View Article : Google Scholar : PubMed/NCBI

21 

White UA and Stephens JM: Transcriptional factors that promote formation of white adipose tissue. Mol Cell Endocrinol. 318:10–14. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Karin M, Liu ZG and Zandi E: AP-1 function and regulation. Curr Opin Cell Biol. 9:240–246. 1997. View Article : Google Scholar : PubMed/NCBI

23 

Distel RJ, Ro HS, Rosen BS, Groves DL and Spiegelman BM: Nucleoprotein complexes that regulate gene expression in adipocyte differentiation: Direct participation of c-fos. Cell. 49:835–844. 1987. View Article : Google Scholar : PubMed/NCBI

24 

Knebel B, Kotzka J, Lehr S, Hartwig S, Avci H, Jacob S, Nitzgen U, Schiller M, März W, Hoffmann MM, et al: A mutation in the c-fos gene associated with congenital generalized lipodystrophy. Orphanet J Rare Dis. 8:1192013. View Article : Google Scholar : PubMed/NCBI

25 

Maeda T and Horiuchi N: Simvastatin suppresses leptin expression in 3T3-L1 adipocytes via activation of the cyclic AMP-PKA pathway induced by inhibition of protein prenylation. J Biochem. 145:771–781. 2009. View Article : Google Scholar : PubMed/NCBI

26 

Maeda T, Suzuki A, Yuzawa S, Baba Y, Kimura Y and Kato Y: Mineral trioxide aggregate induces osteoblastogenesis via Atf6. Bone Rep. 2:36–43. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Hirose K, Isogai E, Mizugai H and Ueda I: Adhesion of Porphyromonas gingivalis fimbriae to human gingival cell line Ca9-22. Oral Microbiol Immunol. 11:402–406. 1996. View Article : Google Scholar : PubMed/NCBI

28 

Ogawa M and Nishikawa S, Ikuta K, Yamamura F, Naito M, Takahashi K and Nishikawa S: B cell ontogeny in murine embryo studied by a culture system with the monolayer of a stromal cell clone, ST2: B cell progenitor develops first in the embryonal body rather than in the yolk sac. EMBO J. 7:1337–1343. 1988. View Article : Google Scholar : PubMed/NCBI

29 

Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:156–159. 1987. View Article : Google Scholar : PubMed/NCBI

30 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

31 

Nagaoka M, Maeda T, Chatani M, Handa K, Yamakawa T, Kiyohara S, Negishi-Koga T, Kato Y, Takami M, Niida S, et al: A delphinidin-enriched maqui berry extract improves bone metabolism and protects against bone loss in osteopenic mouse models. Antioxidants (Basel). 8:3862019. View Article : Google Scholar : PubMed/NCBI

32 

Dignam JD, Lebovitz RM and Roeder RG: Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1475–1489. 1983. View Article : Google Scholar : PubMed/NCBI

33 

Maeda T, Suzuki A, Koga K, Miyamoto C, Maehata Y, Ozawa S, Hata RI, Nagashima Y, Nabeshima K, Miyazaki K and Kato Y: TRPM5 mediates acidic extracellular pH signaling and TRPM5 inhibition reduces spontaneous metastasis in mouse B16-BL6 melanoma cells. Oncotarget. 8:78312–78326. 2017. View Article : Google Scholar : PubMed/NCBI

34 

Hellman LM and Fried MG: Electrophoretic mobility shift assay (EMSA) for detecting protein-nucleic acid interactions. Nat Protoc. 2:1849–1861. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Cornelius P, MacDougald OA and Lane MD: Regulation of adipocyte development. Annu Rev Nutr. 14:99–129. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Maeda T, Kawane T and Horiuchi N: Statins augment vascular endothelial growth factor expression in osteoblastic cells via inhibition of protein prenylation. Endocrinology. 144:681–692. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Garin-Shkolnik T, Rudich A, Hotamisligil GS and Rubinstein M: FABP4 attenuates PPARγ and adipogenesis and is inversely correlated with PPARγ in adipose tissues. Diabetes. 63:900–911. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Tseng C and Kolonin MG: Proteolytic isoforms of SPARC induce adipose stromal cell mobilization in obesity. Stem Cells. 34:174–190. 2016. View Article : Google Scholar : PubMed/NCBI

39 

Kawakita F, Kanamaru H, Asada R and Suzuki H: Potential roles of matricellular proteins in stroke. Exp Neurol. 322:1130572019. View Article : Google Scholar : PubMed/NCBI

40 

Suzuki K, Zhu B, Rittling SR, Denhardt DT, Goldberg HA, McCulloch CA and Sodek J: Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. J Bone Miner Res. 17:1486–1497. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Lynch JM, Maillet M, Vanhoutte D, Schloemer A, Sargent MA, Blair NS, Lynch KA, Okada T, Aronow BJ, Osinska H, et al: A thrombospondin-dependent pathway for a protective ER stress response. Cell. 149:1257–1268. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Grigoriadis AE, Wang ZQ, Cecchini MG, Hofstetter W, Felix R, Fleisch HA and Wagner EF: c-Fos: A key regulator of osteoclast-macrophage lineage determination and bone remodeling. Science. 266:443–448. 1994. View Article : Google Scholar : PubMed/NCBI

43 

Wang ZQ, Ovitt C, Grigoriadis AE, Möhle-Steinlein U, Rüther U and Wagner EF: Bone and haematopoietic defects in mice lacking c-fos. Nature. 360:741–745. 1992. View Article : Google Scholar : PubMed/NCBI

44 

Boyce BF, Yamashita T, Yao Z, Zhang Q, Li F and Xing L: Roles for NF-kappaB and c-Fos in osteoclasts. J Bone Miner Metab. 23 (Suppl 1):S11–S15. 2005. View Article : Google Scholar : PubMed/NCBI

45 

Jochum W, David JP, Elliott C, Wutz A, Plenk H Jr, Matsuo K and Wagner EF: Increased bone formation and osteosclerosis in mice overexpressing the transcription factor Fra-1. Nat Med. 6:980–984. 2000. View Article : Google Scholar : PubMed/NCBI

46 

Schwabe K, Garcia M, Ubieta K, Hannemann N, Herbort B, Luther J, Noël D, Jorgensen C, Casteilla L, David JP, et al: Inhibition of osteoarthritis by adipose-derived stromal cells overexpressing Fra-1 in mice. Arthritis Rheumatol. 68:138–151. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Eferl R, Hasselblatt P, Rath M, Popper H, Zenz R, Komnenovic V, Idarraga MH, Kenner L and Wagner EF: Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1. Proc Natl Acad Sci USA. 105:10525–10530. 2008. View Article : Google Scholar : PubMed/NCBI

48 

Kveiborg M, Sabatakos G, Chiusaroli R, Wu M, Philbrick WM, Horne WC and Baron R: DeltaFosB induces osteosclerosis and decreases adipogenesis by two independent cell-autonomous mechanisms. Mol Cell Biol. 24:2820–2830. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Hasenfuss SC, Bakiri L, Thomsen MK, Williams EG, Auwerx J and Wagner EF: Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers. Cell Metab. 19:84–95. 2014. View Article : Google Scholar : PubMed/NCBI

50 

Wagner EF and Eferl R: Fos/AP-1 proteins in bone and the immune system. Immunol Rev. 208:126–140. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Luther J, Ubieta K, Hannemann N, Jimenez M, Garcia M, Zech C, Schett G, Wagner EF and Bozec A: Fra-2/AP-1 controls adipocyte differentiation and survival by regulating PPARγ and hypoxia. Cell Death Differ. 21:655–664. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Roschger P, Matsuo K, Misof BM, Tesch W, Jochum W, Wagner EF, Fratzl P and Klaushofer K: Normal mineralization and nanostructure of sclerotic bone in mice overexpressing Fra-1. Bone. 34:776–782. 2004. View Article : Google Scholar : PubMed/NCBI

53 

Cohen DR, Ferreira PC, Gentz R, Franza BR Jr and Curran T: The product of a fos-related gene, fra-1, binds cooperatively to the AP-1 site with Jun: Transcription factor AP-1 is comprised of multiple protein complexes. Genes Dev. 3:173–184. 1989. View Article : Google Scholar : PubMed/NCBI

54 

Yan C, Wang H, Aggarwal B and Boyd DD: A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NF-kappaB motif drives the transition from a repressed to an activated state of gene expression. FASEB J. 18:540–541. 2004. View Article : Google Scholar : PubMed/NCBI

55 

Mansergh FC, Wells T, Elford C, Evans SL, Perry MJ, Evans MJ and Evans BA: Osteopenia in Sparc (osteonectin)-deficient mice: Characterization of phenotypic determinants of femoral strength and changes in gene expression. Physiol Genomics. 32:64–73. 2007. View Article : Google Scholar : PubMed/NCBI

56 

Kos K, Wong S, Tan B, Gummesson A, Jernas M, Franck N, Kerrigan D, Nystrom FH, Carlsson LM, Randeva HS, et al: Regulation of the fibrosis and angiogenesis promoter SPARC/osteonectin in human adipose tissue by weight change, leptin, insulin, and glucose. Diabetes. 58:1780–1788. 2009. View Article : Google Scholar : PubMed/NCBI

57 

Tartare-Deckert S, Chavey C, Monthouel MN, Gautier N and Van Obberghen E: The matricellular protein SPARC/osteonectin as a newly identified factor up-regulated in obesity. J Biol Chem. 276:22231–22237. 2001. View Article : Google Scholar : PubMed/NCBI

58 

Lee SH, Lee JA, Park HS, Song YS, Jang YJ, Kim JH, Lee YJ and Heo Y: Associations among SPARC mRNA expression in adipose tissue, serum SPARC concentration and metabolic parameters in Korean women. Obesity (Silver Spring). 21:2296–2302. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Hatori T, Maeda T, Suzuki A, Takahashi K and Kato Y: SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis. Mol Med Rep 27: 50, 2023.
APA
Hatori, T., Maeda, T., Suzuki, A., Takahashi, K., & Kato, Y. (2023). SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis. Molecular Medicine Reports, 27, 50. https://doi.org/10.3892/mmr.2023.12937
MLA
Hatori, T., Maeda, T., Suzuki, A., Takahashi, K., Kato, Y."SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis". Molecular Medicine Reports 27.2 (2023): 50.
Chicago
Hatori, T., Maeda, T., Suzuki, A., Takahashi, K., Kato, Y."SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis". Molecular Medicine Reports 27, no. 2 (2023): 50. https://doi.org/10.3892/mmr.2023.12937
Copy and paste a formatted citation
x
Spandidos Publications style
Hatori T, Maeda T, Suzuki A, Takahashi K and Kato Y: SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis. Mol Med Rep 27: 50, 2023.
APA
Hatori, T., Maeda, T., Suzuki, A., Takahashi, K., & Kato, Y. (2023). SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis. Molecular Medicine Reports, 27, 50. https://doi.org/10.3892/mmr.2023.12937
MLA
Hatori, T., Maeda, T., Suzuki, A., Takahashi, K., Kato, Y."SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis". Molecular Medicine Reports 27.2 (2023): 50.
Chicago
Hatori, T., Maeda, T., Suzuki, A., Takahashi, K., Kato, Y."SPARC is a decoy counterpart for c‑Fos and is associated with osteoblastic differentiation of bone marrow stromal cells by inhibiting adipogenesis". Molecular Medicine Reports 27, no. 2 (2023): 50. https://doi.org/10.3892/mmr.2023.12937
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team