Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer (Review)

  • Authors:
    • Ye Zeng
    • Xing‑Hong Yao
    • Zhi‑Ping Yan
    • Jing‑Xia Liu
    • Xiao‑Heng Liu
  • View Affiliations

  • Published online on: June 1, 2016     https://doi.org/10.3892/ol.2016.4661
  • Pages: 379-382
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Abstract

The developmental process of epithelial-mesenchymal transition (EMT) occurs when epithelial cells acquire invasive mesenchymal cell characteristics, and the activation of this process has been indicated to be involved in tumor progression. EMT could be induced by growth factors, cytokines and matrix metalloproteinases (MMPs). sphingosine-1-phosphate (S1P) is a biologically-active lipid that plays an important role in cancer metastasis. S1P also contributes to the activation of EMT. However, the mechanism underlying S1P‑induced EMT is unclear. Increased evidence has demonstrated that the cell surface glycocalyx is closed associated with S1P and plays an important role in tumor progression, suggesting that S1P-induced EMT could be Snail-MMP signaling-dependent. Thus, we hypothesize that an S1P-glycocalyx-Snail-MMP signaling axis mediates S1P‑induced EMT. This is an essential step towards improved understanding of the underlying mechanism involved in S1P-regulted EMT, and the development of novel diagnostic and anticancer therapeutic strategies.
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July-2016
Volume 12 Issue 1

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zeng Y, Yao XH, Yan ZP, Liu JX and Liu XH: Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer (Review). Oncol Lett 12: 379-382, 2016
APA
Zeng, Y., Yao, X., Yan, Z., Liu, J., & Liu, X. (2016). Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer (Review). Oncology Letters, 12, 379-382. https://doi.org/10.3892/ol.2016.4661
MLA
Zeng, Y., Yao, X., Yan, Z., Liu, J., Liu, X."Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer (Review)". Oncology Letters 12.1 (2016): 379-382.
Chicago
Zeng, Y., Yao, X., Yan, Z., Liu, J., Liu, X."Potential signaling pathway involved in sphingosine-1-phosphate-induced epithelial-mesenchymal transition in cancer (Review)". Oncology Letters 12, no. 1 (2016): 379-382. https://doi.org/10.3892/ol.2016.4661