Cross regulation of signaling pathways in gastrointestinal stromal tumor Corrigendum in /10.3892/ol.2023.14103

Qi,Yijun; Zhao,Wendi; Wang,Zhengguang; Xie,Qingsong; Cao,Jing; Meng,Xiangling

doi:10.3892/ol.2018.9494

November-2018 Volume 16 Issue 5

Full Size Image

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

An International Open Access Journal Devoted to General Medicine.

November-2018 Volume 16 Issue 5

Full Size Image

Article

Cross regulation of signaling pathways in gastrointestinal stromal tumor

Corrigendum in: /10.3892/ol.2023.14103

Authors:
- Yijun Qi
- Wendi Zhao
- Zhengguang Wang
- Qingsong Xie
- Jing Cao
- Xiangling Meng
View Affiliations / Copyright

Affiliations: Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China, Department of Pathology, Anhui Medical University, Hefei, Anhui 230032, P.R. China, Laboratory Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230032, P.R. China
Pages: 6770-6776
|
Published online on: September 24, 2018

https://doi.org/10.3892/ol.2018.9494
Expand metrics +

Abstract

The Sonic hedgehog (Shh) signaling pathway may be interrelated with other signaling pathways, such as the phosphoinositide 3‑kinase (PI3K) and mitogen‑activated protein kinase (MAPK) pathways in gastrointestinal stromal tumor (GIST). The present study investigated the interaction among Shh, PI3K and MAPK signaling pathways in GIST cells. The expression of PI3K, MAPK and Shh signaling pathways in GIST‑H1 cells were upregulated by endothelial growth factor (EGF) and recombinant Shh (N‑shh) stimulation, and were downregulated by specific inhibitors of each signaling pathway. The proliferation rate of GIST‑H1 cells were significantly increased under EGF or N‑shh treatment (P<0.01). In addition, this effect was partially prevented by the pretreatment of the inhibitors of these signaling pathways. In summary, a cross regulation exists among the Shh, PI3K and MAPK signaling pathways in GIST‑H‑1 cells. The combined use of the inhibitors of these signaling pathways is a potentially novel option for GIST targeted therapy.

View Figures

View References

1	Foo WC, Liegl-Atzwanger B and Lazar AJ: Pathology of gastrointestinal stromal tumors. Clin Med Insights Pathol. 5:23–33. 2012. View Article : Google Scholar : PubMed/NCBI
2	DeMatteo RP, Lewis JJ, Leung D, Mudan SS, Woodruff JM and Brennan MF: Two hundred gastrointestinal stromal tumors: Recurrence patterns and prognostic factors for survival. Ann Surg. 231:51–58. 2000. View Article : Google Scholar : PubMed/NCBI
3	Tsutsui S, Matsuyama A, Yamamoto M, Takeuchi H, Oshiro Y, Ishida T and Maehara Y: The Akt expression correlates with the VEGF-A and -C expression as well as the microvessel and lymphatic vessel density in breast cancer. Oncol Rep. 23:621–630. 2010. View Article : Google Scholar : PubMed/NCBI
4	Zhang H, Fagan DH, Zeng X, Freeman KT, Sachdev D and Yee D: Inhibition of cancer cell proliferation and metastasis by insulin receptor downregulation. Oncogene. 29:2517–2527. 2010. View Article : Google Scholar : PubMed/NCBI
5	Daniels M, Lurkin I, Pauli R, Erbstösser E, Hildebrandt U, Hellwig K, Zschille U, Lüders P, Krüger G, Knolle J, et al: Spectrum of KIT/PDGFRA/BRAF mutations and Phosphatidylinositol-3-Kinase pathway gene alterations in gastrointestinal stromal tumors (GIST). Cancer Lett. 312:43–54. 2011. View Article : Google Scholar : PubMed/NCBI
6	Wancket LM, Frazier WJ and Liu Y: Mitogen-activated protein kinase phosphatase (MKP)-1 in immunology, physiology and disease. Life Sci. 90:237–248. 2012. View Article : Google Scholar : PubMed/NCBI
7	Zhao C, Chen A, Jamieson CH, Fereshteh M, Abrahamsson A, Blum J, Kwon HY, Kim J, Chute JP, Rizzieri D, et al: Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 458:776–779. 2009. View Article : Google Scholar : PubMed/NCBI
8	Yoshizaki A, Nakayama T, Naito S, Wen CY and Sekine I: Expressions of sonic hedgehog, patched, smoothened and Gli-1 in human intestinal stromal tumors and their correlation with prognosis. World J Gastroenterol. 12:5687–5691. 2006. View Article : Google Scholar : PubMed/NCBI
9	Long B, Zhu H, Zhu C, Liu T and Meng W: Activation of the Hedgehog pathway in chronic myelogeneous leukemia patients. J Exp Clin Cancer Res. 30:82011. View Article : Google Scholar : PubMed/NCBI
10	Qi Y, Zhao W, Wang Z and Meng X: Expression of Shh signaling pathway factors in gastrointestinal stromal tumor tissues and their associations with clinical pathological factors. Int J Clin Exp Pathol. 9:2841–2848. 2016.