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Article

Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach

  • Authors:
    • Yi Chai
    • Feng Tan
    • Sumin Ye
    • Feixiang Liu
    • Qiaoling Fan
  • View Affiliations / Copyright

    Affiliations: Department of Formulaology of Traditional Chinese Medicine, School of Basic Medical Science, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, P.R. China
  • Pages: 468-481
    |
    Published online on: September 26, 2018
       https://doi.org/10.3892/ol.2018.9508
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Abstract

Osteoporosis (OP) is an age‑related disease, and osteoporotic fracture is one of the major causes of disability and mortality in elderly patients (>70 years old). As the pathogenesis and molecular mechanism of OP remain unclear, the identification of disease biomarkers is important for guiding research and providing therapeutic targets. In the present study, core genes and microRNAs (miRNAs) associated with OP were identified. Differentially expressed genes (DEGs) between human mesenchymal stem cell specimens from normal osseous tissues and OP tissues were detected using the GEO2R tool of the Gene Expression Omnibus database and Morpheus. Network topological parameters were determined using NetworkAnalyzer. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses were performed using the Database for Annotation, Visualization and Integrated Discovery, and ClueGO. Cytoscape with the Search Tool for the Retrieval of Interacting Genes and Molecular Complex Detection plug‑in was used to visualize protein‑protein interactions (PPIs). Additionally, miRNA‑gene regulatory modules were predicted using CyTargetLinker in order to guide future research. In total, 915 DEGs were identified, including 774 upregulated and 141 downregulated genes. Enriched GO terms and pathways were determined, including ‘nervous system development’, ‘regulation of molecular function’, ‘glutamatergic synapse pathway’ and ‘pathways in cancer’. The node degrees of DEGs followed power‑law distributions. A PPI network with 541 nodes and 1,431 edges was obtained. Overall, 3 important modules were identified from the PPI network. The following 10 genes were identified as core genes based on high degrees of connectivity: Albumin, PH domain leucine‑rich repeat‑containing protein phosphatase 2 (PHLPP2), DNA topoisomerase 2‑α, kininogen 1 (KNG1), interleukin 2 (IL2), leucine‑rich repeats and guanylate kinase domain containing, phosphatidylinositol‑4,5‑bisphosphate 3‑kinase catalytic subunit γ (PIK3CG), leptin, transferrin and RNA polymerase II subunit A (POLR2A). Additionally, 15 miRNA‑target interactions were obtained using CyTargetLinker. Overall, 7 miRNAs co‑regulated IL2, 3 regulated PHLPP2, 3 regulated KNG1, 1 regulated PIK3CG and 1 modulated POLR2A. These results indicate potential biomarkers in the pathogenesis of OP and therapeutic targets.
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View References

1 

Body JJ, Bergmann P, Boonen S, Boutsen Y, Devogelaer JP, Goemaere S, Kaufman JM, Rozenberg S and Reginster JY: Evidence-based guidelines for the pharmacological treatment of postmenopausal osteoporosis: A consensus document by the Belgian Bone Club. Osteoporos Int. 21:1657–1680. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Chen P, Li Z and Hu Y: Prevalence of osteoporosis in China: A meta-analysis and systematic review. BMC Public Health. 16:10392016. View Article : Google Scholar : PubMed/NCBI

3 

Svedbom A, Hernlund E, Ivergård M, Compston J, Cooper C, Stenmark J, McCloskey E, Jönsson B and Kanis JEU; Review Panel of IOF, . Osteoporosis in the European Union: A compendium of country-specific reports. Arch Osteoporos. 8:1372013. View Article : Google Scholar : PubMed/NCBI

4 

Ma M, Chen X, Lu L, Yuan F, Zeng W, Luo S, Yin F and Cai J: Identification of crucial genes related to postmenopausal osteoporosis using gene expression profiling. Aging Clin Exp Res. 28:1067–1074. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Takayanagi H: Osteoimmunology: Shared mechanisms and crosstalk between the immune and bone systems. Nat Rev Immunol. 7:292–304. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Li X, Ge H, Weiszmann J, Hecht R and Li Y, Véniant M, Xu J, Wu X, Lindberg R and Li Y: Inhibition of lipolysis may contribute to the acute regulation of plasma FFA and glucose by FGF21 in ob/ob mice. FEBS Lett. 583:3230–3234. 2009. View Article : Google Scholar : PubMed/NCBI

7 

Hao RH, Gao JL, Li M, Huang W, Zhu DL, Thynn HN, Dong SS and Guo Y: Association between fibroblast growth factor 21 and bone mineral density in adults. Endocrine. 2018. View Article : Google Scholar

8 

Barrett T, Wilhite SE, Ledoux P, Evangelista C, Kim IF, Tomashevsky M, Marshall KA, Phillippy KH, Sherman PM, Holko M, et al: NCBI GEO: Archive for functional genomics data sets-update. Nucleic Acids Res. 41:(Database Issue). D991–D995. 2012. View Article : Google Scholar : PubMed/NCBI

9 

Kanehisa M and Goto S: KEGG: Kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 28:27–30. 2000. View Article : Google Scholar : PubMed/NCBI

10 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. Nature Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Benisch P, Schilling T, Klein-Hitpass L, Frey S, Seefried L, Raaijmakers N, Krug M, Regensburger M, Zeck S, Schinke T, et al: The transcriptional profile of mesenchymal stem cell populations in primary osteoporosis is distinct and shows overexpression of osteogenic inhibitors. PLoS One. 7:e451422012. View Article : Google Scholar : PubMed/NCBI

12 

Venet D, Detours V and Bersini H: A measure of the signal-to-noise ratio of microarray samples and studies using gene correlations. PLoS One. 7:e510132012. View Article : Google Scholar : PubMed/NCBI

13 

Huang da W, Sherman BT and Lempicki RA: Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc. 4:44–57. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Bindea G, Mlecnik B, Hackl H, Charoentong P, Tosolini M, Kirilovsky A, Fridman WH, Pagès F, Trajanoski Z and Galon J: ClueGO: A Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks. Bioinformatics. 25:1091–1093. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Doncheva N, Assenov Y, Domingues F and Albrecht M: Topological analysis and interactive visualization of biological networks and protein structures. Nat Protoc. 7:670–685. 2012. View Article : Google Scholar : PubMed/NCBI

16 

Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:(Database Issue). D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI

19 

Benjamini Y and Hochberg Y: Controlling the false discovery rate: A practical and powerful approach to multiple testing. J Roy Stat Soc Ser B. 57:289–300. 1995.

20 

Kutmon M, Kelder T, Mandaviya P, Evelo CT and Coort SL: CyTargetLinker: A Cytoscape app to integrate regulatory interactions in network analysis. PLoS One. 8:e821602013. View Article : Google Scholar : PubMed/NCBI

21 

Tella SH and Gallagher JC: Prevention and treatment of postmenopausal osteoporosis. J Steroid Biochem Mol Biol. 142:155–170. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Ho SS, Vollmer NL, Refaat MI, Jeon O, Alsberg E, Lee MA and Leach JK: Bone morphogenetic protein-2 promotes human mesenchymal stem cell survival and resultant bone formation when entrapped in photocrosslinked alginate hydrogels. Adv Healthc Mater. 5:2501–2509. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Maslov S and Sneppen K: Specificity and stability in topology of protein networks. Science. 296:910–913. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Wu B, Xie J, Du Z, Wu J, Zhang P, Xu L and Li E: PPI network analysis of mRNA expression profile of ezrin knockdown in esophageal squamous cell carcinoma. Biomed Res Int. 2014:6519542014. View Article : Google Scholar : PubMed/NCBI

25 

Korkmaz V, Kurdoglu Z, Alisik M, Turgut E, Sezgın OO, Korkmaz H, Ergun Y and Erel O: Thiol/disulfide homeostasis in postmenopausal osteoporosis. J Endocrinol Invest. 40:431–435. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Lee EJ, Kim JL, Kim YH, Kang MK, Gong JH and Kang YH: Phloretin promotes osteoclast apoptosis in murine macrophages and inhibits estrogen deficiency-induced osteoporosis in mice. Phytomedicine. 21:1208–1215. 2014. View Article : Google Scholar : PubMed/NCBI

27 

Huang C and Li S: Association of blood neutrophil lymphocyte ratio in the patients with postmenopausal osteoporosis. Pak J Med Sci. 32:762–765. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Spilmont M, Léotoing L, Davicco MJ, Lebecque P, Mercier S, Miot-Noirault E, Pilet P, Rios L, Wittrant Y and Coxam V: Pomegranate and its derivatives can improve bone health through decreased inflammation and oxidative stress in an animal model of postmenopausal osteoporosis. Eur J Nutr. 53:1155–1164. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Wauquier F, Leotoing L, Coxam V, Guicheux J and Wittrant Y: Oxidative stress in bone remodelling and disease. Trends Mol Med. 15:468–477. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Fagerberg L, Hallström BM, Oksvold P, Kampf C, Djureinovic D, Odeberg J, Habuka M, Tahmasebpoor S, Danielsson A, Edlund K, et al: Analysis of the human tissue-specific expression by genome-wide integration of transcriptomics and antibody-based proteomics. Mol Cell Proteomics. 13:397–406. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Hwang SM, Feigenson M, Begun DL, Shull LC, Culley KL, Otero M, Goldring MB, Ta LE, Kakar S, Bradley EW and Westendorf JJ: Phlpp inhibitors block pain and cartilage degradation associated with osteoarthritis. J Orthop Res. 36:1487–1497. 2018. View Article : Google Scholar : PubMed/NCBI

32 

Madabhushi R: The Roles of DNA Topoisomerase IIβ in Transcription. Int J Mol Sci. 19(pii): E19172018. View Article : Google Scholar : PubMed/NCBI

33 

Lang AJ, Mirski SE, Cummings HJ, Yu Q, Gerlach JH and Cole SP: Structural organization of the human TOP2A and TOP2B genes. Gene. 221:255–266. 1998. View Article : Google Scholar : PubMed/NCBI

34 

Kaplan E and Gündüz U: Expression analysis of TOP2A, MSH2 and MLH1 genes in MCF7 cells at different levels of etoposide resistance. Biomed Pharmacother. 66:29–35. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Raguz S, Adams C, Masrour N, Rasul S, Papoutsoglou P, Hu Y, Cazzanelli G, Zhou Y, Patel N, Coombes C, et al: Loss of O6-methylguanine-DNA methyltransferase confers collateral sensitivity to carmustine in topoisomerase II-mediated doxorubicin resistant triple negative breast cancer cells. Biochem Pharmacol. 85:186–196. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Boregowda SV, Krishnappa V, Chambers JW, Lograsso PV, Lai WT, Ortiz LA and Phinney DG: Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53-dependent mechanism: Implications for long-term culture expansion. Stem Cells. 30:975–987. 2012. View Article : Google Scholar : PubMed/NCBI

37 

Zhang F, Wen Y, Guo X, Zhang Y, Wang S, Yang T, Shen H, Chen X, Tan L, Tian Q and Deng HW: Genome-wide pathway-based association study implicates complement system in the development of Kashin-Beck disease in Han Chinese. Bone. 71:36–41. 2015. View Article : Google Scholar : PubMed/NCBI

38 

Li J, Hou Y, Ding X, Hou W, Song B and Zeng Y: Overexpression, purification, molecular characterization and the effect on tumor growth of ribosomal protein L22 from the Giant Panda (Ailuropoda melanoleuca). Mol Biol Rep. 41:3529–3539. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Okuda H, DeBoer K, O'Connor AE, Merriner DJ, Jamsai D and O'Bryan MK: LRGUK1 is part of a multiprotein complex required for manchette function and male fertility. FASEB J. 31:1141–1152. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Laramie JM, Wilk JB, Williamson SL, Nagle MW, Latourelle JC, Tobin JE, Province MA, Borecki IB and Myers RH: Polymorphisms near EXOC4 and LRGUK on chromosome 7q32 are associated with Type 2 Diabetes and fasting glucose; the NHLBI Family Heart Study. BMC Med Genet. 9:462008. View Article : Google Scholar : PubMed/NCBI

41 

Jean S and Kiger AA: Classes of phosphoinositide 3-kinases at a glance. J Cell Sci. 127:923–928. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Kang H, Chang W, Hurley M, Vignery A and Wu D: Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis. Proc Natl Acad Sci USA. 107:12901–12906. 2010. View Article : Google Scholar : PubMed/NCBI

43 

Tariq S, Baig M, Tariq S and Shahzad M: Association of serum leptin with bone mineral density in postmenopausal osteoporotic females. Gynecol Endocrinol. 33:287–291. 2017. View Article : Google Scholar : PubMed/NCBI

44 

Zheng B, Jiang J, Chen Y, Lin M, Du Z, Xiao Y, Luo K and Yan F: Leptin overexpression in bone marrow stromal cells promotes periodontal regeneration in a rat model of osteoporosis. J Periodontol. 88:808–818. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Ramsey J and Mukhopadhyay S: Disentangling the frames, the state of research on the alphavirus 6K and TF proteins. Viruses. 9(pii): E2282017. View Article : Google Scholar : PubMed/NCBI

46 

Worthen C and Enns C: The role of hepatic transferrin receptor 2 in the regulation of iron homeostasis in the body. Front Pharmacol. 5:342014. View Article : Google Scholar : PubMed/NCBI

47 

Zhao DY, Gish G, Braunschweig U, Li Y, Ni Z, Schmitges FW, Zhong G, Liu K, Li W, Moffat J, et al: SMN and symmetric arginine dimethylation of RNA polymerase II C-terminal domain control termination. Nature. 529:48–53. 2016. View Article : Google Scholar : PubMed/NCBI

48 

Hui-Ying X, Da-Hong Z, Li-Juan J and Xiao-Jie L: Anticancer opportunity created by loss of tumor suppressor genes. Technol Cancer Res Treat. 15:729–731. 2016. View Article : Google Scholar : PubMed/NCBI

49 

David CJ, Boyne AR, Millhouse SR and Manley JL: The RNA polymerase II C-terminal domain promotes splicing activation through recruitment of a U2AF65-Prp19 complex. Genes Dev. 25:972–983. 2011. View Article : Google Scholar : PubMed/NCBI

50 

Lauss M, Kriegner A, Vierlinger K and Noehammer C: Characterization of the drugged human genome. Pharmacogenomics. 8:1063–1073. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Bhattarai UR, Katuwal Bhattarai M, Li F and Wang D: Insights into the temporal gene expression pattern in lymantria dispar larvae during the baculovirus induced hyperactive stage. Virol Sin. Jul 25–2018.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

52 

Wang J, Cheng J, Zhang C and Li X: Cardioprotection effects of sevoflurane by regulating the pathway of neuroactive ligand-receptor interaction in patients undergoing coronary artery bypass graft surgery. Comput Math Methods Med. 2017:36182132017. View Article : Google Scholar : PubMed/NCBI

53 

Zhuang Q, Mao W, Xu P, Li H, Sun Z, Li S, Qiu G, Li J and Zhang J: Identification of differential genes expression profiles and pathways of bone marrow mesenchymal stem cells of adolescent idiopathic scoliosis patients by microarray and integrated gene network analysis. Spine (Phila Pa 1976). 41:840–855. 2016. View Article : Google Scholar : PubMed/NCBI

54 

Ciechanover A, Orian A and Schwartz AL: Ubiquitin-mediated proteolysis: Biological regulation via destruction. Bioessays. 22:442–451. 2000. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chai Y, Tan F, Ye S, Liu F and Fan Q: Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach. Oncol Lett 17: 468-481, 2019.
APA
Chai, Y., Tan, F., Ye, S., Liu, F., & Fan, Q. (2019). Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach. Oncology Letters, 17, 468-481. https://doi.org/10.3892/ol.2018.9508
MLA
Chai, Y., Tan, F., Ye, S., Liu, F., Fan, Q."Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach". Oncology Letters 17.1 (2019): 468-481.
Chicago
Chai, Y., Tan, F., Ye, S., Liu, F., Fan, Q."Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach". Oncology Letters 17, no. 1 (2019): 468-481. https://doi.org/10.3892/ol.2018.9508
Copy and paste a formatted citation
x
Spandidos Publications style
Chai Y, Tan F, Ye S, Liu F and Fan Q: Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach. Oncol Lett 17: 468-481, 2019.
APA
Chai, Y., Tan, F., Ye, S., Liu, F., & Fan, Q. (2019). Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach. Oncology Letters, 17, 468-481. https://doi.org/10.3892/ol.2018.9508
MLA
Chai, Y., Tan, F., Ye, S., Liu, F., Fan, Q."Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach". Oncology Letters 17.1 (2019): 468-481.
Chicago
Chai, Y., Tan, F., Ye, S., Liu, F., Fan, Q."Identification of core genes and prediction of miRNAs associated with osteoporosis using a bioinformatics approach". Oncology Letters 17, no. 1 (2019): 468-481. https://doi.org/10.3892/ol.2018.9508
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