Crucial role of the pentose phosphate pathway in malignant tumors (Review)

  • Authors:
    • Lin Jin
    • Yanhong Zhou
  • View Affiliations

  • Published online on: March 5, 2019     https://doi.org/10.3892/ol.2019.10112
  • Pages: 4213-4221
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Abstract

Interest in cancer metabolism has increased in recent years. The pentose phosphate pathway (PPP) is a major glucose catabolism pathway that directs glucose flux to its oxidative branch and leads to the production of a reduced form of nicotinamide adenine dinucleotide phosphate and nucleic acid. The PPP serves a vital role in regulating cancer cell growth and involves many enzymes. The aim of the present review was to describe the recent discoveries associated with the deregulatory mechanisms of the PPP and glycolysis in malignant tumors, particularly in hepatocellular carcinoma, breast and lung cancer.
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May-2019
Volume 17 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Jin L and Jin L: Crucial role of the pentose phosphate pathway in malignant tumors (Review). Oncol Lett 17: 4213-4221, 2019
APA
Jin, L., & Jin, L. (2019). Crucial role of the pentose phosphate pathway in malignant tumors (Review). Oncology Letters, 17, 4213-4221. https://doi.org/10.3892/ol.2019.10112
MLA
Jin, L., Zhou, Y."Crucial role of the pentose phosphate pathway in malignant tumors (Review)". Oncology Letters 17.5 (2019): 4213-4221.
Chicago
Jin, L., Zhou, Y."Crucial role of the pentose phosphate pathway in malignant tumors (Review)". Oncology Letters 17, no. 5 (2019): 4213-4221. https://doi.org/10.3892/ol.2019.10112