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Article Open Access

Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators

  • Authors:
    • Weihua Qian
    • Xin‑Xin Ge
    • Jing Wu
    • Fei‑Ran Gong
    • Meng‑Yao Wu
    • Meng‑Dan Xu
    • Lian Lian
    • Wen‑Jie Wang
    • Wei Li
    • Min Tao
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China, Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China
    Copyright: © Qian et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 571-580
    |
    Published online on: May 21, 2019
       https://doi.org/10.3892/ol.2019.10388
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Abstract

Colorectal cancer (CRC) represents the third most common malignancy worldwide. The aim of the present study was to investigate the predictive values of platelet‑associated indicators, including platelet count (PLT), plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW) in patients with resectable CRC. The current retrospective study included 153 patients who were pathologically diagnosed with resectable CRC. The patients were divided into two groups according to the median value of PLT, PCT, MPV or PDW. To evaluate the changes in PLT, PCT, MPV and PDW following resection and adjuvant chemotherapy, the concept of post‑/pre‑treatment PLT, PCT, MPV and PDW ratios was introduced, where <1 indicated decreased PLT, PCT, MPV and PDW values after treatment, and where ≥1 suggested stable or increased values. It was revealed that a low MPV prior to treatment correlated with a higher tumor stage. Surgery significantly decreased MPV, but had no impact on PLT, PCT or PDW. Adjuvant chemotherapy significantly decreased PLT and PCT, increased MPV and had no effect on PDW. After the whole course of treatment (surgery combined with adjuvant chemotherapy), PLT, PCT and PDW were significantly decreased. Kaplan‑Meier plots illustrated that patients with a post‑/pre‑treatment MPV ratio <1 had poorer overall survival (OS), whereas the post‑/pre‑treatment ratios for PLT, PCT and PDW did not correlate with patient outcome. Multivariate Cox regression analysis revealed that sex, tumor size and the post‑/pre‑treatment MPV ratio were prognostic factors for OS. Therefore, the present results may suggest MPV as a potential prognostic factor in resectable CRC.
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Copy and paste a formatted citation
Spandidos Publications style
Qian W, Ge XX, Wu J, Gong FR, Wu MY, Xu MD, Lian L, Wang WJ, Li W, Tao M, Tao M, et al: Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators. Oncol Lett 18: 571-580, 2019.
APA
Qian, W., Ge, X., Wu, J., Gong, F., Wu, M., Xu, M. ... Tao, M. (2019). Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators. Oncology Letters, 18, 571-580. https://doi.org/10.3892/ol.2019.10388
MLA
Qian, W., Ge, X., Wu, J., Gong, F., Wu, M., Xu, M., Lian, L., Wang, W., Li, W., Tao, M."Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators". Oncology Letters 18.1 (2019): 571-580.
Chicago
Qian, W., Ge, X., Wu, J., Gong, F., Wu, M., Xu, M., Lian, L., Wang, W., Li, W., Tao, M."Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators". Oncology Letters 18, no. 1 (2019): 571-580. https://doi.org/10.3892/ol.2019.10388
Copy and paste a formatted citation
x
Spandidos Publications style
Qian W, Ge XX, Wu J, Gong FR, Wu MY, Xu MD, Lian L, Wang WJ, Li W, Tao M, Tao M, et al: Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators. Oncol Lett 18: 571-580, 2019.
APA
Qian, W., Ge, X., Wu, J., Gong, F., Wu, M., Xu, M. ... Tao, M. (2019). Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators. Oncology Letters, 18, 571-580. https://doi.org/10.3892/ol.2019.10388
MLA
Qian, W., Ge, X., Wu, J., Gong, F., Wu, M., Xu, M., Lian, L., Wang, W., Li, W., Tao, M."Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators". Oncology Letters 18.1 (2019): 571-580.
Chicago
Qian, W., Ge, X., Wu, J., Gong, F., Wu, M., Xu, M., Lian, L., Wang, W., Li, W., Tao, M."Prognostic evaluation of resectable colorectal cancer using platelet‑associated indicators". Oncology Letters 18, no. 1 (2019): 571-580. https://doi.org/10.3892/ol.2019.10388
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