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Article

Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma

  • Authors:
    • Jiayong Yang
    • Yifeng Tian
    • Ruihe Zheng
    • Lei Li
    • Funan Qiu
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, The Fifth Hospital of Xiamen, Xiamen, Fujian 361101, P.R. China, Provincial Clinical College, Fujian Medical University, Fuzhou, Fujian 350004, P.R. China, Eye Institute of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, P.R. China
  • Pages: 1530-1538
    |
    Published online on: May 27, 2019
       https://doi.org/10.3892/ol.2019.10399
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Abstract

The endogenous lipid metabolism network is associated with the occurrence and progression of malignancies. Endocannabinoids and ceramides have demonstrated their anti‑proliferative and pro‑apoptotic properties in a series of cancer studies. The aim of the present study was to evaluate the expression patterns of endocannabinoids and endogenous ceramides in 67 pairs of human hepatocellular carcinoma (HCC) tissues and non‑cancerous counterpart controls. Anandamide (AEA), the major endocannabinoid, was reduced in tumor tissues, probably due to the high expression and activity of fatty acid amide hydrolase. Another important endocannabinoid, 2‑arachidonylglycerol (2‑AG), was elevated in tumor tissues compared with non‑tumor controls, indicating that the biosynthesis of 2‑AG is faster than the degradation of 2‑AG in tumor cells. Furthermore, western blot analysis demonstrated that cannabinoid receptor 1 was downregulated, while cannabinoid receptor 2 was elevated in HCC tissues, in accordance with the alterations in the levels of AEA and 2‑AG, respectively. For HCC tissues, the expression levels of C18:0, 20:0 and 24:0‑ceramides decreased significantly, whereas C12:0, 16:0, 18:1 and 24:1‑ceramides were upregulated, which may be associated with cannabinoid receptor activation and stearoyl‑CoA desaturase protein downregulation. The exact role of endocannabinoids and ceramides in regulating the fate of HCC cells requires further investigation.
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1 

Allemani C, Matsuda T, Di Carlo V, Harewood R, Matz M, Nikšić M, Bonaventure A, Valkov M, Johnson CJ, Estève J, et al: Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): Analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries. Lancet. 391:1023–1075. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Strickaert A, Corbet C, Spinette SA, Craciun L, Dom G, Andry G, Larsimont D, Wattiez R, Dumont JE, Feron O and Maenhaut C: Reprogramming of energetic metabolism: Increased expression and roles of pyruvate carboxylase in papillary thyroid cancer. Thyroid. 2019.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI

3 

Zhou X, Yang X, Sun X, Xu X, Li X, Guo Y, Wang J, Li X, Yao L, Wang H and Shen L: Effect of PTEN loss on metabolic reprogramming in prostate cancer cells. Oncol Lett. 17:2856–2866. 2019.PubMed/NCBI

4 

Li X, Xu H, Lei T, Yang Y, Jing D, Dai S, Luo P and Xu Q: A pulsed electromagnetic field protects against glutamate-induced excitotoxicity by modulating the endocannabinoid system in HT22 cells. Front Neurosci. 11:422017. View Article : Google Scholar : PubMed/NCBI

5 

Dyall SC, Mandhair HK, Fincham REA, Kerr DM, Roche M and Molina-Holgado F: Distinctive effects of eicosapentaenoic and docosahexaenoic acids in regulating neural stem cell fate are mediated via endocannabinoid signalling pathways. Neuropharmacology. 107:387–395. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Cinar R, Godlewski G, Liu J, Tam J, Jourdan T, Mukhopadhyay B, Harvey-White J and Kunos G: Hepatic cannabinoid-1 receptors mediate diet-induced insulin resistance by increasingde novosynthesis of long-chain ceramides. Hepatology. 59:143–153. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Sean M. Emery AHL and David A: Gewirtz: Involvement of the endocannabinoid system in the development and treatment of breast cancer. Virginia commonwealth univ richmond; 2014

8 

Orellana-Serradell O, Poblete CE, Sanchez C, Castellón EA, Gallegos I, Huidobro C, Llanos MN and Contreras HR: Proapoptotic effect of endocannabinoids in prostate cancer cells. Oncol Rep. 33:1599–1608. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Ligresti A, Bisogno T, Matias I, De Petrocellis L, Cascio MG, Cosenza V, D'argenio G, Scaglione G, Bifulco M, Sorrentini I and Di Marzo V: Possible endocannabinoid control of colorectal cancer growth. Gastroenterology. 125:677–687. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Galve-Roperh I, Sánchez C, Cortés ML, Gómez del Pulgar T, Izquierdo M and Guzmán M: Anti-tumoral action of cannabinoids: Involvement of sustained ceramide accumulation and extracellular signal-regulated kinase activation. Nat Med. 6:313–319. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Igal RA: Stearoyl CoA desaturase-1: New insights into a central regulator of cancer metabolism. Biochim Biophys Acta. 12:1865–1880. 2016. View Article : Google Scholar

12 

Chen L, Ren J, Yang L, Li Y, Fu J, Li Y, Tian Y, Qiu F, Liu Z and Qiu Y: Stearoyl-CoA desaturase-1 mediated cell apoptosis in colorectal cancer by promoting ceramide synthesis. Sci Rep. 6:196652016. View Article : Google Scholar : PubMed/NCBI

13 

Li X, Wenes M, Romero P, Huang SC, Fendt SM and Ho PC: Navigating metabolic pathways to enhance antitumour immunity and immunotherapy. Nat Rev Clin Oncol. 2019.(Epub ahead of print). View Article : Google Scholar

14 

Mittal S and El-Serag HB: Epidemiology of HCC: consider the population. J Clin Gastroenterol. 47:S2–S6. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Chen L, Chen H, Li Y, Li L, Qiu Y and Ren J: Endocannabinoid and ceramide levels are altered in patients with colorectal cancer. Oncol Rep. 34:447–454. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Yang W, Lu Y, Xu Y, Xu L, Zheng W, Wu Y, Li L and Shen P: Estrogen represses hepatocellular carcinoma (HCC) growth via inhibiting alternative activation of tumor-associated macrophages (TAMs). J Biol Chem. 287:40140–40149. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Zhou J, Sun HC, Wang Z, Cong WM, Wang JH, Zeng MS, Yang JM, Bie P, Liu LX, Wen TF, et al: Guidelines for diagnosis and treatment of primary liver cancer in China (2017 Edition). Liver Cancer. 7:235–260. 2018. View Article : Google Scholar : PubMed/NCBI

19 

Fu J, Gaetani S, Oveisi F, Lo Verme J, Serrano A, Rodríguez De Fonseca F, Rosengarth A, Luecke H, Di Giacomo B, Tarzia G and Piomelli D: Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-alpha. Nature. 425:90–93. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Bobrov MY, Shevchenko VP, Yudushkin IA, Rogov SI, Remov MN, Fomina-Ageeva EV, Gretskaya NM, Nagaev IY, Kuklev DV and Bezuglov VV: Hydrolysis of anandamide and eicosapentaenoic acid ethanolamide in mouse splenocytes. Biochemistry. 65:615–619. 2000.PubMed/NCBI

21 

Nomura DK, Long JZ, Niessen S, Hoover HS, Ng SW and Cravatt BF: Monoacylglycerol lipase regulates a fatty acid network that promotes cancer pathogenesis. Cell. 140:49–61. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Morad SA and Cabot MC: Ceramide-orchestrated signalling in cancer cells. Nat Rev Cancer. 13:51–65. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Matsui H, Yokoyama T, Sekiguchi K, Iijima D, Sunaga H, Maniwa M, Ueno M, Iso T, Arai M and Kurabayashi M: Stearoyl-CoA desaturase-1 (SCD1) augments saturated fatty acid-induced lipid accumulation and inhibits apoptosis in cardiac myocytes. PLoS One. 7:e332832012. View Article : Google Scholar : PubMed/NCBI

24 

Massi P, Valenti M, Vaccani A, Gasperi V, Perletti G, Marras E, Fezza F, Maccarrone M and Parolaro D: 5-Lipoxygenase and anandamide hydrolase (FAAH) mediate the antitumor activity of cannabidiol, a non-psychoactive cannabinoid. J Neurochem. 104:1091–1100. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Zhou L, Ding L, Yin P, Lu X, Wang X, Niu J, Gao P and Xu G: Serum metabolic profiling study of hepatocellular carcinoma infected with hepatitis B or hepatitis C virus by using liquid chromatography-mass spectrometry. J Proteome Res. 11:5433–5442. 2012. View Article : Google Scholar : PubMed/NCBI

26 

Xu X, Liu Y, Huang S, Liu G, Xie C, Zhou J, Fan W, Li Q, Wang Q, Zhong D and Miao X: Overexpression of cannabinoid receptors CB1 and CB2 correlates with improved prognosis of patients with hepatocellular carcinoma. Cancer Genet Cytogenet. 171:31–38. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Mukhopadhyay B, Schuebel K, Mukhopadhyay P, Cinar R, Godlewski G, Xiong K, Mackie K, Lizak M, Yuan Q, Goldman D and Kunos G: Cannabinoid receptor 1 promotes hepatocellular carcinoma initiation and progression through multiple mechanisms. Hepatology. 61:1615–1626. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Louvet A, Teixeira-Clerc F, Chobert MN, Deveaux V, Pavoine C, Zimmer A, Pecker F, Mallat A and Lotersztajn S: Cannabinoid CB2 receptors protect against alcoholic liver disease by regulating Kupffer cell polarization in mice. Hepatology. 54:1217–1226. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Teixeira-Clerc F, Belot MP, Manin S, Deveaux V, Cadoudal T, Chobert MN, Louvet A, Zimmer A, Tordjmann T, Mallat A and Lotersztajn S: Beneficial paracrine effects of cannabinoid receptor 2 on liver injury and regeneration. Hepatology. 52:1046–1059. 2010. View Article : Google Scholar : PubMed/NCBI

30 

Blázquez C, Casanova ML, Planas A, Gómez Del Pulgar T, Villanueva C, Fernández-Aceñero MJ, Aragonés J, Huffman JW, Jorcano JL and Guzmán M: Inhibition of tumor angiogenesis by cannabinoids. FASEB J. 17:529–531. 2003. View Article : Google Scholar : PubMed/NCBI

31 

Hermanson DJ and Marnett LJ: Cannabinoids, endocannabinoids, and cancer. Cancer Metast Rev. 30:599–612. 2011. View Article : Google Scholar

32 

Ravi J, Sneh A, Shilo K, Nasser MW, Nasser MW and Ganju RK: FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway. Oncotarget. 5:2475–2486. 2014. View Article : Google Scholar : PubMed/NCBI

33 

Nomura DK, Lombardi DP, Chang JW, Niessen S, Ward AM, Long JZ, Hoover HH and Cravatt BF: Monoacylglycerol lipase exerts dual control over endocannabinoid and fatty acid pathways to support prostate cancer. Chem Biol. 18:846–856. 2011. View Article : Google Scholar : PubMed/NCBI

34 

Cianchi F, Papucci L, Schiavone N, Lulli M, Magnelli L, Vinci MC, Messerini L, Manera C, Ronconi E, Romagnani P, et al: Cannabinoid receptor activation induces apoptosis through tumor necrosis factor α–mediated ceramide de novo synthesis in colon cancer cells. Clin Cancer Res. 14:7691–7700. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Karahatay S, Thomas K, Koybasi S, Senkal CE, Elojeimy S, Liu X, Bielawski J, Day TA, Gillespie MB, Sinha D, et al: Clinical relevance of ceramide metabolism in the pathogenesis of human head and neck squamous cell carcinoma (HNSCC): Attenuation of C(18)-ceramide in HNSCC tumors correlates with lymphovascular invasion and nodal metastasis. Cancer Lett. 256:101–111. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Befeler AS and Di Bisceglie AM: Hepatocellular carcinoma: Diagnosis and treatment. Gastroenterology. 122:1609–1619. 2002. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Tian Y, Zheng R, Li L and Qiu F: Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma. Oncol Lett 18: 1530-1538, 2019.
APA
Yang, J., Tian, Y., Zheng, R., Li, L., & Qiu, F. (2019). Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma. Oncology Letters, 18, 1530-1538. https://doi.org/10.3892/ol.2019.10399
MLA
Yang, J., Tian, Y., Zheng, R., Li, L., Qiu, F."Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma". Oncology Letters 18.2 (2019): 1530-1538.
Chicago
Yang, J., Tian, Y., Zheng, R., Li, L., Qiu, F."Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma". Oncology Letters 18, no. 2 (2019): 1530-1538. https://doi.org/10.3892/ol.2019.10399
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Tian Y, Zheng R, Li L and Qiu F: Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma. Oncol Lett 18: 1530-1538, 2019.
APA
Yang, J., Tian, Y., Zheng, R., Li, L., & Qiu, F. (2019). Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma. Oncology Letters, 18, 1530-1538. https://doi.org/10.3892/ol.2019.10399
MLA
Yang, J., Tian, Y., Zheng, R., Li, L., Qiu, F."Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma". Oncology Letters 18.2 (2019): 1530-1538.
Chicago
Yang, J., Tian, Y., Zheng, R., Li, L., Qiu, F."Endocannabinoid system and the expression of endogenous ceramides in human hepatocellular carcinoma". Oncology Letters 18, no. 2 (2019): 1530-1538. https://doi.org/10.3892/ol.2019.10399
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