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Article Open Access

Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer

  • Authors:
    • Wenyong Zhou
    • Tao Liu
    • Gaowa Saren
    • Li Liao
    • Wentao Fang
    • Heng Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, P.R. China, Department of Oncology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China, Department of Intensive Care, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China
    Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1145-1156
    |
    Published online on: May 30, 2019
       https://doi.org/10.3892/ol.2019.10414
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Abstract

Non‑small cell lung cancer (NSCLC) is the primary subtype of lung cancer. Long non‑coding RNAs (lncRNAs) have been reported to serve prominent roles in cancer progression. However, the expression patterns and potential roles of lncRNAs in NSCLC remain to be elucidated. In the present study, four public datasets were analyzed to identify differentially expressed lncRNAs (DElncs) in NSCLC. A further dataset, GSE19188, was analyzed to validate the findings. A total of 38 upregulated and 31 downregulated lncRNAs were identified in NSCLC, compared with samples from healthy controls. Among these, 12 lncRNAs were associated with the progression of NSCLC, and dysregulated between high grade (stage III and IV) and low grade (stage II) NSCLC samples. Moreover, dysregulation of lncRNA‑SIGLEC17P, GGTA1P, A2M‑AS1, LINC00938, GVINP1, LINC00667 and TMPO‑AS1 was associated with overall survival time in patients with NSCLC. Co‑expression analyses, combined with the construction of protein‑protein interaction networks, were performed to reveal the potential roles of key lncRNAs in NSCLC. The present study revealed a series of lncRNAs involved in the progression of NSCLS, which may serve as novel biomarkers for the disease.
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Copy and paste a formatted citation
Spandidos Publications style
Zhou W, Liu T, Saren G, Liao L, Fang W and Zhao H: Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer. Oncol Lett 18: 1145-1156, 2019.
APA
Zhou, W., Liu, T., Saren, G., Liao, L., Fang, W., & Zhao, H. (2019). Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer. Oncology Letters, 18, 1145-1156. https://doi.org/10.3892/ol.2019.10414
MLA
Zhou, W., Liu, T., Saren, G., Liao, L., Fang, W., Zhao, H."Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer". Oncology Letters 18.2 (2019): 1145-1156.
Chicago
Zhou, W., Liu, T., Saren, G., Liao, L., Fang, W., Zhao, H."Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer". Oncology Letters 18, no. 2 (2019): 1145-1156. https://doi.org/10.3892/ol.2019.10414
Copy and paste a formatted citation
x
Spandidos Publications style
Zhou W, Liu T, Saren G, Liao L, Fang W and Zhao H: Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer. Oncol Lett 18: 1145-1156, 2019.
APA
Zhou, W., Liu, T., Saren, G., Liao, L., Fang, W., & Zhao, H. (2019). Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer. Oncology Letters, 18, 1145-1156. https://doi.org/10.3892/ol.2019.10414
MLA
Zhou, W., Liu, T., Saren, G., Liao, L., Fang, W., Zhao, H."Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer". Oncology Letters 18.2 (2019): 1145-1156.
Chicago
Zhou, W., Liu, T., Saren, G., Liao, L., Fang, W., Zhao, H."Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer". Oncology Letters 18, no. 2 (2019): 1145-1156. https://doi.org/10.3892/ol.2019.10414
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