Open Access

Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer

  • Authors:
    • Wenyong Zhou
    • Tao Liu
    • Gaowa Saren
    • Li Liao
    • Wentao Fang
    • Heng Zhao
  • View Affiliations

  • Published online on: May 30, 2019     https://doi.org/10.3892/ol.2019.10414
  • Pages: 1145-1156
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Non‑small cell lung cancer (NSCLC) is the primary subtype of lung cancer. Long non‑coding RNAs (lncRNAs) have been reported to serve prominent roles in cancer progression. However, the expression patterns and potential roles of lncRNAs in NSCLC remain to be elucidated. In the present study, four public datasets were analyzed to identify differentially expressed lncRNAs (DElncs) in NSCLC. A further dataset, GSE19188, was analyzed to validate the findings. A total of 38 upregulated and 31 downregulated lncRNAs were identified in NSCLC, compared with samples from healthy controls. Among these, 12 lncRNAs were associated with the progression of NSCLC, and dysregulated between high grade (stage III and IV) and low grade (stage II) NSCLC samples. Moreover, dysregulation of lncRNA‑SIGLEC17P, GGTA1P, A2M‑AS1, LINC00938, GVINP1, LINC00667 and TMPO‑AS1 was associated with overall survival time in patients with NSCLC. Co‑expression analyses, combined with the construction of protein‑protein interaction networks, were performed to reveal the potential roles of key lncRNAs in NSCLC. The present study revealed a series of lncRNAs involved in the progression of NSCLS, which may serve as novel biomarkers for the disease.
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August-2019
Volume 18 Issue 2

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Spandidos Publications style
Zhou W, Liu T, Saren G, Liao L, Fang W and Zhao H: Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer. Oncol Lett 18: 1145-1156, 2019
APA
Zhou, W., Liu, T., Saren, G., Liao, L., Fang, W., & Zhao, H. (2019). Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer. Oncology Letters, 18, 1145-1156. https://doi.org/10.3892/ol.2019.10414
MLA
Zhou, W., Liu, T., Saren, G., Liao, L., Fang, W., Zhao, H."Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer". Oncology Letters 18.2 (2019): 1145-1156.
Chicago
Zhou, W., Liu, T., Saren, G., Liao, L., Fang, W., Zhao, H."Comprehensive analysis of differentially expressed long non‑coding RNAs in non‑small cell lung cancer". Oncology Letters 18, no. 2 (2019): 1145-1156. https://doi.org/10.3892/ol.2019.10414