Screening and identification of key biomarkers in lung squamous cell carcinoma by bioinformatics analysis
- Authors:
- Jun Man
- Xiaomei Zhang
- Huan Dong
- Simin Li
- Xiaolin Yu
- Lihong Meng
- Xiaofeng Gu
- Hong Yan
- Jinwei Cui
- Yuxin Lai
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Affiliations: Department of Internal Medicine of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, P.R. China, Department of Respiratory Medicine, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing 100078, P.R. China - Published online on: September 16, 2019 https://doi.org/10.3892/ol.2019.10873
- Pages: 5185-5196
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Copyright: © Man et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
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|
Youlden DR, Cramb SM and Baade PD: The International Epidemiology of Lung Cancer: Geographical distribution and secular trends. J Thorac Oncol. 3:819–831. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lazarus KA, Hadi F, Zambon E, Bach K, Santolla MF, Watson JK, Correia LL, Das M, Ugur R, Pensa S, et al: BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma. Nat Commun. 9:33272018. View Article : Google Scholar : PubMed/NCBI | |
|
Kris MG, Johnson BE, Kwiatkowski DJ, Iafrate AJ, Wistuba II, Aronson SL, Engelman JA, Shyr Y, Khuri FR, Rudin CM, et al: Identification of driver mutations in tumor specimens from 1,000 patients with lung adenocarcinoma: The NCI's Lung Cancer Mutation Consortium (LCMC). J Clin Oncol. 29:CRA75062011. View Article : Google Scholar | |
|
Chan BA and Hughes BG: Targeted therapy for non-small cell lung cancer: Current standards and the promise of the future. Transl Lung Cancer Res. 4:36–54. 2015.PubMed/NCBI | |
|
Vayshlya NA, Zinovyeva MV, Sass AV, Kopantzev EP, Vinogradova TV and Sverdlov ED: Increased expression of BIRC5 in non-small cell lung cancer and esophageal squamous cell carcinoma does not correlate with the expression of its inhibitors SMAC/DIABLO and PML. Mol Biol. 42:579–587. 2008. View Article : Google Scholar | |
|
Li S, Sun X, Miao S, Liu J and Jiao W: Differential protein-coding gene and long noncoding RNA expression in smoking-related lung squamous cell carcinoma. Thorac Cancer. 8:672–681. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ganapathy-Kanniappan S, Geschwind JF, Kunjithapatham R, Buijs M, Vossen JA, Tchernyshyov I, Cole RN, Syed LH, Rao PP, Ota S and Vali M: Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pyruvylated during 3-bromopyruvate mediated cancer cell death. Anticancer Res. 29:4909–4918. 2009.PubMed/NCBI | |
|
Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, Keating MJ and Huang P: Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res. 65:613–621. 2005.PubMed/NCBI | |
|
Dawany NB and Tozeren A: Asymmetric microarray data produces gene lists highly predictive of research literature on multiple cancer types. BMC Bioinformatics. 11:4832010. View Article : Google Scholar : PubMed/NCBI | |
|
Dawany NB, Dampier WN and Tozeren A: Large-scale integration of microarray data reveals genes and pathways common to multiple cancer types. Int J Cancer. 128:2881–2891. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Lin J, Marquardt G, Mullapudi N, Wang T, Han W, Shi M, Keller S, Zhu C, Locker J and Spivack SD: Lung cancer transcriptomes refined with laser capture microdissection. Am J Pathol. 184:2868–2884. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Rohrbeck A, Neukirchen J, Rosskopf M, Pardillos GG, Geddert H, Schwalen A, Gabbert HE, von Haeseler A, Pitschke G, Schott M, et al: Gene expression profiling for molecular distinction and characterization of laser captured primary lung cancers. J Transl Med. 6:692008. View Article : Google Scholar : PubMed/NCBI | |
|
Boelens MC, van den Berg A, Fehrmann RS, Geerlings M, de Jong WK, te Meerman GJ, Sietsma H, Timens W, Postma DS and Groen HJ: Current smoking-specific gene expression signature in normal bronchial epithelium is enhanced in squamous cell lung cancer. J Pathol. 218:182–191. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Huang DW, Sherman BT, Tan Q, Kir J, Liu D, Bryant D, Guo Y, Stephens R, Baseler MW, Lane HC and Lempicki RA: DAVID Bioinformatics Resources: Expanded annotation database and novel algorithms to better extract biology from large gene lists. Nucleic Acids Res. 35:W169–W175. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Kanehisa M, Furumichi M, Tanabe M, Sato Y and Morishima K: KEGG: New perspectives on genomes, pathways, diseases and drugs. Nucleic Acids Res. 45:D353–D361. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al: Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Szklarczyk D, Franceschini A, Wyder S, Forslund K, Heller D, Huerta-Cepas J, Simonovic M, Roth A, Santos A, Tsafou KP, et al: STRING v10: Protein-protein interaction networks, integrated over the tree of life. Nucleic Acids Res. 43:D447–D452. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Smoot ME, Ono K, Ruscheinski J, Wang PL and Ideker T: Cytoscape 2.8: New features for data integration and network visualization. Bioinformatics. 27:431–432. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Bader GD and Hogue CW: An automated method for finding molecular complexes in large protein interaction networks. BMC Bioinformatics. 4:22003. View Article : Google Scholar : PubMed/NCBI | |
|
Scardoni G, Tosadori G, Faizan M, Spoto F, Fabbri F and Laudanna C: Biological network analysis with CentiScaPe: Centralities and experimental dataset integration. F1000Res. 3:1392014. View Article : Google Scholar : PubMed/NCBI | |
|
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI | |
|
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Discov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Mangan ME, Williams JM, Lathe SM, Karolchik D and Lathe WC III: UCSC genome browser: Deep support for molecular biomedical research. Biotechnol Annu Rev. 14:63–108. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Hou J, Aerts J, den Hamer B, van Ijcken W, den Bakker M, Riegman P, van der Leest C, van der Spek P, Foekens JA, Hoogsteden HC, et al: Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One. 5:e103122010. View Article : Google Scholar : PubMed/NCBI | |
|
Garber ME, Troyanskaya OG, Schluens K, Petersen S, Thaesler Z, Pacyna-Gengelbach M, van de Rijn M, Rosen GD, Perou CM, Whyte RI, et al: Diversity of gene expression in adenocarcinoma of the lung. Proc Natl Acad Sci USA. 98:13784–13789. 2001. View Article : Google Scholar : PubMed/NCBI | |
|
Wachi S, Yoneda K and Wu R: Interactome-transcriptome analysis reveals the high centrality of genes differentially expressed in lung cancer tissues. Bioinformatics. 21:4205–4208. 2005. View Article : Google Scholar : PubMed/NCBI | |
|
Hou J, Aerts J, den Hamer B, van Ijcken W, den Bakker M, Riegman P, van der Leest C, van der Spek P, Foekens JA, Hoogsteden HC, et al: Gene expression-based classification of non-small cell lung carcinomas and survival prediction. PLoS One. 5:e103122010. View Article : Google Scholar : PubMed/NCBI | |
|
Hou GX, Liu P, Yang J and Wen S: Mining expression and progQixing M, Gaochao D, Wenjie X, Anpeng W, Bing C, Weidong M, Lin X and Feng J: Microarray analyses reveal genes related to progression and prognosis of esophageal squamous cell carcinoma. Oncotarget. 8:78838–78850. 2017.PubMed/NCBI | |
|
Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: a cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Siegel RL, Miller KD and Jemal A: Cancer statistics, 2017. CA Cancer J Clin. 67:7–30. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Sholl LM, Aisner DL, Varella-Garcia M, Berry LD, Dias-Santagata D, Wistuba II, Chen H, Fujimoto J, Kugler K, Franklin WA, et al: Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium ExperienceJ Thorac Oncol; 10. pp. 768–777. 2015, PubMed/NCBI | |
|
Mantripragada K and Khurshid H: Targeting genomic alterations in squamous cell lung cancer. Front Oncol. 3:1952013. View Article : Google Scholar : PubMed/NCBI | |
|
Heist RS, Sequist LV and Engelman JA: Genetic changes in squamous cell lung cancer: A review. J Thorac Oncol. 7:924–933. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Cancer Genome Atlas Research Network, . Comprehensive genomic characterization of squamous cell lung cancers. Nature. 489:519–525. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Brambilla C, Laffaire J, Lantuejoul S, Moro-Sibilot D, Mignotte H, Arbib F, Toffart AC, Petel F, Hainaut P, Rousseaux S, et al: Lung squamous cell carcinomas with basaloid histology represent a specific molecular entity. Clin Cancer Res. 20:5777–5786. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Yao W, Bai Y, Li Y, Guo L, Zeng P, Wang Y, Qi B, Liu S, Qin X, Li Y and Zhao B: Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma. Tumour Biol. 37:4305–4312. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Lee CH, Lee MK, Kang CD, Kim YD, Park DY, Kim JY, Sol MY and Suh KS: Differential expression of hypoxia inducible factor-1 alpha and tumor cell proliferation between squamous cell carcinomas and adenocarcinomas among operable non-small cell lung carcinomas. J Korean Med Sci. 18:196–203. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Hirano T, Franzén B, Kato H, Ebihara Y and Auer G: Genesis of squamous cell lung carcinoma. Sequential changes of proliferation, DNA ploidy, and p53 expression. Am J Pathol. 144:296–302. 1994.PubMed/NCBI | |
|
Liu GM and Zhang YM: Targeting FBPase is an emerging novel approach for cancer therapy. Cancer Cell Int. 18:362018. View Article : Google Scholar : PubMed/NCBI | |
|
Hanahan D and Weinberg RA: Hallmarks of cancer: The next generation. Cell. 144:646–674. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Keku T, Millikan R, Worley K, Winkel S, Eaton A, Biscocho L, Martin C and Sandler R: 5,10-methylenetetrahydrofolate reductase codon 677 and 1298 polymorphisms and colon cancer in African Americans and whites. Cancer Epidemiol Biomarkers Prev. 11:1611–1621. 2002.PubMed/NCBI | |
|
Ferlazzo N, Currò M, Zinellu A, Caccamo D, Isola G, Ventura V, Carru C, Matarese G and Ientile R: Influence of MTHFR genetic background on p16 and MGMT methylation in oral squamous cell cancer. Int J Mol Sci. 18:E7242017. View Article : Google Scholar : PubMed/NCBI | |
|
Fujii T, Toyooka S, Ichimura K, Fujiwara Y, Hotta K, Soh J, Suehisa H, Kobayashi N, Aoe M, Yoshino T, et al: ERCC1 protein expression predicts the response of cisplatin-based neoadjuvant chemotherapy in non-small-cell lung cancer. Lung Cancer. 59:377–384. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Kasai D, Ozasa H, Oguri T, Miyazaki M, Uemura T, Takakuwa O, Kunii E, Ohkubo H, Maeno K and Niimi A: Thymidylate synthase gene copy number as a predictive marker for response to pemetrexed treatment of lung adenocarcinoma. Anticancer Res. 33:1935–1940. 2013.PubMed/NCBI | |
|
Lu Y, Zhuo C, Cui B, Liu Z, Zhou P, Lu Y and Wang B: TYMS serves as a prognostic indicator to predict the lymph node metastasis in Chinese patients with colorectal cancer. Clin Biochem. 46:1478–1483. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
da Silva Nogueira J Jr, de Lima Marson FA and Sílvia Bertuzzo C: Thymidylate synthase gene (TYMS) polymorphisms in sporadic and hereditary breast cancer. BMC Res Notes. 5:6762012. View Article : Google Scholar : PubMed/NCBI | |
|
Shichijo S, Azuma K, Komatsu N, Ito M, Maeda Y, Ishihara Y and Itoh K: Two proliferation-related proteins, TYMS and PGK1, could be new cytotoxic T lymphocyte-directed tumor-associated antigens of HLA-A2+ colon cancer. Clin Cancer Res. 10:5828–5836. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Chao YL and Anders CK: TYMS gene polymorphisms in breast cancer patients receiving 5-fluorouracil-based chemotherapy. Clin Breast Cancer. 18:e301–e304. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
He Y, Penney ME, Negandhi AA, Parfrey PS, Savas S and Yilmaz YE: XRCC3 Thr241Met and TYMS variable number tandem repeat polymorphisms are associated with time-to-metastasis in colorectal cancer. PLoS One. 13:e01923162018. View Article : Google Scholar : PubMed/NCBI | |
|
Knizhnik AV, Kovaleva OB, Laktionov KK, Mochal'nikova VV, Komel'kov AV, Chevkina EM and Zborovskaia IB: Arf6, RalA and BIRC5 protein expression in non small cell lung cancer. Mol Biol (Mosk). 45:307–315. 2011.(In Russian). View Article : Google Scholar : PubMed/NCBI | |
|
Yu X, Zhang Y, Cavazos D, Ma X, Zhao Z, Du L and Pertsemlidis A: miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer. Cell Death Dis. 9:1932018. View Article : Google Scholar : PubMed/NCBI | |
|
Phiboonchaiyanan PP, Petpiroon N, Sritularak B and Chanvorachote P: Phoyunnanin E induces apoptosis of non-small cell lung cancer cells via p53 activation and down-regulation of survivin. Anticancer Res. 38:6281–6290. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Ganapathy-Kanniappan S: Evolution of GAPDH as a druggable target of tumor glycolysis? Expert Opin Ther Targets. 22:295–298. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Hao L, Zhou X, Liu S, Sun M, Song Y, Du S, Sun B, Guo C, Gong L, Hu J, et al: Elevated GAPDH expression is associated with the proliferation and invasion of lung and esophageal squamous cell carcinomas. Proteomics. 15:3087–3100. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Mo ML, Chen Z, Li J, Li HL, Sheng Q, Ma HY, Zhang FX, Hua YW, Zhang X, Sun DQ, et al: Use of serum circulating CCNB2 in cancer surveillance. Int J Biol Markers. 25:2010. View Article : Google Scholar | |
|
Takashima S, Saito H, Takahashi N, Imai K, Kudo S, Atari M, Saito Y, Motoyama S and Minamiya Y: Strong expression of cyclin B2 mRNA correlates with a poor prognosis in patients with non-small cell lung cancer. Tumour Biol. 35:4257–4265. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Lei CY, Wang W, Zhu YT, Fang WY and Tan WL: The decrease of cyclin B2 expression inhibits invasion and metastasis of bladder cancer. Urol Oncol. 34:237.e1–e10. 2016. View Article : Google Scholar | |
|
Wang XC, Yue X, Zhang RX, Liu TY, Pan ZZ, Yang MJ, Lu ZH, Wang ZY, Peng JH, Le LY, et al: Genome-wide RNAi screening identifies RFC4 as a factor that mediates radioresistance in colorectal cancer by facilitating nonhomologous end joining repair. Clin Cancer Res. 25:4567–4579. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Xiang J, Fang L, Luo Y, Yang Z, Liao Y, Cui J, Huang M, Yang Z, Huang Y, Fan X, et al: Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer. J Transl Med. 12:3202014. View Article : Google Scholar : PubMed/NCBI | |
|
Liu YZ, Wang BS, Jiang YY, Cao J, Hao JJ, Zhang Y, Xu X, Cai Y and Wang MR: MCMs expression in lung cancer: Implication of prognostic significance. J Cancer. 8:3641–3647. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Behrens C, Solis LM, Lin H, Yuan P, Tang X, Kadara H, Riquelme E, Galindo H, Moran CA, Kalhor N, et al: EZH2 protein expression associates with the early pathogenesis, tumor progression, and prognosis of non-small cell lung carcinoma. Clin Cancer Res. 19:6556–6565. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Shi R, Li M, Raghavan V, Tam S, Cabanero M, Pham NA, Shepherd FA, Moghal N and Tsao MS: Targeting the CDK4/6-Rb pathway enhances response to PI3K inhibition in PIK3CA-mutant lung squamous cell carcinoma. Clin Cancer Res. 24:5990–6000. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Chen L and Pan J: Dual cyclin-dependent kinase 4/6 inhibition by PD-0332991 induces apoptosis and senescence in oesophageal squamous cell carcinoma cells. Br J Pharmacol. 174:2427–2443. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Ma Y, Lin D, Sun W, Xiao T, Yuan J, Han N, Guo S, Feng X, Su K, Mao Y, et al: Expression of targeting protein for xklp2 associated with both malignant transformation of respiratory epithelium and progression of squamous cell lung cancer. Clin Cancer Res. 12:1121–1127. 2006. View Article : Google Scholar : PubMed/NCBI | |
|
Mollinari C, Kleman JP, Jiang W, Schoehn G, Hunter T and Margolis RL: PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone. J Cell Biol. 157:1175–1186. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Zhan P, Xi GM, Liu HB, Liu YF, Xu WJ, Zhu Q, Zhou ZJ, Miao YY, Wang XX, Jin JJ, et al: Protein regulator of cytokinesis-1 expression: Prognostic value in lung squamous cell carcinoma patients. J Thorac Dis. 9:2054–2060. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Huang J, Zhou Y, Thomas GS, Gu Z, Yang Y, Xu H, Tricot G and Zhan F: NEDD8 inhibition overcomes CKS1B-induced drug resistance by upregulation of p21 in multiple myeloma. Clin Cancer Res. 21:5532–5542. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Zhan F, Colla S, Wu X, Chen B, Stewart JP, Kuehl WM, Barlogie B and Shaughnessy JD Jr: CKS1B, overexpressed in aggressive disease, regulates multiple myeloma growth and survival through SKP2- and p27Kip1-dependent and -independent mechanisms. Blood. 109:4995–5001. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Romero Arenas MA, Whitsett TG, Aronova A, Henderson SA, LoBello J, Habra MA, Grubbs EG, Lee JE, Sircar K, Zarnegar R, et al: Protein expression of PTTG1 as a diagnostic biomarker in adrenocortical carcinoma. Ann Surg Oncol. 25:801–807. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Guo XC, Li L, Gao ZH, Zhou HW, Li J and Wang QQ: The long non-coding RNA PTTG3P promotes growth and metastasis of cervical cancer through PTTG1. Aging (Albany NY). 11:1333–1341. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Huang JL, Cao SW, Ou QS, Yang B, Zheng SH, Tang J, Chen J, Hu YW, Zheng L and Wang Q: The long non-coding RNA PTTG3P promotes cell growth and metastasis via up-regulating PTTG1 and activating PI3K/AKT signaling in hepatocellular carcinoma. Mol Cancer. 17:932018. View Article : Google Scholar : PubMed/NCBI | |
|
You H, Lin H and Zhang Z: CKS2 in human cancers: Clinical roles and current perspectives (Review). Mol Clin Oncol. 3:459–463. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Hauge S, Naucke C, Hasvold G, Joel M, Rødland GE, Juzenas P, Stokke T and Syljuåsen RG: Combined inhibition of Wee1 and Chk1 gives synergistic DNA damage in S-phase due to distinct regulation of CDK activity and CDC45 loading. Oncotarget. 8:10966–10979. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Jensen JB, Munksgaard PP, Sørensen CM, Fristrup N, Birkenkamp-Demtroder K, Ulhøi BP, Jensen KM, Ørntoft TF and Dyrskjøt L: High expression of karyopherin-α2 defines poor prognosis in non-muscle-invasive bladder cancer and in patients with invasive bladder cancer undergoing radical cystectomy. Eur Urol. 59:841–848. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Goto Y, Kurozumi A, Arai T, Nohata N, Kojima S, Okato A, Kato M, Yamazaki K, Ishida Y, Naya Y, et al: Impact of novel miR-145-3p regulatory networks on survival in patients with castration-resistant prostate cancer. Br J Cancer. 117:409–420. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Garnett MJ, Mansfeld J, Godwin C, Matsusaka T, Wu J, Russell P, Pines J and Venkitaraman AR: UBE2S elongates ubiquitin chains on APC/C substrates to promote mitotic exit. Nat Cell Biol. 11:1363–1369. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Akter KA, Hyodo T, Asano E, Sato N, Mansour MA, Ito S, Hamaguchi M and Senga T: Erratum to: UBE2S is associated with malignant characteristics of breast cancer cells. Tumor Biol. 37:69992016. View Article : Google Scholar | |
|
Ben-Eliezer I, Pomerantz Y, Galiani D, Nevo N and Dekel N: Appropriate expression of Ube2C and Ube2S controls the progression of the first meiotic division. FASEB J. 29:4670–4681. 2015. View Article : Google Scholar : PubMed/NCBI |
