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Review Open Access

Effects of aspirin on the gastrointestinal tract: Pros vs. cons (Review)

  • Authors:
    • Zhuoya Li
    • Zheng Wang
    • Baile Shen
    • Chen Chen
    • Xiaoyun Ding
    • Haojun Song
  • View Affiliations / Copyright

    Affiliations: Department of Internal Medicine, The Medical School of Ningbo University, Ningbo, Zhejiang 315000, P.R. China, Department of Gastroenterology, Ningbo First Hospital, Ningbo, Zhejiang 315000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2567-2578
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    Published online on: July 6, 2020
       https://doi.org/10.3892/ol.2020.11817
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Abstract

Acetylsalicylic acid, also known as aspirin, is often used in clinical antipyretic, analgesic and antiplatelet therapy. Aspirin can cause numerous side effects in the gastrointestinal (GI) tract, ranging from unpleasant GI symptoms without gastric mucosal lesions to ulcer bleeding and even death. However, recent studies have found that aspirin can significantly prevent GI tumors. Despite impressive advances in cancer research, screening and treatment options, GI tumors remain a leading cause of death worldwide. Prevention is a far better option than treatment for tumors. Therefore, the present review assesses the pros and cons of aspirin on the GI tract and, on this the basis, the appropriate dose of aspirin to protect it.
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1 

Jemal A, Center MM, DeSantis C and Ward EM: Global patterns of cancer incidence and mortality rates and trends. Cancer Epidemiol Biomarkers Prev. 19:1893–1907. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Onyoh EF, Hsu WF, Chang LC, Lee YC, Wu MS and Chiu HM: The rise of colorectal cancer in asia: Epidemiology, screening, and management. Curr Gastroenterol Rep. 21:362019. View Article : Google Scholar : PubMed/NCBI

4 

Rahman R, Asombang AW and Ibdah JA: Characteristics of gastric cancer in Asia. World J Gastroenterol. 20:4483–4490. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Wick JY: Aspirin: A history, A love story. Consult Pharm. 27:322–329. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Amsterdam EA, Wenger NK, Brindis RG, Casey DE, Ganiats TG, Holmes DR, Jaffe AS, Jneid H, Kelly RF, Kontos MC, et al: 2014 AHA/ACC Guideline for the management of patients with Non-ST-Elevation acute coronary syndromes: Executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. J Am Colle Cardiol. 64:2645–2687. 2014. View Article : Google Scholar

7 

Antithrombotic Trialists' (ATT) Collaboration, . Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, Peto R, Buring J, Hennekens C, Kearney P, et al: Aspirin in the primary and secondary prevention of vascular disease: Collaborative meta-analysis of individual participant data from randomised trials. Lancet. 373:1849–1860. 2009. View Article : Google Scholar : PubMed/NCBI

8 

Roffi M, Patrono C, Collet J, Mueller C, Valgimigli M, Andreotti F, Bax J, Borger M, Brotons C, Chew DP, et al: 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation. Task Force for the management of acute coronary syndromes in patients presenting without persistent ST-Segment Elevation of the European Society of Cardiology (ESC). G Ital Cardiol (Rome). 17:831–872. 2016.(In Italian). PubMed/NCBI

9 

Smith DK, Demetriou T and Weber C: Aspirin for primary prevention: USPSTF recommendations for CVD and colorectal cancer. J Fam Pract. 68:146–151. 2019.PubMed/NCBI

10 

Ventura L, Miccinesi G, Barchielli A, Manneschi G, Puliti D, Mantellini P, Orso F and Zappa M: Does low-dose aspirin use for cardiovascular disease prevention reduce colorectal cancer deaths? A comparison of two cohorts in the Florence district, Italy. Eur J Cancer Prev. 27:134–139. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Bibbins-Domingo K; U.S. Preventive Services Task Force, : Aspirin use for the primary prevention of cardiovascular disease and colorectal cancer: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med. 164:836–845. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Cea Soriano L, Soriano-Gabarró M and García Rodríguez LA: Incidence of colorectal cancer in new users and non-users of low-dose aspirin without existing cardiovascular disease: A cohort study using The Health Improvement Network. Int J Cardiol. 248:376–381. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Soon S, Chia WJ, Redekop K and Wee HL: A Cost-effectiveness analysis of aspirin in the primary prevention of cardiovascular diseases and colorectal cancer. Value Health. 18:A4622015. View Article : Google Scholar

14 

Lanas A and Gargallo CJ: Management of low-dose aspirin and clopidogrel in clinical practice: A gastrointestinal perspective. J Gastroenterol. 50:626–637. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Lanas A and Scheiman J: Low-dose aspirin and upper gastrointestinal damage: Epidemiology, prevention and treatment. Curr Med Res Opin. 23:163–173. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Yuhara H, Corley DA, Nakahara F, Nakajima T, Koike J, Igarashi M, Suauki T and Mine T: Aspirin and non-aspirin NSAIDs increase risk of colonic diverticular bleeding: A systematic review and meta-analysis. J Gastroenterol. 49:992–1000. 2014. View Article : Google Scholar : PubMed/NCBI

17 

Strum WB: Colorectal adenomas. N Engl J Med. 374:1065–1075. 2016. View Article : Google Scholar : PubMed/NCBI

18 

Giovannucci E, Rimm E, Stampfer M, Colditz G, Ascherio A and Willett WC: Aspirin use and the risk for colorectal cancer and adenoma in male health professionals. Ann Intern Med. 121:241–246. 1994. View Article : Google Scholar : PubMed/NCBI

19 

Thun MJ, Namboodiri MM and Heath C Jr: Aspirin use and reduced risk of fatal colon cancer. N Engl J Med. 325:1593–1596. 1991. View Article : Google Scholar : PubMed/NCBI

20 

Sandler R, Halabi S, Baron J, Budinger S, Paskett E, Keresztes R, Petrelli N, Pipas J, Karp D, Loprinzi CL, et al: A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. N Engl J Med. 348:883–890. 2003. View Article : Google Scholar : PubMed/NCBI

21 

Baron JA, Cole BF, Sandler RS, Haile RW, Ahnen D, Bresalier R, McKeown-Eyssen G, Summers RW, Rothstein R, Burke CA, et al: A randomized trial of aspirin to prevent colorectal adenomas. N Engl J Med. 348:891–899. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Half E, Bercovich D and Rozen P: Familial adenomatous polyposis. Orphanet J Rare Dis. 4:222009. View Article : Google Scholar : PubMed/NCBI

23 

Aihara H, Kumar N and Thompson CC: Diagnosis, surveillance, and treatment strategies for familial adenomatous polyposis: Rationale and update. Eur J Gastroenterol Hepatol. 26:255–262. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Iwama T, Tamura K, Morita T, Hirai T, Hasegawa H, Koizumi K, Shirouzu K, Sugihara K, Yamamura T, Muto T, et al: A clinical overview of familial adenomatous polyposis derived from the database of the polyposis registry of Japan. Int J Clin Oncol. 9:308–316. 2004. View Article : Google Scholar : PubMed/NCBI

25 

Jasperson K and Burt RW: The genetics of colorectal cancer. Surg Oncol Clin N Am. 24:683–703. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Ishikawa H: Chemoprevention of carcinogenesis in familial tumors. Int J Clin Oncol. 9:299–303. 2004. View Article : Google Scholar : PubMed/NCBI

27 

Ishikawa H, Wakabayashi K, Suzuki S, Mutoh M, Hirata K, Nakamura T, Takeyama I, Kawano A, Gondo N, Abe T, et al: Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: Double-blind, randomized clinical trial. Cancer Med. 2:50–56. 2013. View Article : Google Scholar : PubMed/NCBI

28 

Burn J, Bishop DT, Chapman PD, Elliott F, Bertario L, Dunlop MG, Eccles D, Ellis A, Evans DG, Fodde R, et al: A randomized placebo-controlled prevention trial of aspirin and/or resistant starch in young people with familial adenomatous polyposis. Cancer Prev Res (Phila). 4:655–665. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Cea Soriano L, Soriano-Gabarró M and Garcia Rodríiguez LA: Incidence of colorectal cancer in new users and non-users of low-dose aspirin without existing cardiovascular disease: A cohort study using The Health Improvement Network. Int J Cardiol. 248:376–381. 2017. View Article : Google Scholar : PubMed/NCBI

30 

Cao Y, Nishihara R, Wu K, Wang M, Ogino S, Willett WC, Spiegelman D, Fuchs CS, Giovannucci EL and Chan AT: Population-wide impact of long-term use of aspirin and the risk for cancer. JAMA Oncol. 2:762–769. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Thun MJ, Henley SJ and Patrono C: Nonsteroidal Anti-inflammatory drugs as anticancer agents: Mechanistic, pharmacologic, and clinical issues. J Nat Cancer Inst. 94:252–266. 2002. View Article : Google Scholar : PubMed/NCBI

32 

Rothwell PM, Price JF, Fowkes FG, Zanchetti A, Roncaglioni MC, Tognoni G, Lee R, Belch JF, Wilson M, Mehta Z and Meade TW: Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: Analysis of the time course of risks and benefits in 51 randomised controlled trials. Lancet. 379:1602–1612. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Chubak J, Whitlock EP, Williams SB, Kamineni A, Burda BU, Buist DS and Anderson ML: Aspirin for the prevention of cancer incidence and mortality: Systematic evidence reviews for the U.S. Preventive Services Task Force. Ann Intern Med. 164:814–825. 2016. View Article : Google Scholar : PubMed/NCBI

34 

Flossmann E and Rothwell PM; British Doctors Aspirin Trial and the UK-TIA Aspirin Trial, : Effect of aspirin on long-term risk of colorectal cancer: Consistent evidence from randomised and observational studies. Lancet. 369:1603–1613. 2007. View Article : Google Scholar : PubMed/NCBI

35 

Rothwell PM, Wilson M, Elwin CE, Norrving B, Algra A, Warlow CP and Meade TW: Long-term effect of aspirin on colorectal cancer incidence and mortality: 20-year follow-up of five randomised trials. Lancet. 376:1741–1750. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Li XF, Xu BZ and Wang SZ: Aspirin inhibits the proliferation and migration of gastric cancer cells in p53-knockout mice. Oncol Lett. 12:3183–3186. 2016. View Article : Google Scholar : PubMed/NCBI

37 

Ratnasinghe LD, Graubard BI, Kahle L, Tangrea JA, Taylor PR and Hawk E: Aspirin use and mortality from cancer in a prospective cohort study. Anticancer Res. 24:3177–3184. 2004.PubMed/NCBI

38 

Thun MJ, Namboodiri MM, Calle EE, Flanders WD and Heath CW Jr: Aspirin use and risk of fatal cancer. Cancer Res. 53:1322–1327. 1993.PubMed/NCBI

39 

Rothwell PM, Fowkes FGR, Belch JFF, Ogawa H, Warlow CP and Meade TW: Effect of daily aspirin on long-term risk of death due to cancer: Analysis of individual patient data from randomised trials. Lancet. 377:31–41. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Farrow DC, Vaughan TL, Hansten PD, Stanford JL, Risch HA, Gammon MD, Chow WH, Dubrow R, Ahsan H, Mayne ST, et al: Use of aspirin and other nonsteroidal anti-inflammatory drugs and risk of esophageal and gastric cancer. Cancer Epidemiol Biomarkers Prev. 7:97–102. 1998.PubMed/NCBI

41 

Vaughan TL, Dong LM, Blount PL, Ayub K, Odze RD, Sanchez CA, Rabinovitch PS and Reid BJ: Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett's oesophagus: A prospective study. Lancet Oncol. 6:945–952. 2005. View Article : Google Scholar : PubMed/NCBI

42 

González-Pérez A, Rodríguez LAG and LópezRidaura R: Effects of non-steroidal anti-inflammatory drugs on cancer sites other than the colon and rectum: A meta-analysis. BMC Cancer. 3:282003. View Article : Google Scholar : PubMed/NCBI

43 

Liu JF, Jamieson GG, Wu TC, Zhu GJ and Drew PA: A preliminary study on the postoperative survival of patients given aspirin after resection for squamous cell carcinoma of the esophagus or adenocarcinoma of the cardia. Ann Surg Oncol. 16:1397–1402. 2009. View Article : Google Scholar : PubMed/NCBI

44 

Frouws MA, Bastiaannet E, Langley RE, Chia WK, van Herk-Sukel MP, Lemmens VE, Putter H, Hartgrink HH, Bonsing BA, Van de Velde CJ, et al: Effect of low-dose aspirin use on survival of patients with gastrointestinal malignancies; an observational study. Br J Cancer. 116:405–413. 2017. View Article : Google Scholar : PubMed/NCBI

45 

Macfarlane TV, Murchie P and Watson MC: Aspirin and other non-steroidal anti-inflammatory drug prescriptions and survival after the diagnosis of head and neck and oesophageal cancer. Cancer Epidemiol. 39:1015–1022. 2015. View Article : Google Scholar : PubMed/NCBI

46 

Bosetti C, Rosato V, Gallus S, Cuzick J and La Vecchia C: Aspirin and cancer risk: A quantitative review to 2011. Ann Oncol. 23:1403–1415. 2012. View Article : Google Scholar : PubMed/NCBI

47 

Jankowski JAZ, de Caestecker J, Love SB, Reilly G, Watson P, Sanders S, Ang Y, Morris D, Bhandari P, Brooks C, et al: Esomeprazole and aspirin in Barrett's oesophagus (AspECT): A randomised factorial trial. Lancet. 392:400–408. 2018. View Article : Google Scholar : PubMed/NCBI

48 

Spence AD, Busby J, Johnston BT, Baron JA, Hughes CM, Coleman HG and Cardwell CR: Low-Dose aspirin use does not increase survival in 2 independent population-based cohorts of patients with esophageal or gastric cancer. Gastroenterology. 154:849–860.e1. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Choi JH, Lee SH, Huh G, Chun JW, You MS, Paik WH, Ryu JK and Kim YT: The association between use of statin or aspirin and pancreatic ductal adenocarcinoma: A nested case-control study in a Korean nationwide cohort. Cancer Med. 8:7419–7430. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Sahasrabuddhe VV, Gunja MZ, Graubard BI, Trabert B, Schwartz LM, Park Y, Hollenbeck AR, Freedman ND and McGlynn KA: Nonsteroidal Anti-inflammatory drug use, chronic liver disease, and hepatocellular carcinoma. J Natl Cancer Inst. 104:1808–1814. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Coogan PF, Rosenberg L, Palmer JR, Strom BL, Zauber AG, Stolley PD and Shapiro S: Nonsteroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel. Cancer Epidemiol Biomarkers Prev. 9:119–123. 2000.PubMed/NCBI

52 

Petrick JL, Sahasrabuddhe VV, Chan AT, Alavanja MC, Beane-Freeman LE, Buring JE, Chen J, Chong DQ, Freedman ND, Fuchs CS, et al: NSAID use and risk of hepatocellular carcinoma and intrahepatic cholangiocarcinoma: The liver cancer pooling project. Cancer Prev Res. 8:1156–1162. 2015. View Article : Google Scholar

53 

Singh S, Singh PP, Roberts LR and Sanchez W: Chemopreventive strategies in hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol. 11:45–54. 2013. View Article : Google Scholar : PubMed/NCBI

54 

Hawk ET, Umar A and Viner JL: Colorectal cancer chemoprevention-an overview of the science 1 1 This article was prepared in our capacity as employees of the U.S. Federal Government. Gastroenterology. 126:1423–1447. 2004. View Article : Google Scholar : PubMed/NCBI

55 

Elwood PC, Gallagher AM, Duthie GG, Mur LA and Morgan G: Aspirin, salicylates, and cancer. Lancet. 373:1301–1309. 2009. View Article : Google Scholar : PubMed/NCBI

56 

Pasche B, Wang M, Pennison M and Jimenez H: Prevention and treatment of cancer with aspirin: Where do we stand? Semin Oncol. 41:397–401. 2014. View Article : Google Scholar : PubMed/NCBI

57 

Mahboubi Rabbani SMI and Zarghi A: Selective COX-2 inhibitors as anticancer agents: A patent review (2014–2018). Expert Opin Ther Pat. 29:407–427. 2019. View Article : Google Scholar : PubMed/NCBI

58 

Poorani R, Bhatt AN, Dwarakanath BS and Das UN: COX-2, aspirin and metabolism of arachidonic, eicosapentaenoic and docosahexaenoic acids and their physiological and clinical significance. Eur J Pharmacol. 785:116–132. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Wang D and Dubois RN: Prostaglandins and cancer. Gut. 55:115–122. 2006. View Article : Google Scholar : PubMed/NCBI

60 

Chell S, Kaidi A, Williams AC and Paraskeva C: Mediators of PGE2 synthesis and signalling downstream of COX-2 represent potential targets for the prevention/treatment of colorectal cancer. Biochim Biophys Acta. 1766:104–119. 2006.PubMed/NCBI

61 

Chan AT, Ogino S and Fuchs CS: Aspirin and the risk of colorectal cancer in relation to the expression of COX-2. N Engl J Med. 356:2131–2142. 2007. View Article : Google Scholar : PubMed/NCBI

62 

Zhang L, Yu J, Park BH, Kinzler KW and Vogelstein B: Role of BAX in the apoptotic response to anticancer agents. Science. 290:989–992. 2000. View Article : Google Scholar : PubMed/NCBI

63 

Zhang Z and Dubois RN: Par-4, a proapoptotic gene, is regulated by NSAIDs in human colon carcinoma cells. Gastroenterol. 118:1012–1017. 2000. View Article : Google Scholar

64 

Kashfi K and Rigas B: Non-COX-2 targets and cancer: Expanding the molecular target repertoire of chemoprevention. Biochem Pharmacol. 70:969–986. 2005. View Article : Google Scholar : PubMed/NCBI

65 

Shureiqi I, Xu X, Chen D, Lotan R, Morris JS, Fischer SM and Lippman SM: Nonsteroidal anti-inflammatory drugs induce apoptosis in esophageal cancer cells by restoring 15-lipoxygenase-1 expression. Cancer Res. 61:4879–4884. 2001.PubMed/NCBI

66 

Elmore S: Apoptosis: A review of programmed cell death. Toxicol Pathol. 35:495–516. 2007. View Article : Google Scholar : PubMed/NCBI

67 

McIlhatton MA, Tyler J, Burkholder S, Ruschoff J, Rigas B, Kopelovich L and Fishel R: Nitric Oxide-donating aspirin derivatives suppress microsatellite instability in mismatch repair-deficient and hereditary nonpolyposis colorectal cancer cells. Cancer Res. 67:10966–10975. 2007. View Article : Google Scholar : PubMed/NCBI

68 

Rüschoff J, Wallinger S, Dietmaier W, Bocker T, Brockhoff G, Hofstädter F and Fishel R: Aspirin suppresses the mutator phenotype associated with hereditary nonpolyposis colorectal cancer by genetic selection. Proc Natl Acad Sci USA. 95:11301–11306. 1998. View Article : Google Scholar : PubMed/NCBI

69 

Goel A, Chang DK, Ricciardiello L, Gasche C and Boland CR: A novel mechanism for aspirin-mediated growth inhibition of human colon cancer cells. Clin Cancer Res. 9:383–390. 2003.PubMed/NCBI

70 

Huang Z, Fang W, Liu W, Wang L, Liu B and Liu S and Liu S: Aspirin induces Beclin-1-dependent autophagy of human hepatocellular carcinoma cell. Eur J Pharmacol. 823:58–64. 2018. View Article : Google Scholar : PubMed/NCBI

71 

Bhattacharya A and Eissa NT: Autophagy and autoimmunity crosstalks. Front Immunol. 4:882013. View Article : Google Scholar : PubMed/NCBI

72 

Henry WS, Laszewski T, Tsang T, Beca F, Beck AH, McAllister SS and Toker A: Aspirin suppresses growth in PI3K-mutant breast cancer by activating AMPK and inhibiting mTORC1 signaling. Cancer Res. 77:790–801. 2017. View Article : Google Scholar : PubMed/NCBI

73 

Liu W, Jiang Y, Sun J, Geng S, Pan Z, Prinz RA, Wang C, Sun J, Jiao X and Xu X: Activation of TGF-β-activated kinase 1 (TAK1) restricts Salmonella Typhimurium growth by inducing AMPK activation and autophagy. Cell Death Dis. 9:5702018. View Article : Google Scholar : PubMed/NCBI

74 

Hardie DG, Ross FA and Hawley SA: AMP-Activated protein kinase: A target for drugs both ancient and modern. Chem Biol. 19:1222–1236. 2012. View Article : Google Scholar : PubMed/NCBI

75 

Kostadinov RL, Kuhner MK, Li X, Sanchez CA, Galipeau PC, Paulson TG, Sather CL, Srivastava A, Odze RD, Blount PL, et al: NSAIDs modulate clonal evolution in Barrett's esophagus. PLoS Genet. 9:e10035532013. View Article : Google Scholar : PubMed/NCBI

76 

Drew DA, Cao Y and Chan AT: Aspirin and colorectal cancer: The promise of precision chemoprevention. Nat Rev Cancer. 16:173–186. 2016. View Article : Google Scholar : PubMed/NCBI

77 

Gala MK and Chan AT: Molecular pathways: Aspirin and Wnt signaling-a molecularly targeted approach to cancer prevention and treatment. Clin Cancer Res. 21:1543–1548. 2015. View Article : Google Scholar : PubMed/NCBI

78 

Yeomans ND, Lanas AI, Talley NJ, Thomson AB, Daneshjoo R, Eriksson B, Appelman-Eszczuk S, Långström G, Naesdal J, Serrano P, et al: Prevalence and incidence of gastroduodenal ulcers during treatment with vascular protective doses of aspirin. Aliment Pharmacol Ther. 22:795–801. 2005. View Article : Google Scholar : PubMed/NCBI

79 

Cayla G, Collet JP, Silvain J, Thiefin G, Woimant F and Montalescot G: Prevalence and clinical impact of Upper Gastrointestinal Symptoms in subjects treated with low dose aspirin: The UGLA survey. Int J Cardiol. 156:69–75. 2012. View Article : Google Scholar : PubMed/NCBI

80 

Biondi-Zoccai GG, Lotrionte M, Agostoni P, Abbate A, Fusaro M, Burzotta F, Testa L, Sheiban I and Sangiorgi G: A systematic review and meta-analysis on the hazards of discontinuing or not adhering to aspirin among 50,279 patients at risk for coronary artery disease. Eur Heart J. 27:2667–2674. 2006. View Article : Google Scholar : PubMed/NCBI

81 

Baron JA, Senn S, Voelker M, Lanas A, Laurora I, Thielemann W, Bruckner A and McCarthy D: Gastrointestinal adverse effects of short-term aspirin use: A meta-analysis of published randomized controlled trials. Drugs R D. 13:9–16. 2013. View Article : Google Scholar : PubMed/NCBI

82 

Cayla G, Collet JP, Silvain J, Thiefin G, Woimant F and Montalescot G: Prevalence and clinical impact of Upper Gastrointestinal Symptoms in subjects treated with low dose aspirin: The UGLA survey. Int J Cardiol. 156:69–75. 2012. View Article : Google Scholar : PubMed/NCBI

83 

Yeomans ND and Naesdal J: Systematic review: Ulcer definition in NSAID ulcer prevention trials. Aliment Pharmacol Ther. 27:465–472. 2008. View Article : Google Scholar : PubMed/NCBI

84 

Cryer B and Feldman M: Effects of very low dose daily, long-term aspirin therapy on gastric, duodenal, and rectal prostaglandin levels and on mucosal injury in healthy humans. Gastroenterology. 117:17–25. 1999. View Article : Google Scholar : PubMed/NCBI

85 

Papatheodoridis GV, Sougioultzis S and Archimandritis AJ: Effects of Helicobacter pylori and nonsteroidal anti-inflammatory drugs on peptic ulcer disease: Systematic review. Clin Gastroenterol Hepatol. 4:130–142. 2006. View Article : Google Scholar : PubMed/NCBI

86 

Huang JQ, Sridhar S and Hunt RH: Role of Helicobacter pylori infection and non-steroidal anti-inflammatory drugs in peptic-ulcer disease: A meta-analysis. Lancet. 359:14–22. 2002. View Article : Google Scholar : PubMed/NCBI

87 

Thorat MA and Cuzick J: Prophylactic use of aspirin: Systematic review of harms and approaches to mitigation in the general population. Eur J Epidemiol. 30:5–18. 2015. View Article : Google Scholar : PubMed/NCBI

88 

Iwamoto J, Mizokami Y, Shimokobe K, Ito M, Hirayama T, Saito Y, Ikegami T, Honda A and Matsuzaki Y: Clinical features of gastroduodenal ulcer in Japanese patients taking low-dose aspirin. Dig Dis Sci. 55:2270–2274. 2010. View Article : Google Scholar : PubMed/NCBI

89 

Garcia Rodriguez LA, Martin-Perez M, Hennekens CH, Rothwell PM and Lanas A: Bleeding Risk with long-term low-dose aspirin: A systematic review of observational studies. PLoS One. 11:e01600462016. View Article : Google Scholar : PubMed/NCBI

90 

McNeil JJ, Wolfe R, Woods RL, Tonkin AM, Donnan GA, Nelson MR, Reid CM, Lockery JE, Kirpach B, Storey E, et al: Effect of aspirin on cardiovascular events and bleeding in the healthy elderly. N Engl J Med. 379:1509–1518. 2018. View Article : Google Scholar : PubMed/NCBI

91 

de Abajo FJ and García Rodríguez LA: Risk of upper gastrointestinal bleeding and perforation associated with low-dose aspirin as plain and enteric-coated formulations. BMC Clin Pharmacol. 1:12001. View Article : Google Scholar : PubMed/NCBI

92 

Lanas A, Serrano P, Bajador E, Esteva F, Benito R and Sáinz R: Evidence of aspirin use in both upper and lower gastrointestinal perforation. Gastroenterology. 112:683–689. 1997. View Article : Google Scholar : PubMed/NCBI

93 

Yamada A, Sugimoto T, Kondo S, Ohta M, Watabe H, Maeda S, Togo G, Yamaji Y, Ogura K, Okamoto M, et al: Assessment of the risk factors for colonic diverticular hemorrhage. Dis Colon Rectum. 51:116–120. 2008. View Article : Google Scholar : PubMed/NCBI

94 

Lanas Á, Carrera-Lasfuentes P, Arguedas Y, García S, Bujanda L, Calvet X, Ponce J, Perez-Aísa Á, Castro M, Muñoz M, et al: Risk of upper and lower gastrointestinal bleeding in patients taking nonsteroidal anti-inflammatory drugs, antiplatelet agents, or anticoagulants. Clin Gastroenterol Hepatol. 13:906–912.e2. 2015. View Article : Google Scholar : PubMed/NCBI

95 

Hirata Y, Kataoka H, Shimura T, Mizushima T, Mizoshita T, Tanida S, Kamiya T and Joh T: Incidence of gastrointestinal bleeding in patients with cardiovascular disease: Buffered aspirin versus enteric-coated aspirin. Scand J Gastroenterol. 46:803–809. 2011. View Article : Google Scholar : PubMed/NCBI

96 

Nagata N, Niikura R, Aoki T, Shimbo T, Kishida Y, Sekine K, Tanaka S, Watanabe K, Sakurai T, Yokoi C, et al: Colonic diverticular hemorrhage associated with the use of nonsteroidal anti-inflammatory drugs, low-dose aspirin, antiplatelet drugs, and dual therapy. J Gastroenterol Hepatol. 29:1786–1793. 2014. View Article : Google Scholar : PubMed/NCBI

97 

Reichert MC, Krawczyk M, Appenrodt B, Casper M, Friesenhahn-Ochs B, Grünhage F, Jüngst C, Zimmer V, Lammert F and Dauer M: Selective association of nonaspirin NSAIDs with risk of diverticulitis. Int J Colorectal Dis. 33:423–430. 2018. View Article : Google Scholar : PubMed/NCBI

98 

Strate LL, Liu YL, Huang ES, Giovannucci EL and Chan AT: Use of aspirin or nonsteroidal anti-inflammatory drugs increases risk for diverticulitis and diverticular bleeding. Gastroenterology. 140:1427–1433. 2011. View Article : Google Scholar : PubMed/NCBI

99 

O'Connor N, Dargan PI and Jones AL: Hepatocellular damage from non-steroidal anti-inflammatory drugs. QJM. 96:787–791. 2003. View Article : Google Scholar : PubMed/NCBI

100 

McNeil JJ, Nelson MR, Woods RL, Lockery JE, Wolfe R, Reid CM, Kirpach B, Shah RC, Ives DG, Storey E, et al: Effect of aspirin on all-cause mortality in the healthy elderly. N Engl J Med. 379:1519–1528. 2018. View Article : Google Scholar : PubMed/NCBI

101 

Burn J, Gerdes AM, Macrae F, Mecklin JP, Moeslein G, Olschwang S, Eccles D, Evans DG, Maher ER, Bertario L, et al: Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: An analysis from the CAPP2 randomised controlled trial. Lancet. 378:2081–2087. 2011. View Article : Google Scholar : PubMed/NCBI

102 

Würtz M and Grove EL: Interindividual variability in the efficacy of oral antiplatelet drugs: Definitions, mechanisms and clinical importance. Curr Pharm Des. 18:5344–5361. 2012. View Article : Google Scholar : PubMed/NCBI

103 

Rocca B and Petrucci G: Variability in the responsiveness to low-dose aspirin: Pharmacological and disease-related mechanisms. Thrombosis. 2012:3767212012. View Article : Google Scholar : PubMed/NCBI

104 

Joharatnam-Hogan N, Cafferty F, Hubner R, Swinson D, Sothi S, Gupta K, Falk S, Patel K, Warner N, Kunene V, et al: Aspirin as an adjuvant treatment for cancer: Feasibility results from the Add-Aspirin randomised trial. Lancet Gastroenterol Hepatol. 4:854–862. 2019. View Article : Google Scholar : PubMed/NCBI

105 

Kaufman DW, Kelly JP, Wiholm BE, Laszlo A, Sheehan JE, Koff RS and Shapiro S: The risk of acute major upper gastrointestinal bleeding among users of aspirin and ibuprofen at various levels of alcohol consumption. Am J Gastroenterol. 94:3189–3196. 1999. View Article : Google Scholar : PubMed/NCBI

106 

Hernández-Díaz S and García Rodríguez LA: Cardioprotective aspirin users and their excess risk of upper gastrointestinal complications. BMC Med. 4:22–20. 2006. View Article : Google Scholar : PubMed/NCBI

107 

Bhatt DL, Scheiman J, Abraham NS, Antman EM, Chan FK, Furberg CD, Johnson DA, Mahaffey KW and Quigley EM; American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents, : ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A Report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents. Circulation. 118:1894–1909. 2008. View Article : Google Scholar : PubMed/NCBI

108 

Kelly JP, Kaufman DW, Jurgelon JM, Sheehan J, Koff RS and Shapiro S: Risk of aspirin-associated major upper-gastrointestinal bleeding with enteric-coated or buffered product. Lancet. 348:1413–1416. 1996. View Article : Google Scholar : PubMed/NCBI

109 

Lin KJ, Hernández-Díaz S and García Rodríguez LA: Acid suppressants reduce risk of gastrointestinal bleeding in patients on antithrombotic or anti-inflammatory therapy. Gastroenterology. 141:71–79. 2011. View Article : Google Scholar : PubMed/NCBI

110 

Sylvester KW, Cheng JW and Mehra MR: Esomeprazole and aspirin fixed combination for the prevention of cardiovascular events. Vasc Health Risk Manag. 9:245–254. 2013.PubMed/NCBI

111 

Lanas A, Polo-Tomas M and Casado-Arroyo R: The aspirin cardiovascular/gastrointestinal risk calculator-a tool to aid clinicians in practice. Aliment Pharmacol Ther. 37:738–748. 2013. View Article : Google Scholar : PubMed/NCBI

112 

Mo C, Sun G, Lu ML, Zhang L, Wang YZ, Sun X and Yang YS: Proton pump inhibitors in prevention of low-dose aspirin-associated upper gastrointestinal injuries. World J Gastroenterol. 21:5382–5392. 2015. View Article : Google Scholar : PubMed/NCBI

113 

Scally B, Emberson JR, Spata E, Reith C, Davies K, Halls H, Holland L, Wilson K, Bhala N, Hawkey C, et al: Effects of gastroprotectant drugs for the prevention and treatment of peptic ulcer disease and its complications: A meta-analysis of randomised trials. Lancet Gastroenterol Hepatol. 3:231–241. 2018. View Article : Google Scholar : PubMed/NCBI

114 

Whellan DJ, Goldstein JL, Cryer BL, Eisen GM, Lanas A, Miller AB, Scheiman JM, Fort JG, Zhang Y and O'Connor C: PA32540 (a coordinated-delivery tablet of enteric-coated aspirin 325 mg and immediate-release omeprazole 40 mg) versus enteric-coated aspirin 325 mg alone in subjects at risk for aspirin-associated gastric ulcers: Results of two 6-month, phase 3 studies. Am Heart J. 168:495–502.e4. 2014. View Article : Google Scholar : PubMed/NCBI

115 

Martín Merino E, Johansson S, Nagy P and García Rodríguez LA: Effect of baseline gastrointestinal risk and use of proton pump inhibitors on frequency of discontinuation of aspirin for secondary cardiovascular prevention in united kingdom primary care. Am J Cardiol. 112:1075–1082. 2013. View Article : Google Scholar : PubMed/NCBI

116 

Dey AB: World report on ageing and health. Indian J Med Res. 145:1502017. View Article : Google Scholar

117 

Hull MA, Sprange K, Hepburn T, Tan W, Shafayat A, Rees CJ, Clifford G, Logan RF, Loadman PM, Williams EA, et al: Eicosapentaenoic acid and aspirin, alone and in combination, for the prevention of colorectal adenomas (seAFOod Polyp Prevention trial): A multicentre, randomised, double-blind, placebo-controlled, 2×2 factorial trial. Lancet. 392:2583–2594. 2018. View Article : Google Scholar : PubMed/NCBI

118 

Cole BF, Logan RF, Halabi S, Benamouzig R, Sandler RS, Grainge MJ, Chaussade S and Baron JA: Aspirin for the chemoprevention of colorectal adenomas: Meta-analysis of the randomized trials. J Natl Cancer Inst. 101:256–266. 2009. View Article : Google Scholar : PubMed/NCBI

119 

Cook NR, Lee IM, Zhang SM, Moorthy MV and Buring JE: Alternate-day, low-dose aspirin and cancer risk: Long-term observational follow-up of a randomized trial. Ann Intern Med. 159:77–85. 2013. View Article : Google Scholar : PubMed/NCBI

120 

Kuan YC, Huang KW, Lin CL, Luo JC and Kao CH: Effects of aspirin or clopidogrel on colorectal cancer chemoprevention in patients with type 2 diabetes mellitus. Cancers (Basel). 11:14682019. View Article : Google Scholar

121 

Rothwell PM, Wilson M, Price JF, Belch JF, Meade TW and Mehta Z: Effect of daily aspirin on risk of cancer metastasis: A study of incident cancers during randomised controlled trials. Lancet. 379:1591–1601. 2012. View Article : Google Scholar : PubMed/NCBI

122 

Chan FK, Leung Ki EL, Wong GL, Ching JY, Tse YK, Au KW, Wu JC and Ng SC: Risks of bleeding recurrence and cardiovascular events with continued aspirin use after lower gastrointestinal hemorrhage. Gastroenterology. 151:271–277. 2016. View Article : Google Scholar : PubMed/NCBI

123 

Casado Arroyo R, Polo-Tomas M, Roncales MP, Scheiman J and Lanas A: Lower GI bleeding is more common than upper among patients on dual antiplatelet therapy: Long-term follow-up of a cohort of patients commonly using PPI co-therapy. Heart. 98:718–723. 2012. View Article : Google Scholar : PubMed/NCBI

124 

Smecuol E, Pinto Sanchez MI, Suarez A, Argonz JE, Sugai E, Vazquez H, Litwin N, Piazuelo E, Meddings JB, Bai JC and Lanas A: Low-dose aspirin affects the small bowel mucosa: Results of a pilot study with a multidimensional assessment. Clin Gastroenterol Hepatol. 7:524–529. 2009. View Article : Google Scholar : PubMed/NCBI

125 

Moore RA, Derry S and McQuay HJ: Faecal blood loss with aspirin, nonsteroidal anti-inflammatory drugs and cyclo-oxygenase-2 selective inhibitors: Systematic review of randomized trials using autologous chromium-labelled erythrocytes. Arthritis Res Ther. 10:R72008. View Article : Google Scholar : PubMed/NCBI

126 

Endo H, Higurashi T, Hosono K, Sakai E, Sekino Y, Iida H, Sakamoto Y, Koide T, Takahashi H, Yoneda M, et al: Efficacy of Lactobacillus casei treatment on small bowel injury in chronic low-dose aspirin users: A pilot randomized controlled study. J Gastroenterol. 46:894–905. 2011. View Article : Google Scholar : PubMed/NCBI

127 

Montalto M, Gallo A, Curigliano V, D'Onofrio F, Santoro L, Covino M, Dalvai S, Gasbarrini A and Gasbarrini G: Clinical trial: The effects of a probiotic mixture on non-steroidal anti-inflammatory drug enteropathy-a randomized, double-blind, cross-over, placebo-controlled study. Aliment Pharmacol Ther. 32:209–214. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Z, Wang Z, Shen B, Chen C, Ding X and Song H: Effects of aspirin on the gastrointestinal tract: Pros vs. cons (Review). Oncol Lett 20: 2567-2578, 2020.
APA
Li, Z., Wang, Z., Shen, B., Chen, C., Ding, X., & Song, H. (2020). Effects of aspirin on the gastrointestinal tract: Pros vs. cons (Review). Oncology Letters, 20, 2567-2578. https://doi.org/10.3892/ol.2020.11817
MLA
Li, Z., Wang, Z., Shen, B., Chen, C., Ding, X., Song, H."Effects of aspirin on the gastrointestinal tract: Pros vs. cons (Review)". Oncology Letters 20.3 (2020): 2567-2578.
Chicago
Li, Z., Wang, Z., Shen, B., Chen, C., Ding, X., Song, H."Effects of aspirin on the gastrointestinal tract: Pros vs. cons (Review)". Oncology Letters 20, no. 3 (2020): 2567-2578. https://doi.org/10.3892/ol.2020.11817
Copy and paste a formatted citation
x
Spandidos Publications style
Li Z, Wang Z, Shen B, Chen C, Ding X and Song H: Effects of aspirin on the gastrointestinal tract: Pros vs. cons (Review). Oncol Lett 20: 2567-2578, 2020.
APA
Li, Z., Wang, Z., Shen, B., Chen, C., Ding, X., & Song, H. (2020). Effects of aspirin on the gastrointestinal tract: Pros vs. cons (Review). Oncology Letters, 20, 2567-2578. https://doi.org/10.3892/ol.2020.11817
MLA
Li, Z., Wang, Z., Shen, B., Chen, C., Ding, X., Song, H."Effects of aspirin on the gastrointestinal tract: Pros vs. cons (Review)". Oncology Letters 20.3 (2020): 2567-2578.
Chicago
Li, Z., Wang, Z., Shen, B., Chen, C., Ding, X., Song, H."Effects of aspirin on the gastrointestinal tract: Pros vs. cons (Review)". Oncology Letters 20, no. 3 (2020): 2567-2578. https://doi.org/10.3892/ol.2020.11817
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