Open Access

USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling

  • Authors:
    • Xingchao Song
    • Weibin Yang
    • Chao Wu
    • Yamin Han
    • Yaowu Lu
  • View Affiliations

  • Published online on: July 8, 2020     https://doi.org/10.3892/ol.2020.11824
  • Pages: 2897-2905
  • Copyright: © Song et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

X‑linked ubiquitin‑specific peptidase 9 (USP9X) serves important roles in the development and progression of various human cancers. However, its role and molecular mechanism in liver cancer require further elucidation. In the present study, USP9X was found to be upregulated in liver cancer tissues. At the same time, overexpression of USP9X promoted the proliferation, invasiveness and migration of liver cancer cells, which were subsequently suppressed by USP9X silencing. On a molecular level, the results revealed that USP9X knockdown suppressed elements of the Janus kinase 2 (JAK2)/STAT3 signaling pathway, including JAK2, STAT3, matrix metalloproteinase‑2 and c‑Myc. By contrast, overexpression of USP9X had the opposite effect. In conclusion, the results of the present study suggest that USP9X is upregulated in patients with liver cancer, which may accelerate the proliferation, invasiveness and migration of liver cancer cells by regulating the JAK2/STAT3 signaling pathway.

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September-2020
Volume 20 Issue 3

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Song X, Yang W, Wu C, Han Y and Lu Y: USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling. Oncol Lett 20: 2897-2905, 2020
APA
Song, X., Yang, W., Wu, C., Han, Y., & Lu, Y. (2020). USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling. Oncology Letters, 20, 2897-2905. https://doi.org/10.3892/ol.2020.11824
MLA
Song, X., Yang, W., Wu, C., Han, Y., Lu, Y."USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling". Oncology Letters 20.3 (2020): 2897-2905.
Chicago
Song, X., Yang, W., Wu, C., Han, Y., Lu, Y."USP9X promotes the proliferation, invasion and metastasis of liver cancer cells through regulating the JAK2/STAT3 signaling". Oncology Letters 20, no. 3 (2020): 2897-2905. https://doi.org/10.3892/ol.2020.11824