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Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival

  • Authors:
    • Yie Yang
    • Xiao Liu
    • Rui Li
    • Mengyu Zhang
    • Hong Wang
    • Yiqing Qu
  • View Affiliations / Copyright

    Affiliations: Department of Clinical Laboratory, Shandong Provincial Qianfoshan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan, Shandong 250012, P.R. China, Department of Pulmonary and Critical Care Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P.R. China, Department of Thoracic Surgery, Shandong Provincial Qianfoshan Hospital, The First Hospital Affiliated with Shandong First Medical University, Jinan, Shandong 250012, P.R. China, Department of Pulmonary and Critical Care Medicine, Qilu Hospital of Shandong University, Jinan, Shandong 250012, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 348
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    Published online on: October 10, 2020
       https://doi.org/10.3892/ol.2020.12211
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Abstract

Kinesin family member 3A (KIF3A) plays a crucial role in the carcinogenesis of different types of human cancer. The present study aimed to identify the role of KIF3A in the carcinogenesis of non‑small cell lung cancer (NSCLC). KIF3A protein expression was determined in 163 patients with NSCLC using immunohistochemistry staining. The prognosis of patients with NSCLC was determined using Kaplan‑Meier survival and Cox regression analyses. The function of KIF3A on the carcinogenesis and metastasis of NSCLC was determined in vitro. Furthermore, a protein‑protein interaction (PPI) network of KIF3A was constructed and the potential interacting molecules were identified using bioinformatic analysis. The protein expression levels of KIF3A were significantly lower in the NSCLC tissues compared with that in the adjacent tissues, and low KIF3A expression level was associated with unfavorable survival outcomes in patients with NSCLC. Furthermore, KIF3A knockdown increased proliferation, invasion and metastasis, and inhibited apoptosis of NSCLC cells. KIF3A was demonstrated to interact with intraflagellar transport 57 (IFT57) in the PPI network. In addition, validation analyses indicated that KIF3A mRNA expression levels were positively correlated with IFT57 mRNA expression levels in clinical NSCLC samples and NSCLC cell lines. Taken together, the results of the present study suggested that KIF3A is a key tumor suppressor gene for carcinogenesis and metastasis of NSCLC, it may also function as a biomarker and interacts with IFT57 in the progression of NSCLC.
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Copy and paste a formatted citation
Spandidos Publications style
Yang Y, Liu X, Li R, Zhang M, Wang H and Qu Y: Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival. Oncol Lett 20: 348, 2020.
APA
Yang, Y., Liu, X., Li, R., Zhang, M., Wang, H., & Qu, Y. (2020). Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival. Oncology Letters, 20, 348. https://doi.org/10.3892/ol.2020.12211
MLA
Yang, Y., Liu, X., Li, R., Zhang, M., Wang, H., Qu, Y."Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival". Oncology Letters 20.6 (2020): 348.
Chicago
Yang, Y., Liu, X., Li, R., Zhang, M., Wang, H., Qu, Y."Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival". Oncology Letters 20, no. 6 (2020): 348. https://doi.org/10.3892/ol.2020.12211
Copy and paste a formatted citation
x
Spandidos Publications style
Yang Y, Liu X, Li R, Zhang M, Wang H and Qu Y: Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival. Oncol Lett 20: 348, 2020.
APA
Yang, Y., Liu, X., Li, R., Zhang, M., Wang, H., & Qu, Y. (2020). Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival. Oncology Letters, 20, 348. https://doi.org/10.3892/ol.2020.12211
MLA
Yang, Y., Liu, X., Li, R., Zhang, M., Wang, H., Qu, Y."Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival". Oncology Letters 20.6 (2020): 348.
Chicago
Yang, Y., Liu, X., Li, R., Zhang, M., Wang, H., Qu, Y."Kinesin family member 3A inhibits the carcinogenesis of non‑small cell lung cancer and prolongs survival". Oncology Letters 20, no. 6 (2020): 348. https://doi.org/10.3892/ol.2020.12211
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