Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
February-2021 Volume 21 Issue 2

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML

  • Supplementary Files
    • Supplementary_Data.pdf
Article Open Access

Development of a prognostic model of glioma based on immune‑related genes

  • Authors:
    • Jing-Jing Wang
    • Han Wang
    • Bao-Long Zhu
    • Xiang Wang
    • Yong-Hong Qian
    • Lei Xie
    • Wen-Jie Wang
    • Jie Zhu
    • Xing-Yu Chen
    • Jing-Mei Wang
    • Zhi-Liang Ding
  • View Affiliations / Copyright

    Affiliations: Department of Oncology, Taizhou Hospital of Traditional Chinese Medicine, Taizhou, Jiangsu 225300, P.R. China, Department of Oncology, Jining Cancer Hospital, Jining, Shandong 272000, P.R. China, Department of Radio‑Oncology, Taizhou Hospital of Traditional Chinese Medicine, Taizhou, Jiangsu 225300, P.R. China, Department of Radio‑Oncology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China, Department of Oncology, Changzhou Traditional Chinese Medical Hospital, Changzhou, Jiangsu, 213003, P.R. China, Department of General Surgery, Taizhou Fourth People's Hospital, Taizhou, Jiangsu 225300, P.R. China, Department of Geriatrics, The First Affiliated Hospital of Zhejiang University, Hangzhou, Zhejiang 310002, P.R. China, Department of Neurosurgery, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China
    Copyright: © Wang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 116
    |
    Published online on: December 15, 2020
       https://doi.org/10.3892/ol.2020.12377
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Glioma is the most common type of primary brain cancer, and the prognosis of most patients with glioma, and particularly that of patients with glioblastoma, is poor. Tumor immunity serves an important role in the development of glioma. However, immunotherapy for glioma has not been completely successful, and thus, comprehensive examination of the immune‑related genes (IRGs) of glioma is required. In the present study, differentially expressed genes (DEGs) and differentially expressed IRGs (DEIRGs) were identified using the edgeR package. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis was used for functional enrichment analysis of DEIRGs. Survival‑associated IRGs were selected via univariate Cox regression analysis. A The Cancer Genome Atlas prognostic model and GSE43378 validation model were established using lasso‑penalized Cox regression analysis. Based on the median risk score value, patients were divided into high‑risk and low‑risk groups for clinical analysis. Receiver operating characteristic curve and nomogram analyses were used to assess the accuracy of the models. Reverse transcription‑quantitative PCR was performed to measure the expression levels of relevant genes, such as cyclin‑dependent kinase 4 (CDK4), interleukin 24 (IL24), NADPH oxidase 4 (NOX4), bone morphogenetic protein 2 (BMP2) and baculoviral IAP repeat containing 5 (BIRC5). A total of 3,238 DEGs, including 1,950 upregulated and 1,288 downregulated DEGs, and 97 DEIRGs, including 60 upregulated and 37 downregulated DEIRGs, were identified. ‘Neuroactive ligand‑receptor interaction’ and ‘Cytokine‑cytokine receptor interaction’ were the most significantly enriched pathways according to KEGG pathway analysis. A prognostic model and a validation prognostic model were created for glioma, including 15 survival‑associated IRGs (FCER1G, NOX4, TRIM5, SOCS1, APOBEC3C, BIRC5, VIM, TNC, BMP2, CMTM3, IL24, JAG1, CALCRL, HNF4G and CDK4). Furthermore, multivariate Cox regression analysis results suggested that age, high WHO Grade by histopathology, wild type isocitrate dehydrogenase 1 and high risk score were independently associated with poor overall survival. The infiltration of B cells, CD8+ T cells, dendritic cells, macrophages and neutrophils was positively associated with the prognostic risk score. In the present study, several clinically significant survival‑associated IRGs were identified, and a prognosis evaluation model of glioma was established.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Chowdhury FA, Hossain MK, Mostofa AGM, Akbor MM and Bin Sayeed MS: Therapeutic potential of thymoquinone in glioblastoma treatment: Targeting major gliomagenesis signaling pathways. Biomed Res Int. 2018:40106292018. View Article : Google Scholar : PubMed/NCBI

2 

Ostrom QT, Gittleman H, Truitt G, Boscia A, Kruchko C and Barnholtz-Sloan JS: CBTRUS statistical report: Primary brain and other central nervous system tumors diagnosed in the United States in 2011–2015. Neuro Oncol. 20 (Suppl 4):iv1–iv86. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Dewitt JC, Mock A and Louis DN: The 2016 WHO classification of central nervous system tumors: What neurologists need to know. Curr Opin Neurol. 30:643–649. 2017. View Article : Google Scholar : PubMed/NCBI

4 

Walker AE, Robins M and Weinfeld FD: Epidemiology of brain tumors The national survey of intracranial neoplasms. Neurology. 35:219–226. 1985. View Article : Google Scholar : PubMed/NCBI

5 

Amankulor NM, Kim Y, Arora S, Kargl J, Szulzewsky F, Hanke M, Margineantu DH, Rao A, Bolouri H, Delrow J, et al: Mutant IDH1 regulates the tumor-associated immune system in gliomas. Genes Dev. 31:774–786. 2017. View Article : Google Scholar : PubMed/NCBI

6 

Venur VA, Peereboom DM and Ahluwalia MS: Current medical treatment of glioblastoma. Cancer Treat Res. 163:103–115. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Kang JH and Adamson C: Novel chemotherapeutics and other therapies for treating high-grade glioma. Expert Opin Investig Drugs. 24:1361–1379. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Shannon K, Koehne W, Heyman MB and Koerper MA: Relapsing post-hepatitis aplastic anemia. Immunosuppressive therapy. Clin Pediatr (Phila). 29:25–29. 1990. View Article : Google Scholar : PubMed/NCBI

9 

Giraldo NA, Becht E, Remark R, Damotte D, Sautès-Fridman C and Fridman WH: The immune contexture of primary and metastatic human tumour. Curr Opin Immunol. 27:8–15. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Kim R, Emi M and Tanabe K: Cancer immunoediting from immune surveillance to immune escape. Immunology. 121:1–14. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Finocchiaro G and Pellegatta S: Immunotherapy for glioma: Getting closer to the clinical arena? Curr Opin Neurol. 24:641–647. 2011. View Article : Google Scholar : PubMed/NCBI

12 

Borisov KE and Sakaeva DD: The immunosuppressive microenvironment of malignant gliomas. Arkh Patol. 77:54–63. 2015.(In Russian). View Article : Google Scholar : PubMed/NCBI

13 

Liu J, Lichtenberg T, Hoadley KA, Poisson LM, Lazar AJ, Cherniack AD, Kovatich AJ, Benz CC, Levine DA, Lee AV, et al: Abstract 3287: An integrated TCGA pan-cancer clinical data resource to drive high quality survival outcome analytics. Cancer Res. 78 (Suppl 13):S32872018.

14 

Kawaguchi A, Yajima N, Tsuchiya N, Homma J, Sano M, Natsumeda M, Takahashi H, Fujii Y, Kakuma T and Yamanaka R: Gene expression signature-based prognostic risk score in patients with glioblastoma. Cancer Sci. 104:1205–1210. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Bhattacharya S, Andorf S, Gomes L, Dunn P, Schaefer H, Pontius J, Berger P, Desborough V, Smith T, Campbell J, et al: ImmPort: Disseminating data to the public for the future of immunology. Immunol Res. 58:234–239. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Macklaim JM, Fernandes AD, Di Bella JM, Hammond JA, Reid G and Gloor GB: Comparative meta-RNA-seq of the vaginal microbiota and differential expression by Lactobacillus iners in health and dysbiosis. Microbiome. 1:122013. View Article : Google Scholar : PubMed/NCBI

17 

Lee S, Han S, Ju HS, Kim SY, Won HJ, Shin YM, Kim PN, An J, Lee D, Kim KM, et al: A patient-based nomogram for predicting overall survival after radiofrequency ablation for hepatocellular carcinoma. J Vasc Interv Radiol. 26:1787–1794.e1. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Zeelen C, Paus C, Draper D, Heskamp S, Signore A, Galli F, Griessinger CM and Aarntzen EH: In-vivo imaging of tumor-infiltrating immune cells: Implications for cancer immunotherapy. Q J Nucl Med Mol Imaging. 62:56–77. 2018.PubMed/NCBI

19 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Ivliev AE, ‘t Hoen PA and Sergeeva MG: Coexpression network analysis identifies transcriptional modules related to proastrocytic differentiation and sprouty signaling in glioma. Cancer Res. 70:10060–10070. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Zhang J, Bu X, Wang H, Zhu Y, Geng Y, Nihira NT, Tan Y, Ci Y, Wu F, Dai X, et al: Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance. Nature. 553:91–95. 2018. View Article : Google Scholar : PubMed/NCBI

22 

Scimè A, Li L, Ciavarra G and Whyte P: Cyclin D1/cdk4 can interact with E2F4/DP1 and disrupts its DNA-binding capacity. J Cell Physiol. 214:568–581. 2008. View Article : Google Scholar : PubMed/NCBI

23 

Dean JL, Mcclendon AK, Hickey TE, Butler LM, Tilley WD, Witkiewicz AK and Knudsen ES: Therapeutic response to CDK4/6 inhibition in breast cancer defined by ex vivo analyses of human tumors. Cell Cycle. 11:2756–2761. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Silber J, Lim DA, Petritsch C, Persson AI, Maunakea AK, Yu M, Vandenberg SR, Ginzinger DG, James CD, Costello JF, et al: miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med. 6:142008. View Article : Google Scholar : PubMed/NCBI

25 

Szöcs K, Lassègue B, Sorescu D, Hilenski LL, Valppu L, Couse TL, Wilcox JN, Quinn MT, Lambeth JD and Griendling KK: Upregulation of Nox-based NAD(P)H oxidases in restenosis after carotid injury. Arterioscler Thromb Vasc Biol. 22:21–27. 2002. View Article : Google Scholar : PubMed/NCBI

26 

Li Y, Han N, Yin T, Huang L, Liu S, Liu D, Xie C and Zhang M: Lentivirus-mediated Nox4 shRNA invasion and angiogenesis and enhances radiosensitivity in human glioblastoma. Oxid Med Cell Longev. 2014:5817322014. View Article : Google Scholar : PubMed/NCBI

27 

Gressot LV, Doucette T, Yang Y, Fuller GN, Manyam G, Rao A, Latha K and Rao G: Analysis of the inhibitors of apoptosis identifies BIRC3 as a facilitator of malignant progression in glioma. Oncotarget. 8:12695–12704. 2017. View Article : Google Scholar : PubMed/NCBI

28 

Zhao H, Zhang X, Han Z, Wang Z and Wang Y: Plasma anti-BIRC5 IgG may be a useful marker for evaluating the prognosis of nonsmall cell lung cancer. Febs Open Bio. 8:829–835. 2018. View Article : Google Scholar : PubMed/NCBI

29 

Zhang H, Geng D, Gao J, Qi Y, Shi Y, Wang Y, Jiang Y, Zhang Y, Fu J, Dong Y, et al: Expression and significance of Hippo/YAP signaling in glioma progression. Tumour Biol. 37:15665–15676. 2016. View Article : Google Scholar

30 

Ma YF, Ren Y, Wu CJ, Zhao XH, Xu H, Wu DZ, Xu J, Zhang XL and Ji Y: Interleukin (IL)-24 transforms the tumor microenvironment and induces anticancer immunity in a murine model of colon cancer. Mol Immunol. 75:11–20. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Nagakawa H, Shimozato O, Yu L, Wada A, Kawamura K, Li Q, Chada S, Tada Y, Takiguchi Y, Tatsumi K and Tagawa M: Expression of a murine homolog of apoptosis-inducing human IL-24/MDA-7 in murine tumors fails to induce apoptosis or produce anti-tumor effects. Cell Immunol. 275:90–97. 2012. View Article : Google Scholar : PubMed/NCBI

32 

Zhou A, Lin K, Zhang S, Chen Y, Zhang N, Xue J, Wang Z, Aldape KD, Xie K, Woodgett JR and Huang S: Nuclear GSK3β promotes tumorigenesis by phosphorylating KDM1A and inducing its deubiquitylation by USP22. Nat Cell Biol. 18:954–966. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Yang X, Li D, Cheng S, Fan K, Sheng L, Zhang J, Feng B and Xu Z: The correlation of bone morphogenetic protein 2 with poor prognosis in glioma patients. Tumour Biol. 35:11091–11095. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Hollinger DM and Rossiter RJ: Chemical studies of peripheral nerve during wallerian degeneration. V. B-Glucuronidase. Biochem J. 52:659–663. 1952. View Article : Google Scholar : PubMed/NCBI

35 

Tong L, Yi L, Liu P, Abeysekera IR, Hai L, Li T, Tao Z, Ma H, Xie Y, Huang Y, et al: Tumour cell dormancy as a contributor to the reduced survival of GBM patients who received standard therapy. Oncol Rep. 40:463–471. 2018.PubMed/NCBI

36 

Nijaguna MB, Patil V, Hegde AS, Chandramouli BA, Arivazhagan A, Santosh V and Somasundaram K: An eighteen serum cytokine signature for discriminating glioma from normal healthy individuals. PLoS One. 10:e01375242015. View Article : Google Scholar : PubMed/NCBI

37 

Zhou L, Tang H, Wang F, Chen L, Ou S, Wu T, Xu J and Guo K: Bioinformatics analyses of significant genes, related pathways and candidate prognostic biomarkers in glioblastoma. Mol Med Rep. 18:4185–4196. 2018.PubMed/NCBI

38 

Pal J, Patil V, Kumar A, Kaur K, Sarkar C and Somasundaram K: Loss-of-function mutations in Calcitonin receptor (CALCR) identify highly aggressive glioblastoma with poor outcome. Clin Cancer Res. 24:1448–1458. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Reon BJ, Anaya J, Zhang Y, Mandell J, Purow B, Abounader R and Dutta A: Expression of lncRNAs in low-grade gliomas and glioblastoma multiforme: An in silico analysis. PLoS Med. 13:e10021922016. View Article : Google Scholar : PubMed/NCBI

40 

Li M and Yu XQ: Genetic determinants of IgA nephropathy: Eastern perspective. Semin Nephrol. 38:455–460. 2018. View Article : Google Scholar : PubMed/NCBI

41 

Feagan BG, Schreiber S, Wolf DC, Axler JL, Kaviya A, James A, Curtis RI, Geransar P, Stallmach A, Ehehalt R, et al: Sustained clinical remission with vedolizumab in patients with moderate-to-severe ulcerative colitis. Inflamm Bowel Dis. 25:1028–1035. 2019. View Article : Google Scholar : PubMed/NCBI

42 

Magistroni R, D'Agati VD, Appel GB and Kiryluk K: New developments in the genetics, pathogenesis, and therapy of IgA nephropathy. Kidney Int. 88:974–989. 2015. View Article : Google Scholar : PubMed/NCBI

43 

Chen X, Zang W, Xue F, Shen Z and Zhang Q: Bioinformatics analysis reveals potential candidate drugs for different subtypes of glioma. Neurol Sci. 34:1139–1143. 2013. View Article : Google Scholar : PubMed/NCBI

44 

Fu H, Ge B, Chen D, Wu Y, Luo Q, Li X, Zheng C and Tang Q: Phytanoyl-CoA 2-hydroxylase-interacting protein-like gene is a therapeutic target gene for glioblastoma multiforme. Med Sci Monit. 25:2583–2590. 2019. View Article : Google Scholar : PubMed/NCBI

45 

Hussain M, Shah Z, Abbas N, Javeed A, Mukhtar MM and Zhang J: Targeting tumor-associated immune suppression with selective protein kinase A type I (PKAI) inhibitors may enhance cancer immunotherapy. Med Hypotheses. 86:56–59. 2016. View Article : Google Scholar : PubMed/NCBI

46 

Sang W, Wang Y, Zhang C, Zhang D, Sun C, Niu M, Zhang Z, Wei X, Pan B, Chen W, et al: MiR-150 impairs inflammatory cytokine production by targeting ARRB-2 after blocking CD28/B7 costimulatory pathway. Immunol Lett. 172:1–10. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Lv P, Wang W, Cao Z, Zhao D, Zhao G, Li D, Qi L and Xu J: Fsk and IBMX inhibit proliferation and proapoptotic of glioma stem cells via activation of cAMP signaling pathway. J Cell Biochem. 120:321–331. 2019. View Article : Google Scholar : PubMed/NCBI

48 

Daniel PM, Filiz G and Mantamadiotis T: Sensitivity of GBM cells to cAMP agonist-mediated apoptosis correlates with CD44 expression and agonist resistance with MAPK signaling. Cell Death Dis. 7:e24942016. View Article : Google Scholar : PubMed/NCBI

49 

Han SJ, Zygourakis C, Lim M and Parsa AT: Immunotherapy for glioma: Promises and challenges. Neurosurg Clin N Am. 23:357–370. 2012. View Article : Google Scholar : PubMed/NCBI

50 

Bullard DE, Gillespie GY, Mahaley MS and Bigner DD: Immunobiology of human glioma. Semin Oncol. 13:94–109. 1986.PubMed/NCBI

51 

Winfield JB: Role of phagocytosis in macrophage function in an in vitro primary immune system. Cell Immunol. 2:690–695. 1971. View Article : Google Scholar : PubMed/NCBI

52 

Mantovani A, Marchesi F, Malesci A, Laghi L and Allavena P: Tumour-associated macrophages as treatment targets in oncology. Nat Rev Clin Oncol. 14:399–416. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Choi J, Gyamfi J, Jang H and Koo JS: The role of tumor-associated macrophage in breast cancer biology. Histol Histopathol. 33:133–145. 2018.PubMed/NCBI

54 

Yin J, Valin KL, Dixon ML and Leavenworth JW: The role of microglia and macrophages in CNS homeostasis, autoimmunity, and cancer. J Immunol Res. 2017:51506782017. View Article : Google Scholar : PubMed/NCBI

55 

Abediankenari S, Janbabaei Mollae G, Ghasemi M, Yousefzadeh Y, Bahrami M and Alimoghaddam K: Vaccination of diffuse large B-cell lymphoma patients with antigen-primed dendritic cells. Acta Med Iran. 51:284–288. 2013.PubMed/NCBI

56 

Gardner A and Ruffell B: Dendritic cells and cancer immunity. Trends Immunol. 37:855–865. 2016. View Article : Google Scholar : PubMed/NCBI

57 

Steinman RM and Banchereau J: Taking dendritic cells into medicine. Nature. 449:419–426. 2007. View Article : Google Scholar : PubMed/NCBI

58 

Wang JZ, Zhang YH, Guo XH, Zhang HY and Zhang Y: The double-edge role of B cells in mediating antitumor T-cell immunity: Pharmacological strategies for cancer immunotherapy. Int Immunopharmacol. 36:73–85. 2016. View Article : Google Scholar : PubMed/NCBI

59 

Seifert M and Küppers R: Human memory B cells. Leukemia. 30:2283–2292. 2016. View Article : Google Scholar : PubMed/NCBI

60 

Ahrén B, Taborsky GJ Jr and Porte D Jr: Neuropeptidergic versus cholinergic and adrenergic regulation of islet hormone secretion. Diabetologia. 29:827–836. 1986. View Article : Google Scholar : PubMed/NCBI

61 

Liang W and Ferrara N: The complex role of neutrophils in tumor angiogenesis and metastasis. Cancer Immunol Res. 4:83–91. 2016. View Article : Google Scholar : PubMed/NCBI

62 

Massara M, Persico P, Bonavita O, Mollica Poeta V, Locati M, Simonelli M and Bonecchi R: Neutrophils in gliomas. Front Immunol. 8:13492017. View Article : Google Scholar : PubMed/NCBI

63 

Ocana A, Nieto-Jiménez C, Pandiella A and Templeton AJ: Neutrophils in cancer: Prognostic role and therapeutic strategies. Mol Cancer. 16:1372017. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Wang J, Wang H, Zhu B, Wang X, Qian Y, Xie L, Wang W, Zhu J, Chen X, Wang J, Wang J, et al: Development of a prognostic model of glioma based on immune‑related genes. Oncol Lett 21: 116, 2021.
APA
Wang, J., Wang, H., Zhu, B., Wang, X., Qian, Y., Xie, L. ... Ding, Z. (2021). Development of a prognostic model of glioma based on immune‑related genes. Oncology Letters, 21, 116. https://doi.org/10.3892/ol.2020.12377
MLA
Wang, J., Wang, H., Zhu, B., Wang, X., Qian, Y., Xie, L., Wang, W., Zhu, J., Chen, X., Wang, J., Ding, Z."Development of a prognostic model of glioma based on immune‑related genes". Oncology Letters 21.2 (2021): 116.
Chicago
Wang, J., Wang, H., Zhu, B., Wang, X., Qian, Y., Xie, L., Wang, W., Zhu, J., Chen, X., Wang, J., Ding, Z."Development of a prognostic model of glioma based on immune‑related genes". Oncology Letters 21, no. 2 (2021): 116. https://doi.org/10.3892/ol.2020.12377
Copy and paste a formatted citation
x
Spandidos Publications style
Wang J, Wang H, Zhu B, Wang X, Qian Y, Xie L, Wang W, Zhu J, Chen X, Wang J, Wang J, et al: Development of a prognostic model of glioma based on immune‑related genes. Oncol Lett 21: 116, 2021.
APA
Wang, J., Wang, H., Zhu, B., Wang, X., Qian, Y., Xie, L. ... Ding, Z. (2021). Development of a prognostic model of glioma based on immune‑related genes. Oncology Letters, 21, 116. https://doi.org/10.3892/ol.2020.12377
MLA
Wang, J., Wang, H., Zhu, B., Wang, X., Qian, Y., Xie, L., Wang, W., Zhu, J., Chen, X., Wang, J., Ding, Z."Development of a prognostic model of glioma based on immune‑related genes". Oncology Letters 21.2 (2021): 116.
Chicago
Wang, J., Wang, H., Zhu, B., Wang, X., Qian, Y., Xie, L., Wang, W., Zhu, J., Chen, X., Wang, J., Ding, Z."Development of a prognostic model of glioma based on immune‑related genes". Oncology Letters 21, no. 2 (2021): 116. https://doi.org/10.3892/ol.2020.12377
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team