Downregulation of long non‑coding RNA LINC‑PINT serves as a diagnostic and prognostic biomarker in patients with non‑small cell lung cancer
- Chunjie Zhang
- Cuixue Gong
- Jianzhao Li
- Jiaying Tang
Affiliations: Department of Clinical Laboratory, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China, Outpatient Dressing Room, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China, Department of Pathology, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China, Department of Blood Transfusion, Zibo Central Hospital, Zibo, Shandong 255036, P.R. China
- Published online on: January 18, 2021 https://doi.org/10.3892/ol.2021.12471
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Long non‑coding RNAs (lncRNAs) play an important role in gene regulation. Several lncRNAs have been demonstrated to be associated with the diagnosis and prognosis of non‑small cell lung cancer (NSCLC). The present study aimed to investigate the role of lncRNA long intragenic non‑protein‑coding RNA p53‑induced transcript (LINC‑PINT) in NSCLC to identify a novel non‑invasive biomarker for the diagnosis and prognosis of patients with NSCLC. Reverse transcription‑quantitative PCR analysis was performed to detect LINC‑PINT expression in the tissue and serum samples of patients with NSCLC. The diagnostic and prognostic values of LINC‑PINT were assessed via the receiver operating characteristic curve, and Kaplan‑Meier and Cox regression analyses, respectively. The results demonstrated that LINC‑PINT expression was significantly downregulated in NSCLC serum samples and tissues. In addition, serum LINC‑PINT exhibited diagnostic value in patients with NSCLC, and may be used to predict prognosis. Furthermore, aberrant LINC‑PINT expression in tumor tissues was significantly associated with lymph node metastasis, tumor size, differentiation and TNM stage. Taken together, the results of the present study suggest that lncRNA LINC‑PINT may be an independent diagnostic and prognostic biomarker in NSCLC.