Altered glycolysis results in drug‑resistant in clinical tumor therapy (Review)

  • Authors:
    • Jinghui Peng
    • Yangyang Cui
    • Shipeng Xu
    • Xiaowei Wu
    • Yue Huang
    • Wenbin Zhou
    • Shui Wang
    • Ziyi Fu
    • Hui Xie
  • View Affiliations

  • Published online on: March 11, 2021     https://doi.org/10.3892/ol.2021.12630
  • Article Number: 369
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Abstract

Cancer cells undergo metabolic reprogramming, including increased glucose metabolism, fatty acid synthesis and glutamine metabolic rates. These enhancements to three major metabolic pathways are closely associated with glycolysis, which is considered the central component of cancer cell metabolism. Increasing evidence suggests that dysfunctional glycolysis is commonly associated with drug resistance in cancer treatment, and aberrant glycolysis plays a significant role in drug‑resistant cancer cells. Studies on the development of drugs targeting these abnormalities have led to improvements in the efficacy of tumor treatment. The present review discusses the changes in glycolysis targets that cause drug resistance in cancer cells, including hexokinase, pyruvate kinase, pyruvate dehydrogenase complex, glucose transporters, and lactate, as well the underlying molecular mechanisms and corresponding novel therapeutic strategies. In addition, the association between increased oxidative phosphorylation and drug resistance is introduced, which is caused by metabolic plasticity. Given that aberrant glycolysis has been identified as a common metabolic feature of drug‑resistant tumor cells, targeting glycolysis may be a novel strategy to develop new drugs to benefit patients with drug‑resistance.
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May-2021
Volume 21 Issue 5

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Peng J, Cui Y, Xu S, Wu X, Huang Y, Zhou W, Wang S, Fu Z and Xie H: Altered glycolysis results in drug‑resistant in clinical tumor therapy (Review). Oncol Lett 21: 369, 2021
APA
Peng, J., Cui, Y., Xu, S., Wu, X., Huang, Y., Zhou, W. ... Xie, H. (2021). Altered glycolysis results in drug‑resistant in clinical tumor therapy (Review). Oncology Letters, 21, 369. https://doi.org/10.3892/ol.2021.12630
MLA
Peng, J., Cui, Y., Xu, S., Wu, X., Huang, Y., Zhou, W., Wang, S., Fu, Z., Xie, H."Altered glycolysis results in drug‑resistant in clinical tumor therapy (Review)". Oncology Letters 21.5 (2021): 369.
Chicago
Peng, J., Cui, Y., Xu, S., Wu, X., Huang, Y., Zhou, W., Wang, S., Fu, Z., Xie, H."Altered glycolysis results in drug‑resistant in clinical tumor therapy (Review)". Oncology Letters 21, no. 5 (2021): 369. https://doi.org/10.3892/ol.2021.12630