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Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma

  • Authors:
    • Nobuhiko Nakagawa
    • Fuminori Sonohara
    • Katsuhito Tanaka
    • Yuki Sunagawa
    • Yoshikuni Inokawa
    • Hideki Takami
    • Masamichi Hayashi
    • Suguru Yamada
    • Mitsuro Kanda
    • Chie Tanaka
    • Goro Nakayama
    • Masahiko Koike
    • Yasuhiro Kodera
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterological Surgery, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466‑8550, Japan
    Copyright: © Nakagawa et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 538
    |
    Published online on: May 19, 2021
       https://doi.org/10.3892/ol.2021.12799
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Abstract

N6‑methyladenosine (m6A), the most abundant internal RNA modification, serves a critical role in cancer development. However, the clinical implications of m6A in hepatocellular carcinoma (HCC) remain unclear. The present study sought to reveal the potential roles of m6A readers, which recognize m6A, in HCC. A total of 177 HCC and paired non‑cancerous liver tissues from patients who underwent hepatectomy were analysed using quantitative PCR for the expression of m6A readers: YT521‑B homology domain family 1 (YTHDF1) and YT521‑B homology domain family 2 (YTHDF2). The expression levels of both YTHDF1 and YTHDF2 were not significantly different between tumour and non‑cancerous tissues (P=0.93 and P=0.7, respectively). Analysis of the association between clinical features and m6A reader expression revealed that YTHDF1 expression was associated with formation of capsule (P=0.02), whereas low YTHDF2 expression was associated with septal formation (P=0.02). Furthermore, high YTHDF1 expression and high YTHDF2 expression were significantly associated with shorter recurrence‑free survival (RFS) [YTHDF1: Mean survival time (MST), 34.0 vs. 19.0 months, P=0.014; YTHDF2: MST, 30.1 vs. 12.9 months, P=0.0032], whereas YTHDF1 and YTHDF2 expression was not significantly associated with overall survival (OS) (YTHDF1: MST, 99.4 vs. 70.2 months, P=0.74; YTHDF2: MST, 98.4 vs. 64.1 months, P=0.28). According to multivariate analysis, serosal invasion [hazard ratio (HR), 2.39; 95% CI 1.30‑4.42; P=0.005), portal vein or hepatic vein invasion (HR, 2.82; 95% CI 1.26‑6.28; P=0.01) and YTHDF2 expression in HCC tissues (HR, 1.85; 95% CI 1.09‑3.15; P=0.02) were identified as significant independent prognostic factors for RFS. α‑fetoprotein (HR, 1.79; 95% CI 1.10‑2.92; P=0.02), serosal invasion (HR, 1.99; 95% CI 1.17‑3.34; P=0.01) and portal vein or hepatic vein invasion (HR, 3.02; 95% CI 1.38‑6.61; P=0.006) were identified as significant independent prognostic factors for OS. In conclusion, the present study revealed that high YTHDF2 expression, an m6A reader, in HCC tissues was associated with cancer recurrence.
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Copy and paste a formatted citation
Spandidos Publications style
Nakagawa N, Sonohara F, Tanaka K, Sunagawa Y, Inokawa Y, Takami H, Hayashi M, Yamada S, Kanda M, Tanaka C, Tanaka C, et al: Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma. Oncol Lett 22: 538, 2021.
APA
Nakagawa, N., Sonohara, F., Tanaka, K., Sunagawa, Y., Inokawa, Y., Takami, H. ... Kodera, Y. (2021). Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma. Oncology Letters, 22, 538. https://doi.org/10.3892/ol.2021.12799
MLA
Nakagawa, N., Sonohara, F., Tanaka, K., Sunagawa, Y., Inokawa, Y., Takami, H., Hayashi, M., Yamada, S., Kanda, M., Tanaka, C., Nakayama, G., Koike, M., Kodera, Y."Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma". Oncology Letters 22.1 (2021): 538.
Chicago
Nakagawa, N., Sonohara, F., Tanaka, K., Sunagawa, Y., Inokawa, Y., Takami, H., Hayashi, M., Yamada, S., Kanda, M., Tanaka, C., Nakayama, G., Koike, M., Kodera, Y."Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma". Oncology Letters 22, no. 1 (2021): 538. https://doi.org/10.3892/ol.2021.12799
Copy and paste a formatted citation
x
Spandidos Publications style
Nakagawa N, Sonohara F, Tanaka K, Sunagawa Y, Inokawa Y, Takami H, Hayashi M, Yamada S, Kanda M, Tanaka C, Tanaka C, et al: Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma. Oncol Lett 22: 538, 2021.
APA
Nakagawa, N., Sonohara, F., Tanaka, K., Sunagawa, Y., Inokawa, Y., Takami, H. ... Kodera, Y. (2021). Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma. Oncology Letters, 22, 538. https://doi.org/10.3892/ol.2021.12799
MLA
Nakagawa, N., Sonohara, F., Tanaka, K., Sunagawa, Y., Inokawa, Y., Takami, H., Hayashi, M., Yamada, S., Kanda, M., Tanaka, C., Nakayama, G., Koike, M., Kodera, Y."Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma". Oncology Letters 22.1 (2021): 538.
Chicago
Nakagawa, N., Sonohara, F., Tanaka, K., Sunagawa, Y., Inokawa, Y., Takami, H., Hayashi, M., Yamada, S., Kanda, M., Tanaka, C., Nakayama, G., Koike, M., Kodera, Y."Novel prognostic implications of YTH domain family 2 in resected hepatocellular carcinoma". Oncology Letters 22, no. 1 (2021): 538. https://doi.org/10.3892/ol.2021.12799
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