Glyoxalase 1 and protein kinase Cλ as potential therapeutic targets for late‑stage breast cancer
- Authors:
- Hitomi Motomura
- Ayaka Ozaki
- Shoma Tamori
- Chotaro Onaga
- Yuka Nozaki
- Yuko Waki
- Ryoko Takasawa
- Kazumi Yoshizawa
- Yasunari Mano
- Tsugumichi Sato
- Kazunori Sasaki
- Hitoshi Ishiguro
- Yohei Miyagi
- Yoji Nagashima
- Kouji Yamamoto
- Keiko Sato
- Takehisa Hanawa
- Sei-Ichi Tanuma
- Shigeo Ohno
- Kazunori Akimoto
-
Affiliations: Department of Medicinal and Life Sciences, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278‑8510, Japan, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba 278‑8510, Japan, Department of Molecular Biology, Yokohama City University, School of Medicine, Kanagawa 236‑0004, Japan, Department of Urology, Yokohama City University Graduate School of Medicine, Kanagawa 236‑0004, Japan, Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Kanagawa 241‑8515, Japan, Department of Surgical Pathology, Tokyo Women's Medical University Hospital, Tokyo 162‑8666, Japan, Department of Biostatistics, Yokohama City University, School of Medicine, Kanagawa 236‑0004, Japan, Department of Information Sciences, Faculty of Science and Technology, Tokyo University of Science, Chiba 278‑8510, Japan - Published online on: May 24, 2021 https://doi.org/10.3892/ol.2021.12808
- Article Number: 547
-
Copyright: © Motomura et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
This article is mentioned in:
Abstract
World Cancer Research Fund (WCRF), . Breast cancer statistics. Breast cancer is the most common cancer in women worldwide. WCRF, London. 2018.https://www.wcrf.org/dietandcancer/cancer-trends/breast-cancer-statistics | |
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI | |
Maughan KL, Lutterbie MA and Ham PS: Treatment of breast cancer. Am Fam Physician. 81:1339–1346. 2010.PubMed/NCBI | |
van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, et al: A gene-expression signature as a predictor of survival in breast cancer. N Engl J Med. 347:1999–2009. 2002. View Article : Google Scholar : PubMed/NCBI | |
Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jeffrey SS, Rees CA, Pollack JR, Ross DT, Johnsen H, Akslen LA, et al: Molecular portraits of human breast tumours. Nature. 406:747–752. 2000. View Article : Google Scholar : PubMed/NCBI | |
Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, Hastie T, Eisen MB, van de Rijn M, Jeffrey SS, et al: Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA. 98:10869–10874. 2001. View Article : Google Scholar | |
Herschkowitz JI, Simin K, Weigman VJ, Mikaelian I, Usary J, Hu Z, Rasmussen KE, Jones LP, Assefnia S, Chandrasekharan S, et al: Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors. Genome Biol. 8:R762007. View Article : Google Scholar : PubMed/NCBI | |
Badve S, Dabbs DJ, Schnitt SJ, Baehner FL, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, et al: Basal-like and triple-negative breast cancers: A critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol. 24:157–167. 2011. View Article : Google Scholar : PubMed/NCBI | |
Warburg O, Wind F and Negelein E: The metabolism of tumors in the body. J Gen Physiol. 8:519–530. 1927. View Article : Google Scholar : PubMed/NCBI | |
Gatenby RA and Gillies RJ: Why do cancers have high aerobic glycolysis? Nat Rev Cancer. 4:891–899. 2004. View Article : Google Scholar : PubMed/NCBI | |
Sakamoto H, Mashima T, Sato S, Hashimoto Y, Yamori T and Tsuruo T: Selective activation of apoptosis program by S-p-bromobenzylglutathione cyclopentyl diester in glyoxalase I-overexpressing human lung cancer cells. Clin Cancer Res. 7:2513–2518. 2001.PubMed/NCBI | |
Cheng WL, Tsai MM, Tsai CY, Huang YH, Chen CY, Chi HC, Tseng YH, Chao IW, Lin WC, Wu SM, et al: Glyoxalase-I is a novel prognosis factor associated with gastric cancer progression. PLoS One. 7:e343522012. View Article : Google Scholar : PubMed/NCBI | |
Ranganathan S and Tew KD: Analysis of glyoxalase-I from normal and tumor tissue from human colon. Biochim Biophys Acta. 1182:311–316. 1993. View Article : Google Scholar : PubMed/NCBI | |
Zhang S, Liang X, Zheng X, Huang H, Chen X, Wu K, Wang B and Ma S: Glo1 genetic amplification as a potential therapeutic target in hepatocellular carcinoma. Int J Clin Exp Pathol. 7:2079–2090. 2014.PubMed/NCBI | |
Baunacke M, Horn LC, Trettner S, Engel KM, Hemdan NY, Wiechmann V, Stolzenburg JU, Bigl M and Birkenmeier G: Exploring glyoxalase 1 expression in prostate cancer tissues: Targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties. Prostate. 74:48–60. 2014. View Article : Google Scholar : PubMed/NCBI | |
Kreycy N, Gotzian C, Fleming T, Flechtenmacher C, Grabe N, Plinkert P, Hess J and Zaoui K: Glyoxalase 1 expression is associated with an unfavorable prognosis of oropharyngeal squamous cell carcinoma. BMC Cancer. 17:3822017. View Article : Google Scholar : PubMed/NCBI | |
Zou XY, Ding D, Zhan N, Liu XM, Pan C and Xia YM: Glyoxalase I is differentially expressed in cutaneous neoplasms and contributes to the progression of squamous cell carcinoma. J Invest Dermatol. 135:589–598. 2015. View Article : Google Scholar : PubMed/NCBI | |
Bair WB III, Cabello CM, Uchida K, Bause AS and Wondrak GT: GLO1 overexpression in human malignant melanoma. Melanoma Res. 20:85–96. 2010. View Article : Google Scholar : PubMed/NCBI | |
Rulli A, Carli L, Romani R, Baroni T, Giovannini E, Rosi G and Talesa V: Expression of glyoxalase I and II in normal and breast cancer tissues. Breast Cancer Res Treat. 66:67–72. 2001. View Article : Google Scholar : PubMed/NCBI | |
Peng HT, Chen J, Liu TY, Wu YQ, Lin XH, Lai YH and Huang YF: Up-regulation of the tumor promoter Glyoxalase-1 indicates poor prognosis in breast cancer. Int J Clin Exp Pathol. 10:10852–10862. 2017.PubMed/NCBI | |
Tamori S, Nozaki Y, Motomura H, Nakane H, Katayama R, Onaga C, Kikuchi E, Shimada N, Suzuki Y, Noike M, et al: Glyoxalase 1 gene is highly expressed in basal-like human breast cancers and contributes to survival of ALDH1-positive breast cancer stem cells. Oncotarget. 9:36515–36529. 2018. View Article : Google Scholar : PubMed/NCBI | |
Zhang D, Tai LK, Wong LL, Chiu LL, Sethi SK and Koay ES: Proteomic study reveals that proteins involved in metabolic and detoxification pathways are highly expressed in HER-2/neu-positive breast cancer. Mol Cell Proteomics. 4:1686–1696. 2005. View Article : Google Scholar : PubMed/NCBI | |
Gandalovičová A, Vomastek T, Rosel D and Brábek J: Cell polarity signaling in the plasticity of cancer cell invasiveness. Oncotarget. 7:25022–25049. 2016. View Article : Google Scholar | |
Akimoto K, Mizuno K, Osada S, Hirai S, Tanuma S, Suzuki K and Ohno S: A new member of the third class in the protein kinase C family, PKC lambda, expressed dominantly in an undifferentiated mouse embryonal carcinoma cell line and also in many tissues and cells. J Biol Chem. 269:12677–12683. 1994. View Article : Google Scholar : PubMed/NCBI | |
Suzuki A, Akimoto K and Ohno S: Protein kinase C lambda/iota (PKClambda/iota): A PKC isotype essential for the development of multicellular organisms. J Biochem. 133:9–16. 2003. View Article : Google Scholar : PubMed/NCBI | |
Ohno S: Intercellular junctions and cellular polarity: The PAR-aPKC complex, a conserved core cassette playing fundamental roles in cell polarity. Curr Opin Cell Biol. 13:641–648. 2001. View Article : Google Scholar : PubMed/NCBI | |
Parker PJ, Justilien V, Riou P, Linch M and Fields AP: Atypical protein kinase Cι as a human oncogene and therapeutic target. Biochem Pharmacol. 88:1–11. 2014. View Article : Google Scholar : PubMed/NCBI | |
Murray NR, Jamieson L, Yu W, Zhang J, Gökmen-Polar Y, Sier D, Anastasiadis P, Gatalica Z, Thompson EA and Fields AP: Protein kinase Ciota is required for Ras transformation and colon carcinogenesis in vivo. J Cell Biol. 164:797–802. 2004. View Article : Google Scholar : PubMed/NCBI | |
Kojima Y, Akimoto K, Nagashima Y, Ishiguro H, Shirai S, Chishima T, Ichikawa Y, Ishikawa T, Sasaki T, Kubota Y, et al: The overexpression and altered localization of the atypical protein kinase C lambda/iota in breast cancer correlates with the pathologic type of these tumors. Hum Pathol. 39:824–831. 2008. View Article : Google Scholar : PubMed/NCBI | |
Paul A, Gunewardena S, Stecklein SR, Saha B, Parelkar N, Danley M, Rajendran G, Home P, Ray S, Jokar I, et al: PKCλ/ι signaling promotes triple-negative breast cancer growth and metastasis. Cell Death Differ. 21:1469–1481. 2014. View Article : Google Scholar : PubMed/NCBI | |
Mizushima T, Asai-Sato M, Akimoto K, Nagashima Y, Taguri M, Sasaki K, Nakaya MA, Asano R, Tokinaga A, Kiyono T, et al: Aberrant expression of the cell polarity regulator aPKCλ/ι is associated with disease progression in cervical intraepithelial Neoplasia (CIN): A possible marker for predicting CIN prognosis. Int J Gynecol Pathol. 35:106–117. 2016. View Article : Google Scholar : PubMed/NCBI | |
Tokinaga-Uchiyama A, Mizushima T, Akimoto K, Nagashima Y, Sasaki K, Nakaya MA, Ohashi K, Kubota K, Maruyama Y, Kato H, et al: Aberrant nuclear localization of aPKCλ/ι is associated with poorer prognosis in uterine cervical cancer. Gynecol Pathol. 38:301–309. 2019. View Article : Google Scholar : PubMed/NCBI | |
Baba J, Kioi M, Akimoto K, Nagashima Y, Taguri M, Inayama Y, Aoki I, Ohno S, Mitsudo K and Tohnai I: Atypical protein kinase Cλ/ι expression is associated with malignancy of oral squamous cell carcinoma. Anticancer Res. 38:6291–6297. 2018. View Article : Google Scholar : PubMed/NCBI | |
Ishiguro H, Akimoto K, Nagashima Y, Kagawa E, Sasaki T, Sano JY, Takagawa R, Fujinami K, Sasaki K, Aoki I, et al: Coexpression of aPKCλ/ι and IL-6 in prostate cancer tissue correlates with biochemical recurrence. Cancer Sci. 102:1576–1581. 2011. View Article : Google Scholar : PubMed/NCBI | |
Ishiguro H, Akimoto K, Nagashima Y, Kojima Y, Sasaki T, Ishiguro-Imagawa Y, Nakaigawa N, Ohno S, Kubota Y and Uemura H: aPKClambda/iota promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6. Proc Natl Acad Sci USA. 106:16369–16374. 2009. View Article : Google Scholar : PubMed/NCBI | |
Regala RP, Weems C, Jamieson L, Khoor A, Edell ES, Lohse CM and Fields AP: Atypical protein kinase C iota is an oncogene in human non-small cell lung cancer. Cancer Res. 65:8905–8911. 2005. View Article : Google Scholar : PubMed/NCBI | |
Eder AM, Sui X, Rosen DG, Nolden LK, Cheng KW, Lahad JP, Kango-Singh M, Lu KH, Warneke CL, Atkinson EN, et al: Atypical PKCiota contributes to poor prognosis through loss of apical-basal polarity and cyclin E overexpression in ovarian cancer. Proc Natl Acad Sci USA. 102:12519–12524. 2005. View Article : Google Scholar : PubMed/NCBI | |
Scotti ML, Bamlet WR, Smyrk TC, Fields AP and Murray NR: Protein kinase Ciota is required for pancreatic cancer cell transformed growth and tumorigenesis. Cancer Res. 70:2064–2074. 2010. View Article : Google Scholar : PubMed/NCBI | |
Kato S, Akimoto K, Nagashima Y, Ishiguro H, Kubota K, Kobayashi N, Hosono K, Watanabe S, Sekino Y, Sato T, et al: aPKCλ/ι is a beneficial prognostic marker for pancreatic neoplasms. Pancreatology. 13:360–368. 2013. View Article : Google Scholar : PubMed/NCBI | |
Takagawa R, Akimoto K, Ichikawa Y, Akiyama H, Kojima Y, Ishiguro H, Inayama Y, Aoki I, Kunisaki C, Endo I, et al: High expression of atypical protein kinase C lambda/iota in gastric cancer as a prognostic factor for recurrence. Ann Surg Oncol. 17:81–88. 2010. View Article : Google Scholar : PubMed/NCBI | |
Nozaki Y, Motomura H, Tamori S, Kimura Y, Onaga C, Kanai S, Ishihara Y, Ozaki A, Hara Y, Harada Y, et al: High PKCλ expression is required for ALDH1-positive cancer stem cell function and indicates a poor clinical outcome in late-stage breast cancer patients. PLoS One. 15:e02357472020. View Article : Google Scholar : PubMed/NCBI | |
Motomura H, Nozaki Y, Onaga C, Ozaki A, Tamori S, Shiina TA, Kanai S, Ohira C, Hara Y, Harada Y, et al: High expression of c-Met, PKCλ and ALDH1A3 predicts a poor prognosis in late-stage breast cancer. Anticancer Res. 40:35–52. 2020. View Article : Google Scholar : PubMed/NCBI | |
Akimoto K, Takahashi R, Moriya S, Nishioka N, Takayanagi J, Kimura K, Fukui Y, Osada SI, Mizuno K, Hirai SI, et al: EGF or PDGF receptors activate atypical PKClambda through phosphatidylinositol 3-kinase. EMBO J. 15:788–798. 1996. View Article : Google Scholar : PubMed/NCBI | |
Kotani K, Ogawa W, Matsumoto M, Kitamura T, Sakaue H, Hino Y, Miyake K, Sano W, Akimoto K, Ohno S and Kasuga M: Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes. Mol Cell Biol. 18:6971–6982. 1998. View Article : Google Scholar : PubMed/NCBI | |
Farese RV: Function and dysfunction of aPKC isoforms for glucose transport in insulin-sensitive and insulin-resistant states. Am J Physiol Endocrinol Metab. 283:E1–E11. 2002. View Article : Google Scholar : PubMed/NCBI | |
Akimoto K, Nakaya M, Yamanaka T, Tanaka J, Matsuda S, Weng QP, Avruch J and Ohno S: Atypical protein kinase Clambda binds and regulates p70 S6 kinase. Biochem J. 335:417–424. 1998. View Article : Google Scholar : PubMed/NCBI | |
Regala RP, Weems C, Jamieson L, Copland JA, Thompson EA and Fields AP: Atypical protein kinase Ciota plays a critical role in human lung cancer cell growth and tumorigenicity. J Biol Chem. 280:31109–31115. 2005. View Article : Google Scholar : PubMed/NCBI | |
Riddell M, Nakayama A, Hikita T, Mirzapourshafiyi F, Kawamura T and Pasha A: aPKC controls endothelial growth by modulating c-Myc via FoxO1 DNA-binding ability. Nat Commun. 9:53572018. View Article : Google Scholar : PubMed/NCBI | |
Szablewski L: Expression of glucose transporters in cancers. Biochim Biophys Acta. 1835:164–169. 2013.PubMed/NCBI | |
Hussein YR, Bandyopadhyay S, Semaan A, Ahmed Q, Albashiti B, Jazaerly T, Nahleh Z and Ali-Fehmi R: Glut-1 expression correlates with basal-like breast cancer. Transl Oncol. 4:321–327. 2011. View Article : Google Scholar : PubMed/NCBI | |
Bosch RR, Bazuine M, Span PN, Willems PH, Olthaar AJ, van Rennes H, Maassen JA, Tack CJ, Hermus AR and Sweep CG: Regulation of GLUT1-mediated glucose uptake by PKClambda-PKCbeta(II) interactions in 3T3-L1 adipocytes. Biochem J. 384:349–355. 2004. View Article : Google Scholar : PubMed/NCBI | |
Varghese F, Bukhari AB, Malhotra R and De A: IHC Profiler: An open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples. PLoS One. 9:e968012014. View Article : Google Scholar : PubMed/NCBI | |
Nozaki Y, Tamori S, Inada M, Katayama R, Nakane H, Minamishima O, Onodera Y, Abe M, Shiina S, Tamura K, et al: Correlation between c-Met and ALDH1 contributes to the survival and tumor-sphere formation of ALDH1 positive breast cancer stem cells and predicts poor clinical outcome in breast cancer. Genes Cancer. 8:628–639. 2017. View Article : Google Scholar : PubMed/NCBI | |
Sato K and Akimoto K: Expression levels of KMT2C and SLC20A1 identified by information-theoretical analysis are powerful prognostic biomarkers in estrogen receptor-positive breast cancer. Clin Breast Cancer. 17:e135–e142. 2017. View Article : Google Scholar : PubMed/NCBI | |
Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, et al: The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature. 486:346–352. 2012. View Article : Google Scholar : PubMed/NCBI | |
Pereira B, Chin SF, Rueda OM, Vollan HK, Provenzano E, Bardwell HA, Pugh M, Jones L, Russell R, Sammut SJ, et al: The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes. Nat Commun. 7:114792016. View Article : Google Scholar : PubMed/NCBI | |
Cerami E, Gao J, Dogrusoz U, Gross BE, Sumer SO, Aksoy BA, Jacobsen A, Byrne CJ, Heuer ML, Larsson E, et al: The cBio cancer genomics portal: An open platform for exploring multidimensional cancer genomics data. Cancer Dicov. 2:401–404. 2012. View Article : Google Scholar : PubMed/NCBI | |
Gao J, Aksoy BA, Dogrusoz U, Dresdner G, Gross B, Sumer SO, Sun Y, Jacobsen A, Sinha R, Larsson E, et al: Integrative analysis of complex cancer genomics and clinical profiles using the cBioPortal. Sci Signal. 6:pl12013. View Article : Google Scholar : PubMed/NCBI | |
Cancer Genome Atlas Network, . Comprehensive molecular portraits of human breast tumours. Nature. 490:61–70. 2012. View Article : Google Scholar : PubMed/NCBI | |
Rhodes DR, Yu J, Shanker K, Deshpande N, Varambally R, Ghosh D, Barrette T, Pandey A and Chinnaiyan AM: ONCOMINE: A cancer microarray database and integrated data-mining platform. Neoplasia. 6:1–6. 2004. View Article : Google Scholar : PubMed/NCBI | |
Takasawa R, Tao A, Saeki K, Shionozaki N, Tanaka R, Uchiro H, Takahashi S, Yoshimori A and Tanuma S: Discovery of a new type inhibitor of human glyoxalase I by myricetin-based 4-point pharmacophore. Bioorg. Med Chem Lett. 21:4337–4342. 2011. View Article : Google Scholar : PubMed/NCBI | |
Stallings-Mann M, Jamieson L, Regala RP, Weems C, Murray NR and Fields AP: A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells. Cancer Res. 66:1767–1774. 2006. View Article : Google Scholar : PubMed/NCBI | |
Trani M, Sorrentino A, Busch C and Landström M: Pro-apoptotic effect of aurothiomalate in prostate cancer cells. Cell Cycle. 8:306–313. 2009. View Article : Google Scholar : PubMed/NCBI | |
Chiavarina B, Nokin MJ, Durieux F, Bianchi E, Turtoi A, Peulen O, Peixoto P, Irigaray P, Uchida K, Belpomme D, et al: Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes. Oncotarget. 5:5472–5482. 2014. View Article : Google Scholar : PubMed/NCBI | |
Justilien V and Fields AP: Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation. Oncogene. 28:3597–3607. 2009. View Article : Google Scholar : PubMed/NCBI | |
Guo Y, Zhang Y, Yang X, Lu P, Yan X, Xiao F, Zhou H, Wen C, Shi M, Lu J and Meng QH: Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2. Cancer Biol Ther. 17:169–180. 2016. View Article : Google Scholar : PubMed/NCBI | |
Singh S, Brocker C, Koppaka V, Chen Y, Jackson BC and Matsumoto A: Aldehyde dehydrogenases in cellular responses to oxidative/electrophilic stress. Free Radic Biol Med. 56:89–101. 2013. View Article : Google Scholar : PubMed/NCBI | |
Kang Y, Edwards LG and Thornalley PJ: Effect of methylglyoxal on human leukaemia 60 cell growth: Modification of DNA G1 growth arrest and induction of apoptosis. Leuk Res. 20:97–405. 1996. View Article : Google Scholar | |
Liu L, Lei B, Wang L, Chang C, Yang H, Liu J, Huang G and Xie W: Protein kinase C-iota-mediated glycolysis promotes non-small-cell lung cancer progression. Onco Targets Ther. 12:5835–5848. 2019. View Article : Google Scholar : PubMed/NCBI | |
Tisdale EJ: Glyceraldehyde-3-phosphate dehydrogenase is phosphorylated by protein kinase Ciota/lambda and plays a role in microtubule dynamics in the early secretory pathway. J Biol Chem. 277:3334–3341. 2002. View Article : Google Scholar : PubMed/NCBI | |
Tisdale EJ: Rab2 interacts directly with atypical protein kinase C (aPKC) iota/lambda and inhibits aPKCiota/lambda-dependent glyceraldehyde-3-phosphate dehydrogenase phosphorylation. J Biol Chem. 278:52524–52530. 2003. View Article : Google Scholar : PubMed/NCBI | |
Kim JY, Valencia T, Abu-Baker S, Linares J, Lee SJ, Yajima T, Chen J, Eroshkin A, Castilla EA, Brill LM, et al: c-Myc phosphorylation by PKCζ represses prostate tumorigenesis. Proc Natl Acad Sci USA. 110:6418–6423. 2013. View Article : Google Scholar : PubMed/NCBI | |
Osthus RC, Shim H, Kim S, Li Q, Reddy R, Mukherjee M, Xu Y, Wonsey D, Lee LA and Dang CV: Deregulation of glucose transporter 1 and glycolytic gene expression by c-Myc. J Biol Chem. 275:21797–21800. 2000. View Article : Google Scholar : PubMed/NCBI | |
Gjyshi O, Bottero V, Veettil MV, Dutta S, Singh VV and Chikoti L: Kaposi's sarcoma-associated herpesvirus induces Nrf2 during de novo infection of endothelial cells to create a microenvironment conducive to infection. PLoS Pathog. 10:e10044602014. View Article : Google Scholar : PubMed/NCBI | |
Ma L, Tao Y, Duran A, Llado V, Galvez A, Barger JF, Castilla EA, Chen J, Yajima T, Porollo A, et al: Control of nutrient stress-induced metabolic reprogramming by PKCζ in tumorigenesis. Cell. 152:599–611. 2013. View Article : Google Scholar : PubMed/NCBI | |
Franchet C, Duprez-Paumier R and Lacroix-Triki M: Molecular taxonomy of luminal breast cancer in 2015. Bull Cancer. 102 (6 Suppl 1):S34–S46. 2015.(In French). View Article : Google Scholar : PubMed/NCBI | |
Liu Z, Zhang XS and Zhang S: Breast tumor subgroups reveal diverse clinical prognostic power. Sci Rep. 4:40022014. View Article : Google Scholar : PubMed/NCBI |