Open Access

Role of the CTRP family in tumor development and progression (Review)

  • Authors:
    • Mowei Kong
    • Yu Gao
    • Xiang Guo
    • Yuyu Xie
    • Yamei Yu
  • View Affiliations

  • Published online on: August 10, 2021     https://doi.org/10.3892/ol.2021.12984
  • Article Number: 723
  • Copyright: © Kong et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

C1q tumor necrosis factor‑related proteins (CTRPs), which are members of the adipokine superfamily, have gained significant interest in the recent years. CTRPs are homologs of adiponectin with numerous functions and are closely associated with metabolic diseases, such as abnormal glucose and lipid metabolism and diabetes. Previous studies have demonstrated that CTRPs are highly involved in the regulation of numerous physiological and pathological processes, including glycolipid metabolism, protein kinase pathways, cell proliferation, cell apoptosis and inflammation. CTRPs also play important roles in the development and progression of numerous types of tumor, including liver, colon and lung cancers. This observation can be attributed to the fact that diabetes, obesity and insulin resistance are independent risk factors for tumorigenesis. Numerous CTRPs, including CTRP3, CTRP4, CTRP6 and CTRP8, have been reported to be associated with tumor progression by activating multiple signal pathways. CTRPs could therefore be considered as diagnostic markers and therapeutic targets in some cancers. However, the underlying mechanisms of CTRPs in tumorigenesis remain unknown. The present review aimed to determine the roles and underlying mechanisms of CTRPs in tumorigenesis, which may help the development of novel cancer treatments in the future.
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October-2021
Volume 22 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Kong M, Gao Y, Guo X, Xie Y and Yu Y: Role of the CTRP family in tumor development and progression (Review). Oncol Lett 22: 723, 2021
APA
Kong, M., Gao, Y., Guo, X., Xie, Y., & Yu, Y. (2021). Role of the CTRP family in tumor development and progression (Review). Oncology Letters, 22, 723. https://doi.org/10.3892/ol.2021.12984
MLA
Kong, M., Gao, Y., Guo, X., Xie, Y., Yu, Y."Role of the CTRP family in tumor development and progression (Review)". Oncology Letters 22.4 (2021): 723.
Chicago
Kong, M., Gao, Y., Guo, X., Xie, Y., Yu, Y."Role of the CTRP family in tumor development and progression (Review)". Oncology Letters 22, no. 4 (2021): 723. https://doi.org/10.3892/ol.2021.12984