Open Access

Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series

  • Authors:
    • Tomofumi Naruse
    • Kohei Furukawa
    • Taro Miyoshi
    • Kota Morishita
    • Mitsunobu Otsuru
    • Masahiro Umeda
  • View Affiliations

  • Published online on: October 19, 2022     https://doi.org/10.3892/ol.2022.13551
  • Article Number: 431
  • Copyright: © Naruse et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Salvage surgery for recurrent oral squamous cell carcinoma (OSCC) often leads to a poor quality of life (QOL). The present study described three cases that resulted in favorable locoregional control with cetuximab in combination with radiotherapy (Cmab + RT). Case 1 had regional recurrence of OSCC at the lower right mastoid area 4 months after primary surgery. Case 2 had regional recurrence of OSCC at the parotid area 7 months after primary surgery. Case 3 had local recurrence of OSCC at the masticatory muscle and Rouviere's lymph nodes 1 year and 3 months after primary surgery. In all cases, Cmab + RT was performed, and disease‑free survival was confirmed 4 months, 2 years and 6 months, and 10 months after Cmab + RT, respectively. Immunohistochemically, all resected tumors had no expression of 110‑kDa catalytic subunit of class IA phosphatidylinositol 3‑kinase (PI3Kp110α). In conclusion, if salvage surgery for recurrent OSCC results in a significantly low QOL, then shifting to chemoradiotherapy may be appropriate as a treatment strategy. In addition, strong evidence indicated that PI3Kp110α expression is associated with Cmab therapy efficacy.
View Figures
View References

Related Articles

Journal Cover

December-2022
Volume 24 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Naruse T, Furukawa K, Miyoshi T, Morishita K, Otsuru M and Umeda M: Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series. Oncol Lett 24: 431, 2022
APA
Naruse, T., Furukawa, K., Miyoshi, T., Morishita, K., Otsuru, M., & Umeda, M. (2022). Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series. Oncology Letters, 24, 431. https://doi.org/10.3892/ol.2022.13551
MLA
Naruse, T., Furukawa, K., Miyoshi, T., Morishita, K., Otsuru, M., Umeda, M."Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series". Oncology Letters 24.6 (2022): 431.
Chicago
Naruse, T., Furukawa, K., Miyoshi, T., Morishita, K., Otsuru, M., Umeda, M."Complete response of recurrent oral squamous cell carcinoma treated with cetuximab in combination with radiotherapy: A case series". Oncology Letters 24, no. 6 (2022): 431. https://doi.org/10.3892/ol.2022.13551