Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
Oncology Letters
Join Editorial Board Propose a Special Issue
Print ISSN: 1792-1074 Online ISSN: 1792-1082
Journal Cover
December-2022 Volume 24 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2022 Volume 24 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways

  • Authors:
    • Yi Li
    • Yuanxiu Leng
    • Yudi Dong
    • Yongxiang Song
    • Qiaoyuan Wu
    • Ni Jiang
    • Hui Dong
    • Fang Chen
    • Qing Luo
    • Chen Cheng
  • View Affiliations / Copyright

    Affiliations: Department of Cancer Research Laboratory, Department of Pathology, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China, Department of Oncology, Guihang Guiyang Hospital, Guiyang, Guizhou 550000, P.R. China, Department of Thoracic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563003, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 441
    |
    Published online on: October 25, 2022
       https://doi.org/10.3892/ol.2022.13561
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Although great progress has been made in the early diagnosis and targeted therapy of lung adenocarcinoma (LUAD), the survival of patients with LUAD remains unsatisfactory. There is an urgent requirement for new biomarkers to guide the diagnosis, prognosis and treatment of LUAD. Following an initial bioinformatics screen, the present study focused on cyclin B1 (CCNB1) in LUAD. A total of 94 patients with LUAD from a single hospital were included in the study. CCNB1 protein expression was detected and scored in 94 LUAD samples and 30 normal tissue samples by immunohistochemistry. The associations between CCNB1 expression and the clinicopathological features of the patients with LUAD were analyzed. Furthermore, the relationship between prognosis and the CCNB1 expression level was analyzed using Cox regression and survival analyses. Weighted gene co‑expression network analysis and RNA‑sequencing were also applied to identify the potential molecular mechanisms of CCNB1 in LUAD. CCNB1 was highly expressed in patients with LUAD and was associated with poor prognosis. It may affect the expression of CPLX1, PPIF, SRPK2, KRT8, SLC20A1 and CBX2 genes and function via different pathways. CCNB1 has the potential to become a novel prognostic target for LUAD.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Siegel RL, Miller KD and Jemal A: Cancer statistics, 2020. CA Cancer J Clin. 70:7–30. 2020. View Article : Google Scholar : PubMed/NCBI

2 

Chen Z, Fillmore CM, Hammerman PS, Kim CF and Wong KK: Non-small-cell lung cancers: A heterogeneous set of diseases. Nat Rev Cancer. 14:535–546. 2014. View Article : Google Scholar : PubMed/NCBI

3 

Xia L, Zhu Y, Zhang C, Deng S, Deng Y, Yang Z, Mei J and Liu L: Decreased expression of EFCC1 and its prognostic value in lung adenocarcinoma. Ann Transl Med. 7:6722019. View Article : Google Scholar : PubMed/NCBI

4 

Macheleidt IF, Dalvi PS, Lim SY, Meemboor S, Meder L, Käsgen O, Müller M, Kleemann K, Wang L, Nurnberg P, et al: Preclinical studies reveal that LSD1 inhibition results in tumor growth arrest in lung adenocarcinoma independently of driver mutations. Mol Oncol. 12:1965–1979. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Lim W, Bae H, Bazer FW and Song G: Ephrin A1 promotes proliferation of bovine endometrial cells with abundant expression of proliferating cell nuclear antigen and cyclin D1 changing the cell population at each stage of the cell cycle. J Cell Physiol. 234:4864–4873. 2019. View Article : Google Scholar : PubMed/NCBI

6 

Hydbring P, Malumbres M and Sicinski P: Non-canonical functions of cell cycle cyclins and cyclin-dependent kinases. Nat Rev Mol Cell Biol. 17:280–292. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Braschi B, Denny P, Gray K, Jones T, Seal R, Tweedie S, Yates B and Bruford E: Genenames.org: The HGNC and VGNC resources in 2019. Nucleic Acids Res. 47(D1): D786–D792. 2019. View Article : Google Scholar : PubMed/NCBI

8 

Vishnoi N and Yao J: Single-cell, single-mRNA analysis of Ccnb1 promoter regulation. Sci Rep. 7:20652017. View Article : Google Scholar : PubMed/NCBI

9 

Liu D, Xu W, Ding X, Yang Y, Su B and Fei K: Polymorphisms of CCNB1 associated with the clinical outcomes of platinum-based chemotherapy in Chinese NSCLC patients. J Cancer. 8:3785–3794. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Wei LJ, Li JA, Bai DM and Song Y: miR-223-RhoB signaling pathway regulates the proliferation and apoptosis of colon adenocarcinoma. Chem Biol Interact. 289:9–14. 2018. View Article : Google Scholar : PubMed/NCBI

11 

Li W, Dong Q, Li L, Zhang Z, Cai X and Pan X: Prognostic significance of claudin-1 and cyclin B1 protein expression in patients with hypopharyngeal squamous cell carcinoma. Oncol Lett. 11:2995–3002. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Chai N, Xie HH, Yin JP, Sa KD, Guo Y, Wang M, Liu J, Zhang XF, Zhang X, Yin H, et al: FOXM1 promotes proliferation in human hepatocellular carcinoma cells by transcriptional activation of CCNB1. Biochem Biophys Res Commun. 500:924–929. 2018. View Article : Google Scholar : PubMed/NCBI

13 

Gu J, Liu X, Li J and He Y: MicroRNA-144 inhibits cell proliferation, migration and invasion in human hepatocellular carcinoma by targeting CCNB1. Cancer Cell Int. 19:152019. View Article : Google Scholar : PubMed/NCBI

14 

Fang Y, Liang X, Jiang W, Li J, Xu J and Cai X: Cyclin b1 suppresses colorectal cancer invasion and metastasis by regulating e-cadherin. PLoS One. 10:e01268752015. View Article : Google Scholar : PubMed/NCBI

15 

Sit M, Aktas G, Ozer B, Kocak MZ, Erkus E, Erkol H, Yaman S and Savli H: Mean platelet volume: An overlooked herald of malignant thyroid nodules. Acta Clin Croat. 58:417–420. 2019.PubMed/NCBI

16 

Wang Y, Ruan Y and Wu S: ET-1 regulates the human umbilical vein endothelial cell cycle by adjusting the ERβ/FOXN1 signaling pathway. Ann Transl Med. 8:14992020. View Article : Google Scholar : PubMed/NCBI

17 

Brcic L, Heidinger M, Sever AZ, Zacharias M, Jakopovic M, Fediuk M, Maier A, Quehenberger F, Seiwerth S and Popper H: Prognostic value of cyclin A2 and B1 expression in lung carcinoids. Pathology. 51:481–486. 2019. View Article : Google Scholar : PubMed/NCBI

18 

Wang F, Chen X, Yu X and Lin Q: Degradation of CCNB1 mediated by APC11 through UBA52 ubiquitination promotes cell cycle progression and proliferation of non-small cell lung cancer cells. Am J Transl Res. 11:7166–7185. 2019.PubMed/NCBI

19 

Bao B, Yu X and Zheng W: MiR-139-5p targeting CCNB1 modulates proliferation, migration, invasion and cell cycle in lung adenocarcinoma. Mol Biotechnol. 64:852–860. 2022. View Article : Google Scholar : PubMed/NCBI

20 

Leon LM, Gautier M, Allan R, Ilié M, Nottet N, Pons N, Paquet A, Lebrigand K, Truchi M, Fassy J, et al: Correction: The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress. Oncogene. 40:26212021. View Article : Google Scholar : PubMed/NCBI

21 

Aran D, Camarda R, Odegaard J, Paik H, Oskotsky B, Krings G, Goga A, Sirota M and Butte AJ: Comprehensive analysis of normal adjacent to tumor transcriptomes. Nat Commun. 8:10772017. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

23 

Arora S, Singh P, Rahmani AH, Almatroodi SA, Dohare R and Syed MA: Unravelling the role of miR-20b-5p, CCNB1, HMGA2 and E2F7 in development and progression of non-small cell lung cancer (NSCLC). Biology (Basel). 9:2012020.PubMed/NCBI

24 

Fang L, Du WW, Awan FM, Dong J and Yang BB: The circular RNA circ-Ccnb1 dissociates Ccnb1/Cdk1 complex suppressing cell invasion and tumorigenesis. Cancer Lett. 459:216–226. 2019. View Article : Google Scholar : PubMed/NCBI

25 

Zhan Q, Antinore MJ, Wang XW, Carrier F, Smith ML, Harris CC and Fornace AJ Jr: Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene. 18:2892–2900. 1999. View Article : Google Scholar : PubMed/NCBI

26 

Vairapandi M, Balliet AG, Hoffman B and Liebermann DA: GADD45b and GADD45g are cdc2/cyclinB1 kinase inhibitors with a role in S and G2/M cell cycle checkpoints induced by genotoxic stress. J Cell Physiol. 192:327–338. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Li M, Shang H, Wang T, Yang SQ and Li L: Huanglian decoction suppresses the growth of hepatocellular carcinoma cells by reducing CCNB1 expression. World J Gastroenterol. 27:939–958. 2021. View Article : Google Scholar : PubMed/NCBI

28 

Ding K, Li W, Zou Z, Zou X and Wang C: CCNB1 is a prognostic biomarker for ER+ breast cancer. Med Hypotheses. 83:359–364. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Chen EB, Qin X, Peng K, Li Q, Tang C, Wei YC, Yu S, Gan L and Liu TS: HnRNPR-CCNB1/CENPF axis contributes to gastric cancer proliferation and metastasis. Aging (Albany NY). 11:7473–7491. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Moon SJ, Kim JH, Kong SH and Shin CS: Protein expression of cyclin B1, transferrin receptor, and fibronectin is correlated with the prognosis of adrenal cortical carcinoma. Endocrinol Metab (Seoul). 35:132–141. 2020. View Article : Google Scholar : PubMed/NCBI

31 

Xing Z and Wang X, Liu J, Zhang M, Feng K and Wang X: Expression and prognostic value of CDK1, CCNA2, and CCNB1 gene clusters in human breast cancer. J Int Med Res. 49:3000605209806472021.PubMed/NCBI

32 

Radhakrishnan A, Nanjappa V, Raja R, Sathe G, Chavan S, Nirujogi RS, Patil AH, Solanki H, Renuse S, Sahasrabuddhe NA, et al: Dysregulation of splicing proteins in head and neck squamous cell carcinoma. Cancer Biol Ther. 17:219–229. 2016. View Article : Google Scholar : PubMed/NCBI

33 

Zhuang L, Yang Z and Meng Z: Upregulation of BUB1B, CCNB1, CDC7, CDC20, and MCM3 in tumor tissues predicted worse overall survival and disease-free survival in hepatocellular carcinoma patients. Biomed Res Int. 2018:78973462018. View Article : Google Scholar : PubMed/NCBI

34 

Fu S, Jin L, Gong T, Pan S, Zheng S, Zhang X, Yang T, Sun Y, Wang Y, Guo J, et al: Effect of sinomenine hydrochloride on radiosensitivity of esophageal squamous cell carcinoma cells. Oncol Rep. 39:1601–1608. 2018.PubMed/NCBI

35 

Chae SW, Sohn JH, Kim DH, Choi YJ, Park YL, Kim K, Cho YH, Pyo JS and Kim JH: Overexpressions of cyclin B1, cdc2, p16 and p53 in human breast cancer: The clinicopathologic correlations and prognostic implications. Yonsei Med J. 52:445–453. 2011. View Article : Google Scholar : PubMed/NCBI

36 

Zhou L, Li J, Zhao YP, Cui QC, Zhou WX, Guo JC, You L, Wu WM and Zhang TP: The prognostic value of cyclin B1 in pancreatic cancer. Med Oncol. 31:1072014. View Article : Google Scholar : PubMed/NCBI

37 

Woldu SL, Hutchinson RC, Krabbe LM, Sanli O and Margulis V: The Rho GTPase signalling pathway in urothelial carcinoma. Nat Rev Urol. 15:83–91. 2018. View Article : Google Scholar : PubMed/NCBI

38 

Lawson CD and Ridley AJ: Rho GTPase signaling complexes in cell migration and invasion. J Cell Biol. 217:447–457. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Zhou B, Wang GZ, Wen ZS, Zhou YC, Huang YC, Chen Y and Zhou GB: Somatic mutations and splicing variants of focal adhesion kinase in non-small cell lung cancer. J Natl Cancer Inst. 110:195–204. 2018. View Article : Google Scholar

40 

Walker S, Foster F, Wood A, Owens T, Brennan K, Streuli CH and Gilmore AP: Oncogenic activation of FAK drives apoptosis suppression in a 3D-culture model of breast cancer initiation. Oncotarget. 7:70336–70352. 2016. View Article : Google Scholar : PubMed/NCBI

41 

Brami-Cherrier K, Gervasi N, Arsenieva D, Walkiewicz K, Boutterin MC, Ortega A, Leonard PG, Seantier B, Gasmi L, Bouceba T, et al: FAK dimerization controls its kinase-dependent functions at focal adhesions. EMBO J. 33:356–370. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Shen Y, Ma Y, Gao M, Lai Y, Wang G, Yu Q, Cui FZ and Liu X: Integrins-FAK-Rho GTPases pathway in endothelial cells sense and response to surface wettability of plasma nanocoatings. ACS Appl Mater Interfaces. 5:5112–5121. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Selamat SA, Chung BS, Girard L, Zhang W, Zhang Y, Campan M, Siegmund KD, Koss MN, Hagen JA, Lam WL, et al: Genome-scale analysis of DNA methylation in lung adenocarcinoma and integration with mRNA expression. Genome Res. 22:1197–1211. 2012. View Article : Google Scholar : PubMed/NCBI

44 

Sanchez-Carbayo M, Socci ND, Lozano J, Saint F and Cordon-Cardo C: Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays. J Clin Oncol. 24:778–789. 2006. View Article : Google Scholar : PubMed/NCBI

45 

Curtis C, Shah SP, Chin SF, Turashvili G, Rueda OM, Dunning MJ, Speed D, Lynch AG, Samarajiwa S, Yuan Y, et al: The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups. Nature. 486:346–352. 2012. View Article : Google Scholar : PubMed/NCBI

46 

Fortier AM, Asselin E and Cadrin M: Keratin 8 and 18 loss in epithelial cancer cells increases collective cell migration and cisplatin sensitivity through claudin1 up-regulation. J Biol Chem. 288:11555–11571. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Galarneau L, Loranger A, Gilbert S and Marceau N: Keratins modulate hepatic cell adhesion, size and G1/S transition. Exp Cell Res. 313:179–194. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Wang Y, He QY, Tsao SW, Cheung YH, Wong A and Chiu JF: Cytokeratin 8 silencing in human nasopharyngeal carcinoma cells leads to cisplatin sensitization. Cancer Lett. 265:188–196. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Mulay SR, Honarpisheh MM, Foresto-Neto O, Shi C, Desai J, Zhao ZB, Marschner JA, Popper B, Buhl EM, Boor P, et al: Mitochondria permeability transition versus necroptosis in oxalate-induced AKI. J Am Soc Nephrol. 30:1857–1869. 2019. View Article : Google Scholar : PubMed/NCBI

50 

Nakagawa T, Shimizu S, Watanabe T, Yamaguchi O, Otsu K, Yamagata H, Inohara H, Kubo T and Tsujimoto Y: Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death. Nature. 434:652–658. 2005. View Article : Google Scholar : PubMed/NCBI

51 

Yang L, Cui Y, Sun X and Wang Y: Overexpression of TICRR and PPIF confer poor prognosis in endometrial cancer identified by gene co-expression network analysis. Aging (Albany NY). 13:4564–4589. 2021. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Leng Y, Dong Y, Song Y, Wu Q, Jiang N, Dong H, Chen F, Luo Q, Cheng C, Cheng C, et al: Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways. Oncol Lett 24: 441, 2022.
APA
Li, Y., Leng, Y., Dong, Y., Song, Y., Wu, Q., Jiang, N. ... Cheng, C. (2022). Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways. Oncology Letters, 24, 441. https://doi.org/10.3892/ol.2022.13561
MLA
Li, Y., Leng, Y., Dong, Y., Song, Y., Wu, Q., Jiang, N., Dong, H., Chen, F., Luo, Q., Cheng, C."Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways". Oncology Letters 24.6 (2022): 441.
Chicago
Li, Y., Leng, Y., Dong, Y., Song, Y., Wu, Q., Jiang, N., Dong, H., Chen, F., Luo, Q., Cheng, C."Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways". Oncology Letters 24, no. 6 (2022): 441. https://doi.org/10.3892/ol.2022.13561
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Leng Y, Dong Y, Song Y, Wu Q, Jiang N, Dong H, Chen F, Luo Q, Cheng C, Cheng C, et al: Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways. Oncol Lett 24: 441, 2022.
APA
Li, Y., Leng, Y., Dong, Y., Song, Y., Wu, Q., Jiang, N. ... Cheng, C. (2022). Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways. Oncology Letters, 24, 441. https://doi.org/10.3892/ol.2022.13561
MLA
Li, Y., Leng, Y., Dong, Y., Song, Y., Wu, Q., Jiang, N., Dong, H., Chen, F., Luo, Q., Cheng, C."Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways". Oncology Letters 24.6 (2022): 441.
Chicago
Li, Y., Leng, Y., Dong, Y., Song, Y., Wu, Q., Jiang, N., Dong, H., Chen, F., Luo, Q., Cheng, C."Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways". Oncology Letters 24, no. 6 (2022): 441. https://doi.org/10.3892/ol.2022.13561
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team