Open Access

Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways

  • Authors:
    • Yi Li
    • Yuanxiu Leng
    • Yudi Dong
    • Yongxiang Song
    • Qiaoyuan Wu
    • Ni Jiang
    • Hui Dong
    • Fang Chen
    • Qing Luo
    • Chen Cheng
  • View Affiliations

  • Published online on: October 25, 2022     https://doi.org/10.3892/ol.2022.13561
  • Article Number: 441
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Although great progress has been made in the early diagnosis and targeted therapy of lung adenocarcinoma (LUAD), the survival of patients with LUAD remains unsatisfactory. There is an urgent requirement for new biomarkers to guide the diagnosis, prognosis and treatment of LUAD. Following an initial bioinformatics screen, the present study focused on cyclin B1 (CCNB1) in LUAD. A total of 94 patients with LUAD from a single hospital were included in the study. CCNB1 protein expression was detected and scored in 94 LUAD samples and 30 normal tissue samples by immunohistochemistry. The associations between CCNB1 expression and the clinicopathological features of the patients with LUAD were analyzed. Furthermore, the relationship between prognosis and the CCNB1 expression level was analyzed using Cox regression and survival analyses. Weighted gene co‑expression network analysis and RNA‑sequencing were also applied to identify the potential molecular mechanisms of CCNB1 in LUAD. CCNB1 was highly expressed in patients with LUAD and was associated with poor prognosis. It may affect the expression of CPLX1, PPIF, SRPK2, KRT8, SLC20A1 and CBX2 genes and function via different pathways. CCNB1 has the potential to become a novel prognostic target for LUAD.
View Figures
View References

Related Articles

Journal Cover

December-2022
Volume 24 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Leng Y, Dong Y, Song Y, Wu Q, Jiang N, Dong H, Chen F, Luo Q, Cheng C, Cheng C, et al: Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways. Oncol Lett 24: 441, 2022
APA
Li, Y., Leng, Y., Dong, Y., Song, Y., Wu, Q., Jiang, N. ... Cheng, C. (2022). Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways. Oncology Letters, 24, 441. https://doi.org/10.3892/ol.2022.13561
MLA
Li, Y., Leng, Y., Dong, Y., Song, Y., Wu, Q., Jiang, N., Dong, H., Chen, F., Luo, Q., Cheng, C."Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways". Oncology Letters 24.6 (2022): 441.
Chicago
Li, Y., Leng, Y., Dong, Y., Song, Y., Wu, Q., Jiang, N., Dong, H., Chen, F., Luo, Q., Cheng, C."Cyclin B1 expression as an independent prognostic factor for lung adenocarcinoma and its potential pathways". Oncology Letters 24, no. 6 (2022): 441. https://doi.org/10.3892/ol.2022.13561