Open Access

Metabolic biomarkers in lung cancer screening and early diagnosis (Review)

  • Authors:
    • Yongjie Xu
    • Xuesi Dong
    • Chao Qin
    • Fei Wang
    • Wei Cao
    • Jiang Li
    • Yiwen Yu
    • Liang Zhao
    • Fengwei Tan
    • Wanqing Chen
    • Ni Li
    • Jie He
  • View Affiliations

  • Published online on: May 3, 2023     https://doi.org/10.3892/ol.2023.13851
  • Article Number: 265
  • Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Late diagnosis is one of the major contributing factors to the high mortality rate of lung cancer, which is now the leading cause of cancer‑associated mortality worldwide. At present, low‑dose CT (LDCT) screening in the high‑risk population, in which lung cancer incidence is higher than that of the low‑risk population is the predominant diagnostic strategy. Although this has efficiently reduced lung cancer mortality in large randomized trials, LDCT screening has high false‑positive rates, resulting in excessive subsequent follow‑up procedures and radiation exposure. Complementation of LDCT examination with biofluid‑based biomarkers has been documented to increase efficacy, and this type of preliminary screening can potentially reduce potential radioactive damage to low‑risk populations and the burden of hospital resources. Several molecular signatures based on components of the biofluid metabolome that can possibly discriminate patients with lung cancer from healthy individuals have been proposed over the past two decades. In the present review, advancements in currently available technologies in metabolomics were reviewed, with particular focus on their possible application in lung cancer screening and early detection.
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June-2023
Volume 25 Issue 6

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Xu Y, Dong X, Qin C, Wang F, Cao W, Li J, Yu Y, Zhao L, Tan F, Chen W, Chen W, et al: Metabolic biomarkers in lung cancer screening and early diagnosis (Review). Oncol Lett 25: 265, 2023
APA
Xu, Y., Dong, X., Qin, C., Wang, F., Cao, W., Li, J. ... He, J. (2023). Metabolic biomarkers in lung cancer screening and early diagnosis (Review). Oncology Letters, 25, 265. https://doi.org/10.3892/ol.2023.13851
MLA
Xu, Y., Dong, X., Qin, C., Wang, F., Cao, W., Li, J., Yu, Y., Zhao, L., Tan, F., Chen, W., Li, N., He, J."Metabolic biomarkers in lung cancer screening and early diagnosis (Review)". Oncology Letters 25.6 (2023): 265.
Chicago
Xu, Y., Dong, X., Qin, C., Wang, F., Cao, W., Li, J., Yu, Y., Zhao, L., Tan, F., Chen, W., Li, N., He, J."Metabolic biomarkers in lung cancer screening and early diagnosis (Review)". Oncology Letters 25, no. 6 (2023): 265. https://doi.org/10.3892/ol.2023.13851