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Case Report Open Access

Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature

  • Authors:
    • Hanin Lataifeh
    • Fawzi Abuhijla
    • Lina Wahbeh
    • Ramiz Abuhijlih
    • Wafa Asha
    • Abdullah Alzibdeh
    • Omar Jaber
    • Issa Mohamad
    • Hikmat Abdel‑Razeq
  • View Affiliations / Copyright

    Affiliations: Department of Radiation Oncology, King Hussein Cancer Center, Amman 11941, Jordan, Department of Pathology, King Hussein Cancer Center, Amman 11941, Jordan, Department of Medical Oncology, King Hussein Cancer Center, Amman 11941, Jordan
    Copyright: © Lataifeh et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 510
    |
    Published online on: September 4, 2025
       https://doi.org/10.3892/ol.2025.15256
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Abstract

Adenoid cystic carcinoma (AdCC) of the breast is a subtype of triple‑negative breast cancer characterized by a distinct indolent behavior, with extremely rare lymphatic involvement and a late onset of distant metastasis occurring several years post‑diagnosis. Due to its favorable prognosis, therapeutic guidelines include surgical resection with adjuvant radiotherapy, with no significant benefit of chemotherapy. The present study discusses the case of a 77‑year‑old female patient who presented with a right‑sided breast mass. Biopsy confirmed a grade 2 AdCC transitioning to a higher grade in some areas. The patient underwent a wide local excision and adjuvant radiotherapy was planned; however, during a simulation computed tomography scan performed 6 weeks after surgery, a complex mass at the ipsilateral axillary tail was detected and proved to be disease recurrence on biopsy. Restaging imaging studies showed metastatic involvement of the regional lymph nodes, lungs, liver, bones and brain. The patient received three cycles of palliative chemotherapy, but then clinically deteriorated and passed away 7 months after the initial diagnosis. Notably, the relatively large tumor size (6.4 cm) and the presence of high‑grade morphology may have contributed to the poor outcome of the patient. In addition, the current case is one of the unique reported instances in the literature where the interval between treatment and recurrence was <3 months, as well as being one of the few cases that exhibited lymphatic involvement. The present report underscores the importance of further understanding the variable presentations of AdCC.
View Figures

Figure 1

(A) Mammogram imaging revealing an
irregular hyperdense mass at the mid-upper right breast, located
9.5 cm away from the nipple as indicated by arrow. (B) Breast
ultrasound (U/S) imaging revealed an irregular, heterogeneous
hypoechoic mass with indistinct margins at the mid-upper right
breast measuring 1.7×1.3×2 cm, with no concerning findings in the
left breast as indicated by arrow. (C) Staging computed tomography
scan revealing an ill-defined soft-tissue lesion as indicated by
arrow. (D) Bone scan showing a lack of active lesions, with no
evidence of metastases.

Figure 2

(A) AdCC of the breast exhibiting
solid and basaloid architecture with the absence of cribriform and
tubular structures, which implies a higher grade tumor via H&E
staining (magnification, ×100; Table
SI). (B) AdCC of the breast exhibiting a higher nuclear grade
and numerous mitotic figures via H&E staining (magnification,
×400). (C) Positive staining for c-Kit (magnification, ×200). AdCC,
adenoid cystic carcinoma.

Figure 3

(A) CT simulation scan detecting a
suspicious lesion in the right axillary region 6 weeks
post-resection (indicated by arrow). (B) Bone scan revealing new
active lesions in the right iliac bone, as indicated by the arrow.
Staging CT scan revealing new innumerable metastatic pulmonary
nodules in (C) both lungs, new minimal right pleural effusion and
thickening suggestive of metastatic deposits and (D) new liver
metastases, new right axillary metastatic lymph nodes, where arrow
indicates one of the liver lesions. CT, computed tomography.

Figure 4

Brain magnetic resonance imaging
detected (A) small right and (B) small left hemispheric lesion
suggestive of metastatic deposits.

Figure 5

Patient timeline of events starting
from diagnosis until mortality. U/S, ultrasound; CT, computed
tomography; ER, Emergency Room; DNR, do not resuscitate.
View References

1 

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A and Bray F: Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 71:209–249. 2021.PubMed/NCBI

2 

Siegel RL, Miller KD, Wagle NS and Jemal A: Cancer statistics, 2023. CA Cancer J Clin. 73:17–48. 2023.PubMed/NCBI

3 

Jordan Ministry of Health, Non-Communicable Diseases Directorate, Jordan Cancer Registry, Cancer Incidence in Jordan, . 2019.

4 

Masood S: Breast cancer subtypes: Morphologic and biologic characterization. Womens Health (Lond). 12:1032016. View Article : Google Scholar : PubMed/NCBI

5 

Bradley PJ: Adenoid cystic carcinoma of the head and neck: A review. Curr Opin Otolaryngol Head Neck Surg. 12:127–132. 2004. View Article : Google Scholar : PubMed/NCBI

6 

Rahouma M, Khairallah S, Baudo M, Al-Thani S, Dabsha A, Shenouda D, Mohamed A, Dimagli A, El Sherbiny M, Kamal M, et al: Epidemiological study of adenoid cystic carcinoma and its outcomes: insights from the surveillance, epidemiology, and end results (SEER) database. Cancers (Basel). 16:33832024. View Article : Google Scholar : PubMed/NCBI

7 

Glazebrook KN, Reynolds C, Smith RL, Gimenez EI and Boughey JC: Adenoid cystic carcinoma of the breast. AJR Am J Roentgenol. 194:1391–1396. 2010. View Article : Google Scholar : PubMed/NCBI

8 

Seethala RR: An update on grading of salivary gland carcinomas. Head Neck Pathol. 3:69–77. 2009. View Article : Google Scholar : PubMed/NCBI

9 

Miyai K, Schwartz MR, Divatia MK, Anton RC, Park YW, Ayala AG and Ro JY: Adenoid cystic carcinoma of breast: Recent advances. World J Clin Cases. 2:732–741. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Kulkarni N, Pezzi CM, Greif JM, Suzanne Klimberg V, Bailey L, Korourian S and Zuraek M: Rare breast cancer: 933 Adenoid cystic carcinomas from the national cancer data base. Ann Surg Oncol. 20:2236–2241. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Ghabach B, Anderson WF, Curtis RE, Huycke MM, Lavigne JA and Dores GM: Adenoid cystic carcinoma of the breast in the United States (1977 to 2006): A population-based cohort study. Breast Cancer Res. 12:R542010. View Article : Google Scholar : PubMed/NCBI

12 

Khoury T, Rosa M, Nayak A, Karabakhtsian R, Fadare O, Li Z, Turner B, Fang Y, Kumarapeli A, Li X, et al: Clinicopathologic predictors of clinical outcomes in mammary adenoid cystic carcinoma: A multi-institutional study. Mod Pathol. 36:1000062023. View Article : Google Scholar : PubMed/NCBI

13 

Rakha EA, El-Sayed ME, Lee AHS, Elston CW, Grainge MJ, Hodi Z, Blamey RW and Ellis IO: Prognostic significance of nottingham histologic grade in invasive breast carcinoma. J Clin Oncol. 26:3153–3158. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Giuliano AE, Edge SB and Hortobagyi GN: Eighth edition of the AJCC cancer staging manual: Breast cancer. Ann Surg Oncol. 25:1783–1785. 2018. View Article : Google Scholar : PubMed/NCBI

15 

Teasdale G and Jennett B: Assessment of coma and impaired consciousness. A practical scale. Lancet. 2:81–84. 1974. View Article : Google Scholar : PubMed/NCBI

16 

Otto RA: Tumours of the upper jaw. By Donald Harrison and Valerie J. Lund, Churchill Livingstone, New York, 1993, 351 pp, $150.00. Head Neck,. 17:275. 1995. View Article : Google Scholar

17 

Andreasen S: Molecular features of adenoid cystic carcinoma with an emphasis on microRNA expression. APMIS. 126 (Suppl 140):S7–S57. 2018. View Article : Google Scholar

18 

Foote FW Jr and Frazell EL: Tumors of the major salivary glands. Cancer. 6:1065–1133. 1953. View Article : Google Scholar : PubMed/NCBI

19 

Ellington CL, Goodman M, Kono SA, Grist W, Wadsworth T, Chen AY, Owonikoko T, Ramalingam S, Shin DM, Khuri FR, et al: Adenoid cystic carcinoma of the head and neck: Incidence and survival trends based on 1973–2007 surveillance, epidemiology, and end results data. Cancer. 118:4444–4451. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Geschickter CF and Copeland MM: Diseases of the breast: Diagnosis, pathology, treatment. J B Lippincott; Philadelphia: 1945, PubMed/NCBI

21 

Rosen PP: Adenoid cystic carcinoma of the breast. A morphologically heterogeneous neoplasm. Pathol Annu. 24:237–254. 1989.PubMed/NCBI

22 

Jang S, Patel PN, Kimple RJ and McCulloch TM: Clinical outcomes and prognostic factors of adenoid cystic carcinoma of the head and neck. Anticancer Res. 37:3045–3052. 2017.PubMed/NCBI

23 

Zhang W, Fang Y, Zhang Z and Wang J: Management of adenoid cystic carcinoma of the breast: A single-institution study. Front Oncol. 11:6210122021. View Article : Google Scholar : PubMed/NCBI

24 

Ji J, Zhang F, Duan F, Yang H, Hou J, Liu Y, Dai J, Liao Q, Chen X and Liu Q: Distinct clinicopathological and genomic features in solid and basaloid adenoid cystic carcinoma of the breast. Sci Rep. 12:85042022. View Article : Google Scholar : PubMed/NCBI

25 

Choi Y, Kim SB, Yoon DH, Kim JY, Lee SW and Cho KJ: Clinical characteristics and prognostic factors of adenoid cystic carcinoma of the head and neck. Laryngoscope. 123:1430–1438. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Thomas DN, Asarian A and Xiao P: Adenoid cystic carcinoma of the breast. J Surg Case Rep. 2019:rjy3552019. View Article : Google Scholar : PubMed/NCBI

27 

Kim M, Lee DW, Im J, Suh KJ, Keam B, Moon HG, Im SA, Han W, Park IA and Noh DY: Adenoid cystic carcinoma of the breast: A case series of six patients and literature review. Cancer Res Treat. 46:93–97. 2014. View Article : Google Scholar : PubMed/NCBI

28 

McClenathan JH and de la Roza G: Adenoid cystic breast cancer. Am J Surg. 183:646–649. 2002. View Article : Google Scholar : PubMed/NCBI

29 

Boujelbene N, Khabir A, Boujelbene N, Jeanneret Sozzi W, Mirimanoff RO and Khanfir K: Clinical review-breast adenoid cystic carcinoma. Breast. 21:124–127. 2012. View Article : Google Scholar : PubMed/NCBI

30 

Liu Z, Wang M, Wang Y, Shen X and Li C: Diagnosis of adenoid cystic carcinoma in the breast: A case report and literature review. Arch Med Sci. 18:279–283. 2022. View Article : Google Scholar : PubMed/NCBI

31 

Sheen-Chen SM, Eng HL, Chen WJ, Cheng YF and Ko SF: Adenoid cystic carcinoma of the breast: Truly uncommon or easily overlooked? Anticancer Res. 25:455–458. 2005.PubMed/NCBI

32 

Santamaría G, Velasco M, Zanón G, Farrús B, Molina R, Solé M and Fernández PL: Adenoid cystic carcinoma of the breast: Mammographic appearance and pathologic correlation. AJR Am J Roentgenol. 171:1679–1683. 1998. View Article : Google Scholar : PubMed/NCBI

33 

Murakami R, Kumita SI, Yoshida T, Ishihara K, Kiriyama T, Hakozaki K, Yanagihara K, Iida S and Tsuchiya S: FDG-PET/CT in the diagnosis of recurrent breast cancer. Acta Radiol. 53:12–16. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Yu Y, Schöder H, Zakeri K, Chen L, Kang JJ, McBride SM, Tsai CJ, Gelblum DY, Boyle JO, Cracchiolo JR, et al: Post-operative PET/CT improves the detection of early recurrence of squamous cell carcinomas of the oral cavity. Oral Oncol. 141:1064002023. View Article : Google Scholar : PubMed/NCBI

35 

Kim B, Kim YC, Noh OK, Heo J, Lee HW, Kim JH, Lee JH, Kim JK, Cho O, Oh YT and Chun M: Diagnostic evaluation of simulation CT images for adjuvant radiotherapy in pancreatic adenocarcinoma. Br J Radiol. 90:201702252017. View Article : Google Scholar : PubMed/NCBI

36 

Koss LG, Brannan CD and Ashikari R: Histologic and ultrastructural features of adenoid cystic carcinoma of the breast. Cancer. 26:1271–1279. 1970. View Article : Google Scholar : PubMed/NCBI

37 

Anthony PP and James PD: Adenoid cystic carcinoma of the breast: Prevalence, diagnostic criteria, and histogenesis. J Clin Pathol. 28:647–655. 1975. View Article : Google Scholar : PubMed/NCBI

38 

da Cruz Perez DE, de Abreu Alves F, Nobuko Nishimoto I, de Almeida OP and Kowalski LP: Prognostic factors in head and neck adenoid cystic carcinoma. Oral Oncol. 42:139–146. 2006. View Article : Google Scholar : PubMed/NCBI

39 

Ro JY, Silva EG and Stephen Gallager H: Adenoid cystic carcinoma of the breast. Hum Pathol. 18:1276–1281. 1987. View Article : Google Scholar : PubMed/NCBI

40 

Shin SJ and Rosen PP: Solid variant of mammary adenoid cystic carcinoma with basaloid features: A study of nine cases. Am J Surg Pathol. 26:413–420. 2002. View Article : Google Scholar : PubMed/NCBI

41 

Tan PH, Ellis I, Allison K, Brogi E, Fox SB, Lakhani S, Lazar AJ, Morris EA, Sahin A, Salgado R, et al: The 2019 World Health Organization classification of tumours of the breast. Histopathology. 77:181–185. 2020. View Article : Google Scholar : PubMed/NCBI

42 

Slodkowska E, Xu B, Kos Z, Bane A, Barnard M, Zubovits J, Iyengar P, Faragalla H, Turbin D, Williams P, et al: Predictors of outcome in mammary adenoid cystic carcinoma: A multi-institutional study. Am J Surg Pathol. 44:214–223. 2020. View Article : Google Scholar : PubMed/NCBI

43 

Marco V, Garcia F, Rubio IT, Soler T, Ferrazza L, Roig I, Mendez I, Andreu X, Mínguez CG and Tresserra F: Adenoid cystic carcinoma and basaloid carcinoma of the breast: A clinicopathological study. Rev Esp Patol. 54:242–249. 2021.PubMed/NCBI

44 

Vasudevan G, John AM, D K V and Vallonthaiel AG: Adenoid cystic carcinoma of the breast with late recurrence and high-grade transformation. BMJ Case Rep. 16:e2523362023. View Article : Google Scholar : PubMed/NCBI

45 

Collins K, Prieto VG and Aung PP: Unusual presentations of primary and metastatic adenoid cystic carcinoma involving the skin. Am J Dermatopathol. 42:967–971. 2020. View Article : Google Scholar : PubMed/NCBI

46 

Sołek JM, Braun M, Kalwas M, Jesionek-Kupnicka D and Romańska HM: Adenoid cystic carcinoma of the breast-an uncommon malignancy with unpredictable clinical behaviour. A case series of three patients. Contemp Oncol (Pozn). 24:263–265. 2020.PubMed/NCBI

47 

Mhamdi HA, Kourie HR, Jungels C, Aftimos P, Belbaraka R and Piccart-Gebhart M: Adenoid cystic carcinoma of the breast-an aggressive presentation with pulmonary, kidney, and brain metastases: A case report. J Med Case Rep. 11:3032017. View Article : Google Scholar : PubMed/NCBI

48 

D'Alfonso TM, Mosquera JM, Macdonald TY, Padilla J, Liu YF, Rubin MA and Shin SJ: MYB-NFIB gene fusion in adenoid cystic carcinoma of the breast with special focus paid to the solid variant with basaloid features. Hum Pathol. 45:2270–2280. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Silva I, Tome V and Oliveira J: Adenoid cystic carcinoma of the breast with cerebral metastisation: A clinical novelty. BMJ Case Rep. 2011:bcr08201146922011. View Article : Google Scholar : PubMed/NCBI

50 

Vranić S, Bilalović N, Lee LMJ, Krušlin B, Lilleberg SL and Gatalica Z: PIK3CA and PTEN mutations in adenoid cystic carcinoma of the breast metastatic to kidney. Hum Pathol. 38:1425–1431. 2007. View Article : Google Scholar : PubMed/NCBI

51 

Millar BAM, Kerba M, Youngson B, Lockwood GA and Liu FF: The potential role of breast conservation surgery and adjuvant breast radiation for adenoid cystic carcinoma of the breast. Breast Cancer Res Treat. 87:225–232. 2004. View Article : Google Scholar : PubMed/NCBI

52 

Herzberg AJ, Bossen EH and Walther PJ: Adenoid cystic carcinoma of the breast metastatic to the kidney. A clinically symptomatic lesion requiring surgical management. Cancer. 68:1015–1020. 1991. View Article : Google Scholar : PubMed/NCBI

53 

Koller M, Ram Z, Findler G and Lipshitz M: Brain metastasis: A rare manifestation of adenoid cystic carcinoma of the breast. Surg Neurol. 26:470–472. 1986. View Article : Google Scholar : PubMed/NCBI

54 

Peters GN and Wolff M: Adenoid cystic carcinoma of the breast report of 11 new cases: Review of the literature and discussion of biological behavior. Cancer. 52:680–686. 1983. View Article : Google Scholar : PubMed/NCBI

55 

Lim SK, Kovi JK and Warner OG: Adenoid cystic carcinoma of breast with metastasis: A case report and review of the literature. J Natl Med Assoc. 71:329–330. 1979.PubMed/NCBI

56 

Verani RR and Van der Bel-Kahn J: Mammary adenoid cystic carcinoma with unusual features. Am J Clin Pathol. 59:653–658. 1973. View Article : Google Scholar : PubMed/NCBI

57 

Elsner B: Adenoid cystic carcinoma of the breast. Review of the literature and clinico-pathologic study of seven patients. Pathol Eur. 5:357–364. 1970.PubMed/NCBI

58 

O'Kell RT: Adenoid cystic carcinoma of the breast. Mo Med. 61:855–858. 1964.PubMed/NCBI

59 

Nayer HR: Case report section; cylindroma of the breast with pulmonary metastases. Dis Chest. 31:324–327. 1957. View Article : Google Scholar : PubMed/NCBI

60 

Zhu H and Doğan BE: American joint committee on cancer's staging system for breast cancer, eighth edition: Summary for clinicians. Eur J Breast Health. 17:234–238. 2021. View Article : Google Scholar : PubMed/NCBI

61 

Canyilmaz E, Uslu GH, Memiş Y, Bahat Z, Yildiz K and Yoney A: Adenoid cystic carcinoma of the breast: A case report and literature review. Oncol Lett. 7:1599–1601. 2014. View Article : Google Scholar : PubMed/NCBI

62 

Vranic S, Bender R, Palazzo J and Gatalica Z: A review of adenoid cystic carcinoma of the breast with emphasis on its molecular and genetic characteristics. Hum Pathol. 44:301–309. 2013. View Article : Google Scholar : PubMed/NCBI

63 

Badve S, Dabbs DJ, Schnitt SJ, Baehner FL, Decker T, Eusebi V, Fox SB, Ichihara S, Jacquemier J, Lakhani SR, et al: Basal-like and triple-negative breast cancers: A critical review with an emphasis on the implications for pathologists and oncologists. Mod Pathol. 24:157–167. 2011. View Article : Google Scholar : PubMed/NCBI

64 

Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, Hernandez-Boussard T, Livasy C, Cowan D, Dressler L, et al: Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res. 10:5367–5374. 2004. View Article : Google Scholar : PubMed/NCBI

65 

Wetterskog D, Lopez-Garcia MA, Lambros MB, A'Hern R, Geyer FC, Milanezi F, Cabral MC, Natrajan R, Gauthier A, Shiu KK, et al: Adenoid cystic carcinomas constitute a genomically distinct subgroup of triple-negative and basal-like breast cancers. J Pathol. 226:84–96. 2012. View Article : Google Scholar : PubMed/NCBI

66 

Kilickap S, Kaya Y, Yucel B, Tuncer E, Babacan NA and Elagoz S: Higher Ki67 expression is associates with unfavorable prognostic factors and shorter survival in breast cancer. Asian Pac J Cancer Prev. 15:1381–1385. 2014. View Article : Google Scholar : PubMed/NCBI

67 

Davey MG, Hynes SO, Kerin MJ, Miller N and Lowery AJ: Ki-67 as a prognostic biomarker in invasive breast cancer. Cancers (Basel). 13:44552021. View Article : Google Scholar : PubMed/NCBI

68 

Al Zubidi M, Abdulhussain MM and Mohsin AS: Assessment of the relationship between Ki-67 expression and different clinicopathological factors of adenoid cystic carcinoma: A retrospective immunohistochemical study. Int J Biomed. 15:141–145. 2025.

69 

Bussari S, Jeergal PA, Sarode M, Namazi NA, Kulkarni PG, Deshmukh A and Kulkarni D: Evaluation of proliferative marker Ki-67 in adenoid cystic carcinoma: A retrospective study. J Contemp Dent Pract. 20:211–215. 2019. View Article : Google Scholar : PubMed/NCBI

70 

Persson M, Andrén Y, Mark J, Horlings HM, Persson F and Stenman G: Recurrent fusion of MYB and NFIB transcription factor genes in carcinomas of the breast and head and neck. Proc Natl Acad Sci USA. 106:18740–18744. 2009. View Article : Google Scholar : PubMed/NCBI

71 

Massé J, Truntzer C, Boidot R, Khalifa E, Pérot G, Velasco V, Mayeur L, Billerey-Larmonier C, Blanchard L, Charitansky H, et al: Solid-type adenoid cystic carcinoma of the breast, a distinct molecular entity enriched in NOTCH and CREBBP mutations. Mod Pathol. 33:1041–1055. 2020. View Article : Google Scholar : PubMed/NCBI

72 

Arpino G, Clark GM, Mohsin S, Bardou VJ and Elledge RM: Adenoid cystic carcinoma of the breast: Molecular markers, treatment, and clinical outcome. Cancer. 94:2119–2127. 2002. View Article : Google Scholar : PubMed/NCBI

73 

Marchiò C, Weigelt B and Reis-Filho JS: Adenoid cystic carcinomas of the breast and salivary glands (or ‘The strange case of Dr Jekyll and Mr Hyde’ of exocrine gland carcinomas). J Clin Pathol. 63:220–228. 2010. View Article : Google Scholar : PubMed/NCBI

74 

Cantù G: Adenoid cystic carcinoma. An indolent but aggressive tumour. Part A: From aetiopathogenesis to diagnosis. Acta Otorhinolaryngol Ital. 41:206–214. 2021. View Article : Google Scholar : PubMed/NCBI

75 

Page DL: Adenoid cystic carcinoma of breast, a special histopathologic type with excellent prognosis. Breast Cancer Res Treat. 93:189–190. 2005. View Article : Google Scholar : PubMed/NCBI

76 

Wilson WB and Spell JP: Adenoid cystic carcinoma of breast: A case with recurrence and regional metastasis. Ann Surg. 166:861–864. 1967. View Article : Google Scholar : PubMed/NCBI

77 

Wang S, Ji X, Wei Y, Yu Z and Li N: Adenoid cystic carcinoma of the breast: Review of the literature and report of two cases. Oncol Lett. 4:701–704. 2012. View Article : Google Scholar : PubMed/NCBI

78 

Hodgson NC, Lytwyn A, Bacopulos S and Elavathil L: Adenoid cystic breast carcinoma: High rates of margin positivity after breast conserving surgery. Am J Clin Oncol. 33:28–31. 2010. View Article : Google Scholar : PubMed/NCBI

79 

Khanfir K, Kallel A, Villette S, Belkacémi Y, Vautravers C, Nguyen T, Miller R, Li YX, Taghian AG, Boersma L, et al: Management of adenoid cystic carcinoma of the breast: A rare cancer network study. Int J Radiat Oncol Biol Phys. 82:2118–2124. 2012. View Article : Google Scholar : PubMed/NCBI

80 

Li L, Zhang D and Ma F: Adenoid cystic carcinoma of the breast may be exempt from adjuvant chemotherapy. J Clin Med. 11:44772022. View Article : Google Scholar : PubMed/NCBI

81 

Gomez-Seoane A, Davis A and Oyasiji T: Treatment of adenoid cystic carcinoma of the breast: Is postoperative radiation getting its due credit? Breast. 59:358–366. 2021. View Article : Google Scholar : PubMed/NCBI

82 

Gradishar WJ, Moran MS, Abraham J, Abramson V, Aft R, Agnese D, Allison KH, Anderson B, Bailey J, Burstein HJ, et al: Breast Cancer, Version 3.2024, NCCN Clinical Practice Guidelines in Oncology. J Natl Compr Canc Netw. 22:331–357. 2024. View Article : Google Scholar : PubMed/NCBI

83 

Schulz-Costello K, Fan F, Schmolze D, Arias-Stella JA III, Taylor L, Tseng J, Afkhami M, Rand JG, Jones V, Farmah P and Han M: Solid basaloid adenoid cystic carcinoma of the breast: A high-grade triple negative breast carcinoma which rarely responds to neoadjuvant chemotherapy. Hum Pathol. 157:1057602025. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Lataifeh H, Abuhijla F, Wahbeh L, Abuhijlih R, Asha W, Alzibdeh A, Jaber O, Mohamad I and Abdel‑Razeq H: Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature. Oncol Lett 30: 510, 2025.
APA
Lataifeh, H., Abuhijla, F., Wahbeh, L., Abuhijlih, R., Asha, W., Alzibdeh, A. ... Abdel‑Razeq, H. (2025). Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature. Oncology Letters, 30, 510. https://doi.org/10.3892/ol.2025.15256
MLA
Lataifeh, H., Abuhijla, F., Wahbeh, L., Abuhijlih, R., Asha, W., Alzibdeh, A., Jaber, O., Mohamad, I., Abdel‑Razeq, H."Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature". Oncology Letters 30.5 (2025): 510.
Chicago
Lataifeh, H., Abuhijla, F., Wahbeh, L., Abuhijlih, R., Asha, W., Alzibdeh, A., Jaber, O., Mohamad, I., Abdel‑Razeq, H."Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature". Oncology Letters 30, no. 5 (2025): 510. https://doi.org/10.3892/ol.2025.15256
Copy and paste a formatted citation
x
Spandidos Publications style
Lataifeh H, Abuhijla F, Wahbeh L, Abuhijlih R, Asha W, Alzibdeh A, Jaber O, Mohamad I and Abdel‑Razeq H: Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature. Oncol Lett 30: 510, 2025.
APA
Lataifeh, H., Abuhijla, F., Wahbeh, L., Abuhijlih, R., Asha, W., Alzibdeh, A. ... Abdel‑Razeq, H. (2025). Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature. Oncology Letters, 30, 510. https://doi.org/10.3892/ol.2025.15256
MLA
Lataifeh, H., Abuhijla, F., Wahbeh, L., Abuhijlih, R., Asha, W., Alzibdeh, A., Jaber, O., Mohamad, I., Abdel‑Razeq, H."Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature". Oncology Letters 30.5 (2025): 510.
Chicago
Lataifeh, H., Abuhijla, F., Wahbeh, L., Abuhijlih, R., Asha, W., Alzibdeh, A., Jaber, O., Mohamad, I., Abdel‑Razeq, H."Adenoid cystic carcinoma of the breast with aggressive behavior: A case report and review of the literature". Oncology Letters 30, no. 5 (2025): 510. https://doi.org/10.3892/ol.2025.15256
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