Functional promoter polymorphisms of the macrophage migration inhibitory factor gene in gastric carcinogenesis

  • Authors:
    • Tomiyasu Arisawa
    • Tomomitsu Tahara
    • Tomoyuki Shibata
    • Mitsuo Nagasaka
    • Masakatsu Nakamura
    • Yoshio Kamiya
    • Hiroshi Fujita
    • Daisuke Yoshioka
    • Yuko Arima
    • Masaaki Okubo
    • Ichiro Hirata
    • Hiroshi Nakano
    • Vidal De la Cruz
  • View Affiliations

  • Published online on: January 1, 2008     https://doi.org/10.3892/or.19.1.223
  • Pages: 223-228
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Abstract

The macrophage migration inhibitory factor (MIF) is a key proinflammatory mediator. Two functional polymorphisms have been identified in the promoter region of the MIF gene. We attempted to clarify the associations of these polymorphisms with the development of gastric cancer. The study was performed in 229 patients with gastric cancer and 428 subjects with no evidence of gastric malignancies on the upper gastro-duodenal endoscopy. The severity of histological chronic gastritis was classified according to the updated Sydney system. Overall, the 5-CATT carriers had a reduced risk of developing gastric cancer (OR, 0.67; 96% CI, 0.48-0.93; p=0.015), especially the diffuse type cancer. In subjects >60 years, the adjusted risk for gastric cancer among individuals who were −173C carriers was 1.71 (range, 1.03-2.84; p=0.038) compared to the G/G homozygous genotype. The number of 7-CATT alleles was also positively correlated with the development of intestinal type gastric cancer (adjusted OR, 1.70; 95% CI, 1.02-2.58; p=0.043). In subjects <60 years, the 7/7-CATT homozygous genotype was linked with a risk for the progression of atrophic gastritis (adjusted OR, 8.74; 95% CI, 1.31-58.6; p=0.026). In addition, the number of 7-CATT alleles was significantly correlated with the activity and inflammation scores (p=0.010 and 0.030, respectively). Our results suggested that functional promoter polymorphisms of the MIF gene are associated with the progression of gastric mucosal inflammation and the development of mucosal atrophy at an early stage in life and these genotypes may increase the risk for the subsequent development of gastric cancer, especially the intestinal type, in older subjects.

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January 2008
Volume 19 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Arisawa T, Tahara T, Shibata T, Nagasaka M, Nakamura M, Kamiya Y, Fujita H, Yoshioka D, Arima Y, Okubo M, Okubo M, et al: Functional promoter polymorphisms of the macrophage migration inhibitory factor gene in gastric carcinogenesis. Oncol Rep 19: 223-228, 2008.
APA
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y. ... De la Cruz, V. (2008). Functional promoter polymorphisms of the macrophage migration inhibitory factor gene in gastric carcinogenesis. Oncology Reports, 19, 223-228. https://doi.org/10.3892/or.19.1.223
MLA
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Yoshioka, D., Arima, Y., Okubo, M., Hirata, I., Nakano, H., De la Cruz, V."Functional promoter polymorphisms of the macrophage migration inhibitory factor gene in gastric carcinogenesis". Oncology Reports 19.1 (2008): 223-228.
Chicago
Arisawa, T., Tahara, T., Shibata, T., Nagasaka, M., Nakamura, M., Kamiya, Y., Fujita, H., Yoshioka, D., Arima, Y., Okubo, M., Hirata, I., Nakano, H., De la Cruz, V."Functional promoter polymorphisms of the macrophage migration inhibitory factor gene in gastric carcinogenesis". Oncology Reports 19, no. 1 (2008): 223-228. https://doi.org/10.3892/or.19.1.223