The function of human epidermal growth factor receptor-3 and its role in tumors (Review)

  • Authors:
    • Qin Li
    • Zhenyan Yuan
    • Bangwei Cao
  • View Affiliations

  • Published online on: September 30, 2013     https://doi.org/10.3892/or.2013.2754
  • Pages: 2563-2570
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Abstract

Human epidermal growth factor receptor-3 (HER-3) is the third member of the HER family. It was previously considered not to contain tyrosine kinase activity and catalytic activity and the intracellular region of HER-3 could not bind ATP and be auto-phosphorylated. Thus, the clinical value of HER-3 was ignored. Currently, biochemical analysis has confirmed that the kinase domain of HER-3 is a specific allosteric activator; it acts as a functional activator to activate the recipient kinase (HER-1, HER-2, HER-4). With the in-depth knowledge of its structure and function, studies on the relationship of HER-3 and human tumors are rapidly increasing. HER-3 is closely related to tumorigenesis, progression and metastasis. HER-3 is involved in resistance to targeted therapy, and may serve as a new therapeutic target. The expression of HER-3 helps to predict prognosis and treatment efficacy. HER-3 has become a focus of concern in the HER family and has gained significant attention in the search for cancer treatment.
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December 2013
Volume 30 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Li Q, Yuan Z and Cao B: The function of human epidermal growth factor receptor-3 and its role in tumors (Review). Oncol Rep 30: 2563-2570, 2013
APA
Li, Q., Yuan, Z., & Cao, B. (2013). The function of human epidermal growth factor receptor-3 and its role in tumors (Review). Oncology Reports, 30, 2563-2570. https://doi.org/10.3892/or.2013.2754
MLA
Li, Q., Yuan, Z., Cao, B."The function of human epidermal growth factor receptor-3 and its role in tumors (Review)". Oncology Reports 30.6 (2013): 2563-2570.
Chicago
Li, Q., Yuan, Z., Cao, B."The function of human epidermal growth factor receptor-3 and its role in tumors (Review)". Oncology Reports 30, no. 6 (2013): 2563-2570. https://doi.org/10.3892/or.2013.2754