Downregulation of nucleolar and spindle-associated protein 1 expression suppresses cell migration, proliferation and invasion in renal cell carcinoma

Corrigendum in: /10.3892/or.2020.7875

  • Authors:
    • Lu Fang
    • Meng Zhang
    • Lei Chen
    • Hu Xiong
    • Yukun Ge
    • Wei Lu
    • Xun Wu
    • Baoli Heng
    • Dexin Yu
    • Song Wu
  • View Affiliations

  • Published online on: July 20, 2016     https://doi.org/10.3892/or.2016.4955
  • Pages: 1506-1516
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Abstract

Nucleolar and spindle-associated protein 1 (NUSAP1) is a microtubule-binding protein that plays an essential role in mitosis and cancer. Previous studies have demonstrated that NUSAP1 expression is relatively elevated in several malignancies. However, the biological roles of NUSAP1 in renal cell carcinoma (RCC) remain unknown. In the present study, we firstly performed reverse transcription‑polymerase chain reaction (RT-PCR) and western blot analysis to reveal that the expression of NUSAP1 was relatively elevated in clear cell RCC (ccRCC) tissue specimens and RCC cell lines. Immunohistochemical analysis showed that upregulation of NUSAP1 was significantly correlated with Fuhrman grade (P<0.001), tumor size (P=0.016), clinical stage (P<0.001) and distant metastasis (P=0.023). Additionally, high expression of NUSAP1 was closely associated with a shorter overall survival time of the ccRCC patients (P=0.006). Furthermore, we investigated the biological behaviors of RCC cells in vitro, and we identified that NUSAP1 depletion inhibited RCC cell migration, proliferation and invasion, and apoptosis was induced and the cell cycle was arrested. On the basis of our studies, NUSAP1 was identified as a potential prognostic indicator and a novel therapeutic target for RCC patients.
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September-2016
Volume 36 Issue 3

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Fang L, Zhang M, Chen L, Xiong H, Ge Y, Lu W, Wu X, Heng B, Yu D, Wu S, Wu S, et al: Downregulation of nucleolar and spindle-associated protein 1 expression suppresses cell migration, proliferation and invasion in renal cell carcinoma Corrigendum in /10.3892/or.2020.7875. Oncol Rep 36: 1506-1516, 2016
APA
Fang, L., Zhang, M., Chen, L., Xiong, H., Ge, Y., Lu, W. ... Wu, S. (2016). Downregulation of nucleolar and spindle-associated protein 1 expression suppresses cell migration, proliferation and invasion in renal cell carcinoma Corrigendum in /10.3892/or.2020.7875. Oncology Reports, 36, 1506-1516. https://doi.org/10.3892/or.2016.4955
MLA
Fang, L., Zhang, M., Chen, L., Xiong, H., Ge, Y., Lu, W., Wu, X., Heng, B., Yu, D., Wu, S."Downregulation of nucleolar and spindle-associated protein 1 expression suppresses cell migration, proliferation and invasion in renal cell carcinoma Corrigendum in /10.3892/or.2020.7875". Oncology Reports 36.3 (2016): 1506-1516.
Chicago
Fang, L., Zhang, M., Chen, L., Xiong, H., Ge, Y., Lu, W., Wu, X., Heng, B., Yu, D., Wu, S."Downregulation of nucleolar and spindle-associated protein 1 expression suppresses cell migration, proliferation and invasion in renal cell carcinoma Corrigendum in /10.3892/or.2020.7875". Oncology Reports 36, no. 3 (2016): 1506-1516. https://doi.org/10.3892/or.2016.4955