DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression

  • Authors:
    • Hongling Zhang
    • Xuhong Chen
    • Dongming Li
    • Lulu Cui
    • Xin Li
    • Xiufeng Ye
    • Xiaochun Wan
  • View Affiliations

  • Published online on: May 30, 2017     https://doi.org/10.3892/or.2017.5685
  • Pages: 377-383
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Abstract

Decoy receptor 3 (DcR3), a decoy molecule belonging to the tumor necrosis factor receptor superfamily (TNFRSF), is a soluble receptor that can neutralize the biological effects of three other TNFSF members, namely, Fas ligand (FasL/TNFSF6/CD95L), LIGHT (TNFSF14) and TNF-like molecule 1A (TL1A/TNFSF15). DcR3 expression is increased in tumor cells. As such, DcR3 has been considered a potential biomarker to predict cancer invasion and progression of inflammation. However, the molecular mechanisms of DcR3 in tumor progression and metastasis remain poorly described. In the present study, DcR3 induced cytoskeleton remodeling, inhibited E-cadherin expression, and promoted cancer cell migration. Immunofluorescence and flow cytometry demonstrated that DcR3 expression was increased in hepatoma cells, whereas E-cadherin expression was significantly downregulated. Immunohistochemistry revealed that DcR3 and E-cadherin exhibited an opposite expression pattern between normal and cancerous liver tissues. Moreover, DcR3 treatment promoted IκBα degradation and p65 nuclear translocation. Therefore, the present study uncovered the mechanism underlying the function of DcR3 in cancer cell migration and provides evidence that DcR3 may be a potential target for cancer therapy.
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July-2017
Volume 38 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhang H, Chen X, Li D, Cui L, Li X, Ye X and Wan X: DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression. Oncol Rep 38: 377-383, 2017
APA
Zhang, H., Chen, X., Li, D., Cui, L., Li, X., Ye, X., & Wan, X. (2017). DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression. Oncology Reports, 38, 377-383. https://doi.org/10.3892/or.2017.5685
MLA
Zhang, H., Chen, X., Li, D., Cui, L., Li, X., Ye, X., Wan, X."DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression". Oncology Reports 38.1 (2017): 377-383.
Chicago
Zhang, H., Chen, X., Li, D., Cui, L., Li, X., Ye, X., Wan, X."DcR3 promotes hepatoma cell migration by downregulating E-cadherin expression". Oncology Reports 38, no. 1 (2017): 377-383. https://doi.org/10.3892/or.2017.5685