Open Access

Gene module analysis of juvenile myelomonocytic leukemia and screening of anticancer drugs

  • Authors:
    • Wencheng Zhao
    • Lin Wang
    • Yongbin Yu
  • View Affiliations

  • Published online on: September 18, 2018     https://doi.org/10.3892/or.2018.6709
  • Pages: 3155-3170
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Juvenile myelomonocytic leukemia (JMML) is a rare but severe primary hemopoietic system tumor of childhood, most frequent in children 4 years and younger. There are currently no specific anticancer therapies targeting JMML, and the underlying gene expression changes have not been revealed. To define molecular targets and possible biomarkers for early diagnosis, optimal treatment, and prognosis, we conducted microarray data analysis using the Gene Expression Omnibus, and constructed protein‑protein interaction networks of all differentially expressed genes. Modular bioinformatics analysis revealed four core functional modules for JMML. We analyzed the Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway functions associated with these modules. Using the CMap database, nine potential anticancer drugs were identified that modulate expression levels of many JMML‑associated genes. In addition, we identified possible miRNAs and transcription factors regulating these differentially expressed genes. This study defines a new research strategy for developing JMML‑targeted chemotherapies.
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December-2018
Volume 40 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Spandidos Publications style
Zhao W, Wang L and Yu Y: Gene module analysis of juvenile myelomonocytic leukemia and screening of anticancer drugs. Oncol Rep 40: 3155-3170, 2018
APA
Zhao, W., Wang, L., & Yu, Y. (2018). Gene module analysis of juvenile myelomonocytic leukemia and screening of anticancer drugs. Oncology Reports, 40, 3155-3170. https://doi.org/10.3892/or.2018.6709
MLA
Zhao, W., Wang, L., Yu, Y."Gene module analysis of juvenile myelomonocytic leukemia and screening of anticancer drugs". Oncology Reports 40.6 (2018): 3155-3170.
Chicago
Zhao, W., Wang, L., Yu, Y."Gene module analysis of juvenile myelomonocytic leukemia and screening of anticancer drugs". Oncology Reports 40, no. 6 (2018): 3155-3170. https://doi.org/10.3892/or.2018.6709