Open Access

RUNX family: Oncogenes or tumor suppressors (Review)

  • Authors:
    • Beatriz Andrea Otálora‑Otálora
    • Berta Henríquez
    • Liliana López‑Kleine
    • Adriana Rojas
  • View Affiliations

  • Published online on: May 6, 2019     https://doi.org/10.3892/or.2019.7149
  • Pages: 3-19
  • Copyright: © Otálora‑Otálora et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Runt‑related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, specific regulatory abilities and experimental evidence of RUNX proteins will be analyzed to demonstrate their oncogenic potential and tumor suppressor abilities during oncogenic processes, suggesting their importance as biomarkers of cancer. Additionally, the importance of continuing with the molecular studies of RUNX proteins' and its dual functions in cancer will be underlined in order to apply it in the future development of specific diagnostic methods and therapies against different types of cancer.
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July-2019
Volume 42 Issue 1

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Otálora‑Otálora BA, Henríquez B, López‑Kleine L and Rojas A: RUNX family: Oncogenes or tumor suppressors (Review). Oncol Rep 42: 3-19, 2019
APA
Otálora‑Otálora, B.A., Henríquez, B., López‑Kleine, L., & Rojas, A. (2019). RUNX family: Oncogenes or tumor suppressors (Review). Oncology Reports, 42, 3-19. https://doi.org/10.3892/or.2019.7149
MLA
Otálora‑Otálora, B. A., Henríquez, B., López‑Kleine, L., Rojas, A."RUNX family: Oncogenes or tumor suppressors (Review)". Oncology Reports 42.1 (2019): 3-19.
Chicago
Otálora‑Otálora, B. A., Henríquez, B., López‑Kleine, L., Rojas, A."RUNX family: Oncogenes or tumor suppressors (Review)". Oncology Reports 42, no. 1 (2019): 3-19. https://doi.org/10.3892/or.2019.7149