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Review Open Access

RUNX family: Oncogenes or tumor suppressors (Review)

  • Authors:
    • Beatriz Andrea Otálora‑Otálora
    • Berta Henríquez
    • Liliana López‑Kleine
    • Adriana Rojas
  • View Affiliations / Copyright

    Affiliations: Medicine Faculty, National University of Colombia, Bogotá 111321, Colombia, School of Biochemistry, Medicine and Science Faculty, San Sebastián University, Santiago 7510157, Chile, Statistics Department, National University of Colombia, Bogotá 111321, Colombia, Instituto de Genética Humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá 110231, Colombia
    Copyright: © Otálora‑Otálora et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3-19
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    Published online on: May 6, 2019
       https://doi.org/10.3892/or.2019.7149
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Abstract

Runt‑related transcription factor (RUNX) proteins belong to a transcription factors family known as master regulators of important embryonic developmental programs. In the last decade, the whole family has been implicated in the regulation of different oncogenic processes and signaling pathways associated with cancer. Furthermore, a suppressor tumor function has been also reported, suggesting the RUNX family serves key role in all different types of cancer. In this review, the known biological characteristics, specific regulatory abilities and experimental evidence of RUNX proteins will be analyzed to demonstrate their oncogenic potential and tumor suppressor abilities during oncogenic processes, suggesting their importance as biomarkers of cancer. Additionally, the importance of continuing with the molecular studies of RUNX proteins' and its dual functions in cancer will be underlined in order to apply it in the future development of specific diagnostic methods and therapies against different types of cancer.
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Copy and paste a formatted citation
Spandidos Publications style
Otálora‑Otálora BA, Henríquez B, López‑Kleine L and Rojas A: RUNX family: Oncogenes or tumor suppressors (Review). Oncol Rep 42: 3-19, 2019.
APA
Otálora‑Otálora, B.A., Henríquez, B., López‑Kleine, L., & Rojas, A. (2019). RUNX family: Oncogenes or tumor suppressors (Review). Oncology Reports, 42, 3-19. https://doi.org/10.3892/or.2019.7149
MLA
Otálora‑Otálora, B. A., Henríquez, B., López‑Kleine, L., Rojas, A."RUNX family: Oncogenes or tumor suppressors (Review)". Oncology Reports 42.1 (2019): 3-19.
Chicago
Otálora‑Otálora, B. A., Henríquez, B., López‑Kleine, L., Rojas, A."RUNX family: Oncogenes or tumor suppressors (Review)". Oncology Reports 42, no. 1 (2019): 3-19. https://doi.org/10.3892/or.2019.7149
Copy and paste a formatted citation
x
Spandidos Publications style
Otálora‑Otálora BA, Henríquez B, López‑Kleine L and Rojas A: RUNX family: Oncogenes or tumor suppressors (Review). Oncol Rep 42: 3-19, 2019.
APA
Otálora‑Otálora, B.A., Henríquez, B., López‑Kleine, L., & Rojas, A. (2019). RUNX family: Oncogenes or tumor suppressors (Review). Oncology Reports, 42, 3-19. https://doi.org/10.3892/or.2019.7149
MLA
Otálora‑Otálora, B. A., Henríquez, B., López‑Kleine, L., Rojas, A."RUNX family: Oncogenes or tumor suppressors (Review)". Oncology Reports 42.1 (2019): 3-19.
Chicago
Otálora‑Otálora, B. A., Henríquez, B., López‑Kleine, L., Rojas, A."RUNX family: Oncogenes or tumor suppressors (Review)". Oncology Reports 42, no. 1 (2019): 3-19. https://doi.org/10.3892/or.2019.7149
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