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Article Open Access

Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression

  • Authors:
    • Ji‑Min Li
    • Guan‑Min Jiang
    • Liang Zhao
    • Fang Yang
    • Wei‑Qi Yuan
    • Hao Wang
    • Yi‑Qin Luo
  • View Affiliations / Copyright

    Affiliations: Department of Laboratory Medicine, The Affiliated Anhui Provincial Hospital of Anhui Medical University, Hefei, Anhui 230000, P.R. China, Department of Clinical Laboratory, The Fifth Affiliated Hospital, Sun Yat‑sen University, Zhuhai, Guangdong 510140, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1725-1734
    |
    Published online on: August 22, 2019
       https://doi.org/10.3892/or.2019.7291
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Abstract

Oxaliplatin (Oxa)‑based chemotherapy is widely used as the first‑line treatment for colorectal cancer (CRC). However, Oxa‑resistance is common for many postoperative CRC patients. To explore drug resistance in CRC, an Oxa‑resistant cell line, HCT116/Oxa, was established from parental HCT116 cells. These Oxa‑resistant cells exhibited characteristics of epithelial‑mesenchymal transition (EMT) and a higher migratory capacity than parental cells. Protein profiles of HCT116/Oxa and HCT116 cells were compared using a tandem mass tag‑based quantitative proteomics technique. The protein dehydrogenase/reductase SDR family member 2 (DHRS2) was revealed to be highly expressed in HCT116/Oxa cells. Silencing of DHRS2 in HCT116/Oxa cells effectively restored Oxa‑sensitivity by suppressing the expression of excision repair cross‑complementing group 1 protein via a p53‑dependent pathway, and reversed the EMT phenotype. Overall, the suppression of DHRS2 expression may be a promising strategy for the prevention of Oxa‑resistance in CRC.
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1 

Saika K and Sobue T: Cancer statistics in the world. Gan To Kagaku Ryoho. 40:2475–2480. 2013.(In Japanese). PubMed/NCBI

2 

Arredondo J, Baixauli J, Pastor C, Chopitea A, Sola JJ, González I, A-Cienfuegos J, Martínez P, Rodriguez J and Hernández-Lizoain JL: Mid-term oncologic outcome of a novel approach for locally advanced colon cancer with neoadjuvant chemotherapy and surgery. Clin Transl Oncol. 19:379–385. 2017. View Article : Google Scholar : PubMed/NCBI

3 

Holohan C, Van Schaeybroeck S, Longley DB and Johnston PG: Cancer drug resistance: An evolving paradigm. Nat Rev Cancer. 13:714–726. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Brabletz T, Kalluri R, Nieto MA and Weinberg RA: EMT in cancer. Nat Rev Cancer. 18:128–134. 2018. View Article : Google Scholar : PubMed/NCBI

5 

Thiery JP, Acloque H, Huang RY and Nieto MA: Epithelial-mesenchymal transitions in development and disease. Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI

6 

Olaussen KA, Dunant A, Fouret P, Brambilla E, André F, Haddad V, Taranchon E, Filipits M, Pirker R, Popper HH, et al: DNA repair by ERCC1 in non-small-cell lung cancer and cisplatin-based adjuvant chemotherapy. N Engl J Med. 355:983–991. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Wang J, Chen Y, Xiang F, Li M, Li H, Chi J and Ren K: Suppression of TGF-β1 enhances chemosensitivity of cisplatin-resistant lung cancer cells through the inhibition of drug-resistant proteins. Artif Cells Nanomed Biotechnol. 46:1505–1512. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Wu Y, Jin D, Wang X, Du J, Di W, An J, Shao C and Guo J: UBE2C induces cisplatin resistance via ZEB1/2-dependent upregulation of ABCG2 and ERCC1 in NSCLC cells. J Oncol. 2019:86078592019. View Article : Google Scholar : PubMed/NCBI

9 

Hsu DS, Lan HY, Huang CH, Tai SK, Chang SY, Tsai TL, Chang CC, Tzeng CH, Wu KJ, Kao JY and Yang MH: Regulation of excision repair cross-complementation group 1 by Snail contributes to cisplatin resistance in head and neck cancer. Clin Cancer Res. 16:4561–4571. 2010. View Article : Google Scholar : PubMed/NCBI

10 

He S, Carman CV, Lee JH, Lan B, Koehler S, Atia L, Park CY, Kim JH, Mitchel JA, Park JA, et al: The tumor suppressor p53 can promote collective cellular migration. PLoS One. 14:e02020652019. View Article : Google Scholar : PubMed/NCBI

11 

Donadel G, Garzelli C, Frank R and Gabrielli F: Identification of a novel nuclear protein synthesized in growth-arrested human hepatoblastoma HepG2 cells. Eur J Biochem. 195:723–729. 1991. View Article : Google Scholar : PubMed/NCBI

12 

Gabrielli F and Tofanelli S: Molecular and functional evolution of human DHRS2 and DHRS4 duplicated genes. Gene. 511:461–469. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Bray JE, Marsden BD and Oppermann U: The human short-chain dehydrogenase/reductase (SDR) superfamily: A bioinformatics summary. Chem Biol Interact. 178:99–109. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Bjorkqvist AM, Wolf M, Nordling S, Tammilehto L, Knuuttila A, Kere J, Mattson K and Knuutila S: Deletions at 14q in malignant mesothelioma detected by microsatellite marker analysis. Br J Cancer. 81:1111–1115. 1999. View Article : Google Scholar : PubMed/NCBI

15 

Debiec-Rychter M, Sciot R, Pauwels P, Schoenmakers E, Dal Cin P and Hagemeijer A: Molecular cytogenetic definition of three distinct chromosome arm 14q deletion intervals in gastrointestinal stromal tumors. Genes Chromosomes Cancer. 32:26–32. 2001. View Article : Google Scholar : PubMed/NCBI

16 

Shao JY, Huang XM, Yu XJ, Huang LX, Wu QL, Xia JC, Wang HY, Feng QS, Ren ZF, Ernberg I, et al: Loss of heterozygosity and its correlation with clinical outcome and Epstein-Barr virus infection in nasopharyngeal carcinoma. Anticancer Res. 21:3021–3029. 2001.PubMed/NCBI

17 

Pellegrini S, Censini S, Guidotti S, Iacopetti P, Rocchi M, Bianchi M, Covacci A and Gabrielli F: A human short-chain dehydrogenase/reductase gene: Structure, chromosomal localization, tissue expression and subcellular localization of its product. Biochim Biophys Acta. 1574:215–222. 2002. View Article : Google Scholar : PubMed/NCBI

18 

Peterson LE, Ozen M, Erdem H, Amini A, Gomez L, Nelson CC and Ittmann M: Artificial neural network analysis of DNA microarray-based prostate cancer recurrence. Proceedings of the IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology. 1–8. 2005.

19 

Shedden KA, Taylor JM, Giordano TJ, Kuick R, Misek DE, Rennert G, Schwartz DR, Gruber SB, Logsdon C, Simeone D, et al: Accurate molecular classification of human cancers based on gene expression using a simple classifier with a pathological tree-based framework. Am J Pathol. 163:1985–1995. 2003. View Article : Google Scholar : PubMed/NCBI

20 

Bhattacharyya C, Grate LR, Rizki A, Radisky D, Molina FJ, Jordan MI, Bissell MJ and Mian IS: Simultaneous classification and relevant feature identification in high-dimensional spaces: Application to molecular profiling data. Signal Processing. 83:729–743. 2003. View Article : Google Scholar

21 

Shimonosono M, Idichi T, Seki N, Yamada Y, Arai T, Arigami T, Sasaki K, Omoto I, Uchikado Y, Kita Y, et al: Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR145-3p on gene regulation. Int J Oncol. 54:673–688. 2019.PubMed/NCBI

22 

Yamada H, Arakawa Y, Saito S, Agawa M, Kano Y and Horiguchi-Yamada J: Depsipeptide-resistant KU812 cells show reversible P-glycoprotein expression, hyper-acetylated histones, and modulated gene expression profile. Leukemia research. 30:723–734. 2006. View Article : Google Scholar : PubMed/NCBI

23 

Han Y, Song C, Wang J, Tang H, Peng Z and Lu S: HOXA13 contributes to gastric carcinogenesis through DHRS2 interacting with MDM2 and confers 5-FU resistance by a p53-dependent pathway. Mol Carcinog. 57:722–734. 2018. View Article : Google Scholar : PubMed/NCBI

24 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

25 

Deisenroth C, Thorner AR, Enomoto T, Perou CM and Zhang Y: Mitochondrial Hep27 is a c-Myb target gene that inhibits Mdm2 and stabilizes p53. Mol Cell Biol. 30:3981–3993. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Cunningham D, Atkin W, Lenz HJ, Lynch HT, Minsky B, Nordlinger B and Starling N: Colorectal cancer. Lancet. 375:1030–1047. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Siegel R, Ma J, Zou Z and Jemal A: Cancer statistics, 2014. CA Cancer J Clin. 64:9–29. 2014. View Article : Google Scholar : PubMed/NCBI

28 

Bowden NA: Nucleotide excision repair: Why is it not used to predict response to platinum-based chemotherapy? Cancer Lett. 346:163–171. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Park DJ and Lenz HJ: Determinants of chemosensitivity in gastric cancer. Curr Opin Pharmacol. 6:337–344. 2006. View Article : Google Scholar : PubMed/NCBI

30 

Selvakumaran M, Pisarcik DA, Bao R, Yeung AT and Hamilton TC: Enhanced cisplatin cytotoxicity by disturbing the nucleotide excision repair pathway in ovarian cancer cell lines. Cancer Res. 63:1311–1316. 2003.PubMed/NCBI

31 

Reynolds C, Obasaju C, Schell MJ, Li X, Zheng Z, Boulware D, Caton JR, Demarco LC, O'Rourke MA, Shaw Wright G, et al: Randomized phase III trial of gemcitabine-based chemotherapy with in situ RRM1 and ERCC1 protein levels for response prediction in non-small-cell lung cancer. J Clin Oncol. 27:5808–5815. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Cobo M, Isla D, Massuti B, Montes A, Sanchez JM, Provencio M, Viñolas N, Paz-Ares L, Lopez-Vivanco G, Muñoz MA, et al: Customizing cisplatin based on quantitative excision repair cross-complementing 1 mRNA expression: A phase III trial in non-small-cell lung cancer. J Clin Oncol. 25:2747–2754. 2007. View Article : Google Scholar : PubMed/NCBI

33 

Simon G, Sharma A, Li X, Hazelton T, Walsh F, Chiappori CA, Haur E, Tanvetyanon T, Antonia S, Cantor A and Bepler G: Feasibility and efficacy of molecular analysis-directed individualized therapy in advanced non-small-cell lung cancer. J Clin Oncol. 25:2741–2746. 2007. View Article : Google Scholar : PubMed/NCBI

34 

Kruiswijk F, Labuschagne CF and Vousden KH: p53 in survival, death and metabolic health: A lifeguard with a licence to kill. Nat Rev Mol Cell Biol. 16:393–405. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Liu YC, Chang PY and Chao CC: CITED2 silencing sensitizes cancer cells to cisplatin by inhibiting p53 trans-activation and chromatin relaxation on the ERCC1 DNA repair gene. Nucleic Acids Res. 43:10760–10781. 2015. View Article : Google Scholar : PubMed/NCBI

36 

Wang H, Zhang G, Zhang H, Zhang F, Zhou B, Ning F, Wang HS, Cai SH and Du J: Acquisition of epithelial-mesenchymal transition phenotype and cancer stem cell-like properties in cisplatin-resistant lung cancer cells through AKT/β-catenin/Snail signaling pathway. Eur J Pharmacol. 723:156–166. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Yang AD, Fan F, Camp ER, van Buren G, Liu W, Somcio R, Gray MJ, Cheng H, Hoff PM and Ellis LM: Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res. 12:4147–4153. 2006. View Article : Google Scholar : PubMed/NCBI

38 

Zhou Y, Wang L, Ban X, Zeng T, Zhu Y, Li M, Guan XY and Li Y: DHRS2 inhibits cell growth and motility in esophageal squamous cell carcinoma. Oncogene. 37:1086–1094. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Quail DF and Joyce JA: Microenvironmental regulation of tumor progression and metastasis. Nat Med. 19:1423–1437. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M and Hung MC: Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol. 6:931–940. 2004. View Article : Google Scholar : PubMed/NCBI

41 

Wang SP, Wang WL, Chang YL, Wu CT, Chao YC, Kao SH, Yuan A, Lin CW, Yang SC, Chan WK, et al: p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug. Nat Cell Biol. 11:694–704. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Lin TY and Hsu HY: Ling Zhi-8 reduces lung cancer mobility and metastasis through disruption of focal adhesion and induction of MDM2-mediated Slug degradation. Cancer Lett. 375:340–348. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li JM, Jiang GM, Zhao L, Yang F, Yuan WQ, Wang H and Luo YQ: Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. Oncol Rep 42: 1725-1734, 2019.
APA
Li, J., Jiang, G., Zhao, L., Yang, F., Yuan, W., Wang, H., & Luo, Y. (2019). Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. Oncology Reports, 42, 1725-1734. https://doi.org/10.3892/or.2019.7291
MLA
Li, J., Jiang, G., Zhao, L., Yang, F., Yuan, W., Wang, H., Luo, Y."Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression". Oncology Reports 42.5 (2019): 1725-1734.
Chicago
Li, J., Jiang, G., Zhao, L., Yang, F., Yuan, W., Wang, H., Luo, Y."Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression". Oncology Reports 42, no. 5 (2019): 1725-1734. https://doi.org/10.3892/or.2019.7291
Copy and paste a formatted citation
x
Spandidos Publications style
Li JM, Jiang GM, Zhao L, Yang F, Yuan WQ, Wang H and Luo YQ: Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. Oncol Rep 42: 1725-1734, 2019.
APA
Li, J., Jiang, G., Zhao, L., Yang, F., Yuan, W., Wang, H., & Luo, Y. (2019). Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression. Oncology Reports, 42, 1725-1734. https://doi.org/10.3892/or.2019.7291
MLA
Li, J., Jiang, G., Zhao, L., Yang, F., Yuan, W., Wang, H., Luo, Y."Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression". Oncology Reports 42.5 (2019): 1725-1734.
Chicago
Li, J., Jiang, G., Zhao, L., Yang, F., Yuan, W., Wang, H., Luo, Y."Dehydrogenase/reductase SDR family member 2 silencing sensitizes an oxaliplatin‑resistant cell line to oxaliplatin by inhibiting excision repair cross‑complementing group 1 protein expression". Oncology Reports 42, no. 5 (2019): 1725-1734. https://doi.org/10.3892/or.2019.7291
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