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Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma

  • Authors:
    • Cheng‑Yun Li
    • Wen‑Wen Zhang
    • Ji‑Lian Xiang
    • Xing‑Hua Wang
    • Jun‑Ling Wang
    • Jin Li
  • View Affiliations / Copyright

    Affiliations: Department of Toxicology, School of Public Health, Lanzhou University, Lanzhou, Gansu 730000, P.R. China, Department of Gastroenterology, Third People's Hospital of Gansu Province, Lanzhou, Gansu 730000, P.R. China, Department of Gastrointestinal Surgery, Gansu Wuwei Tumor Hospital, Wuwei, Gansu 733000, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2583-2599
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    Published online on: October 17, 2019
       https://doi.org/10.3892/or.2019.7377
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Abstract

Esophageal squamous cell carcinoma (ESCC) is a prevalent aggressive malignant tumor with poor prognosis. Investigations into the molecular changes that occur as a result of the disease, as well as identification of novel biomarkers for its diagnosis and prognosis, are urgently required. Long non‑coding RNAs (lncRNAs) have been reported to play a critical role in tumor progression. The present study performed data mining analyses for ESCC via an integrated study of accumulated datasets and identification of the differentially expressed lncRNAs from the Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases. The identified intersection of differentially expressed genes (lncRNAs, miRNAs and mRNAs) in ESCC tissues between the GEO and TCGA datasets was investigated. Based on these intersected lncRNAs, the present study constructed a competitive endogenous RNA (ceRNA) network of lncRNAs in ESCC. A total of 81 intersection lncRNAs were identified; 67 of these were included in the ceRNA network. Functional analyses revealed that these 67 key lncRNAs primarily dominated cellular biological processes. The present study then analyzed the associations between the expression levels of these 67 key lncRNAs and the clinicopathological characteristics of the ESCC patients, as well as their survival time using TCGA. The results revealed that 31 of these lncRNAs were associated with tumor grade, tumor‑node‑metastasis (TNM) stage and lymphatic metastasis status (P<0.05). In addition, 15 key lncRNAs were demonstrated to be associated with survival time (P<0.05). Finally, 5 key lncRNAs were selected for validation of their expression levels in 30 patients newly diagnosed with ESCC via reverse transcription‑quantitative PCR (RT‑qPCR). The results suggested that the fold changes in the trends of up‑ and downregulation between GEO, TCGA and RT‑qPCR were consistent. In addition, it was also demonstrated that a select few of these 5 key lncRNAs were significantly associated with TNM stage and lymph node metastasis (P<0.05). The results of the clinically relevant analysis and the aforementioned bioinformatics were similar, hence proving that the bioinformatics analysis used in the present study is credible. Overall, the results from the present study may provide further insight into the functional characteristics of lncRNAs in ESCC through bioinformatics integrative analysis of the GEO and TCGA datasets, and reveal potential diagnostic and prognostic biomarkers for ESCC.
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View References

1 

Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA and Jemal A: Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 68:394–424. 2018. View Article : Google Scholar : PubMed/NCBI

2 

Jiang C, Chen Y, Zhu Y and Xu Y: Systematic review and meta-analysis of the accuracy of 18F-FDG PET/CT for detection of regional lymph node metastasis in esophageal squamous cell carcinoma. J Thorac Dis. 10:6066–6076. 2018. View Article : Google Scholar : PubMed/NCBI

3 

Kim M: Evaluation of a web-based App demonstrating an exclusionary algorithmic approach to TNM cancer staging. JMIR Cancer. 1:e32015. View Article : Google Scholar : PubMed/NCBI

4 

Zhang X, Wang Y, Zhao L, Sang S and Zhang L: Prognostic value of platelet-to-lymphocyte ratio in oncologic outcomes of esophageal cancer: A systematic review and meta-analysis. Int J Biol Markers. Apr 1–2018.(Epub ahead of print). View Article : Google Scholar

5 

Quan J, Pan X, Zhao L, Li Z, Dai K, Yan F, Liu S, Ma H and Lai Y: LncRNA as a diagnostic and prognostic biomarker in bladder cancer: A systematic review and meta-analysis. Onco Targets Ther. 11:6415–6424. 2018. View Article : Google Scholar : PubMed/NCBI

6 

Tian T, Wang M, Lin S, Guo Y, Dai Z, Liu K, Yang P, Dai C, Zhu Y, Zheng Y, et al: The impact of lncRNA dysregulation on clinicopathology and survival of breast cancer: A systematic review and meta-analysis. Mol Ther Nucleic Acids. 12:359–369. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Liu W, Zhang Y, Chen M, Shi L, Xu L and Zou X: A genome-wide analysis of long noncoding RNA profile identifies differentially expressed lncRNAs associated with Esophageal cancer. Cancer Med. 7:4181–4189. 2018. View Article : Google Scholar : PubMed/NCBI

8 

Khadirnaikar S, Narayanan SP and Shukla SK: Decoding the LncRNA transcriptome of esophageal cancer: Identification of clinically relevant LncRNAs. Biomark Med. 12:1083–1093. 2018. View Article : Google Scholar : PubMed/NCBI

9 

Ji S, Yang W, Liu J, Zhao J, Chen L, Ni Q, Long J and Yu X: High throughput gene sequencing reveals altered landscape in DNA damage responses and chromatin remodeling in sporadic pancreatic neuroendocrine tumors. Pancreatology. 18:318–327. 2018. View Article : Google Scholar : PubMed/NCBI

10 

Krishnamurthy A, Ferl RJ and Paul AL: Comparing RNA-Seq and microarray gene expression data in two zones of the Arabidopsis root apex relevant to spaceflight. Appl Plant Sci. 6:e011972018. View Article : Google Scholar : PubMed/NCBI

11 

Hu J, Zhou L, Song Z, Xiong M, Zhang Y, Yang Y, Chen K and Chen Z: The identification of new biomarkers for bladder cancer: A study based on TCGA and GEO datasets. J Cell Physiol. Feb 18–2019.(Epub ahead of print). View Article : Google Scholar

12 

Su H, Hu N, Yang HH, Wang C, Takikita M, Wang QH, Giffen C, Clifford R, Hewitt SM, Shou JZ, et al: Global gene expression profiling and validation in esophageal squamous cell carcinoma and its association with clinical phenotypes. Clin Cancer Res. 17:2955–2966. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Wang Q, Ma C and Kemmner W: Wdr66 is a novel marker for risk stratification and involved in epithelial-mesenchymal transition of esophageal squamous cell carcinoma. BMC Cancer. 13:1372013. View Article : Google Scholar : PubMed/NCBI

14 

Wen J, Yang H, Liu MZ, Luo KJ, Liu H, Hu Y, Zhang X, Lai RC, Lin T, Wang HY and Fu JH: Gene expression analysis of pretreatment biopsies predicts the pathological response of esophageal squamous cell carcinomas to neo-chemoradiotherapy. Ann Oncol. 25:1769–1774. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Guo Y, Chen Z, Zhang L, Zhou F, Shi S, Feng X, Li B, Meng X, Ma X, Luo M, et al: Distinctive microRNA profiles relating to patient survival in esophageal squamous cell carcinoma. Cancer Res. 68:26–33. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Jang HJ, Lee HS, Burt BM, Lee GK, Yoon KA, Park YY, Sohn BH, Kim SB, Kim MS, Lee JM, et al: Integrated genomic analysis of recurrence-associated small non-coding RNAs in oesophageal cancer. Gut. 66:215–225. 2017. View Article : Google Scholar : PubMed/NCBI

17 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar : PubMed/NCBI

18 

Cao B, Yang W, Jin Y, Zhang M, He T, Zhan Q, Herman JG, Zhong G and Guo M: Silencing NKD2 by promoter region hypermethylation promotes esophageal cancer progression by activating Wnt signaling. J Thorac Oncol. 11:1912–1926. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Wang X, Zhu Y, Zhu L, Chen X, Xu Y, Zhao Y, Shao Y, Li F, Jiang Y, Lu J, et al: Eupatilin inhibits the proliferation of human esophageal cancer TE1 cells by targeting the Akt-GSK3β and MAPK/ERK signaling cascades. Oncol Rep. 39:2942–2950. 2018.PubMed/NCBI

20 

Jiang JH, Pi J, Jin H and Cai JY: Oridonin-induced mitochondria-dependent apoptosis in esophageal cancer cells by inhibiting PI3K/AKT/mTOR and Ras/Raf pathways. J Cell Biochem. 120:3736–3746. 2019. View Article : Google Scholar : PubMed/NCBI

21 

He J, Zhao J, Zhu W, Qi D, Wang L, Sun J, Wang B, Ma X, Dai Q and Yu X: MicroRNA biogenesis pathway genes polymorphisms and cancer risk: A systematic review and meta-analysis. PeerJ. 4:e27062016. View Article : Google Scholar : PubMed/NCBI

22 

Hu M, Zhu S, Xiong S, Xue X and Zhou X: MicroRNAs and the PTEN/PI3K/Akt pathway in gastric cancer (Review). Oncol Rep. 41:1439–1454. 2019.PubMed/NCBI

23 

Xiao YF, Yong X, Tang B, Qin Y, Zhang JW, Zhang D, Xie R and Yang SM: Notch and Wnt signaling pathway in cancer: Crucial role and potential therapeutic targets (Review). Int J Oncol. 48:437–449. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Toren P and Zoubeidi A: Targeting the PI3K/Akt pathway in prostate cancer: Challenges and opportunities (Review). Int J Oncol. 45:1793–1801. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Hayashi Y, Nishida T, Tsujii M, Tsutsui S, Yamamoto K, Isohashi F, Yamasaki M, Miyata H, Kato M, Yamada T, et al: Lymph node enlargement after definitive chemoradiotherapy for clinical stage I esophageal squamous cell carcinoma. BMC Cancer. 14:7062014. View Article : Google Scholar : PubMed/NCBI

26 

Cheng YF, Chen HS, Wu SC, Chen HC, Hung WH, Lin CH and Wang BY: Esophageal squamous cell carcinoma and prognosis in Taiwan. Cancer Med. 7:4193–4201. 2018. View Article : Google Scholar : PubMed/NCBI

27 

Mine S, Watanabe M, Kumagai K, Okamura A, Yuda M, Hayami M, Yamashita K, Imamura Y and Ishizuka N: Comparison of mediastinal lymph node metastases from adenocarcinoma of the esophagogastric junction versus lower esophageal squamous cell carcinoma with involvement of the esophagogastric junction. Dis Esophagus. Feb 22–2019.(Epub ahead of print). View Article : Google Scholar :

28 

Huang GW, Xue YJ, Wu ZY, Xu XE, Wu JY, Cao HH, Zhu Y, He JZ, Li CQ, Li EM and Xu LY: A three-lncRNA signature predicts overall survival and disease-free survival in patients with esophageal squamous cell carcinoma. BMC Cancer. 18:1472018. View Article : Google Scholar : PubMed/NCBI

29 

Wang J, Sun D, Wu K, Liu J, Zhao M, Li X, Xu Y and Li B: Genome-wide analysis of long non-coding RNAs in esophageal squamous cell carcinoma reveals their potential role in invasion and metastasis. Thorac Cancer. 10:78–89. 2019. View Article : Google Scholar : PubMed/NCBI

30 

Alaei S, Sadeghi B, Najafi A and Masoudi-Nejad A: LncRNA and mRNA integration network reconstruction reveals novel key regulators in esophageal squamous-cell carcinoma. Genomics. 111:76–89. 2019. View Article : Google Scholar : PubMed/NCBI

31 

Campbell JD, Liu G, Luo L, Xiao J, Gerrein J, Juan-Guardela B, Tedrow J, Alekseyev YO, Yang IV, Correll M, et al: Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data. RNA. 21:164–171. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Collins JE, Wali N, Sealy IM, Morris JA, White RJ, Leonard SR, Jackson DK, Jones MC, Smerdon NC, Zamora J, et al: High-throughput and quantitative genome-wide messenger RNA sequencing for molecular phenotyping. BMC Genomics. 16:5782015. View Article : Google Scholar : PubMed/NCBI

33 

Ozsolak F: Attomole-level genomics with single-molecule direct DNA, cDNA and RNA sequencing technologies. Curr Issues Mol Biol. 18:43–48. 2016.PubMed/NCBI

34 

Lacaze É, Gendron AD, Miller JL, Colson TL, Sherry JP, Giraudo M, Marcogliese DJ and Houde M: Cumulative effects of municipal effluent and parasite infection in yellow perch: A field study using high-throughput RNA-sequencing. Sci Total Environ. 665:797–809. 2019. View Article : Google Scholar : PubMed/NCBI

35 

Ge L, Liu S, Xie L, Sang L, Ma C and Li H: Differential mRNA expression profiling of oral squamous cell carcinoma by high-throughput RNA sequencing. J Biomed Res. 29:2015.(Epub ahead of print). PubMed/NCBI

36 

Gao M, Zhong A, Patel N, Alur C and Vyas D: High throughput RNA sequencing utility for diagnosis and prognosis in colon diseases. World J Gastroenterol. 23:2819–2825. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Ma T, Liang F, Oesterreich S and Tseng GC: A joint bayesian model for integrating microarray and RNA sequencing transcriptomic data. J Comput Biol. 24:647–662. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Yan Y, Li S, Wang S, Rubegni P, Tognetti L, Zhang J and Yan L: Long noncoding RNA HAND2-AS1 inhibits cancer cell proliferation, migration, and invasion in esophagus squamous cell carcinoma by regulating microRNA-21. J Cell Biochem. 120:9564–9571. 2019. View Article : Google Scholar : PubMed/NCBI

39 

Dong Z, Zhang A, Liu S, Lu F, Guo Y, Zhang G, Xu F, Shi Y, Shen S, Liang J and Guo W: Aberrant methylation-mediated silencing of lncRNA MEG3 functions as a ceRNA in esophageal cancer. Mol Cancer Res. 15:800–810. 2017. View Article : Google Scholar : PubMed/NCBI

40 

Huang ZL, Chen RP, Zhou XT, Zhan HL, Hu MM, Liu B, Wu GD and Wu LF: Long non-coding RNA MEG3 induces cell apoptosis in esophageal cancer through endoplasmic reticulum stress. Oncol Rep. 37:3093–3099. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Yang S, Ning Q, Zhang G, Sun H, Wang Z and Li Y: Construction of differential mRNA-lncRNA crosstalk networks based on ceRNA hypothesis uncover key roles of lncRNAs implicated in esophageal squamous cell carcinoma. Oncotarget. 7:85728–85740. 2016. View Article : Google Scholar : PubMed/NCBI

42 

Zang W, Wang T, Wang Y, Chen X, Du Y, Sun Q, Li M, Dong Z and Zhao G: Knockdown of long non-coding RNA TP73-AS1 inhibits cell proliferation and induces apoptosis in esophageal squamous cell carcinoma. Oncotarget. 7:19960–19974. 2016. View Article : Google Scholar : PubMed/NCBI

43 

Zhou XL, Wang WW, Zhu WG, Yu CH, Tao GZ, Wu QQ, Song YQ, Pan P and Tong YS: High expression of long non-coding RNA AFAP1-AS1 predicts chemoradioresistance and poor prognosis in patients with esophageal squamous cell carcinoma treated with definitive chemoradiotherapy. Mol Carcinog. 55:2095–2105. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Shi H, Liu Z, Pei D, Jiang Y, Zhu H and Chen B: Development and validation of nomogram based on lncRNA ZFAS1 for predicting survival in lymph node-negative esophageal squamous cell carcinoma patients. Oncotarget. 8:59048–59057. 2017.PubMed/NCBI

45 

Wang P, Guo Q, Gao Y, Zhi H, Zhang Y, Liu Y, Zhang J, Yue M, Guo M, Ning S, et al: Improved method for prioritization of disease associated lncRNAs based on ceRNA theory and functional genomics data. Oncotarget. 8:4642–4655. 2017.PubMed/NCBI

46 

Hu Q, Tai S and Wang J: Oncogenicity of lncRNA FOXD2-AS1 and its molecular mechanisms in human cancers. Pathol Res Pract. 215:843–848. 2019. View Article : Google Scholar : PubMed/NCBI

47 

Stelzer Y, Sagi I, Yanuka O, Eiges R and Benvenisty N: The noncoding RNA IPW regulates the imprinted DLK1-DIO3 locus in an induced pluripotent stem cell model of Prader-Willi syndrome. Nat Genet. 46:551–557. 2014. View Article : Google Scholar : PubMed/NCBI

48 

Zang Y, Zhou X, Wang Q, Li X and Huang H: LncRNA FIRRE/NF-kB feedback loop contributes to OGD/R injury of cerebral microglial cells. Biochem Biophys Res Commun. 501:131–138. 2018. View Article : Google Scholar : PubMed/NCBI

49 

Su C, Shi K, Cheng X, Han Y, Li Y, Yu D and Liu Z: Long noncoding RNA LINC00472 inhibits proliferation and promotes apoptosis of lung adenocarcinoma cells via regulating miR-24-3p/DEDD. Technol Cancer Res Treat. 17:15330338187904902018. View Article : Google Scholar : PubMed/NCBI

50 

Lu T, Chen D, Wang Y, Sun X, Li S, Miao S, Wo Y, Dong Y, Leng X, Du W and Jiao W: Identification of DNA methylation-driven genes in esophageal squamous cell carcinoma: A study based on the cancer genome atlas. Cancer Cell Int. 19:522019. View Article : Google Scholar : PubMed/NCBI

51 

Yang W, Qu Y, Tan B, Jia Y, Wang N, Hu P and Wang J: Prognostic significance of preoperative IKBKE expression in esophageal squamous cell carcinoma. Onco Targets Ther. 11:1305–1314. 2018. View Article : Google Scholar : PubMed/NCBI

52 

Maehara O, Suda G, Natsuizaka M, Ohnishi S, Komatsu Y, Sato F, Nakai M, Sho T, Morikawa K, Ogawa K, et al: Fibroblast growth factor-2-mediated FGFR/Erk signaling supports maintenance of cancer stem-like cells in esophageal squamous cell carcinoma. Carcinogenesis. 38:1073–1083. 2017. View Article : Google Scholar : PubMed/NCBI

53 

Unger JM, Vaidya R, Hershman DL, Minasian LM and Fleury ME: Systematic review and meta-analysis of the magnitude of structural, clinical, and physician and patient barriers to cancer clinical trial participation. J Natl Cancer Inst. 111:245–255. 2019. View Article : Google Scholar : PubMed/NCBI

54 

Li PD, Hu JL, Ma C, Ma H, Yao J, Chen LL, Chen J, Cheng TT, Yang KY, Wu G, et al: Upregulation of the long non-coding RNA PVT1 promotes esophageal squamous cell carcinoma progression by acting as a molecular sponge of miR-203 and LASP1. Oncotarget. 8:34164–34176. 2017.PubMed/NCBI

55 

Bao J, Zhou C, Zhang J, Mo J, Ye Q, He J and Diao J: Upregulation of the long noncoding RNA FOXD2-AS1 predicts poor prognosis in esophageal squamous cell carcinoma. Cancer Biomark. 21:527–533. 2018. View Article : Google Scholar : PubMed/NCBI

56 

Kang M, Ren M, Li Y, Fu Y, Deng M and Li C: Exosome-mediated transfer of lncRNA PART1 induces gefitinib resistance in esophageal squamous cell carcinoma via functioning as a competing endogenous RNA. J Exp Clin Cancer Res. 37:1712018. View Article : Google Scholar : PubMed/NCBI

57 

Chen LP, Wang H, Zhang Y, Chen QX, Lin TS, Liu ZQ and Zhou YY: Robust analysis of novel mRNA-lncRNA cross talk based on ceRNA hypothesis uncovers carcinogenic mechanism and promotes diagnostic accuracy in esophageal cancer. Cancer Manag Res. 11:347–358. 2018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li CY, Zhang WW, Xiang JL, Wang XH, Wang JL and Li J: Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma. Oncol Rep 42: 2583-2599, 2019.
APA
Li, C., Zhang, W., Xiang, J., Wang, X., Wang, J., & Li, J. (2019). Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma. Oncology Reports, 42, 2583-2599. https://doi.org/10.3892/or.2019.7377
MLA
Li, C., Zhang, W., Xiang, J., Wang, X., Wang, J., Li, J."Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma". Oncology Reports 42.6 (2019): 2583-2599.
Chicago
Li, C., Zhang, W., Xiang, J., Wang, X., Wang, J., Li, J."Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma". Oncology Reports 42, no. 6 (2019): 2583-2599. https://doi.org/10.3892/or.2019.7377
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Spandidos Publications style
Li CY, Zhang WW, Xiang JL, Wang XH, Wang JL and Li J: Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma. Oncol Rep 42: 2583-2599, 2019.
APA
Li, C., Zhang, W., Xiang, J., Wang, X., Wang, J., & Li, J. (2019). Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma. Oncology Reports, 42, 2583-2599. https://doi.org/10.3892/or.2019.7377
MLA
Li, C., Zhang, W., Xiang, J., Wang, X., Wang, J., Li, J."Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma". Oncology Reports 42.6 (2019): 2583-2599.
Chicago
Li, C., Zhang, W., Xiang, J., Wang, X., Wang, J., Li, J."Integrated analysis highlights multiple long non‑coding RNAs and their potential roles in the progression of human esophageal squamous cell carcinoma". Oncology Reports 42, no. 6 (2019): 2583-2599. https://doi.org/10.3892/or.2019.7377
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