Open Access

Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer

  • Authors:
    • Lihong Zhou
    • Hua Sui
    • Ting Wang
    • Ru Jia
    • Zhaozhou Zhang
    • Jie Fu
    • Yuanyuan Feng
    • Ningning Liu
    • Qing Ji
    • Yan Wang
    • Bimeng Zhang
    • Qi Li
    • Yan Li
  • View Affiliations

  • Published online on: February 12, 2020     https://doi.org/10.3892/or.2020.7498
  • Pages: 1159-1168
  • Copyright: © Zhou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Tumor angiogenesis is an important factor which precipitates recurrence and metastasis of colorectal cancer (CRC). Angiogenesis is also a significant feature which accompanies invasion and metastasis of CRC. Tumor hypoxia activates hypoxia inducible factor (HIF), which promotes angiogenesis in CRC. HIF significantly promotes cell proliferation and angiogenesis in CRC, facilitating invasion and metastasis. Tanshinone IIA (Tan IIA) has been revealed to effectively inhibit angiogenesis in CRC, although the underlying mechanism remains to be determined. The aim of the present study was to determine the effects of HIF‑1α on hypoxia induced angiogenesis in CRC cells, the effects of Tan IIA on the expression of pro‑angiogenic factors in CRC cells, and on human umbilical vein endothelial cell (HUVEC) tube formation in normal and hypoxic conditions. The results of the present study revealed that Tan IIA not only decreased HIF‑1α expression and inhibited the secretion level of vascular endothelial growth factor and basic fibroblast growth factor, but also efficiently decreased proliferation, tube formation and metastasis of HUVECs. The results highlight the potential of Tan IIA‑mediated targeting of HIF‑1α as a potential therapeutic option for treatment of patients with CRC.

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April 2020
Volume 43 Issue 4

Print ISSN: 1021-335X
Online ISSN:1791-2431

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APA
Zhou, L., Sui, H., Wang, T., Jia, R., Zhang, Z., Fu, J. ... Li, Y. (2020). Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer. Oncology Reports, 43, 1159-1168. https://doi.org/10.3892/or.2020.7498
MLA
Zhou, L., Sui, H., Wang, T., Jia, R., Zhang, Z., Fu, J., Feng, Y., Liu, N., Ji, Q., Wang, Y., Zhang, B., Li, Q., Li, Y."Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer". Oncology Reports 43.4 (2020): 1159-1168.
Chicago
Zhou, L., Sui, H., Wang, T., Jia, R., Zhang, Z., Fu, J., Feng, Y., Liu, N., Ji, Q., Wang, Y., Zhang, B., Li, Q., Li, Y."Tanshinone IIA reduces secretion of pro‑angiogenic factors and inhibits angiogenesis in human colorectal cancer". Oncology Reports 43, no. 4 (2020): 1159-1168. https://doi.org/10.3892/or.2020.7498