Open Access

Role of RASA1 in cancer: A review and update (Review)

  • Authors:
    • Yanhua Zhang
    • Yue Li
    • Quanyue Wang
    • Bo Su
    • Hui Xu
    • Yang Sun
    • Pei Sun
    • Rumeng Li
    • Xiaochun Peng
    • Jun Cai
  • View Affiliations

  • Published online on: October 13, 2020     https://doi.org/10.3892/or.2020.7807
  • Pages: 2386-2396
  • Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis. As a result, RASA1 also contributes to pathological processes in vascular diseases and tumour formation. This review focuses on the role of RASA1 in multiple tumours types in the lung, intestines, liver, and breast. Furthermore, we discuss the potential mechanisms of RASA1 and its downstream effects through Ras/RAF/MEK/ERK or Ras/PI3K/AKT signalling. Moreover, miRNAs are capable of regulating RASA1 and could be a novel targeted treatment strategy for tumours.
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December-2020
Volume 44 Issue 6

Print ISSN: 1021-335X
Online ISSN:1791-2431

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Copy and paste a formatted citation
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Spandidos Publications style
Zhang Y, Li Y, Wang Q, Su B, Xu H, Sun Y, Sun P, Li R, Peng X, Cai J, Cai J, et al: Role of RASA1 in cancer: A review and update (Review). Oncol Rep 44: 2386-2396, 2020
APA
Zhang, Y., Li, Y., Wang, Q., Su, B., Xu, H., Sun, Y. ... Cai, J. (2020). Role of RASA1 in cancer: A review and update (Review). Oncology Reports, 44, 2386-2396. https://doi.org/10.3892/or.2020.7807
MLA
Zhang, Y., Li, Y., Wang, Q., Su, B., Xu, H., Sun, Y., Sun, P., Li, R., Peng, X., Cai, J."Role of RASA1 in cancer: A review and update (Review)". Oncology Reports 44.6 (2020): 2386-2396.
Chicago
Zhang, Y., Li, Y., Wang, Q., Su, B., Xu, H., Sun, Y., Sun, P., Li, R., Peng, X., Cai, J."Role of RASA1 in cancer: A review and update (Review)". Oncology Reports 44, no. 6 (2020): 2386-2396. https://doi.org/10.3892/or.2020.7807