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Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR

  • Authors:
    • Shuqiu Chen
    • Haihong Ye
    • Fanger Gong
    • Suming Mao
    • Cong Li
    • Bin Xu
    • Yu Ren
    • Rui Yu
  • View Affiliations / Copyright

    Affiliations: Department of Urology, Zhongda Hospital, Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department of Urology, Ningbo Urology and Nephrology Hospital, Ningbo, Zhejiang 315100, P.R. China, Department of Biochemistry and Molecular Biology, Zhejiang Key Laboratory of Pathophysiology, Medical School, Ningbo University, Ningbo, Zhejiang 315210, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Article Number: 38
    |
    Published online on: February 22, 2021
       https://doi.org/10.3892/or.2021.7989
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Abstract

Renal cell carcinoma (RCC) is a common type of kidney cancer that lacks effective therapeutic options. Ginsenoside compound K (CK), an active metabolite of ginsenosides, has been reported to induce apoptosis in various types of cancer cells. However, the effects of CK in RCC remain to be elucidated. Thus, the aim of the present study was to investigate the antitumor effects of CK on RCC cells. The effects of CK on the proliferation, migration, invasion, cell cycle and apoptosis of RCC cell lines (Caki‑1 and 768‑O) were investigated using MTT, wound healing, Transwell and flow cytometry assays, respectively. Changes in the expression levels of long non‑coding RNAs (lncRNAs) and proteins were measured via reverse transcription‑quantitative PCR and western blotting, respectively. Transfections with testis associated oncogenic (THOR) small interfering RNA and pcDNA were performed to knock down and overexpress lncRNA THOR, respectively. It was found that CK could effectively inhibit the proliferation, migration and invasion of RCC cells. CK also induced cell cycle arrest and caspase‑dependent apoptosis in RCC cells. Furthermore, the generation of reactive oxygen species and inhibition of the lncRNA THOR played important roles in the antitumour effects of CK in RCC cells. The present data revealed that CK was a potent antitumour agent against RCC.
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Copy and paste a formatted citation
Spandidos Publications style
Chen S, Ye H, Gong F, Mao S, Li C, Xu B, Ren Y and Yu R: Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR. Oncol Rep 45: 38, 2021.
APA
Chen, S., Ye, H., Gong, F., Mao, S., Li, C., Xu, B. ... Yu, R. (2021). Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR. Oncology Reports, 45, 38. https://doi.org/10.3892/or.2021.7989
MLA
Chen, S., Ye, H., Gong, F., Mao, S., Li, C., Xu, B., Ren, Y., Yu, R."Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR". Oncology Reports 45.4 (2021): 38.
Chicago
Chen, S., Ye, H., Gong, F., Mao, S., Li, C., Xu, B., Ren, Y., Yu, R."Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR". Oncology Reports 45, no. 4 (2021): 38. https://doi.org/10.3892/or.2021.7989
Copy and paste a formatted citation
x
Spandidos Publications style
Chen S, Ye H, Gong F, Mao S, Li C, Xu B, Ren Y and Yu R: Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR. Oncol Rep 45: 38, 2021.
APA
Chen, S., Ye, H., Gong, F., Mao, S., Li, C., Xu, B. ... Yu, R. (2021). Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR. Oncology Reports, 45, 38. https://doi.org/10.3892/or.2021.7989
MLA
Chen, S., Ye, H., Gong, F., Mao, S., Li, C., Xu, B., Ren, Y., Yu, R."Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR". Oncology Reports 45.4 (2021): 38.
Chicago
Chen, S., Ye, H., Gong, F., Mao, S., Li, C., Xu, B., Ren, Y., Yu, R."Ginsenoside compound K exerts antitumour effects in renal cell carcinoma via regulation of ROS and lncRNA THOR". Oncology Reports 45, no. 4 (2021): 38. https://doi.org/10.3892/or.2021.7989
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