Role of reactive oxygen species in tumors based on the ‘seed and soil’ theory: A complex interaction (Review)
- Authors:
- Wei Liang
- Xinying He
- Jianqiang Bi
- Tingting Hu
- Yunchuan Sun
-
Affiliations: Department of Radiation Oncology, Hebei Province Cangzhou Hospital of Integrated Traditional and Western Medicine, Affiliated Hospital of Hebei Medical University, Cangzhou, Hebei 061000, P.R. China - Published online on: July 29, 2021 https://doi.org/10.3892/or.2021.8159
- Article Number: 208
-
Copyright: © Liang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
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|
Nosaka Y and Nosaka AY: Generation and detection of reactive oxygen species in photocatalysis. Chem Rev. 117:11302–11336. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Kumari S, Badana AK, G MM GS and Malla RR: Reactive oxygen species: A key constituent in cancer survival. Biomark Insights. 13:11772719187553912018. View Article : Google Scholar : PubMed/NCBI | |
|
Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M and Telser J: Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell Biol. 39:44–84. 2007. View Article : Google Scholar : PubMed/NCBI | |
|
Yang B, Chen Y and Shi J: Reactive oxygen species (ROS)-based nanomedicine. Chem Rev. 119:4881–4985. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Cruces-Sande A, Rodríguez-Pérez AI, Herbello-Hermelo P, Bermejo-Barrera P, Méndez-Álvarez E, Labandeira-García JL and Soto-Otero R: Copper increases brain oxidative stress and enhances the ability of 6-hydroxydopamine to cause dopaminergic degeneration in a rat model of parkinsons disease. Mol Neurobiol. 56:2845–2854. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Gorrini C, Harris IS and Mak TW: Modulation of oxidative stress as an anticancer strategy. Nat Rev Drug Discov. 12:931–947. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Chatterjee R and Chatterjee J: ROS and oncogenesis with special reference to EMT and stemness. Eur J Cell Biol. 99:1510732020. View Article : Google Scholar : PubMed/NCBI | |
|
Okon IS and Zou MH: Mitochondrial ROS and cancer drug resistance: Implications for therapy. Pharmacol Res. 100:170–174. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Birben E, Sahiner UM, Sackesen C, Erzurum S and Kalayci O: Oxidative stress and antioxidant defense. World Allergy Organ J. 5:9–19. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Parekh A, Das S, Parida S, Das CK, Dutta D, Mallick SK, Wu PH, Kumar BNP, Bharti R, Dey G, et al: Multi-nucleated cells use ROS to induce breast cancer chemo-resistance in vitro and in vivo. Oncogene. 37:4546–4561. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Li Z, Guo D, Yin X, Ding S, Shen M, Zhang R, Wang Y and Xu R: Zinc oxide nanoparticles induce human multiple myeloma cell death via reactive oxygen species and Cyt-C/Apaf-1/Caspase-9/Caspase-3 signaling pathway in vitro. Biomed Pharmacother. 122:1097122020. View Article : Google Scholar : PubMed/NCBI | |
|
Xia B and Wang J: Effects of adenosine on apoptosis of ovarian cancer a2780 cells via ROS and caspase pathways. Onco Targets Ther. 12:9473–9480. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Hanahan D and Coussens LM: Accessories to the crime: Functions of cells recruited to the tumor microenvironment. Cancer Cell. 21:309–322. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Guo X, Cheng Y, Zhao X, Luo Y, Chen J and Yuan WE: Advances in redox-responsive drug delivery systems of tumor microenvironment. J Nanobiotechnology. 16:742018. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng J and Gao P: Toward normalization of the tumor microenvironment for cancer therapy. Integr Cancer Ther. 18:15347354198623522019. View Article : Google Scholar : PubMed/NCBI | |
|
Paget S: The distribution of secondary growths in cancer of the breast. 1889. Cancer Metastasis Rev. 8:98–101. 1989.PubMed/NCBI | |
|
Langley RR and Fidler IJ: The seed and soil hypothesis revisited-the role of tumor-stroma interactions in metastasis to different organs. Int J Cancer. 128:2527–2535. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Akhtar M, Haider A, Rashid S and Al-Nabet ADMH: Pagets ‘seed and soil’ theory of cancer metastasis: An idea whose time has come. Adv Anat Patho. 26:69–74. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhao Y, Li J, Li D, Wang Z, Zhao J, Wu X, Sun Q, Lin PP, Plum P, Damanakis A, et al: Tumor biology and multidisciplinary strategies of oligometastasis in gastrointestinal cancers. Semin Cancer Biol. 60:334–343. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Malla R, Surepalli N, Farran B, Malhotra SV and Nagaraju GP: Reactive oxygen species (ROS): Critical roles in breast tumor microenvironment. Crit Rev Oncol Hematol. 160:1032852021. View Article : Google Scholar : PubMed/NCBI | |
|
Kuo CL, Chou HY, Chiu YC, Cheng AN, Fan CC, Chang YN, Chen CH, Jiang SS, Chen NJ and Lee AY: Mitochondrial oxidative stress by Lon-PYCR1 maintains an immunosuppressive tumor microenvironment that promotes cancer progression and metastasis. Cancer Lett. 474:138–150. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
An J, Hu YG, Cheng K, Li C, Hou XL, Wang GL, Zhang XS, Liu B, Zhao YD and Zhang MZ: ROS-augmented and tumor-microenvironment responsive biodegradable nanoplatform for enhancing chemo-sonodynamic therapy. Biomaterials. 234:1197612020. View Article : Google Scholar : PubMed/NCBI | |
|
Arfin S, Jha NK, Jha SK, Kesari KK, Ruokolainen J, Roychoudhury S, Rathi B and Kumar D: Oxidative stress in cancer cell metabolism. Antioxidants (Basel). 10:6422021. View Article : Google Scholar : PubMed/NCBI | |
|
Mirzaei S, Hushmandi K, Zabolian A, Saleki H, Torabi SMR, Ranjbar A, SeyedSaleh S, Sharifzadeh SO, Khan H, Ashrafizadeh M, et al: Elucidating role of reactive oxygen species (ROS) in cisplatin chemotherapy: A focus on molecular pathways and possible therapeutic strategies. Molecules. 26:23822021. View Article : Google Scholar : PubMed/NCBI | |
|
Igney FH and Krammer PH: Death and anti-death: Tumour resistance to apoptosis. Nat Rev Cancer. 2:277–288. 2002. View Article : Google Scholar : PubMed/NCBI | |
|
Saxena N, Yadav P and Kumar O: The Fas/Fas ligand apoptotic pathway is involved in abrin-induced apoptosis. Toxicol Sci. 135:103–118. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Jo E, Jang HJ, Yang KE, Jang MS, Huh YH, Yoo HS, Park JS, Jang IS and Park SJ: Cordyceps militaris induces apoptosis in ovarian cancer cells through TNF-α/TNFR1-mediated inhibition of NF-κB phosphorylation. BMC Complement Med Ther. 20:12020. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang P, Wang H, Chen Y, Lodhi A, Sun C, Sun F, Yan L, Deng Y and Ma H: DR5 related autophagy can promote apoptosis in gliomas after irradiation. Biochem Biophys Res Commun. 522:910–916. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Bergeron S, Beauchemin M and Bertrand R: Camptothecin- and etoposide-induced apoptosis in human leukemia cells is independent of cell death receptor-3 and −4 aggregation but accelerates tumor necrosis factor-related apoptosis-inducing ligand-mediated cell death. Mol Cancer Ther. 3:1659–1669. 2004.PubMed/NCBI | |
|
Brenner C, Cadiou H, Vieira HL, Zamzami N, Marzo I, Xie Z, Leber B, Andrews D, Duclohier H, Reed JC and Kroemer G: Bcl-2 and Bax regulate the channel activity of the mitochondrial adenine nucleotide translocator. Oncogene. 19:329–336. 2000. View Article : Google Scholar : PubMed/NCBI | |
|
Sun KX and Xia HW: Pachymic acid inhibits growth and induces cell cycle arrest and apoptosis in gastric cancer SGC-7901 cells. Oncol Lett. 16:2517–2524. 2018.PubMed/NCBI | |
|
Haque M and Islam M: Pleurotus mushroom induces apoptosis by altering the balance of proapoptotic and antiapoptotic genes in breast cancer cells and inhibits tumor sphere formation. Medicina (Kaunas). 55:7162019. View Article : Google Scholar : PubMed/NCBI | |
|
Kim JS, Cho IA, Kang KR, Lim H, Kim TH, Yu SK, Kim HJ, Lee SA, Moon SM, Chun HS, et al: Reversine induces caspase-dependent apoptosis of human osteosarcoma cells through extrinsic and intrinsic apoptotic signaling pathways. Genes Genomics. 41:657–665. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Kuranaga E: Beyond apoptosis: Caspase regulatory mechanisms and functions in vivo. Genes Cells. 17:83–97. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Moloney JN and Cotter TG: ROS signalling in the biology of cancer. Semin Cell Dev Biol. 80:50–64. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Lin S, Li Y, Zamyatnin AA Jr, Werner J and Bazhin AV: Reactive oxygen species and colorectal cancer. J Cell Physiol. 233:5119–5132. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Lin B, Chen H, Liang D, Lin W, Qi X, Liu H and Deng X: Acidic pH and high-H2O2 dual tumor microenvironment-responsive nanocatalytic graphene oxide for cancer selective therapy and recognition. ACS Appl Mater Interfaces. 11:11157–11166. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Choi EJ and Jeon SM: NRF2-driven redox metabolism takes center stage in cancer metabolism from an outside-in perspective. Arch Pharm Res. 43:321–336. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Um HD: Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: A review focusing on mitochondrial respiration and reactive oxygen species. Oncotarget. 7:5193–5203. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
You L, Dong X, Ni B, Fu J, Yang C, Yin X, Leng X and Ni J: Triptolide induces apoptosis through fas death and mitochondrial pathways in HepaRG cell line. Front Pharmacol. 9:8132018. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu Q, Guo Y, Chen S, Fu D, Li Y, Li Z and Ni C: Irinotecan induces autophagy-dependent apoptosis and positively regulates ROS-related JNK- and p38-MAPK pathways in gastric cancer cells. Onco Targets Ther. 13:2807–2817. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Zang YQ, Feng YY, Luo YH, Zhai YQ, Ju XY, Feng YC, Sheng YN, Wang JR, Yu CQ and Jin CH: Quinalizarin induces ROS-mediated apoptosis via the MAPK, STAT3 and NF-κB signaling pathways in human breast cancer cells. Mol Med Rep. 20:4576–4586. 2019.PubMed/NCBI | |
|
Hwang KE, Park C, Kwon SJ, Kim YS, Park DS, Lee MK, Kim BR, Park SH, Yoon KH, Jeong ET, et al: Synergistic induction of apoptosis by sulindac and simvastatin in A549 human lung cancer cells via reactive oxygen species-dependent mitochondrial dysfunction. Int J Oncol. 43:262–270. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang T, He WH, Feng LL and Huang HG: Effect of doxorubicin-induced ovarian toxicity on mouse ovarian granulosa cells. Regul Toxicol Pharmacol. 86:1–10. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Liu H, Jiang W, Wang Q, Hang L and Wang Y and Wang Y: ROS-sensitive biomimetic nanocarriers modulate tumor hypoxia for synergistic photodynamic chemotherapy. Biomater Sci. 7:3706–3716. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Lopes TZ, de Moraes FR, Tedesco AC, Arni RK, Rahal P and Calmon MF: Berberine associated photodynamic therapy promotes autophagy and apoptosis via ROS generation in renal carcinoma cells. Biomed Pharmacother. 123:1097942020. View Article : Google Scholar : PubMed/NCBI | |
|
Mowers EE, Sharifi MN and Macleod KF: Functions of autophagy in the tumor microenvironment and cancer metastasis. FEBS J. 285:1751–1766. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Gao L, Loveless J, Shay C and Teng Y: Targeting ROS-mediated crosstalk between autophagy and apoptosis in cancer. Adv Exp Med Biol. 1260:1–12. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Li L, Tan J, Miao Y, Lei P and Zhang Q: ROS and autophagy: Interactions and molecular regulatory mechanisms. Cell Mol Neurobiol. 35:615–621. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Z, Wang H, Fang S and Xu C: Roles of endoplasmic reticulum stress and autophagy on H2O2-induced oxidative stress injury in HepG2 cells. Mol Med Rep. 18:4163–4174. 2018.PubMed/NCBI | |
|
Lien JC, Lin MW, Chang SJ, Lai KC, Huang AC, Yu FS and Chung JG: Tetrandrine induces programmed cell death in human oral cancer CAL 27 cells through the reactive oxygen species production and caspase-dependent pathways and associated with beclin-1-induced cell autophagy. Environ Toxicol. 32:329–343. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Kim KY, Park KI, Kim SH, Yu SN, Park SG, Kim YW, Seo YK, Ma JY and Ahn SC: Inhibition of autophagy promotes salinomycin-induced apoptosis via reactive oxygen species-mediated PI3K/AKT/mTOR and ERK/p38 MAPK-dependent signaling in human prostate cancer cells. Int J Mol Sci. 18:10882017. View Article : Google Scholar : PubMed/NCBI | |
|
Wei B, Huang Q, Huang S, Mai W and Zhong X: Trichosanthin-induced autophagy in gastric cancer cell MKN-45 is dependent on reactive oxygen species (ROS) and NF-κB/p53 pathway. J Pharmacol Sci. 131:77–83. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Li L, Chen Y and Gibson SB: Starvation-induced autophagy is regulated by mitochondrial reactive oxygen species leading to AMPK activation. Cell Signa. 25:50–65. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ and Han J: RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis. Science. 325:332–336. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Schenk B and Fulda S: Reactive oxygen species regulate Smac mimetic/TNFα-induced necroptotic signaling and cell death. Oncogene. 34:5796–5806. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Gong P, Kong C and Tian X: Bufalin engages in RIP1-dependent and ROS-dependent programmed necroptosis in breast cancer cells by targeting the RIP1/RIP3/PGAM5 pathway. Anticancer Drugs. 30:e07702019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang Z, Huang D, Wu R and Han J: RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome. Nat Commun. 8:143292017. View Article : Google Scholar : PubMed/NCBI | |
|
Pawlikowska M, Piotrowski J, Jędrzejewski T, Kozak W, Slominski AT and Brożyna AA: Coriolus versicolor-derived protein-bound polysaccharides trigger the caspase-independent cell death pathway in amelanotic but not melanotic melanoma cells. Phytother Res. 34:173–183. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, et al: RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis. Nat Cell Biol. 20:186–197. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Tu HC, Ren D, Wang GX, Chen DY, Westergard TD, Kim H, Sasagawa S, Hsieh JJ and Cheng EH: The p53-cathepsin axis cooperates with ROS to activate programmed necrotic death upon DNA damage. Proc Natl Acad Sci USA. 106:1093–1098. 2009. View Article : Google Scholar : PubMed/NCBI | |
|
Ying Y and Padanilam BJ: Regulation of necrotic cell death: p53, PARP1 and cyclophilin D-overlapping pathways of regulated necrosis? Cell Mol Life Sci. 73:2309–2324. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng Q and Hou W: Regulation of angiogenesis by microRNAs in cancer. Mol Med Rep. 24:5832021. View Article : Google Scholar : PubMed/NCBI | |
|
Aggarwal V, Tuli HS, Varol A, Thakral F, Yerer MB, Sak K, Varol M, Jain A, Khan MA and Sethi G: Role of reactive oxygen species in cancer progression: Molecular mechanisms and recent advancements. Biomolecules. 9:7352019. View Article : Google Scholar : PubMed/NCBI | |
|
Liu B, Cui LS, Zhou B, Zhang LL, Liu ZH and Zhang L: Monocarbonyl curcumin analog A2 potently inhibits angiogenesis by inducing ROS-dependent endothelial cell death. Acta Pharmacol Sin. 40:1412–1423. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Watson EC, Grant ZL and Coultas L: Endothelial cell apoptosis in angiogenesis and vessel regression. Cell Mol Life Sci. 74:4387–4403. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Sakamaki K: Regulation of endothelial cell death and its role in angiogenesis and vascular regression. Curr Neurovasc Res. 1:305–315. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Miao Y, Cui L, Chen Z and Zhang L: Gene expression profiling of DMU-212-induced apoptosis and anti-angiogenesis in vascular endothelial cells. Pharm Biol. 54:660–666. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Li GH, Lin XL, Zhang H, Li S, He XL, Zhang K, Peng J, Tang YL, Zeng JF, Zhao Y, et al: Ox-Lp(a) transiently induces HUVEC autophagy via an ROS-dependent PAPR-1-LKB1-AMPK-mTOR pathway. Atherosclerosis. 243:223–235. 2015.Corrigendum in: Atherosclerosis 250: 189, 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Topalovski M, Hagopian M, Wang M and Brekken RA: Hypoxia and transforming growth factor β cooperate to induce fibulin-5 expression in pancreatic cancer. J Biol Chem. 291:22244–22252. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Zeferino RC, Mota NSRS, Grinevicius VMAS, Filipe KB, Sulis PM, Silva FRMB, Filho DW, Pich CT and Pedrosa RC: Targeting ROS overgeneration by N-benzyl-2-nitro-1-imidazole-acetamide as a potential therapeutic reposition approach for cancer therapy. Invest New Drugs. 38:785–799. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Duraipandy N, Dharunya G, Lakra R, Korapatti PS and Syamala Kiran M: Fabrication of plumbagin on silver nanoframework for tunable redox modulation: Implications for therapeutic angiogenesis. J Cell Physiol. 234:13110–13127. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Cao J, Liu X, Yang Y, Wei B, Li Q, Mao G, He Y, Li Y, Zheng L, Zhang Q, et al: Decylubiquinone suppresses breast cancer growth and metastasis by inhibiting angiogenesis via the ROS/p53/ BAI1 signaling pathway. Angiogenesis. 23:325–338. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Nurmik M, Ullmann P, Rodriguez F, Haan S and Letellier E: In search of definitions: Cancer-associated fibroblasts and their markers. Int J Cancer. 146:895–905. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Liao Z, Tan ZW, Zhu P and Tan NS: Cancer-associated fibroblasts in tumor microenvironment-Accomplices in tumor malignancy. Cell Immunol. 343:1037292019. View Article : Google Scholar : PubMed/NCBI | |
|
Pereira BA, Vennin C, Papanicolaou M, Chambers CR, Herrmann D, Morton JP, Cox TR and Timpson P: CAF Subpopulations: A new reservoir of stromal targets in pancreatic cancer. Trends Cancer. 5:724–741. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Kim BG, Sung JS, Jang Y, Cha YJ, Kang S, Han HH, Lee JH and Cho NH: Compression-induced expression of glycolysis genes in CAFs correlates with EMT and angiogenesis gene expression in breast cancer. Commun Biol. 2:3132019. View Article : Google Scholar : PubMed/NCBI | |
|
Eiro N, González L, Martínez-Ordoñez A, Fernandez-Garcia B, González LO, Cid S, Dominguez F, Perez-Fernandez R and Vizoso FJ: Cancer-associated fibroblasts affect breast cancer cell gene expression, invasion and angiogenesis. Cell Oncol (Dordr). 41:369–378. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Takahashi H, Sakakura K, Kudo T, Toyoda M, Kaira K, Oyama T and Chikamatsu K: Cancer-associated fibroblasts promote an immunosuppressive microenvironment through the induction and accumulation of protumoral macrophages. Oncotarget. 8:8633–8647. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yan Y, Chen X, Wang X, Zhao Z, Hu W, Zeng S, Wei J, Yang X, Qian L, Zhou S, et al: The effects and the mechanisms of autophagy on the cancer-associated fibroblasts in cancer. J Exp Clin Cancer Res. 38:1712019. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang X, Schönrogge M, Eichberg J, Wendt EHU, Kumstel S, Stenzel J, Lindner T, Jaster R, Krause B, Vollmar B and Zechner D: Blocking autophagy in cancer-associated fibroblasts supports chemotherapy of pancreatic cancer cells. Front Oncol. 8:5902018. View Article : Google Scholar : PubMed/NCBI | |
|
Attieh Y and Vignjevic D: The hallmarks of CAFs in cancer invasion. Eur J Cell Biol. 95:493–502. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Yao Q, Qu X, Yang Q, Wei M and Kong B: CLIC4 mediates TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiation in ovarian cancer. Oncol Rep. 22:541–548. 2009.PubMed/NCBI | |
|
Sampson N, Brunner E, Weber A, Puhr M, Schäfer G, Szyndralewiez C and Klocker H: Inhibition of Nox4-dependent ROS signaling attenuates prostate fibroblast activation and abrogates stromal-mediated protumorigenic interactions. Int J Cancer. 143:383–395. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Toullec A, Gerald D, Despouy G, Bourachot B, Cardon M, Lefort S, Richardson M, Rigaill G, Parrini MC, Lucchesi C, et al: Oxidative stress promotes myofibroblast differentiation and tumour spreading. EMBO Mol Med. 2:211–230. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Martinez-Outschoorn UE, Lisanti MP and Sotgia F: Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Semin Cancer Biol. 25:47–60. 2014. View Article : Google Scholar : PubMed/NCBI | |
|
Lisanti MP, Martinez-Outschoorn UE, Chiavarina B, Pavlides S, Whitaker-Menezes D, Tsirigos A, Witkiewicz A, Lin Z, Balliet R, Howell A and Sotgia F: Understanding the ‘lethal’ drivers of tumor-stroma co-evolution: Emerging role(s) for hypoxia, oxidative stress and autophagy/mitophagy in the tumor micro-environment. Cancer Biol Ther. 10:537–542. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, et al: Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment. Cell Cycle. 9:3515–3533. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Bernard M, Yang B, Migneault F, Turgeon J, Dieudé M, Olivier MA, Cardin GB, El-Diwany M, Underwood K, Rodier F and Hébert MJ: Autophagy drives fibroblast senescence through MTORC2 regulation. Autophagy. 16:2004–2016. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Urbano AM: Otto Warburg: The journey towards the seminal discovery of tumor cell bioenergetic reprogramming. Biochim Biophys Acta Mol Basis Dis. 1867:1659652021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang D, Wang Y, Shi Z, Liu J, Sun P, Hou X, Zhang J, Zhao S, Zhou BP and Mi J: Metabolic reprogramming of cancer-associated fibroblasts by IDH3α downregulation. Cell Rep. 10:1335–1348. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Martinez-Outschoorn UE, Goldberg A, Lin Z, Ko YH, Flomenberg N, Wang C, Pavlides S, Pestell RG, Howell A, Sotgia F and Lisanti MP: Anti-estrogen resistance in breast cancer is induced by the tumor microenvironment and can be overcome by inhibiting mitochondrial function in epithelial cancer cells. Cancer Biol Ther. 12:924–938. 2011. View Article : Google Scholar : PubMed/NCBI | |
|
Feng X, Xu W, Li Z, Song W, Ding J and Chen X: Immunomodulatory nanosystems. Adv Sci (Weinh). 6:19001012019. View Article : Google Scholar : PubMed/NCBI | |
|
Hamieh M, Dobrin A, Cabriolu A, van der Stegen SJC, Giavridis T, Mansilla-Soto J, Eyquem J, Zhao Z, Whitlock BM, Miele MM, et al: CAR T cell trogocytosis and cooperative killing regulate tumour antigen escape. Nature. 568:112–116. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Strickler JH, Hanks BA and Khasraw M: Tumor mutational burden as a predictor of immunotherapy response: Is more always better? Clin Cancer Res. 27:1236–1241. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Carreau N and Pavlick A: Revolutionizing treatment of advanced melanoma with immunotherapy. Surg Oncol. Jan 12–2019.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI | |
|
Boyero L, Sánchez-Gastaldo A, Alonso M, Noguera-Uclés JF, Molina-Pinelo S and Bernabé-Caro R: Primary and acquired resistance to immunotherapy in lung cancer: Unveiling the mechanisms underlying of immune checkpoint blockade therapy. Cancers (Basel). 12:37292020. View Article : Google Scholar : PubMed/NCBI | |
|
Anichini A, Perotti VE, Sgambelluri F and Mortarini R: Immune escape mechanisms in non small cell lung cancer. Cancers (Basel). 12:36052020. View Article : Google Scholar : PubMed/NCBI | |
|
Marshall LA, Marubayashi S, Jorapur A, Jacobson S, Zibinsky M, Robles O, Hu DX, Jackson JJ, Pookot D, Sanchez J, et al: Tumors establish resistance to immunotherapy by regulating Treg recruitment via CCR4. J Immunother Cancer. 8:e0007642020. View Article : Google Scholar : PubMed/NCBI | |
|
Mima K, Kosumi K, Baba Y, Hamada T, Baba H and Ogino S: The microbiome, genetics, and gastrointestinal neoplasms: The evolving field of molecular pathological epidemiology to analyze the tumor-immune-microbiome interaction. Hum Genet. 140:725–746. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Ali AMR, Tsai JW, Leung CH, Lin H, Ravi V, Conley AP, Lazar AJ, Wang WL and Nathenson MJ: The immune microenvironment of uterine adenosarcomas. Clin Sarcoma Res. 10:52020. View Article : Google Scholar : PubMed/NCBI | |
|
Kosmaczewska A, Ciszak L, Potoczek S and Frydecka I: The significance of Treg cells in defective tumor immunity. Arch Immunol Ther Exp (Warsz). 56:181–191. 2008. View Article : Google Scholar : PubMed/NCBI | |
|
Lindau D, Gielen P, Kroesen M, Wesseling P and Adema GJ: The immunosuppressive tumour network: Myeloid-derived suppressor cells, regulatory T cells and natural killer T cells. Immunology. 138:105–115. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Augustin RC, Delgoffe GM and Najjar YG: Characteristics of the tumor microenvironment that influence immune cell functions: Hypoxia, oxidative stress, metabolic alterations. Cancers (Basel). 12:38022020. View Article : Google Scholar : PubMed/NCBI | |
|
Lötscher J and Balmer ML: Sensing between reactions-how the metabolic microenvironment shapes immunity. Clin Exp Immunol. 197:161–169. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Kotsafti A and Scarpa M, Castagliuolo I and Scarpa M: Reactive oxygen species and antitumor immunity-from surveillance to evasion. Cancers (Basel). 12:17482020. View Article : Google Scholar : PubMed/NCBI | |
|
Yin Y, Jiang X, Sun L, Li H, Su C, Zhang Y, Xu G, Li X, Zhao C, Chen Y, Xu H and Zhang K: Continuous inertial cavitation evokes massive ROS for reinforcing sonodynamic therapy and immunogenic cell death against breast carcinoma. Nano Today. 36:1010092021. View Article : Google Scholar : PubMed/NCBI | |
|
Yang J, Ma S, Xu R, Wei Y, Zhang J, Zuo T, Wang Z, Deng H, Yang N and Shen Q: Smart biomimetic metal organic frameworks based on ROS-ferroptosis-glycolysis regulation for enhanced tumor chemo-immunotherapy. J Control Release. 334:21–33. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Nakamura Y, Zhenjie Z, Oya K, Tanaka R, Ishitsuka Y, Okiyama N, Watanabe R and Fujisawa Y: Poor lymphocyte infiltration to primary tumors in acral lentiginous melanoma and mucosal melanoma compared to cutaneous melanoma. Front Oncol. 10:5247002020. View Article : Google Scholar : PubMed/NCBI | |
|
Murphy MP and Siegel RM: Mitochondrial ROS fire up T cell activation. Immunity. 38:201–202. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Kaminski MM, Sauer SW, Klemke CD, Süss D, Okun JG, Krammer PH and Gülow K: Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: Mechanism of ciprofloxacin-mediated immunosuppression. J Immunol. 184:4827–4841. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Li Y, Liang R, Zhang X, Wang J, Shan C, Liu S, Li L and Zhang S: Copper chaperone for superoxide dismutase promotes breast cancer cell proliferation and migration ROS-Mediated MAPK/ERK signaling. Front Pharmacol. 10:3562019. View Article : Google Scholar : PubMed/NCBI | |
|
Ball JA, Vlisidou I, Blunt MD, Wood W and Ward SG: Hydrogen peroxide triggers a dual signaling axis to selectively suppress activated human T lymphocyte migration. J Immunol. 198:3679–3689. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Kuang Z, Zhang D, Gao Y, Ying M and Wang T: Reactive oxygen species in immune cells: A new antitumor target. Biomed Pharmacother. 133:1109782021. View Article : Google Scholar : PubMed/NCBI | |
|
Belikov AV, Schraven B and Simeoni L: T cells and reactive oxygen species. J Biomed Sci. 22:852015. View Article : Google Scholar : PubMed/NCBI | |
|
Scharping NE, Rivadeneira DB, Menk AV, Vignali PDA, Ford BR, Rittenhouse NL, Peralta R, Wang Y, Wang Y, DePeaux K, et al: Mitochondrial stress induced by continuous stimulation under hypoxia rapidly drives T cell exhaustion. Nat Immunol. 22:205–215. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Franco F, Jaccard A, Romero P, Yu YR and Ho PC: Metabolic and epigenetic regulation of T-cell exhaustion. Nat Metab. 2:1001–1012. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Salas-Benito D, Conde E, Tamayo-Uria I, Mancheño U, Elizalde E, Garcia-Ros D, Aramendia JM, Muruzabal JC, Alcaide J, Guillen-Grima F, et al: The mutational load and a T-cell inflamed tumour phenotype identify ovarian cancer patients rendering tumour-reactive T cells from PD-1+tumour-infiltrating lymphocytes. Br J Cancer. 124:1138–1149. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Kumar A, Chamoto K, Chowdhury PS and Honjo T: Tumors attenuating the mitochondrial activity in T cells escape from PD-1 blockade therapy. Elife. 9:e523302020. View Article : Google Scholar : PubMed/NCBI | |
|
Chamoto K, Chowdhury PS, Kumar A, Sonomura K, Matsuda F, Fagarasan S and Honjo T: Mitochondrial activation chemicals synergize with surface receptor PD-1 blockade for T cell-dependent antitumor activity. Proc Natl Acad Sci USA. 114:E761–E770. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Xia Y, Jia C, Xue Q, Jiang J, Xie Y, Wang R, Ran Z, Xu F, Zhang Y and Ye T: Antipsychotic drug trifluoperazine suppresses colorectal cancer by inducing G0/G1 arrest and apoptosis. Front Pharmacol. 10:10292019. View Article : Google Scholar : PubMed/NCBI | |
|
Bailly C: Regulation of PD-L1 expression on cancer cells with ROS-modulating drugs. Life Sci. 246:1174032020. View Article : Google Scholar : PubMed/NCBI | |
|
Liu K, Du S, Gao P and Zheng J: Verteporfin suppresses the proliferation, epithelial-mesenchymal transition and stemness of head and neck squamous carcinoma cells via inhibiting YAP1. J Cancer. 10:4196–4207. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Marangoni F, Zhakyp A, Corsini M, Geels SN, Carrizosa E, Thelen M, Mani V, Prüßmann JN, Warner RD, Ozga AJ, et al: Expansion of tumor-associated Treg cells upon disruption of a CTLA-4-dependent feedback loop. Cell. Jun 21–2021.(Epub ahead of print). View Article : Google Scholar : PubMed/NCBI | |
|
Ni D, Tang T, Lu Y, Xu K, Shao Y, Saaoud F, Saredy J, Liu L, Drummer C 4th, Sun Y, et al: Canonical secretomes, innate immune caspase-1-, 4/11-gasdermin D non-canonical secretomes and exosomes may contribute to maintain treg-ness for treg immunosuppression, tissue repair and modulate anti-tumor immunity via ROS pathways. Front Immunol. 12:6782012021. View Article : Google Scholar : PubMed/NCBI | |
|
Hang S, Paik D, Yao L, Kim E, Trinath J, Lu J, Ha S, Nelson BN, Kelly SP, Wu L, et al: Bile acid metabolites control T(H)17 and T(reg) cell differentiation. Nature. 576:143–148. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Kunisada Y, Eikawa S, Tomonobu N, Domae S, Uehara T, Hori S, Furusawa Y, Hase K, Sasaki A and Udono H: Attenuation of CD4 + CD25 + regulatory T cells in the tumor microenvironment by metformin, a type 2 diabetes drug. EBioMedicine. 25:154–164. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Yu X, Lao Y, Teng XL, Li S, Zhou Y, Wang F, Guo X, Deng S, Chang Y, Wu X, et al: SENP3 maintains the stability and function of regulatory T cells via BACH2 deSUMOylation. Nat Commun. 9:31572018. View Article : Google Scholar : PubMed/NCBI | |
|
Maj T, Wang W, Crespo J, Zhang H, Wang W, Wei S, Zhao L, Vatan L, Shao I, Szeliga W, et al: Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor. Nat Immunol. 18:1332–1341. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Betten A, Dahlgren C, Mellqvist UH, Hermodsson S and Hellstrand K: Oxygen radical-induced natural killer cell dysfunction: Role of myeloperoxidase and regulation by serotonin. J Leukoc Biol. 75:1111–1115. 2004. View Article : Google Scholar : PubMed/NCBI | |
|
Zheng X, Qian Y, Fu B, Jiao D, Jiang Y, Chen P, Shen Y, Zhang H, Sun R, Tian Z and Wei H: Mitochondrial fragmentation limits NK cell-based tumor immunosurveillance. Nat Immunol. 20:1656–1667. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Mimura K, Kua LF, Shimasaki N, Shiraishi K, Nakajima S, Siang LK, Shabbir A, So J, Yong WP and Kono K: Upregulation of thioredoxin-1 in activated human NK cells confers increased tolerance to oxidative stress. Cancer Immunol Immunother. 66:605–613. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Aydin E, Johansson J, Nazir FH, Hellstrand K and Martner A: Role of NOX2-derived reactive oxygen species in NK cell-mediated control of murine melanoma metastasis. Cancer Immunol Res. 5:804–811. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Aurelius J, Martner A, Riise RE, Romero AI, Palmqvist L, Brune M, Hellstrand K and Thorén FB: Chronic myeloid leukemic cells trigger poly(ADP-ribose) polymerase-dependent inactivation and cell death in lymphocytes. J Leukoc Biol. 93:155–160. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Gu FF, Zhang K, Ma LL, Liu YY, Li C, Hu Y, Yang QF, Liang JY, Zeng YL, Wang Y and Liu L: The superior ability of human BDCA3 + (CD141 +) dendritic cells (DCs) to cross-present antigens derived from necrotic lung cancer cells. Front Immunol. 11:12672020. View Article : Google Scholar : PubMed/NCBI | |
|
Paardekooper LM, Vos W and van den Bogaart G: Oxygen in the tumor microenvironment: Effects on dendritic cell function. Oncotarget. 10:883–896. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Giovanelli P, Sandoval TA and Cubillos-Ruiz JR: Dendritic cell metabolism and function in tumors. Trends Immunol. 40:699–718. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Chougnet CA, Thacker RI, Shehata HM, Hennies CM, Lehn MA, Lages CS and Janssen EM: Loss of phagocytic and antigen cross-presenting capacity in aging dendritic cells is associated with mitochondrial dysfunction. J Immunol. 195:2624–2632. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Mao D, Hu F, Yi Z, Kenry, Xu S, Yan S, Luo Z, Wu W, Wang Z, Kong D, et al: AIEgen-coupled upconversion nanoparticles eradicate solid tumors through dual-mode ROS activation. Sci Adv. 6:eabb27122020. View Article : Google Scholar : PubMed/NCBI | |
|
Wang C, Li P, Liu L, Pan H, Li H, Cai L and Ma Y: Self-adjuvanted nanovaccine for cancer immunotherapy: Role of lysosomal rupture-induced ROS in MHC class I antigen presentation. Biomaterials. 79:88–100. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Oberkampf M, Guillerey C, Mouriès J, Rosenbaum P, Fayolle C, Bobard A, Savina A, Ogier-Denis E, Enninga J, Amigorena S, et al: Mitochondrial reactive oxygen species regulate the induction of CD8 T cells by plasmacytoid dendritic cells. Nature Commun. 9:22412018. View Article : Google Scholar : PubMed/NCBI | |
|
DeNardo D and Ruffell B: Macrophages as regulators of tumour immunity and immunotherapy. Nat Rev Immunol. 19:369–382. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Allavena P, Anfray C, Ummarino A and Andón FT: Therapeutic manipulation of tumor-associated macrophages: Facts and hopes from a clinical and translational perspective. Clin Cancer Res. 27:3291–3297. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhang J, Li H, Wu Q, Chen Y, Deng Y, Yang Z, Zhang L and Liu B: Tumoral NOX4 recruits M2 tumor-associated macrophages via ROS/PI3K signaling-dependent various cytokine production to promote NSCLC growth. Redox Biol. 22:1011162019. View Article : Google Scholar : PubMed/NCBI | |
|
Li L, Sun F, Han L, Liu X, Xiao Y, Gregory AD, Shapiro SD, Xiao G and Qu Z: PDLIM2 repression by ROS in alveolar macrophages promotes lung tumorigenesis. JCI Insight. 6:e1443942021. View Article : Google Scholar : PubMed/NCBI | |
|
Lin X, Zheng W, Liu J, Zhang Y, Qin H, Wu H, Xue B, Lu Y and Shen P: Oxidative stress in malignant melanoma enhances tumor necrosis factor-α secretion of tumor-associated macrophages that promote cancer cell invasion. Antioxid Redox Signal. 19:1337–1355. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Griess B, Mir S, Datta K and Teoh-Fitzgerald M: Scavenging reactive oxygen species selectively inhibits M2 macrophage polarization and their pro-tumorigenic function in part, via Stat3 suppression. Free Radic Biol Med. 147:48–60. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ruan J, Ouyang M, Zhang W, Luo Y and Zhou D: The effect of PD-1 expression on tumor-associated macrophage in T cell lymphoma. Clin Transl Oncol. 23:1134–1141. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Wei Y, Huang CX, Xiao X, Chen DP, Shan H, He H and Kuang DM: B cell heterogeneity, plasticity, and functional diversity in cancer microenvironments. Oncogene. Jun 29–2021.(Epub ahead of print). View Article : Google Scholar | |
|
Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, et al: B cells and tertiary lymphoid structures promote immunotherapy response. Nature. 577:549–555. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Cabrita R, Lauss M, Sanna A, Donia M, Skaarup Larsen M, Mitra S, Johansson I, Phung B, Harbst K, et al: Tertiary lymphoid structures improve immunotherapy and survival in melanoma. Nature. 577:561–565. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Petitprez F, de Reyniès A, Keung EZ, Chen TW, Sun CM, Calderaro J, Jeng YM, Hsiao LP, Lacroix L, Bougoüin A, et al: B cells are associated with survival and immunotherapy response in sarcoma. Nature. 577:556–560. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Jang JW, Thuy PX, Lee JW and Moon EY: CXCR4 promotes B cell viability by the cooperation of nuclear factor (erythroid-derived 2)-like 2 and hypoxia-inducible factor-1α under hypoxic conditions. Cell Death Dis. 12:3302021. View Article : Google Scholar : PubMed/NCBI | |
|
Feng YY, Tang M, Suzuki M, Gunasekara C, Anbe Y, Hiraoka Y, Liu J, Grasberger H, Ohkita M, Matsumura Y, et al: Essential role of NADPH oxidase-dependent production of reactive oxygen species in maintenance of sustained B Cell receptor signaling and b cell proliferation. J Immunol. 202:2546–2557. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Jang KJ, Mano H, Aoki K, Hayashi T, Muto A, Nambu Y, Takahashi K, Itoh K, Taketani S, Nutt SL, et al: Mitochondrial function provides instructive signals for activation-induced B-cell fates. Nat Commun. 6:67502015. View Article : Google Scholar : PubMed/NCBI | |
|
Onnis A, Cianfanelli V, Cassioli C, Samardzic D, Pelicci PG, Cecconi F and Baldari CT: The pro-oxidant adaptor p66SHC promotes B cell mitophagy by disrupting mitochondrial integrity and recruiting LC3-II. Autophagy. 14:2117–2138. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Onnis A, Cassioli C, Finetti F and Baldari CT: Regulation of selective B cell autophagy by the pro-oxidant adaptor p66SHC. Front Cell Dev Biol. 8:1932020. View Article : Google Scholar : PubMed/NCBI | |
|
Yin K, Xia X, Rui K, Wang T and Wang S: Myeloid-derived suppressor cells: A new and pivotal player in colorectal cancer progression. Front Oncol. 10:6101042020. View Article : Google Scholar : PubMed/NCBI | |
|
Ohl K and Tenbrock K: Reactive oxygen species as regulators of MDSC-mediated immune suppression. Front Immunol. 9:24992018. View Article : Google Scholar : PubMed/NCBI | |
|
Kusmartsev S and Gabrilovich DI: Inhibition of myeloid cell differentiation in cancer: The role of reactive oxygen species. J Leukoc Biol. 74:186–196. 2003. View Article : Google Scholar : PubMed/NCBI | |
|
Park MJ, Lee SH, Kim EK, Lee EJ, Baek JA, Park SH, Kwok SK and Cho ML: Interleukin-10 produced by myeloid-derived suppressor cells is critical for the induction of Tregs and attenuation of rheumatoid inflammation in mice. Sci Rep. 8:37532018. View Article : Google Scholar : PubMed/NCBI | |
|
Fortin C, Yang Y and Huang X: Monocytic myeloid-derived suppressor cells regulate T-cell responses against vaccinia virus. Eur J Immunol. 47:1022–1031. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Zhu J, Huang X and Yang Y: Myeloid-derived suppressor cells regulate natural killer cell response to adenovirus-mediated gene transfer. J Virol. 86:13689–13696. 2012. View Article : Google Scholar : PubMed/NCBI | |
|
Dong G, Yang Y, Li X, Yao X, Zhu Y, Zhang H, Wang H, Ma Q, Zhang J, Shi H, et al: Granulocytic myeloid-derived suppressor cells contribute to IFN-I signaling activation of B cells and disease progression through the lncRNA NEAT1-BAFF axis in systemic lupus erythematosus. Biochim Biophys Acta Mol Basis Dis. 1866:1655542020. View Article : Google Scholar : PubMed/NCBI | |
|
Jaufmann J, Lelis FJN, Teschner AC, Fromm K, Rieber N, Hartl D and Beer-Hammer S: Human monocytic myeloid-derived suppressor cells impair B-cell phenotype and function in vitro. Eur J Immunol. 50:33–47. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Lelis FJN, Jaufmann J, Singh A, Fromm K, Teschner AC, Pöschel S, Schäfer I, Beer-Hammer S, Rieber N and Hartl D: Myeloid-derived suppressor cells modulate B-cell responses. Immunol Lett. 188:108–115. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Satoh H, Moriguchi T, Taguchi K, Takai J, Maher JM, Suzuki T, Winnard PT Jr, Raman V, Ebina M, Nukiwa T and Yamamoto M: Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung. Carcinogenesis. 31:1833–1843. 2010. View Article : Google Scholar : PubMed/NCBI | |
|
Saleh R and Elkord E: Acquired resistance to cancer immunotherapy: Role of tumor-mediated immunosuppression. Semin Cancer Biol. 65:13–27. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Hernández ÁP, Juanes-Velasco P, Landeira-Viñuela A, Bareke H, Montalvillo E, Góngora R and Fuentes M: Restoring the immunity in the tumor microenvironment: Insights into immunogenic cell death in onco-therapies. Cancers (Basel). 13:28212021. View Article : Google Scholar : PubMed/NCBI | |
|
Galluzzi L, Buqué A, Kepp O, Zitvogel L and Kroemer G: Immunogenic cell death in cancer and infectious disease. Nat Rev Immunol. 17:97–111. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Li Z, Zhu L, Sun H, Shen Y, Hu D, Wu W, Wang Y, Qian C and Sun M: Fluorine assembly nanocluster breaks the shackles of immunosuppression to turn the cold tumor hot. Proc Natl Acad Sci USA. 117:32962–32969. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Deng H, Yang W, Zhou Z, Tian R, Lin L, Ma Y, Song J and Chen X: Targeted scavenging of extracellular ROS relieves suppressive immunogenic cell death. Nat Commun. 11:49512020. View Article : Google Scholar : PubMed/NCBI | |
|
Garg AD, Dudek AM, Ferreira GB, Verfaillie T, Vandenabeele P, Krysko DV, Mathieu C and Agostinis P: ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death. Autophagy. 9:1292–1307. 2013. View Article : Google Scholar : PubMed/NCBI | |
|
Buono R and Longo VD: Starvation, stress resistance, and cancer. Trends Endocrinol Metab. 29:271–280. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Li XX, Wang ZJ, Zheng Y, Guan YF, Yang PB, Chen X, Peng C, He JP, Ai YL, Wu SF, et al: Nuclear receptor Nur77 facilitates melanoma cell survival under metabolic stress by protecting fatty acid oxidation. Mol Cell. 69:480–492 e7. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Sullivan LB and Chandel NS: Mitochondrial reactive oxygen species and cancer. Cancer Metab. 2:172014. View Article : Google Scholar : PubMed/NCBI | |
|
Wu Z, Zuo M, Zeng L, Cui K, Liu B, Yan C, Chen L, Dong J, Shangguan F, Hu W, et al: OMA1 reprograms metabolism under hypoxia to promote colorectal cancer development. EMBO Rep. 22:e508272020.PubMed/NCBI | |
|
Wang YP, Zhou W, Wang J, Huang X, Zuo Y, Wang TS, Gao X, Xu YY, Zou SW, Liu YB, et al: Arginine Methylation of MDH1 by CARM1 inhibits glutamine metabolism and suppresses pancreatic cancer. Mol Cell. 64:673–687. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Panieri E, Telkoparan-Akillilar P, Suzen S and Saso L: The NRF2/KEAP1 axis in the regulation of tumor metabolism: Mechanisms and therapeutic perspectives. Biomolecules. 10:7912020. View Article : Google Scholar : PubMed/NCBI | |
|
Shao S, Qin T, Qian W, Yue Y, Xiao Y, Li X, Zhang D, Wang Z, Ma Q and Lei J: Positive feedback in Cav-1-ROS signalling in PSCs mediates metabolic coupling between PSCs and tumour cells. J Cell Mol Med. 24:9397–9408. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Ilkhani K, Bastami M, Delgir S, Safi A, Talebian S and Alivand MR: The engaged role of tumor microenvironment in cancer metabolism: Focusing on cancer-associated fibroblast and exosome mediators. Anticancer Agents Med Chem. 21:254–266. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Zhai Y, Chai L and Chen J: The relationship between the expressions of tumor associated fibroblasts Cav-1 and MCT4 and the prognosis of papillary carcinoma of breast. Pak J Pharm Sci. 30 (Suppl 1):S263–S372. 2017. | |
|
Ngwa VM, Edwards DN, Philip M and Chen J: Microenvironmental metabolism regulates antitumor immunity. Cancer Res. 79:4003–4008. 2019. View Article : Google Scholar : PubMed/NCBI | |
|
Song M, Sandoval TA, Chae CS, Chopra S, Tan C, Rutkowski MR, Raundhal M, Chaurio RA, Payne KK, Konrad C, et al: IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity. Nature. 562:423–428. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Gottesman MM, Lavi O, Hall MD and Gillet JP: Toward a better understanding of the complexity of cancer drug resistance. Annu Rev Pharmacol Toxicol. 56:85–102. 2016. View Article : Google Scholar : PubMed/NCBI | |
|
Cui Q, Wang JQ, Assaraf YG, Ren L, Gupta P, Wei L, Ashby CR Jr, Yang DH and Chen ZS: Modulating ROS to overcome multidrug resistance in cancer. Drug Resist Updat. 41:1–25. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Jadhao M, Tsai EM, Yang HC, Chen YF, Liang SS, Wang TN, Teng YN, Huang HW, Wang LF and Chiu CC: The long-term DEHP exposure confers multidrug resistance of triple-negative breast cancer cells through ABC transporters and intracellular ROS. Antioxidants (Basel). 10:9492021. View Article : Google Scholar : PubMed/NCBI | |
|
Lee SY, Jeong EK, Ju MK, Jeon HM, Kim MY, Kim CH, Park HG, Han SI and Kang HS: Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation. Mol Cancer. 16:102017. View Article : Google Scholar : PubMed/NCBI | |
|
Ge W, Zhao K, Wang X, Li H, Yu M, He M, Xue X, Zhu Y, Zhang C, Cheng Y, et al: iASPP is an antioxidative factor and drives cancer growth and drug resistance by competing with Nrf2 for Keap1 Binding. Cancer Cell. 32:561–573.e6. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Wang L, Leite de Oliveira R, Huijberts S, Bosdriesz E, Pencheva N, Brunen D, Bosma A, Song JY, Zevenhoven J, Los-de Vries GT, et al: An acquired vulnerability of drug-resistant melanoma with therapeutic potential. Cell. 173:1413–1425.e14. 2018. View Article : Google Scholar : PubMed/NCBI | |
|
Menéndez ST, Gallego B, Murillo D, Rodríguez A and Rodríguez R: Cancer stem cells as a source of drug resistance in bone sarcomas. J Clin Med. 10:26212021. View Article : Google Scholar : PubMed/NCBI | |
|
Choi HJ, Jhe YL, Kim J, Lim JY, Lee JE, Shin MK and Cheong JH: FoxM1-dependent and fatty acid oxidation-mediated ROS modulation is a cell-intrinsic drug resistance mechanism in cancer stem-like cells. Redox Biol. 36:1015892020. View Article : Google Scholar : PubMed/NCBI | |
|
Banerjee S, Mukherjee S, Bhattacharya A, Basak U, Chakraborty S, Paul S, Khan P, Jana K, Hazra TK and Das T: Pyridoxine enhances chemo-responsiveness of breast cancer stem cells via redox reconditioning. Free Radic Biol Med. 152:152–165. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Li D, Fu Z, Chen R, Zhao X, Zhou Y, Zeng B, Yu M, Zhou Q, Lin Q, Gao W, et al: Inhibition of glutamine metabolism counteracts pancreatic cancer stem cell features and sensitizes cells to radiotherapy. Oncotarget. 6:31151–31163. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Tsai TL, Lai YH, Hw Chen H and Su WC: Overcoming radiation resistance by iron-platinum metal alloy nanoparticles in human copper transport 1-overexpressing cancer cells via mitochondrial disturbance. Int J Nanomedicine. 16:2071–2085. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Li Q, Zhang J, Li J, Ye H, Li M, Hou W, Li H and Wang Z: Glutathione-activated NO-/ROS-generation nanoparticles to modulate the tumor hypoxic microenvironment for enhancing the effect of HIFU-combined chemotherapy. ACS Appl Mater Interfaces. 13:26808–26823. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Chen W, Yu D, Sun SY and Li F: Nanoparticles for co-delivery of osimertinib and selumetinib to overcome osimertinib-acquired resistance in non-small cell lung cancer. Acta Biomater. 29:258–268. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Banstola A, Poudel K, Pathak S, Shrestha P, Kim JO, Jeong JH and Yook S: Hypoxia-mediated ROS amplification triggers mitochondria-mediated apoptotic cell death via PD-L1/ROS-responsive, dual-targeted, drug-laden thioketal nanoparticles. ACS Appl Mater Interfaces. 13:22955–22969. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Cen J, Zhang L, Liu F, Zhang F and Ji BS: Long-term alteration of reactive oxygen species led to multidrug resistance in MCF-7 cells. Oxid Med Cell Longev. 2016:70534512016. View Article : Google Scholar : PubMed/NCBI | |
|
Wang J, Liu L, Cen J and Ji B: BME, a novel compound of anthraquinone, down regulated P-glycoprotein expression in doxorubicin-resistant human myelogenous leukemia (K562/DOX) cells via generation of reactive oxygen species. Chem Biol Interact. 239:139–145. 2015. View Article : Google Scholar : PubMed/NCBI | |
|
Murciano-Goroff YR, Warner AB and Wolchok JD: The future of cancer immunotherapy: Microenvironment-targeting combinations. Cell Res. 30:507–519. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Reina-Campos M, Moscat J and Diaz-Meco M: Metabolism shapes the tumor microenvironment. Curr Opin Cell Biol. 48:47–53. 2017. View Article : Google Scholar : PubMed/NCBI | |
|
Chen X and Cubillos-Ruiz J: Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer. 21:71–88. 2021. View Article : Google Scholar : PubMed/NCBI | |
|
Andrews AM, Tennant MD and Thaxton JE: Stress relief for cancer immunotherapy: Implications for the ER stress response in tumor immunity. Cancer Immunol Immunother. 70:1165–1175. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Harris IS and DeNicola GM: The Complex Interplay between Antioxidants and ROS in Cancer. Trends Cell Biol. 30:440–451. 2020. View Article : Google Scholar : PubMed/NCBI | |
|
Cheung EC, Lee P, Ceteci F, Nixon C, Blyth K, Sansom OJ and Vousden KH: Opposing effects of TIGAR- and RAC1-derived ROS on Wnt-driven proliferation in the mouse intestine. Genes Dev. 30:52–63. 2016. View Article : Google Scholar : PubMed/NCBI |
