Treatment results of esophageal carcinoma of clinical T3, T4M0: historical comparison between neoadjuvant chemoradiotherapy followed by surgery or definitive radiotherapy and conventional surgery.

Murakami,M; Kuroda,Y; Matsusue,S; Okamoto,Y; Nakajima,T; Nishimura,S; Kusumi,F; Hajiro,K; Takeda,H

doi:10.3892/or.7.3.571

May-Jun 2000 Volume 7 Issue 3

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May-Jun 2000 Volume 7 Issue 3

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Article

Treatment results of esophageal carcinoma of clinical T3, T4M0: historical comparison between neoadjuvant chemoradiotherapy followed by surgery or definitive radiotherapy and conventional surgery.

Authors:
- M Murakami
- Y Kuroda
- S Matsusue
- Y Okamoto
- T Nakajima
- S Nishimura
- F Kusumi
- K Hajiro
- H Takeda
View Affiliations / Copyright

Affiliations: Health and Welfare Department, Hyogo Prefectural Government, Chuou-ku, Kobe, Hyogo Prefecture 650-8567, Japan.
Pages: 571-579
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Published online on: May 1, 2000

https://doi.org/10.3892/or.7.3.571
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Abstract

We investigated results for thoracic T3-T4 esophageal squamous cell carcinoma in two strategies. The protocol group (46 patients) consisted of neoadjuvant chemoradiotherapy (44 Gy, CDDP, 5-FU), followed by either definitive radiotherapy (total 70 Gy) for responders or surgery for non-responders. The surgery group (26 patients) underwent esophagectomy with regional lymph node dissection. Nineteen of them received postoperative radiotherapy. Surgical candidates in both groups received intraoperative radiotherapy for abdominal lymphatics since 1991. In the protocol group, 23 patients underwent radical surgery after neoadjuvant chemoradiotherapy and the remaining 23 underwent definitive radiotherapy. The rates of recurrence were 64% in the protocol group, and 62% in the surgery group. Overall 3- and 5-year survival rates were 48% and 31% in the protocol group compared to those of 30% and 30% in the surgery group. The rate of the was 39% in the protocol group. There was no mortality in either group. Our protocol had at least comparable prognostic values with historical conventional surgery, and was excellent in having feasibility for organ preservation.

Journals

International Journal of Molecular Medicine

International Journal of Oncology

Molecular Medicine Reports

Oncology Reports

Experimental and Therapeutic Medicine

Oncology Letters

Biomedical Reports

Molecular and Clinical Oncology

World Academy of Sciences Journal

International Journal of Functional Nutrition

International Journal of Epigenetics

Medicine International

Treatment results of esophageal carcinoma of clinical T3, T4M0: historical comparison between neoadjuvant chemoradiotherapy followed by surgery or definitive radiotherapy and conventional surgery.

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