Lead Editor:
Dr Yongting Luo,
China Agricultural University,
China
Cardiovascular disease (CVD) remains a leading cause of death worldwide. Studies from both basic science and clinic trials lead to a tight causal relationship between oxidative stress and cardiovascular disorders, including atherosclerosis, arterial stenosis, hypertension, cardiac hypertrophy, myocardial infarction, heart failure and ischemia/reperfusion injury. The imbalanced oxidative stress in cardiovascular cells results from severe accumulation of reactive oxygen species (ROS) and impaired antioxidant defence system in response to vascular injury. As a consequent, the alteration in oxidative states acts as key determinants driving disease pathology and progression through exerting detrimental effects on both vascular beds and myocardium. Over the last decades, an emerging but compelling body of research has tried to target oxidative stress using naturally exogenous antioxidants with the aim to reduce CVD risk and improve disease outcome. Indeed, some antioxidants (e.g., coQ10, vitamin E, vitamin C, lycopene, quercetin, beta-carotene and resveratrol) showed encouraging results in improving cardiovascular health by acting analogous to first line therapy or as adjuvants. Mechanistically, bioactive antioxidants, whose biological effects are either structure-, protective- or storage-related, are favourable to cardiovascular healthiness through multiple ways, involving ROS scavenging, mitochondrial homeostasis, immuno-modulation, as well as epigenome regulation. Despite of the great achievements in this field, there are still many important issues to be addressed, including but not limited to low therapeutic efficacy of antioxidants in a certain type of CVD, poor pharmaceutical properties, lack of site-specific delivery, as well as unclear mechanisms of action. Therefore, this Research Topic aims to contribute to filling the gap in the knowledge about the identification and development of new forms of antioxidants, their mechanisms, as well as and potential applications in cardiovascular biology and disease management. This Special Issue aims to be an interdisciplinary platform that covers: 1. Identification and characterization of new antioxidant agents (both exogenous and endogenous) for the intervention and treatment of CVD; 2. Defining mode of action of a specific antioxidant on CVD at the molecular and cellular levels; 3. Development and formulation of new carriers (nanoformulations) or deliver strategies aiming to improve the antioxidant activity, biopharmaceutical property or pharmacokinetics of antioxidants, and ultimately enhance the therapeutic efficacy for CVD. We invite well-designed research articles, reviews, as well as meta-analysis addressing all the above important issues.
Submission deadline:
30/10/2026
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