MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway

  • Authors:
    • Hongling Hu
    • Yu Ding
    • Yang Wang
    • Shuang Geng
    • Jue Liu
    • Jinrong He
    • Yang Lu
    • Xueying Li
    • Mingli Yuan
    • Shan Zhu
    • Su Zhao
  • View Affiliations

  • Published online on: October 17, 2017     https://doi.org/10.3892/etm.2017.5322
  • Pages:6105-6112
0

Abstract

Previous results have indicated that mitochondrial ATP‑sensitive potassium (mitoKATP) channels are associated with the hypoxic proliferation of pulmonary artery smooth muscle cells (PASMCs). However, the mechanism underlying the promotive effects of mitoKATP channels on cell proliferation in response to hypoxia remains unknown. mitoKATP channel opening results in a collapse of mitochondrial membrane potential and generation of mitochondrial reactive oxygen species (ROS). As hypoxia‑inducible factor‑1α (HIF‑1α) is a critical oxygen sensor and major transcriptional regulator of the hypoxic adaptive response, the current study assessed whether mitoKATP opening contributes to the chronic proliferation of human PASMCs (hPASMCs) in collaboration with HIF‑1α and its downstream targets under hypoxic conditions. The present study demonstrated that there was crosstalk between mitoKATP channels and HIF‑1α signaling in PASMCs under hypoxic conditions. The results suggest that mitoKATP channels are involved in the proliferation of PASMCs during hypoxia through upregulation of the ROS/HIF/microRNA‑210/iron‑sulfur cluster protein signaling pathway.

Related Articles

Journal Cover

December 2017
Volume 14 Issue 6

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
(total number of cites)

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
APA
Hu, H., Ding, Y., Wang, Y., Geng, S., Liu, J., He, J. ... Zhao, S. (2017). MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway. Experimental and Therapeutic Medicine, 14, 6105-6112. https://doi.org/10.3892/etm.2017.5322
MLA
Hu, H., Ding, Y., Wang, Y., Geng, S., Liu, J., He, J., Lu, Y., Li, X., Yuan, M., Zhu, S., Zhao, S."MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway". Experimental and Therapeutic Medicine 14.6 (2017): 6105-6112.
Chicago
Hu, H., Ding, Y., Wang, Y., Geng, S., Liu, J., He, J., Lu, Y., Li, X., Yuan, M., Zhu, S., Zhao, S."MitoKATP channels promote the proliferation of hypoxic human pulmonary artery smooth muscle cells via the ROS/HIF/miR‑210/ISCU signaling pathway". Experimental and Therapeutic Medicine 14, no. 6 (2017): 6105-6112. https://doi.org/10.3892/etm.2017.5322