Changes and significance of inflammatory cytokines in a rat model of cervical spondylosis

  • Authors:
    • Jianjian Yin
    • Yongjing Huang
    • Gongming Gao
    • Luming Nong
    • Nanwei Xu
    • Dong Zhou
  • View Affiliations

  • Published online on: November 1, 2017     https://doi.org/10.3892/etm.2017.5418
  • Pages:400-406
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Abstract

The aim of the present study was to dynamically observe and discuss the significance of inflammatory cytokines in cervical degenerative disease induced by unbalanced dynamic and static forces in rats. A total of 60 Sprague Dawley rats were randomized into test (n=45) and control (n=15) groups, which were randomly subdivided into three groups corresponding to assessment at one, three and six months post‑operation. The test group included 10, 15 and 20 rats at the corresponding post‑operative stage and the control group had five rats at each time‑point. By excising cervicodorsal muscles and ligaments, an unbalanced dynamic and static rat model was established in the test group. At one, three and six‑months post‑operation, venous serum of test and control group rats was collected and inflammatory cytokines in the serum of all rats were quantitatively determined by ELISA. The results revealed that compared with the control group, the interleukin (IL)‑1β, IL‑10 and tumor necrosis factor‑α levels in the test group were significantly increased at one and three months (P<0.05, <0.01 or <0.001), and that IL‑12 was significantly increased at three months (P<0.05). However, transforming growth factor‑β1 increased at one month but was significantly decreased at three months (P<0.01). IL‑6 did not change significantly throughout the observation period (P>0.05). In conclusion, cervical vertebral stability may be accompanied with changes of inflammatory cytokines.

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January 2018
Volume 15 Issue 1

Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Yin, J., Huang, Y., Gao, G., Nong, L., Xu, N., & Zhou, D. (2018). Changes and significance of inflammatory cytokines in a rat model of cervical spondylosis. Experimental and Therapeutic Medicine, 15, 400-406. https://doi.org/10.3892/etm.2017.5418
MLA
Yin, J., Huang, Y., Gao, G., Nong, L., Xu, N., Zhou, D."Changes and significance of inflammatory cytokines in a rat model of cervical spondylosis". Experimental and Therapeutic Medicine 15.1 (2018): 400-406.
Chicago
Yin, J., Huang, Y., Gao, G., Nong, L., Xu, N., Zhou, D."Changes and significance of inflammatory cytokines in a rat model of cervical spondylosis". Experimental and Therapeutic Medicine 15, no. 1 (2018): 400-406. https://doi.org/10.3892/etm.2017.5418