Cancer stem cells and hypoxia-inducible factors (Review)

  • Authors:
    • Wei-Wei Tong
    • Guang-Hui Tong
    • Yong Liu
  • View Affiliations

  • Published online on: May 22, 2018     https://doi.org/10.3892/ijo.2018.4417
  • Pages: 469-476
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Cancer stem cells (CSCs), also known as tumor-initiating cells, are a subpopulation of tumor cells that exhibit properties similar to those of normal stem cells. Oxygen is an important regulator of cellular metabolism; hypoxia-inducible factors (HIFs) mediate metabolic switches in cells in hypoxic environments. Hypoxia clearly has the potential to exert a significant effect on the maintenance and evolution of CSCs. Both HIF‑1α and HIF‑2α may contribute to the regulation of cellular adaptation to hypoxia and resistance to cancer therapies. This review provides an overview of the roles of HIFs in CSCs. HIF‑1α and HIF‑2α have significant prognostic and predictive value in the clinic and the concept of personalized medicine should be applied in designing clinical trials for HIF inhibitors.
View Figures
View References

Related Articles

Journal Cover

August-2018
Volume 53 Issue 2

Print ISSN: 1019-6439
Online ISSN:1791-2423

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Tong W, Tong G and Liu Y: Cancer stem cells and hypoxia-inducible factors (Review). Int J Oncol 53: 469-476, 2018
APA
Tong, W., Tong, G., & Liu, Y. (2018). Cancer stem cells and hypoxia-inducible factors (Review). International Journal of Oncology, 53, 469-476. https://doi.org/10.3892/ijo.2018.4417
MLA
Tong, W., Tong, G., Liu, Y."Cancer stem cells and hypoxia-inducible factors (Review)". International Journal of Oncology 53.2 (2018): 469-476.
Chicago
Tong, W., Tong, G., Liu, Y."Cancer stem cells and hypoxia-inducible factors (Review)". International Journal of Oncology 53, no. 2 (2018): 469-476. https://doi.org/10.3892/ijo.2018.4417