Open Access

Integrated strategy of differentially expressed genes associated with ulcerative colitis

  • Authors:
    • Juerong Feng
    • Qian Gao
    • Qing Liu
    • Fan Wang
    • Xue Lin
    • Qiu Zhao
    • Jing Liu
    • Jin Li
  • View Affiliations

  • Published online on: September 18, 2017     https://doi.org/10.3892/mmr.2017.7509
  • Pages: 7479-7489
  • Copyright: © Feng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is associated with both genetic and environmental factors; however, the underlying pathogenesis of UC remains unclear. The present study aimed to further explore 12 microarray datasets from patients with UC obtained from the Gene Expression Omnibus repository, for potential genetic pathogenesis of UC through a global bioinformatics view, which included identification of differentially expressed genes (DEGs), functional enrichments, protein‑protein interactions, transcriptional and post‑transcriptional regulation and drug‑gene associations. This integrated analysis screened 233 DEGs that were compared between UC and normal control tissue samples; these included 173 upregulated and 60 downregulated DEGs. Subsequently, transcription factors, such as TATA‑binding protein 1 (TBP1; hsa_TATAAA_V$TATA_01) and nuclear factor-κB (NF-κB; hsa_V$NFKAPPAB_01) and microRNAs (miRNAs; such as miR‑516‑3p and miR‑23a) were revealed to be associated with 233 DEGs. Notably, further analysis indicated that these DEGs were enriched in certain diseases, including inflammation, fibrosis and immune system diseases, and were also associated with some drugs, including prednisone, collagenase and mycophenolate mofetil, which may provide choice for treatment of UC. In conclusion, this study may provide novel insights into discovering potential molecular targets involved in the pathogenesis and treatment of UC.
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November-2017
Volume 16 Issue 5

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Copy and paste a formatted citation
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Spandidos Publications style
Feng J, Gao Q, Liu Q, Wang F, Lin X, Zhao Q, Liu J and Li J: Integrated strategy of differentially expressed genes associated with ulcerative colitis. Mol Med Rep 16: 7479-7489, 2017.
APA
Feng, J., Gao, Q., Liu, Q., Wang, F., Lin, X., Zhao, Q. ... Li, J. (2017). Integrated strategy of differentially expressed genes associated with ulcerative colitis. Molecular Medicine Reports, 16, 7479-7489. https://doi.org/10.3892/mmr.2017.7509
MLA
Feng, J., Gao, Q., Liu, Q., Wang, F., Lin, X., Zhao, Q., Liu, J., Li, J."Integrated strategy of differentially expressed genes associated with ulcerative colitis". Molecular Medicine Reports 16.5 (2017): 7479-7489.
Chicago
Feng, J., Gao, Q., Liu, Q., Wang, F., Lin, X., Zhao, Q., Liu, J., Li, J."Integrated strategy of differentially expressed genes associated with ulcerative colitis". Molecular Medicine Reports 16, no. 5 (2017): 7479-7489. https://doi.org/10.3892/mmr.2017.7509