Present and future of cancer immunotherapy: A tumor microenvironmental perspective (Review)

  • Authors:
    • Yu Yu
    • Jiuwei Cui
  • View Affiliations

  • Published online on: July 26, 2018     https://doi.org/10.3892/ol.2018.9219
  • Pages: 4105-4113
  • Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Modulation of the tumor microenvironment is becoming an increasingly popular research topic in the field of immunotherapy, and studies regarding immune checkpoint blockades and cancer immunotherapy have pushed cancer immunotherapy to a climax. Simultaneously, the manipulation of the immune regulatory pathway can create an effective immunotherapy strategy; however, the tumor microenvironment serves an important role in suppressing the antitumor immunity by its significant heterogeneity. A number of patients with cancer do not have a good response to monotherapy approaches; therefore, combination strategies are required to achieve optimal therapeutic benefits. Targeting the tumor microenvironment may provide a novel strategy for immunotherapy, break down the resistance of conventional cancer therapy and produce the foundation for personalized precision medicine. The present review summarized the research regarding cancer immunotherapy from the perspective of how the tumor microenvironment affects the immune response, with the aim of proposing a novel strategy for cancer immunotherapy and combination therapy.
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October-2018
Volume 16 Issue 4

Print ISSN: 1792-1074
Online ISSN:1792-1082

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Copy and paste a formatted citation
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Spandidos Publications style
Yu Y and Yu Y: Present and future of cancer immunotherapy: A tumor microenvironmental perspective (Review). Oncol Lett 16: 4105-4113, 2018
APA
Yu, Y., & Yu, Y. (2018). Present and future of cancer immunotherapy: A tumor microenvironmental perspective (Review). Oncology Letters, 16, 4105-4113. https://doi.org/10.3892/ol.2018.9219
MLA
Yu, Y., Cui, J."Present and future of cancer immunotherapy: A tumor microenvironmental perspective (Review)". Oncology Letters 16.4 (2018): 4105-4113.
Chicago
Yu, Y., Cui, J."Present and future of cancer immunotherapy: A tumor microenvironmental perspective (Review)". Oncology Letters 16, no. 4 (2018): 4105-4113. https://doi.org/10.3892/ol.2018.9219