Role of Sirtuin 1 in the pathogenesis of ocular disease (Review)

  • Authors:
    • Mengwen Zhou
    • Jing Luo
    • Huiming Zhang
  • View Affiliations

  • Published online on: April 16, 2018     https://doi.org/10.3892/ijmm.2018.3623
  • Pages: 13-20
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Abstract

Sirtuin (SIRT)1, a member of the SIRT family, is a highly conserved NAD+‑dependent histone deacetylase, which has a regulatory role in numerous physiological and pathological processes by removing acetyl groups from various proteins. SIRT1 controls the activity of numerous transcription factors and cofactors, which impacts the downstream gene expression, and eventually alleviates oxidative stress and associated damage. Numerous studies have revealed that dysfunction of SIRT1 is linked with ocular diseases, including cataract, age‑associated macular degeneration, diabetic retinopathy and glaucoma, while ectopic upregulation of SIRT1 protects against various ocular diseases. In the present review, the significant role of SIRT1 and the potential therapeutic value of modulating SIRT1 expression in ocular development and eye diseases is summarized.
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July-2018
Volume 42 Issue 1

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhou M, Luo J and Zhang H: Role of Sirtuin 1 in the pathogenesis of ocular disease (Review). Int J Mol Med 42: 13-20, 2018
APA
Zhou, M., Luo, J., & Zhang, H. (2018). Role of Sirtuin 1 in the pathogenesis of ocular disease (Review). International Journal of Molecular Medicine, 42, 13-20. https://doi.org/10.3892/ijmm.2018.3623
MLA
Zhou, M., Luo, J., Zhang, H."Role of Sirtuin 1 in the pathogenesis of ocular disease (Review)". International Journal of Molecular Medicine 42.1 (2018): 13-20.
Chicago
Zhou, M., Luo, J., Zhang, H."Role of Sirtuin 1 in the pathogenesis of ocular disease (Review)". International Journal of Molecular Medicine 42, no. 1 (2018): 13-20. https://doi.org/10.3892/ijmm.2018.3623