β-catenin deacetylation is essential for WNT‑induced proliferation of breast cancer cells

  • Authors:
    • Shao-Hua Wang
    • Ning Li
    • Yao Wei
    • Qiu-Rong Li
    • Ze-Ping Yu
  • View Affiliations

  • Published online on: January 8, 2014     https://doi.org/10.3892/mmr.2014.1889
  • Pages: 973-978
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Abstract

Deregulation of the WNT signaling pathway is associated with the development and progression of breast cancer. β-catenin mutations have been found to constitutively activate β-catenin-T-cell factor (TCF) signaling in other types of cancer. β-catenin acetylation regulates β-catenin-TCF4 interaction in WNT signaling, but it remains unknown whether the acetylation of β-catenin is involved in WNT-induced proliferation of breast cancer cells. In this study, a lower level of acetylated β-catenin (K345) was observed in breast cancer tissues. WNT3A stimulated the downregulation of β-catenin acetylation and promoted the proliferation of MCF7 cells. The K345Q mutation in β-catenin inhibited WNT-induced cell growth and axin2/TCF7 upregulation in breast cancer cells. By contrast, K345R mutants could mimic deacetylated β-catenin to generate the WNT-elicited phenotype. Additionally, the acetylation of β-catenin may prime β-catenin for phosphorylation. Further investigation revealed that the deacetylase HDAC6 was responsible for WNT-induced deacetylation of β-catenin in breast cancer cells. In conclusion, the epigenetic modification of β-catenin may be essential for WNT signaling in breast cancer progression, and blocking the occurrence of β-catenin acetylation may provide a novel therapeutic approach for breast cancer.
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2014-March
Volume 9 Issue 3

Print ISSN: 1791-2997
Online ISSN:1791-3004

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Spandidos
Wang S, Li N, Wei Y, Li Q and Yu Z: β-catenin deacetylation is essential for WNT‑induced proliferation of breast cancer cells. Mol Med Rep 9: 973-978, 2014
APA
Wang, S., Li, N., Wei, Y., Li, Q., & Yu, Z. (2014). β-catenin deacetylation is essential for WNT‑induced proliferation of breast cancer cells. Molecular Medicine Reports, 9, 973-978. https://doi.org/10.3892/mmr.2014.1889
MLA
Wang, S., Li, N., Wei, Y., Li, Q., Yu, Z."β-catenin deacetylation is essential for WNT‑induced proliferation of breast cancer cells". Molecular Medicine Reports 9.3 (2014): 973-978.
Chicago
Wang, S., Li, N., Wei, Y., Li, Q., Yu, Z."β-catenin deacetylation is essential for WNT‑induced proliferation of breast cancer cells". Molecular Medicine Reports 9, no. 3 (2014): 973-978. https://doi.org/10.3892/mmr.2014.1889